Click here to switch to the map view.

The map label for this gene is fabG [C]

Identifier: 86750699

GI number: 86750699

Start: 4113768

End: 4114682

Strand: Direct

Name: fabG [C]

Synonym: RPB_3589

Alternate gene names: 86750699

Gene position: 4113768-4114682 (Clockwise)

Preceding gene: 86750698

Following gene: 86750704

Centisome position: 77.16

GC content: 66.56

Gene sequence:

>915_bases
ATGGCCAAGGCACTCGACGGCAAAGTCATCATCGTCACCGGCGCGGGGCGCGGCATTGGGCGCGAGATCGCGCTGCTCGC
GGCGCGCGAGGGCGCCAAGGTCGTCGTCAACGATCCGGGCGTCGCCGCCGACGGCTCGGGCACTGACGCCTCGCCGGCCG
AGCAGGTGGTCGAGGAGATCAAGAAGGAAGGCGGCATCGCGGTCGCCAATTTCGAAAGCGTGGCGGAAGCCGTGCCGGCC
AGCAAGATCGTCAAGCAGGCGGTCGACACCTGGGGCAAGCTCGACGGCGTCGTCAACAATGCCGGCATCCTGCGCGACGC
GATCTTCCATCGCATGAGCATCGACGCCTTCGAGCAGGTCATCAAGGTGCATCTGATGGGCTCGTTCTACGTGTCGCACG
CTGCCGCGCGCTTGTTCCGCGAGCAGGAGAGCGGGTCGTTCGTGCACTTCACCTCGACCTCGGGGCTGATCGGCAATTTC
GGCCAGGCCAACTACGCCGCCGCCAAGCTCGGCATCGTCGGCCTGTCGAAGTCGATCGCGCTCGACATGCAGCGCTTCAA
CGTCCGCTCCAATTGCGTGTCGCCGTTCGCCTGGTCGCGGCTGATCGGCACCATCCCGACCGAGACCGAAGCCGAAAAGG
CGCGCGTCGCGCGGATGCAGCAGATGGGCCCGGAGAAGATCGCGCCGCTGTCGGTGTTCCTGCTCGGCGATGCGGCGAAG
GACGTCACCGGCCAGATCTTCGCGGTGCGGATGAACGAGATCTTCCTGATGGGCCAGTCGCGCCCGATCCGCTCGGTGCA
CCGCGACGGCGGCTGGACCTGCGAGACGCTGGCCGAGCACGGCATGCCGGCGCTGAAAGGTTCGTTCTACAAGCTCGACC
GCTCCGCCGACATCTTCAACTGGGACGCGATCTGA

Upstream 100 bases:

>100_bases
CCGGCTTCGCTGCGCGACGCCGGGTCGACCTCTCCCCGCGCGCGGGGAGAGGTCATCGCAGACGCATCCACCAACGAACA
ACAACAAGGAGACACACCAC

Downstream 100 bases:

>100_bases
GCATAGCTGCCCTCACCTCTCCCCGCGTGCGGGGAGAGGCTGCACTTCGAGAGTTGCGGTCGCCATGATGATCACCCTCC
CCTGGAGGGGGAGGGTCGCT

Product: Short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MAKALDGKVIIVTGAGRGIGREIALLAAREGAKVVVNDPGVAADGSGTDASPAEQVVEEIKKEGGIAVANFESVAEAVPA
SKIVKQAVDTWGKLDGVVNNAGILRDAIFHRMSIDAFEQVIKVHLMGSFYVSHAAARLFREQESGSFVHFTSTSGLIGNF
GQANYAAAKLGIVGLSKSIALDMQRFNVRSNCVSPFAWSRLIGTIPTETEAEKARVARMQQMGPEKIAPLSVFLLGDAAK
DVTGQIFAVRMNEIFLMGQSRPIRSVHRDGGWTCETLAEHGMPALKGSFYKLDRSADIFNWDAI

Sequences:

>Translated_304_residues
MAKALDGKVIIVTGAGRGIGREIALLAAREGAKVVVNDPGVAADGSGTDASPAEQVVEEIKKEGGIAVANFESVAEAVPA
SKIVKQAVDTWGKLDGVVNNAGILRDAIFHRMSIDAFEQVIKVHLMGSFYVSHAAARLFREQESGSFVHFTSTSGLIGNF
GQANYAAAKLGIVGLSKSIALDMQRFNVRSNCVSPFAWSRLIGTIPTETEAEKARVARMQQMGPEKIAPLSVFLLGDAAK
DVTGQIFAVRMNEIFLMGQSRPIRSVHRDGGWTCETLAEHGMPALKGSFYKLDRSADIFNWDAI
>Mature_303_residues
AKALDGKVIIVTGAGRGIGREIALLAAREGAKVVVNDPGVAADGSGTDASPAEQVVEEIKKEGGIAVANFESVAEAVPAS
KIVKQAVDTWGKLDGVVNNAGILRDAIFHRMSIDAFEQVIKVHLMGSFYVSHAAARLFREQESGSFVHFTSTSGLIGNFG
QANYAAAKLGIVGLSKSIALDMQRFNVRSNCVSPFAWSRLIGTIPTETEAEKARVARMQQMGPEKIAPLSVFLLGDAAKD
VTGQIFAVRMNEIFLMGQSRPIRSVHRDGGWTCETLAEHGMPALKGSFYKLDRSADIFNWDAI

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=245, Percent_Identity=44.0816326530612, Blast_Score=191, Evalue=6e-49,
Organism=Homo sapiens, GI15277342, Length=251, Percent_Identity=32.6693227091633, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=30.0411522633745, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4503817, Length=232, Percent_Identity=25.4310344827586, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI19923817, Length=261, Percent_Identity=27.9693486590038, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI32483357, Length=254, Percent_Identity=26.3779527559055, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI59889578, Length=217, Percent_Identity=27.6497695852535, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI66933014, Length=261, Percent_Identity=29.1187739463602, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI31542939, Length=210, Percent_Identity=30.4761904761905, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=33.0739299610895, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=32.258064516129, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787526, Length=252, Percent_Identity=29.3650793650794, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI87082100, Length=252, Percent_Identity=28.968253968254, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=27.6, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87082160, Length=253, Percent_Identity=26.4822134387352, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=27.3469387755102, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786812, Length=257, Percent_Identity=26.8482490272374, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=30.7086614173228, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789208, Length=260, Percent_Identity=25, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789057, Length=190, Percent_Identity=28.9473684210526, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=247, Percent_Identity=41.7004048582996, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25147288, Length=253, Percent_Identity=33.201581027668, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=32.4110671936759, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17564282, Length=197, Percent_Identity=29.9492385786802, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=199, Percent_Identity=30.1507537688442, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=204, Percent_Identity=28.921568627451, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=298, Percent_Identity=28.5234899328859, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=204, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=207, Percent_Identity=29.4685990338164, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=187, Percent_Identity=29.9465240641711, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=252, Percent_Identity=23.8095238095238, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17567345, Length=182, Percent_Identity=25.8241758241758, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=247, Percent_Identity=28.3400809716599, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=248, Percent_Identity=27.4193548387097, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=258, Percent_Identity=24.031007751938, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=247, Percent_Identity=42.5101214574899, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324126, Length=260, Percent_Identity=30, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI18859837, Length=237, Percent_Identity=41.3502109704641, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=33.469387755102, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=29.4573643410853, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24644339, Length=196, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24640492, Length=200, Percent_Identity=24.5, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=25.4980079681275, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737361, Length=201, Percent_Identity=27.8606965174129, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281364892, Length=199, Percent_Identity=24.6231155778894, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21357673, Length=252, Percent_Identity=26.1904761904762, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 32535; Mature: 32403

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKALDGKVIIVTGAGRGIGREIALLAAREGAKVVVNDPGVAADGSGTDASPAEQVVEEI
CCCCCCCCEEEEECCCCCCCHHEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHH
KKEGGIAVANFESVAEAVPASKIVKQAVDTWGKLDGVVNNAGILRDAIFHRMSIDAFEQV
HHCCCEEEECHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IKVHLMGSFYVSHAAARLFREQESGSFVHFTSTSGLIGNFGQANYAAAKLGIVGLSKSIA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHEECCHHHH
LDMQRFNVRSNCVSPFAWSRLIGTIPTETEAEKARVARMQQMGPEKIAPLSVFLLGDAAK
HHHHHHCHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
DVTGQIFAVRMNEIFLMGQSRPIRSVHRDGGWTCETLAEHGMPALKGSFYKLDRSADIFN
CCCCEEEEEEEEEEEEECCCCCHHHHHCCCCCCHHHHHHCCCCHHCCCEEEECCCCCCEE
WDAI
CCCC
>Mature Secondary Structure 
AKALDGKVIIVTGAGRGIGREIALLAAREGAKVVVNDPGVAADGSGTDASPAEQVVEEI
CCCCCCCEEEEECCCCCCCHHEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHH
KKEGGIAVANFESVAEAVPASKIVKQAVDTWGKLDGVVNNAGILRDAIFHRMSIDAFEQV
HHCCCEEEECHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IKVHLMGSFYVSHAAARLFREQESGSFVHFTSTSGLIGNFGQANYAAAKLGIVGLSKSIA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHEECCHHHH
LDMQRFNVRSNCVSPFAWSRLIGTIPTETEAEKARVARMQQMGPEKIAPLSVFLLGDAAK
HHHHHHCHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
DVTGQIFAVRMNEIFLMGQSRPIRSVHRDGGWTCETLAEHGMPALKGSFYKLDRSADIFN
CCCCEEEEEEEEEEEEECCCCCHHHHHCCCCCCHHHHHHCCCCHHCCCEEEECCCCCCEE
WDAI
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]