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The map label for this gene is sul [H]

Identifier: 86750643

GI number: 86750643

Start: 4045003

End: 4045869

Strand: Direct

Name: sul [H]

Synonym: RPB_3533

Alternate gene names: 86750643

Gene position: 4045003-4045869 (Clockwise)

Preceding gene: 86750641

Following gene: 86750644

Centisome position: 75.87

GC content: 71.28

Gene sequence:

>867_bases
ATGAGCGCAGCGCAGCAAACCCCAGCGCCTCCCACCGCGACCGGCGCCGCCGCGTTGCGGGCGCTGCTGGCGCGCCCGGT
GCCGGTGGTGATGGGCATTCTCAACGTCACCCCCGATTCGTTCTCCGACGGCGGCGACTTTCTCGGGCCCGAGCGGGCGC
GGGCGCATGCGGCGCGGATGATCGCGGACGGCGCCGACATCATCGACATCGGCGCCGAGAGCACCCGCCCCTACGGGTCG
ACGCCGGTCTCGGCCGACGAGGAGCGGCGGCGGCTGGCGCCGGTGCTGGCGGCGGTCGCAGCACTCGGCGCGCCGGTGTC
GATCGACAGCATGAAGGCCGAGGTGGTGGCCTGGGCGCTCGACCATGGGGCTGCGATCGCCAACGACGTCTGGGGCCTGC
AGCGCGATCCGGCGATGGCGGAGGTCGTCGCGGCGCGCGGCGCGCCGGTGATCGTGATGCATAATCGCGACGACGCCGAC
CCGTCGATCGATATCGTCGCTGATATCAACGCGTTCTTCGAACGCTCGCTGGCGATCGCCGCCCGCGCCGGCATCGCCGA
GCACAGCATCGTGCTCGATCCCGGCATCGGCTTCGGCAAGACGCCGCAGCAGAGCATGATCGCGCTGGCGCGGCTGGGCG
CCTTCGCGCATTTCGGCCTGCCCGTGCTGGTCGGCGCCTCGCGCAAGCGTTTCATCAGCACGGTGGCGCCGTCGGAACCG
AAGCAGCGGCTCGGCGGTTCGATCGCCGCGCATCTCATCGCGATGGAGAACGGCGCGCGAATCATCCGCGCCCACGACGT
CGCCGACACCGCGCAGGCGCTCAAAGTCGCGCACGCGATCAGGACCAGCAGCGAGGACAGACGATGA

Upstream 100 bases:

>100_bases
TCACGCCCATCGCTGGCATTAGACAGTACCTCGAATTCGCGTCCCTCCCACAAGACACCCCCGCTTGACTCCCCGCCGCT
TCCCGCGCAAAGCGCTGGCC

Downstream 100 bases:

>100_bases
CCGACACCATCTTCATCACCGGCCTGGTGCTGCACGCGCGGCACGGCGTGATGGATCACGAGACCGAAGTCGGCCAGCGC
TTCGTGATCGATCTCGAACT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSAAQQTPAPPTATGAAALRALLARPVPVVMGILNVTPDSFSDGGDFLGPERARAHAARMIADGADIIDIGAESTRPYGS
TPVSADEERRRLAPVLAAVAALGAPVSIDSMKAEVVAWALDHGAAIANDVWGLQRDPAMAEVVAARGAPVIVMHNRDDAD
PSIDIVADINAFFERSLAIAARAGIAEHSIVLDPGIGFGKTPQQSMIALARLGAFAHFGLPVLVGASRKRFISTVAPSEP
KQRLGGSIAAHLIAMENGARIIRAHDVADTAQALKVAHAIRTSSEDRR

Sequences:

>Translated_288_residues
MSAAQQTPAPPTATGAAALRALLARPVPVVMGILNVTPDSFSDGGDFLGPERARAHAARMIADGADIIDIGAESTRPYGS
TPVSADEERRRLAPVLAAVAALGAPVSIDSMKAEVVAWALDHGAAIANDVWGLQRDPAMAEVVAARGAPVIVMHNRDDAD
PSIDIVADINAFFERSLAIAARAGIAEHSIVLDPGIGFGKTPQQSMIALARLGAFAHFGLPVLVGASRKRFISTVAPSEP
KQRLGGSIAAHLIAMENGARIIRAHDVADTAQALKVAHAIRTSSEDRR
>Mature_287_residues
SAAQQTPAPPTATGAAALRALLARPVPVVMGILNVTPDSFSDGGDFLGPERARAHAARMIADGADIIDIGAESTRPYGST
PVSADEERRRLAPVLAAVAALGAPVSIDSMKAEVVAWALDHGAAIANDVWGLQRDPAMAEVVAARGAPVIVMHNRDDADP
SIDIVADINAFFERSLAIAARAGIAEHSIVLDPGIGFGKTPQQSMIALARLGAFAHFGLPVLVGASRKRFISTVAPSEPK
QRLGGSIAAHLIAMENGARIIRAHDVADTAQALKVAHAIRTSSEDRR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=268, Percent_Identity=44.0298507462687, Blast_Score=204, Evalue=7e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29922; Mature: 29791

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAQQTPAPPTATGAAALRALLARPVPVVMGILNVTPDSFSDGGDFLGPERARAHAARM
CCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
IADGADIIDIGAESTRPYGSTPVSADEERRRLAPVLAAVAALGAPVSIDSMKAEVVAWAL
HHCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DHGAAIANDVWGLQRDPAMAEVVAARGAPVIVMHNRDDADPSIDIVADINAFFERSLAIA
HCCCHHHHHHCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHH
ARAGIAEHSIVLDPGIGFGKTPQQSMIALARLGAFAHFGLPVLVGASRKRFISTVAPSEP
HHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHEECCCHHHHHHHCCCCCH
KQRLGGSIAAHLIAMENGARIIRAHDVADTAQALKVAHAIRTSSEDRR
HHHHCHHHHHHHEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAAQQTPAPPTATGAAALRALLARPVPVVMGILNVTPDSFSDGGDFLGPERARAHAARM
CCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
IADGADIIDIGAESTRPYGSTPVSADEERRRLAPVLAAVAALGAPVSIDSMKAEVVAWAL
HHCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DHGAAIANDVWGLQRDPAMAEVVAARGAPVIVMHNRDDADPSIDIVADINAFFERSLAIA
HCCCHHHHHHCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHH
ARAGIAEHSIVLDPGIGFGKTPQQSMIALARLGAFAHFGLPVLVGASRKRFISTVAPSEP
HHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCHHEECCCHHHHHHHCCCCCH
KQRLGGSIAAHLIAMENGARIIRAHDVADTAQALKVAHAIRTSSEDRR
HHHHCHHHHHHHEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]