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The map label for this gene is phoP [H]

Identifier: 86750565

GI number: 86750565

Start: 3960940

End: 3961713

Strand: Reverse

Name: phoP [H]

Synonym: RPB_3454

Alternate gene names: 86750565

Gene position: 3961713-3960940 (Counterclockwise)

Preceding gene: 86750566

Following gene: 86750564

Centisome position: 74.31

GC content: 67.96

Gene sequence:

>774_bases
TTGTTCATCGGTCATTCACGCCGCCGCCGCTCATCTTCTTCCCGCCGGTCACAACGCCCGTGCATCGAAACTGCGGAGTT
CAAGGTGCGGCTGCTCGTCGTCGAAGATGATCCCGATCTCAACCGCCAGCTCACCACCGCGCTGACCGACGCCGGCTACG
TCGTCGACCGCGCCTTCGACGGCGAGGAGGGGCACTTCCTCGGCGACACCGAGCCCTATGACGCGGTGGTGCTGGACATC
GGCCTGCCGAAGATGGACGGCATCTCGGTGCTGGAAGCCTGGCGCCGCAACGCCCGCGCGATGCCGGTGCTGATCCTGAC
GGCGCGCGACCGCTGGAGCGACAAGGTGCAGGGCTTCGACGCCGGCGCCGACGACTACGTCGCCAAGCCGTTCCACCTCG
AGGAAGTGCTGGCGCGGATCCGCGCGCTGCTGCGCCGCAGCGCCGGCCACGCCCAGTCCGAACTGACCTGTGGGCCGGTG
GTGCTCGACACCCGCACCGGCCGCGTCAGCGTCCGCGGCCATCCGGTCAAGCTGACCTCGCACGAGTATCGGCTGCTGGC
CTATCTGATGCACCATTCCGGCCGGGTGGTGTCGCGCACCGAACTGGTGGAGCATCTCTACGACCAGGATTTCGACCGCG
ACAGCAACACCATCGAGGTGTTCGTCGGCCGCATCCGCAAGAAGCTCGACGTCGACATCATCCAGACCGTGCGCGGCCTC
GGCTATCTGCTGACGCCGCCGCCGGCCGACGCCCAGCTGGCGAACCGCACGTGA

Upstream 100 bases:

>100_bases
GTCTGCGCCGCCACCGGGCAGGACAGCCCCGGCGTCATCGACAGGCTGGTGAAGGCCGTCGTGAAGAAAAAGTAATGCGC
AAGGCGGCCGCGAGGCGGCG

Downstream 100 bases:

>100_bases
GCGAGCGGGCGAGGGCGTCGCTGCAGAAGCCGGGCTGATGCCGAGCCCGGCCGTCCCCGCGCCGCCGCGCCGCCGCACCA
CCTCGCTGGCCACCCGGCTG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MFIGHSRRRRSSSSRRSQRPCIETAEFKVRLLVVEDDPDLNRQLTTALTDAGYVVDRAFDGEEGHFLGDTEPYDAVVLDI
GLPKMDGISVLEAWRRNARAMPVLILTARDRWSDKVQGFDAGADDYVAKPFHLEEVLARIRALLRRSAGHAQSELTCGPV
VLDTRTGRVSVRGHPVKLTSHEYRLLAYLMHHSGRVVSRTELVEHLYDQDFDRDSNTIEVFVGRIRKKLDVDIIQTVRGL
GYLLTPPPADAQLANRT

Sequences:

>Translated_257_residues
MFIGHSRRRRSSSSRRSQRPCIETAEFKVRLLVVEDDPDLNRQLTTALTDAGYVVDRAFDGEEGHFLGDTEPYDAVVLDI
GLPKMDGISVLEAWRRNARAMPVLILTARDRWSDKVQGFDAGADDYVAKPFHLEEVLARIRALLRRSAGHAQSELTCGPV
VLDTRTGRVSVRGHPVKLTSHEYRLLAYLMHHSGRVVSRTELVEHLYDQDFDRDSNTIEVFVGRIRKKLDVDIIQTVRGL
GYLLTPPPADAQLANRT
>Mature_257_residues
MFIGHSRRRRSSSSRRSQRPCIETAEFKVRLLVVEDDPDLNRQLTTALTDAGYVVDRAFDGEEGHFLGDTEPYDAVVLDI
GLPKMDGISVLEAWRRNARAMPVLILTARDRWSDKVQGFDAGADDYVAKPFHLEEVLARIRALLRRSAGHAQSELTCGPV
VLDTRTGRVSVRGHPVKLTSHEYRLLAYLMHHSGRVVSRTELVEHLYDQDFDRDSNTIEVFVGRIRKKLDVDIIQTVRGL
GYLLTPPPADAQLANRT

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=42.2727272727273, Blast_Score=184, Evalue=5e-48,
Organism=Escherichia coli, GI1789402, Length=216, Percent_Identity=44.4444444444444, Blast_Score=177, Evalue=4e-46,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=40.625, Blast_Score=174, Evalue=4e-45,
Organism=Escherichia coli, GI1790552, Length=216, Percent_Identity=42.1296296296296, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=38.3561643835616, Blast_Score=154, Evalue=4e-39,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=34.061135371179, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=34.3891402714932, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=33.6363636363636, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=36.986301369863, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=33.6322869955157, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.5263157894737, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=29.9107142857143, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=29.5154185022026, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=37.037037037037, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=24.4635193133047, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 29028; Mature: 29028

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIGHSRRRRSSSSRRSQRPCIETAEFKVRLLVVEDDPDLNRQLTTALTDAGYVVDRAFD
CCCCCCHHHHCHHHHHHCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCEEEEECCC
GEEGHFLGDTEPYDAVVLDIGLPKMDGISVLEAWRRNARAMPVLILTARDRWSDKVQGFD
CCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHCCCC
AGADDYVAKPFHLEEVLARIRALLRRSAGHAQSELTCGPVVLDTRTGRVSVRGHPVKLTS
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEEECCCEEEECC
HEYRLLAYLMHHSGRVVSRTELVEHLYDQDFDRDSNTIEVFVGRIRKKLDVDIIQTVRGL
CHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GYLLTPPPADAQLANRT
CEEECCCCCCCCCCCCC
>Mature Secondary Structure
MFIGHSRRRRSSSSRRSQRPCIETAEFKVRLLVVEDDPDLNRQLTTALTDAGYVVDRAFD
CCCCCCHHHHCHHHHHHCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCEEEEECCC
GEEGHFLGDTEPYDAVVLDIGLPKMDGISVLEAWRRNARAMPVLILTARDRWSDKVQGFD
CCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHCCCC
AGADDYVAKPFHLEEVLARIRALLRRSAGHAQSELTCGPVVLDTRTGRVSVRGHPVKLTS
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEEECCCEEEECC
HEYRLLAYLMHHSGRVVSRTELVEHLYDQDFDRDSNTIEVFVGRIRKKLDVDIIQTVRGL
CHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GYLLTPPPADAQLANRT
CEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA