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The map label for this gene is ppi [H]

Identifier: 86749990

GI number: 86749990

Start: 3270323

End: 3270886

Strand: Reverse

Name: ppi [H]

Synonym: RPB_2873

Alternate gene names: 86749990

Gene position: 3270886-3270323 (Counterclockwise)

Preceding gene: 86749991

Following gene: 86749989

Centisome position: 61.35

GC content: 65.25

Gene sequence:

>564_bases
ATGATCCGTTTGATAGGCATCATCGCCGCGCTGGTGTTCGCTCTGCCCGCGCTGGCGCAGCCGCTGCCCGCCGGCCTCGA
CAAGCAGAACGCCATCGTCATCGACAGCACCAAGGGGCGGATCGTGATCCAGCTCCGGCCGGACATCGCGCCGCAGCACG
CCGAACGCATCAAGCAGCTCGCCCGCGACGGCTTCTACAACAACGTGCCGTTCCACCGCGTGATGGCCGGCTTCATGGCG
CAGACCGGCGACGGCGAGAAGTTCAACGGCACCGGCGGTTCGAAATATCCGAACCTGAAGCAGGAGTTCTCCAAGGTGCC
GTTCAAACGCGGCATCGTCGGCATGGCCCGGCGCGGCGACAGCGTCGACAGCGCGAACGCGCAGTTCTTCATCATGTTCG
ACGACGGGCCGAGCCTGAACGGGCAGTACACCGTGATCGGCGAAGTGGTGTCCGGCATGGATGTCGTCGACAAGCTGAAG
AAGGCCTCGCCCGGCTCGCCCGGCGGCTCGGTGACCGACCCCGACAAGATGGTCAAGGTCCAGGTCGCCGCCGACGTCAA
GTAA

Upstream 100 bases:

>100_bases
GCGATGGGCGGCGACGTCTCCGCCTTCGTGCCGCCCGATGTCGCGGCCAGTCTGAAATCGAAATTCGCCGGCTAGCCGGC
TTTTGCAATCCGGAGTTTCC

Downstream 100 bases:

>100_bases
GCGGCCGACATGCCGCCGCGCCGACGAAACGTTGTCGCGGCGGTGCTGATCGCATCTGCGATCGGCGCATTGGGCCGTGC
CGCGGTCGCGCAGGAGGCAC

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MIRLIGIIAALVFALPALAQPLPAGLDKQNAIVIDSTKGRIVIQLRPDIAPQHAERIKQLARDGFYNNVPFHRVMAGFMA
QTGDGEKFNGTGGSKYPNLKQEFSKVPFKRGIVGMARRGDSVDSANAQFFIMFDDGPSLNGQYTVIGEVVSGMDVVDKLK
KASPGSPGGSVTDPDKMVKVQVAADVK

Sequences:

