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The map label for this gene is paaE [H]

Identifier: 86750747

GI number: 86750747

Start: 4174767

End: 4175864

Strand: Reverse

Name: paaE [H]

Synonym: RPB_3637

Alternate gene names: 86750747

Gene position: 4175864-4174767 (Counterclockwise)

Preceding gene: 86750748

Following gene: 86750745

Centisome position: 78.32

GC content: 67.3

Gene sequence:

>1098_bases
ATGCCCGCCATGAACATCTCTGCCACCATTCCGCGCTTCCATCCGCTGGTGATCCGCGATCTGCGCCGCGAAGGCCGCGA
CGCGATCTCGCTGAGCTTCACCGTCCCGCCGGATCTCGCCGACGCCTACCAGTTCGCCGCGGGTCAGTATCTGACGCTGC
GCACCACGATGGACGGCGAGGAGGTGCGGCGCTCCTATTCGATCTGCTCGGGCCCCGACGACGGCGAATTGCGGATCGCA
GTGAAGAAGATCGACGGCGGCGCGTTCTCGGTGTGGGCGACCGAGGAGCTGAAAGCCGGCGACACGCTCGACGTGATGAC
GCCGACCGGCCGGTTCGGCGTCGCGCCTGCGCCGGACGAGGTCCGCACCTATGTCGGCTTCGCCGCGGGCTCCGGCATCA
CGCCGATCTTGTCGCTGATCAAGGCCGTGTTGGCGCGCGAGCCGGCGAGCCGGTTCTTCCTGTTCTACGGCAACCGCAGC
ACCGATCAGATCCTGTTTCGCGACACGCTGGAGACGCTCAAGGATCGTTACTTGCAGCGCTTCGCGGTGTTCCACGTTCT
CTCTCAGGAAGAGCAGGACGTGCCGGTGATGCAGGGCCGGCTCGATCGCGACAAGGTGCGGCTGCTGCTGACCGCGATGC
TGCCCGCCGCGAGCGTCGATCACGTCTTCGTCTGCGGCCCGATCGGGATGAGCGACGACGTCGAGGCCGCCTGCCGCGAA
CTCGGCATCGCCGAGGCGCGCATTCATGTCGAGCGCTTCGTCTCCGGCCTCGGCGGCAAGCCGCGACCCAAGGCGGTGGT
CGCGCCGGGCGCGCCGCCGAAAGCGATCGCGTCGCTGATCATCGACGGCAAGCGCCGCGAAGTGCCGGTGGCGGAGGGCG
AGGCGATCCTCGACGCAGCGTTACGTGCCGGCGTTGACCTGCCCTTCGCCTGCAAAGGCGGAATGTGCTCCACTTGCCGC
GCCAAGCTGGTCGAGGGCCAGGCCCCGATGGAGCTGAACTACTCGCTGGAGCCGTGGGAGCTGAAAGCCGGCTTCATCCT
GACCTGCCAGGCGAAACCGACCACCGATCGGGTGGTGGTGGACTACGATCACTTGTAG

Upstream 100 bases:

>100_bases
TTCGGCTCGACCTCCTGCAAGGCGCTGTGGCGCTGCAAGGTGTGCCGCGAGCCGTTCGATTACTTCAAATGTCACTGATA
GGTCAAATGTCATTGAGCCG

Downstream 100 bases:

>100_bases
AGAGCCGGCCGCGCCGAATGGCGCGTGCCGGATGCCGCTATGTCGGCCGGGCACTCATCGTCAGCAGGTCGTAGCGCGCG
ACCGGCTCGTTGTTCTGGTT

Product: phenylacetate-CoA oxygenase/reductase, PaaK subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MPAMNISATIPRFHPLVIRDLRREGRDAISLSFTVPPDLADAYQFAAGQYLTLRTTMDGEEVRRSYSICSGPDDGELRIA
VKKIDGGAFSVWATEELKAGDTLDVMTPTGRFGVAPAPDEVRTYVGFAAGSGITPILSLIKAVLAREPASRFFLFYGNRS
TDQILFRDTLETLKDRYLQRFAVFHVLSQEEQDVPVMQGRLDRDKVRLLLTAMLPAASVDHVFVCGPIGMSDDVEAACRE
LGIAEARIHVERFVSGLGGKPRPKAVVAPGAPPKAIASLIIDGKRREVPVAEGEAILDAALRAGVDLPFACKGGMCSTCR
AKLVEGQAPMELNYSLEPWELKAGFILTCQAKPTTDRVVVDYDHL

Sequences:

>Translated_365_residues
MPAMNISATIPRFHPLVIRDLRREGRDAISLSFTVPPDLADAYQFAAGQYLTLRTTMDGEEVRRSYSICSGPDDGELRIA
VKKIDGGAFSVWATEELKAGDTLDVMTPTGRFGVAPAPDEVRTYVGFAAGSGITPILSLIKAVLAREPASRFFLFYGNRS
TDQILFRDTLETLKDRYLQRFAVFHVLSQEEQDVPVMQGRLDRDKVRLLLTAMLPAASVDHVFVCGPIGMSDDVEAACRE
LGIAEARIHVERFVSGLGGKPRPKAVVAPGAPPKAIASLIIDGKRREVPVAEGEAILDAALRAGVDLPFACKGGMCSTCR
AKLVEGQAPMELNYSLEPWELKAGFILTCQAKPTTDRVVVDYDHL
>Mature_364_residues
PAMNISATIPRFHPLVIRDLRREGRDAISLSFTVPPDLADAYQFAAGQYLTLRTTMDGEEVRRSYSICSGPDDGELRIAV
KKIDGGAFSVWATEELKAGDTLDVMTPTGRFGVAPAPDEVRTYVGFAAGSGITPILSLIKAVLAREPASRFFLFYGNRST
DQILFRDTLETLKDRYLQRFAVFHVLSQEEQDVPVMQGRLDRDKVRLLLTAMLPAASVDHVFVCGPIGMSDDVEAACREL
GIAEARIHVERFVSGLGGKPRPKAVVAPGAPPKAIASLIIDGKRREVPVAEGEAILDAALRAGVDLPFACKGGMCSTCRA
KLVEGQAPMELNYSLEPWELKAGFILTCQAKPTTDRVVVDYDHL

Specific function: May be part of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation [H]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Homo sapiens, GI49574502, Length=219, Percent_Identity=30.5936073059361, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI284448553, Length=218, Percent_Identity=27.0642201834862, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI6552328, Length=218, Percent_Identity=27.0642201834862, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI193794826, Length=218, Percent_Identity=27.0642201834862, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI284448551, Length=251, Percent_Identity=25.8964143426295, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI4503327, Length=218, Percent_Identity=27.0642201834862, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1787658, Length=352, Percent_Identity=45.4545454545455, Blast_Score=321, Evalue=4e-89,
Organism=Escherichia coli, GI1787098, Length=330, Percent_Identity=26.6666666666667, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788903, Length=245, Percent_Identity=28.1632653061224, Blast_Score=85, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6323510, Length=201, Percent_Identity=29.8507462686567, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6322146, Length=219, Percent_Identity=27.3972602739726, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323552, Length=206, Percent_Identity=27.6699029126214, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322699, Length=214, Percent_Identity=23.8317757009346, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR001709
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR011884
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 39764; Mature: 39633

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAMNISATIPRFHPLVIRDLRREGRDAISLSFTVPPDLADAYQFAAGQYLTLRTTMDGE
CCCCCCEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCEEEEEECCCHH
EVRRSYSICSGPDDGELRIAVKKIDGGAFSVWATEELKAGDTLDVMTPTGRFGVAPAPDE
HHHHHHCCCCCCCCCEEEEEEEEECCCEEEEEECHHCCCCCEEEEECCCCCCCCCCCCHH
VRTYVGFAAGSGITPILSLIKAVLAREPASRFFLFYGNRSTDQILFRDTLETLKDRYLQR
HHHHHHECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
FAVFHVLSQEEQDVPVMQGRLDRDKVRLLLTAMLPAASVDHVFVCGPIGMSDDVEAACRE
HHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHH
LGIAEARIHVERFVSGLGGKPRPKAVVAPGAPPKAIASLIIDGKRREVPVAEGEAILDAA
CCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHH
LRAGVDLPFACKGGMCSTCRAKLVEGQAPMELNYSLEPWELKAGFILTCQAKPTTDRVVV
HHCCCCCCCCCCCCCCHHHHHHHHCCCCCEEECCCCCCEEECCCEEEEEECCCCCCEEEE
DYDHL
EECCC
>Mature Secondary Structure 
PAMNISATIPRFHPLVIRDLRREGRDAISLSFTVPPDLADAYQFAAGQYLTLRTTMDGE
CCCCCEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCEEEEEECCCHH
EVRRSYSICSGPDDGELRIAVKKIDGGAFSVWATEELKAGDTLDVMTPTGRFGVAPAPDE
HHHHHHCCCCCCCCCEEEEEEEEECCCEEEEEECHHCCCCCEEEEECCCCCCCCCCCCHH
VRTYVGFAAGSGITPILSLIKAVLAREPASRFFLFYGNRSTDQILFRDTLETLKDRYLQR
HHHHHHECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
FAVFHVLSQEEQDVPVMQGRLDRDKVRLLLTAMLPAASVDHVFVCGPIGMSDDVEAACRE
HHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHH
LGIAEARIHVERFVSGLGGKPRPKAVVAPGAPPKAIASLIIDGKRREVPVAEGEAILDAA
CCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHH
LRAGVDLPFACKGGMCSTCRAKLVEGQAPMELNYSLEPWELKAGFILTCQAKPTTDRVVV
HHCCCCCCCCCCCCCCHHHHHHHHCCCCCEEECCCCCCEEECCCEEEEEECCCCCCEEEE
DYDHL
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD [C]

Metal ions: Iron-Sulfur [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]