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The map label for this gene is gor [H]

Identifier: 86750495

GI number: 86750495

Start: 3868793

End: 3870178

Strand: Reverse

Name: gor [H]

Synonym: RPB_3384

Alternate gene names: 86750495

Gene position: 3870178-3868793 (Counterclockwise)

Preceding gene: 86750496

Following gene: 86750494

Centisome position: 72.59

GC content: 66.09

Gene sequence:

>1386_bases
ATGACCGAGTTCGATACGGATCTGTTCGTCATCGGTGGCGGCTCCGGCGGCGTGCGCGCCGCCCGGATCGCCGCCGGCCA
TGGCGCCCGCGTCATCGTCGCCGAGGAGTATCGCTTCGGCGGCACCTGCGTGATCCGCGGCTGCGTGCCGAAGAAGCTGA
TGGTCTACGCCTCGCATTTCCACCACGACTTCCGCGACGCCGCGGGCTTCGGCTGGACGGTTGCCGAGGCGCAGTTCGAC
TGGCCGACGCTGATCGCCAACAAGGACAAGGAGATCGCGCGGCTCGAGAGCATTTACGCGACCAATGTCGAGAAGTCGGG
CGCCCGCACCGTCAAGGCGCGCGCGGTGTTCGAGGATCCGCACACGCTGCGTCTGTCGACCGGCGAGACGGTGCGCGCCA
AATACGTGCTGATCGCGACCGGCGGCGCGCCCAACCACGGCACGATGATTCCGGGTATCGAACACGTCATCTCGTCGAAC
GAGGTGTTTCATCTGCCGGAACTGCCGAAGCGGATCCTGATCCAGGGCGGCGGCTACATCGCGCTGGAATTCGCCTGCAT
CTTCGCCGGGCTCGGCAGCGACGTCACCCTGGTGTATCGCGGCGACAACATTCTGCGCGGCTTCGACGAGGATGTCCGCA
GCCATGTCCGCACCGAGATGGAGCGGGCCGGCATCAGCATCCTCACCGGCTGCACCGTGGCGAAGGTCGAGAAGCTCGGC
GACGAGTACACCTCGCATCTGTCGAGCGGCTCCAGCATCGCCTCGGACCAGGTGATGTTCGCGATCGGCCGGCATCCCAA
CGTCGCCAATCTCGGCCTGGAAAAGACCGGCGTCGCGATCAATCCGGACAATGGCGGCATCGCCGTCAACGAGTACTGCC
AGACCTCGGTGCCGCACATCTATGCGATCGGCGACGTCACCCATCGCATCAACCTGACGCCGGTGGCGATCCGCGAGGGC
CACGCCTTCGCCGACACCGTGTTCGGCAATCGGCCTGGGCAGGTCGACTACACCAACATCCCGACCGCGGTGTTCTCGCA
GCCGGAGGTCGGCACCGTCGGCCTGACCGAGTCCCAGGCGCGCGCGCTGTACGACCGCGTCGATATCTACAAGGCCGACT
TCCGCCCGATGAAGGCGACGCTGTCGGGCAGCCAGGTCCGCACGCTGATGAAACTGATCGTCGACGCCGACAGCGATCGC
GTGCTCGGCTGCCACATCGTCGGGCCCGAGGCCGGCGAACTGGTCCAGGTGATCGCGATTGCGGTGAAGATGAAGGCGAC
CAAGGCCGACTTCGATTCCACCATGGCACTGCACCCGACCGCGGCCGAAGAACTGGTGACGATGCGGACGCCGACCGCCC
GTTATGTCCGCGACGCCGCCGAATAA

Upstream 100 bases:

>100_bases
TCCAGCCCCACGACGTGACGCTGGATTGCTTCGTCGCCCTCGGCTCCTCGCAATGACGGAGAACTAAGTTTCGAGCCACG
ATTCTCAGGGCGACCACGTC

Downstream 100 bases:

>100_bases
GCCCGCCTGAGCTTTGCCCGAGGTTTGCCCCGGGTTTGCCGCAACCGCGGATTCCGCCGCGCCGTGGCGATTTCCATATT
ATTCGCAACAGCTTGTGACG

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTEFDTDLFVIGGGSGGVRAARIAAGHGARVIVAEEYRFGGTCVIRGCVPKKLMVYASHFHHDFRDAAGFGWTVAEAQFD
WPTLIANKDKEIARLESIYATNVEKSGARTVKARAVFEDPHTLRLSTGETVRAKYVLIATGGAPNHGTMIPGIEHVISSN
EVFHLPELPKRILIQGGGYIALEFACIFAGLGSDVTLVYRGDNILRGFDEDVRSHVRTEMERAGISILTGCTVAKVEKLG
DEYTSHLSSGSSIASDQVMFAIGRHPNVANLGLEKTGVAINPDNGGIAVNEYCQTSVPHIYAIGDVTHRINLTPVAIREG
HAFADTVFGNRPGQVDYTNIPTAVFSQPEVGTVGLTESQARALYDRVDIYKADFRPMKATLSGSQVRTLMKLIVDADSDR
VLGCHIVGPEAGELVQVIAIAVKMKATKADFDSTMALHPTAAEELVTMRTPTARYVRDAAE

Sequences:

>Translated_461_residues
MTEFDTDLFVIGGGSGGVRAARIAAGHGARVIVAEEYRFGGTCVIRGCVPKKLMVYASHFHHDFRDAAGFGWTVAEAQFD
WPTLIANKDKEIARLESIYATNVEKSGARTVKARAVFEDPHTLRLSTGETVRAKYVLIATGGAPNHGTMIPGIEHVISSN
EVFHLPELPKRILIQGGGYIALEFACIFAGLGSDVTLVYRGDNILRGFDEDVRSHVRTEMERAGISILTGCTVAKVEKLG
DEYTSHLSSGSSIASDQVMFAIGRHPNVANLGLEKTGVAINPDNGGIAVNEYCQTSVPHIYAIGDVTHRINLTPVAIREG
HAFADTVFGNRPGQVDYTNIPTAVFSQPEVGTVGLTESQARALYDRVDIYKADFRPMKATLSGSQVRTLMKLIVDADSDR
VLGCHIVGPEAGELVQVIAIAVKMKATKADFDSTMALHPTAAEELVTMRTPTARYVRDAAE
>Mature_460_residues
TEFDTDLFVIGGGSGGVRAARIAAGHGARVIVAEEYRFGGTCVIRGCVPKKLMVYASHFHHDFRDAAGFGWTVAEAQFDW
PTLIANKDKEIARLESIYATNVEKSGARTVKARAVFEDPHTLRLSTGETVRAKYVLIATGGAPNHGTMIPGIEHVISSNE
VFHLPELPKRILIQGGGYIALEFACIFAGLGSDVTLVYRGDNILRGFDEDVRSHVRTEMERAGISILTGCTVAKVEKLGD
EYTSHLSSGSSIASDQVMFAIGRHPNVANLGLEKTGVAINPDNGGIAVNEYCQTSVPHIYAIGDVTHRINLTPVAIREGH
AFADTVFGNRPGQVDYTNIPTAVFSQPEVGTVGLTESQARALYDRVDIYKADFRPMKATLSGSQVRTLMKLIVDADSDRV
LGCHIVGPEAGELVQVIAIAVKMKATKADFDSTMALHPTAAEELVTMRTPTARYVRDAAE

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=41.3943355119826, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI22035672, Length=430, Percent_Identity=35.8139534883721, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI33519430, Length=454, Percent_Identity=35.0220264317181, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI33519428, Length=454, Percent_Identity=35.0220264317181, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI33519426, Length=454, Percent_Identity=35.0220264317181, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI148277065, Length=454, Percent_Identity=35.0220264317181, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI148277071, Length=454, Percent_Identity=35.0220264317181, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI291045266, Length=457, Percent_Identity=33.9168490153173, Blast_Score=241, Evalue=7e-64,
Organism=Homo sapiens, GI291045268, Length=455, Percent_Identity=31.2087912087912, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=28.82096069869, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1789915, Length=433, Percent_Identity=40.8775981524249, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI1786307, Length=456, Percent_Identity=30.2631578947368, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87082354, Length=450, Percent_Identity=28.2222222222222, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI87081717, Length=446, Percent_Identity=27.3542600896861, Blast_Score=144, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI71983419, Length=436, Percent_Identity=39.6788990825688, Blast_Score=267, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI71983429, Length=436, Percent_Identity=39.6788990825688, Blast_Score=267, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI17557007, Length=467, Percent_Identity=31.0492505353319, Blast_Score=224, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI71982272, Length=442, Percent_Identity=32.1266968325792, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI32565766, Length=459, Percent_Identity=30.5010893246187, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=37.9609544468547, Blast_Score=294, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6321091, Length=461, Percent_Identity=29.0672451193059, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6325240, Length=476, Percent_Identity=27.7310924369748, Blast_Score=155, Evalue=9e-39,
Organism=Drosophila melanogaster, GI17737741, Length=484, Percent_Identity=33.8842975206612, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=33.5456475583864, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=33.5456475583864, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=33.5456475583864, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI21358499, Length=458, Percent_Identity=30.3493449781659, Blast_Score=196, Evalue=3e-50,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49728; Mature: 49597

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00076 PYRIDINE_REDOX_1 ; PS00310 LAMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFDTDLFVIGGGSGGVRAARIAAGHGARVIVAEEYRFGGTCVIRGCVPKKLMVYASHF
CCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHH
HHDFRDAAGFGWTVAEAQFDWPTLIANKDKEIARLESIYATNVEKSGARTVKARAVFEDP
HHHHHHHCCCCEEEEECCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECCC
HTLRLSTGETVRAKYVLIATGGAPNHGTMIPGIEHVISSNEVFHLPELPKRILIQGGGYI
CEEEEECCCEEEEEEEEEECCCCCCCCCCCCCHHHHHCCCCEEECCCCCCEEEEECCCEE
ALEFACIFAGLGSDVTLVYRGDNILRGFDEDVRSHVRTEMERAGISILTGCTVAKVEKLG
EEEEEEHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHH
DEYTSHLSSGSSIASDQVMFAIGRHPNVANLGLEKTGVAINPDNGGIAVNEYCQTSVPHI
HHHHHHHCCCCCCCCCCEEEEECCCCCHHCCCCCCCCCEECCCCCCEEECHHHCCCCCEE
YAIGDVTHRINLTPVAIREGHAFADTVFGNRPGQVDYTNIPTAVFSQPEVGTVGLTESQA
EEECCEEEEEECEEEEEECCCCEEHHHCCCCCCEEEECCCCHHHCCCCCCCEECCCHHHH
RALYDRVDIYKADFRPMKATLSGSQVRTLMKLIVDADSDRVLGCHIVGPEAGELVQVIAI
HHHHHHHHEEECCCCCEEEECCHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHH
AVKMKATKADFDSTMALHPTAAEELVTMRTPTARYVRDAAE
HHHHHHCCCCCCCEEEECCCCHHHHEEECCCHHHHHHHCCC
>Mature Secondary Structure 
TEFDTDLFVIGGGSGGVRAARIAAGHGARVIVAEEYRFGGTCVIRGCVPKKLMVYASHF
CCCCCEEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHH
HHDFRDAAGFGWTVAEAQFDWPTLIANKDKEIARLESIYATNVEKSGARTVKARAVFEDP
HHHHHHHCCCCEEEEECCCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECCC
HTLRLSTGETVRAKYVLIATGGAPNHGTMIPGIEHVISSNEVFHLPELPKRILIQGGGYI
CEEEEECCCEEEEEEEEEECCCCCCCCCCCCCHHHHHCCCCEEECCCCCCEEEEECCCEE
ALEFACIFAGLGSDVTLVYRGDNILRGFDEDVRSHVRTEMERAGISILTGCTVAKVEKLG
EEEEEEHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHH
DEYTSHLSSGSSIASDQVMFAIGRHPNVANLGLEKTGVAINPDNGGIAVNEYCQTSVPHI
HHHHHHHCCCCCCCCCCEEEEECCCCCHHCCCCCCCCCEECCCCCCEEECHHHCCCCCEE
YAIGDVTHRINLTPVAIREGHAFADTVFGNRPGQVDYTNIPTAVFSQPEVGTVGLTESQA
EEECCEEEEEECEEEEEECCCCEEHHHCCCCCCEEEECCCCHHHCCCCCCCEECCCHHHH
RALYDRVDIYKADFRPMKATLSGSQVRTLMKLIVDADSDRVLGCHIVGPEAGELVQVIAI
HHHHHHHHEEECCCCCEEEECCHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHH
AVKMKATKADFDSTMALHPTAAEELVTMRTPTARYVRDAAE
HHHHHHCCCCCCCEEEECCCCHHHHEEECCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]