>Translated_187_residues
MIRLIGIIAALVFALPALAQPLPAGLDKQNAIVIDSTKGRIVIQLRPDIAPQHAERIKQLARDGFYNNVPFHRVMAGFMA
QTGDGEKFNGTGGSKYPNLKQEFSKVPFKRGIVGMARRGDSVDSANAQFFIMFDDGPSLNGQYTVIGEVVSGMDVVDKLK
KASPGSPGGSVTDPDKMVKVQVAADVK
>Mature_187_residues
MIRLIGIIAALVFALPALAQPLPAGLDKQNAIVIDSTKGRIVIQLRPDIAPQHAERIKQLARDGFYNNVPFHRVMAGFMA
QTGDGEKFNGTGGSKYPNLKQEFSKVPFKRGIVGMARRGDSVDSANAQFFIMFDDGPSLNGQYTVIGEVVSGMDVVDKLK
KASPGSPGGSVTDPDKMVKVQVAADVK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=135, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI5031987, Length=142, Percent_Identity=36.6197183098592, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI150418007, Length=139, Percent_Identity=37.410071942446, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI45439316, Length=129, Percent_Identity=34.8837209302326, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI10863927, Length=129, Percent_Identity=34.8837209302326, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI5174637, Length=128, Percent_Identity=34.375, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI303305009, Length=130, Percent_Identity=34.6153846153846, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI4826932, Length=131, Percent_Identity=33.587786259542, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI7706339, Length=137, Percent_Identity=31.3868613138686, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI42560244, Length=136, Percent_Identity=33.0882352941176, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI4758950, Length=140, Percent_Identity=33.5714285714286, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1786736, Length=155, Percent_Identity=39.3548387096774, Blast_Score=88, Evalue=3e-19,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=38.2716049382716, Blast_Score=80, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17539498, Length=155, Percent_Identity=34.8387096774194, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=147, Percent_Identity=31.9727891156463, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=141, Percent_Identity=35.4609929078014, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71980594, Length=134, Percent_Identity=33.5820895522388, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71980590, Length=134, Percent_Identity=33.5820895522388, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565860, Length=152, Percent_Identity=34.8684210526316, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17506307, Length=132, Percent_Identity=36.3636363636364, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17566266, Length=146, Percent_Identity=32.8767123287671, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17552782, Length=149, Percent_Identity=32.2147651006711, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532643, Length=141, Percent_Identity=34.0425531914894, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17551284, Length=144, Percent_Identity=34.7222222222222, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551282, Length=144, Percent_Identity=34.7222222222222, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17552780, Length=135, Percent_Identity=32.5925925925926, Blast_Score=63, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=141, Percent_Identity=40.4255319148936, Blast_Score=82, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323562, Length=142, Percent_Identity=35.9154929577465, Blast_Score=75, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320510, Length=140, Percent_Identity=37.8571428571429, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321848, Length=136, Percent_Identity=35.2941176470588, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323246, Length=134, Percent_Identity=33.5820895522388, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI45549139, Length=142, Percent_Identity=38.7323943661972, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24664125, Length=142, Percent_Identity=37.3239436619718, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21357783, Length=142, Percent_Identity=37.3239436619718, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17647301, Length=155, Percent_Identity=33.5483870967742, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17986117, Length=175, Percent_Identity=29.1428571428571, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24652460, Length=135, Percent_Identity=31.1111111111111, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357249, Length=123, Percent_Identity=36.5853658536585, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24650807, Length=136, Percent_Identity=36.7647058823529, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19922376, Length=142, Percent_Identity=28.169014084507, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20130249, Length=131, Percent_Identity=33.587786259542, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20042; Mature: 20042

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRLIGIIAALVFALPALAQPLPAGLDKQNAIVIDSTKGRIVIQLRPDIAPQHAERIKQL
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHH
ARDGFYNNVPFHRVMAGFMAQTGDGEKFNGTGGSKYPNLKQEFSKVPFKRGIVGMARRGD
HHCCCCCCCCHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHCCHHHCCHHHHHCCC
SVDSANAQFFIMFDDGPSLNGQYTVIGEVVSGMDVVDKLKKASPGSPGGSVTDPDKMVKV
CCCCCCCEEEEEECCCCCCCCCEEEHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCEEEE
QVAADVK
EEEECCC
>Mature Secondary Structure
MIRLIGIIAALVFALPALAQPLPAGLDKQNAIVIDSTKGRIVIQLRPDIAPQHAERIKQL
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHH
ARDGFYNNVPFHRVMAGFMAQTGDGEKFNGTGGSKYPNLKQEFSKVPFKRGIVGMARRGD
HHCCCCCCCCHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHCCHHHCCHHHHHCCC
SVDSANAQFFIMFDDGPSLNGQYTVIGEVVSGMDVVDKLKKASPGSPGGSVTDPDKMVKV
CCCCCCCEEEEEECCCCCCCCCEEEHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCEEEE
QVAADVK
EEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA