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The map label for this gene is folB [H]

Identifier: 86750644

GI number: 86750644

Start: 4045866

End: 4046243

Strand: Direct

Name: folB [H]

Synonym: RPB_3534

Alternate gene names: 86750644

Gene position: 4045866-4046243 (Clockwise)

Preceding gene: 86750643

Following gene: 86750645

Centisome position: 75.88

GC content: 66.14

Gene sequence:

>378_bases
ATGACCGACACCATCTTCATCACCGGCCTGGTGCTGCACGCGCGGCACGGCGTGATGGATCACGAGACCGAAGTCGGCCA
GCGCTTCGTGATCGATCTCGAACTCGCCGCCGACCTCACCGAGTCCTCGCGCACCGATCGCCTCGCCGACACCGTGTCCT
ATTCCAACGTGGTGGCCTGCGCCACCGCGGCGTTCAAGGACGCCAACTACAAACTGCTCGAACGCGCCGCCGGCGCGGTC
GCCGACGCGATCCTGGCGGCATTCGACAAAATCGGTTCGGTGAAGATCACCGTGCACAAGCCGCACGCGCCGATCGCGGC
GATCTTCGACGACGTCGGCGTGATCATCACCCGCGCGCGGCAGCCCTCGCATGGCTGA

Upstream 100 bases:

>100_bases
TGGAGAACGGCGCGCGAATCATCCGCGCCCACGACGTCGCCGACACCGCGCAGGCGCTCAAAGTCGCGCACGCGATCAGG
ACCAGCAGCGAGGACAGACG

Downstream 100 bases:

>100_bases
GGCGCTGATCGCGCTCGGCGGCAATGTCGGCGACGTCCGCGCGACGTTCGACAAGGCGATCGCCAATATCTGCGGCATGA
CGCAGGGCGAACTGCTCGCC

Product: dihydroneopterin aldolase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 125; Mature: 124

Protein sequence:

>125_residues
MTDTIFITGLVLHARHGVMDHETEVGQRFVIDLELAADLTESSRTDRLADTVSYSNVVACATAAFKDANYKLLERAAGAV
ADAILAAFDKIGSVKITVHKPHAPIAAIFDDVGVIITRARQPSHG

Sequences:

>Translated_125_residues
MTDTIFITGLVLHARHGVMDHETEVGQRFVIDLELAADLTESSRTDRLADTVSYSNVVACATAAFKDANYKLLERAAGAV
ADAILAAFDKIGSVKITVHKPHAPIAAIFDDVGVIITRARQPSHG
>Mature_124_residues
TDTIFITGLVLHARHGVMDHETEVGQRFVIDLELAADLTESSRTDRLADTVSYSNVVACATAAFKDANYKLLERAAGAVA
DAILAAFDKIGSVKITVHKPHAPIAAIFDDVGVIITRARQPSHG

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin [H]

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=116, Percent_Identity=35.3448275862069, Blast_Score=67, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 13384; Mature: 13253

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTIFITGLVLHARHGVMDHETEVGQRFVIDLELAADLTESSRTDRLADTVSYSNVVAC
CCCEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHH
ATAAFKDANYKLLERAAGAVADAILAAFDKIGSVKITVHKPHAPIAAIFDDVGVIITRAR
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHEEECCC
QPSHG
CCCCC
>Mature Secondary Structure 
TDTIFITGLVLHARHGVMDHETEVGQRFVIDLELAADLTESSRTDRLADTVSYSNVVAC
CCEEEEHHHHHHHHCCCCCCCCCCCCEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHH
ATAAFKDANYKLLERAAGAVADAILAAFDKIGSVKITVHKPHAPIAAIFDDVGVIITRAR
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHEEECCC
QPSHG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]