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The map label for this gene is yeaU [C]

Identifier: 86750736

GI number: 86750736

Start: 4161511

End: 4162596

Strand: Reverse

Name: yeaU [C]

Synonym: RPB_3626

Alternate gene names: 86750736

Gene position: 4162596-4161511 (Counterclockwise)

Preceding gene: 86750738

Following gene: 86750731

Centisome position: 78.07

GC content: 62.52

Gene sequence:

>1086_bases
ATGGATCAGAACATGAAGAAGGACGAATACCGGATCGCCGTCATCCCCGGCGACGGCATCGGCAAGGAGGTGATGCCGGA
AGGGCTTCGTGCGCTCGAAGCCGCCGCGAAGAAGCATCGCGTCAAGCTGAGATTCGATCATTTCGACTTCGCCAGCTATG
ACTATTATGAAAAGCACGGCCAGATGATGCCGGACGATTGGAAGAATCTGATCGGCGGCCACGACGCGATCTTCTTCGGC
GCGGTGGGCTGGCCGCAGAAGATCCCGGACCACATCTCGCTGTGGGGGTCGCTGATCAAGTTCCGTCGCGAGTTCGATCA
ATACGTCAATCTGCGCCCGGTGCGGCTGATGCCTGGCGTGCCGTCGCCGCTCGCCGGGCGCAAGCCGGGCGATATCGATT
TCTGGGTGGTGCGCGAGAACACCGAGGGGGAATATTCATCGGTCGGCGGCCGGATGTTTCCCGACACCGACCGCGAATTC
GTCACCCAGCAGACGGTGATGACGCGGACCGGTGTCGACCGCATCCTGAAATTCGCCTTCGACCTCGCGCAATCGCGGCC
GAAGCGGCATCTGACGTCGGCGACCAAGTCGAACGGCATCTCGATCACCATGCCGTATTGGGACGAGCGGGTCGAGGCGA
TGGCGAAGGCCTATCCCGACGTGACGTGGGACAAGTATCACATCGATATCCTCACCGCGCATTTCGTGCTGCATCCGGAC
TGGTTCGACGTCGTCGTCGGCTCCAACCTGTTCGGCGACATCCTGTCCGATCTCGGCCCGGCCTGTACCGGCACGATCGG
TATTGCGCCGTCGGGCAACATCAATCCGGACGGCGATTTCCCGAGCGTGTTCGAGCCGGTGCACGGCTCGGCGCCGGACA
TTGCGGGGCAGGGCATCGCCAATCCGATCGGGATGATCTGGTCGGGCGCGATGATGCTCGAACACCTCGGTGAGAAGACC
GCTGCGGATTCGATCGTCAAGGCGATCGAGCGGACGCTGGCGGAGGGCACGCTGCGCACGCGTGATCTCGGTGGTCAGGC
CGACACGACGGCTTGCGGCAAAGCTGTGGCGGAAATGGTGGAGTAG

Upstream 100 bases:

>100_bases
CTCGCCGTGGCAAATGTGTGCGGTGCAGCGTTGATCGCCGGCGGCGTTTGGTCCACATCGTTGTCGCCTGCTCGGCTTTC
GAAATCGGCGAACTCACGCG

Downstream 100 bases:

>100_bases
GGACGTGCGCTGCTAACGCCGGATGGCGATGACCGGTCTCTGGCTACGTCGGCCGACCGGGGTGGACGGCTTGCAGATCG
TCCGGCGACGGAGCAGCGGC

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MDQNMKKDEYRIAVIPGDGIGKEVMPEGLRALEAAAKKHRVKLRFDHFDFASYDYYEKHGQMMPDDWKNLIGGHDAIFFG
AVGWPQKIPDHISLWGSLIKFRREFDQYVNLRPVRLMPGVPSPLAGRKPGDIDFWVVRENTEGEYSSVGGRMFPDTDREF
VTQQTVMTRTGVDRILKFAFDLAQSRPKRHLTSATKSNGISITMPYWDERVEAMAKAYPDVTWDKYHIDILTAHFVLHPD
WFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNINPDGDFPSVFEPVHGSAPDIAGQGIANPIGMIWSGAMMLEHLGEKT
AADSIVKAIERTLAEGTLRTRDLGGQADTTACGKAVAEMVE

Sequences:

>Translated_361_residues
MDQNMKKDEYRIAVIPGDGIGKEVMPEGLRALEAAAKKHRVKLRFDHFDFASYDYYEKHGQMMPDDWKNLIGGHDAIFFG
AVGWPQKIPDHISLWGSLIKFRREFDQYVNLRPVRLMPGVPSPLAGRKPGDIDFWVVRENTEGEYSSVGGRMFPDTDREF
VTQQTVMTRTGVDRILKFAFDLAQSRPKRHLTSATKSNGISITMPYWDERVEAMAKAYPDVTWDKYHIDILTAHFVLHPD
WFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNINPDGDFPSVFEPVHGSAPDIAGQGIANPIGMIWSGAMMLEHLGEKT
AADSIVKAIERTLAEGTLRTRDLGGQADTTACGKAVAEMVE
>Mature_361_residues
MDQNMKKDEYRIAVIPGDGIGKEVMPEGLRALEAAAKKHRVKLRFDHFDFASYDYYEKHGQMMPDDWKNLIGGHDAIFFG
AVGWPQKIPDHISLWGSLIKFRREFDQYVNLRPVRLMPGVPSPLAGRKPGDIDFWVVRENTEGEYSSVGGRMFPDTDREF
VTQQTVMTRTGVDRILKFAFDLAQSRPKRHLTSATKSNGISITMPYWDERVEAMAKAYPDVTWDKYHIDILTAHFVLHPD
WFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNINPDGDFPSVFEPVHGSAPDIAGQGIANPIGMIWSGAMMLEHLGEKT
AADSIVKAIERTLAEGTLRTRDLGGQADTTACGKAVAEMVE

Specific function: Has multiple catalytic activities. Apart from catalyzing the oxidation of (+)-tartrate to oxaloglycolate, also converts meso-tartrate to D-glycerate and catalyzes the oxidative decarboxylation of D-malate to pyruvate [H]

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=340, Percent_Identity=30.8823529411765, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI4758582, Length=351, Percent_Identity=30.1994301994302, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI28178821, Length=348, Percent_Identity=28.1609195402299, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI28178816, Length=341, Percent_Identity=27.5659824046921, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI28178838, Length=340, Percent_Identity=29.7058823529412, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI28178819, Length=201, Percent_Identity=30.3482587064677, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI1788101, Length=355, Percent_Identity=65.3521126760563, Blast_Score=489, Evalue=1e-139,
Organism=Escherichia coli, GI87081683, Length=349, Percent_Identity=38.10888252149, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1787381, Length=370, Percent_Identity=28.1081081081081, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71986051, Length=353, Percent_Identity=32.0113314447592, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17550882, Length=351, Percent_Identity=29.9145299145299, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI25144293, Length=357, Percent_Identity=28.2913165266106, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17505779, Length=249, Percent_Identity=30.1204819277108, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6322097, Length=368, Percent_Identity=35.8695652173913, Blast_Score=202, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6324291, Length=345, Percent_Identity=32.7536231884058, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324709, Length=357, Percent_Identity=31.6526610644258, Blast_Score=152, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6319830, Length=363, Percent_Identity=32.5068870523416, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24643268, Length=361, Percent_Identity=31.3019390581717, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24643270, Length=361, Percent_Identity=31.3019390581717, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24661184, Length=345, Percent_Identity=30.7246376811594, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI281362242, Length=361, Percent_Identity=28.2548476454294, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24648872, Length=361, Percent_Identity=28.2548476454294, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI161078639, Length=253, Percent_Identity=30.8300395256917, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI161078635, Length=253, Percent_Identity=30.8300395256917, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI161078637, Length=253, Percent_Identity=30.8300395256917, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI161078633, Length=253, Percent_Identity=30.8300395256917, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24650122, Length=253, Percent_Identity=30.8300395256917, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI20130355, Length=356, Percent_Identity=25.8426966292135, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI45550436, Length=254, Percent_Identity=24.4094488188976, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 40042; Mature: 40042

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQNMKKDEYRIAVIPGDGIGKEVMPEGLRALEAAAKKHRVKLRFDHFDFASYDYYEKHG
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCHHHHHCC
QMMPDDWKNLIGGHDAIFFGAVGWPQKIPDHISLWGSLIKFRREFDQYVNLRPVRLMPGV
CCCCHHHHHHHCCCCEEEEECCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
PSPLAGRKPGDIDFWVVRENTEGEYSSVGGRMFPDTDREFVTQQTVMTRTGVDRILKFAF
CCCCCCCCCCCEEEEEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DLAQSRPKRHLTSATKSNGISITMPYWDERVEAMAKAYPDVTWDKYHIDILTAHFVLHPD
HHHHCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEECCC
WFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNINPDGDFPSVFEPVHGSAPDIAGQGIA
HHHHHHCCHHHHHHHHHCCCHHCCCEECCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCC
NPIGMIWSGAMMLEHLGEKTAADSIVKAIERTLAEGTLRTRDLGGQADTTACGKAVAEMV
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHH
E
C
>Mature Secondary Structure
MDQNMKKDEYRIAVIPGDGIGKEVMPEGLRALEAAAKKHRVKLRFDHFDFASYDYYEKHG
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCHHHHHCC
QMMPDDWKNLIGGHDAIFFGAVGWPQKIPDHISLWGSLIKFRREFDQYVNLRPVRLMPGV
CCCCHHHHHHHCCCCEEEEECCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCC
PSPLAGRKPGDIDFWVVRENTEGEYSSVGGRMFPDTDREFVTQQTVMTRTGVDRILKFAF
CCCCCCCCCCCEEEEEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DLAQSRPKRHLTSATKSNGISITMPYWDERVEAMAKAYPDVTWDKYHIDILTAHFVLHPD
HHHHCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEECCC
WFDVVVGSNLFGDILSDLGPACTGTIGIAPSGNINPDGDFPSVFEPVHGSAPDIAGQGIA
HHHHHHCCHHHHHHHHHCCCHHCCCEECCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCC
NPIGMIWSGAMMLEHLGEKTAADSIVKAIERTLAEGTLRTRDLGGQADTTACGKAVAEMV
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHH
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8053675; 2184888; 8457548 [H]