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The map label for this gene is ppi [H]

Identifier: 86749988

GI number: 86749988

Start: 3269427

End: 3269894

Strand: Reverse

Name: ppi [H]

Synonym: RPB_2871

Alternate gene names: 86749988

Gene position: 3269894-3269427 (Counterclockwise)

Preceding gene: 86749989

Following gene: 86749987

Centisome position: 61.33

GC content: 64.32

Gene sequence:

>468_bases
ATGGCTGACAACGACAACATCCTGATCCTCGAAACCACCCAAGGCGACGTCAAGATCGAGATGCGTCCCGATCTGGCGCC
GAACCACGTCGCCCGCATCAAGGAGCTGGTGCGCGAAGGCTTCTACGACGGCATCGTGTTTCACCGCGTGATCGAGGGCT
TCATGGCGCAGACCGGCTGCCCGCAGGGCACCGGCACCGGCGGCTCCGGCAAGAAGCTGAAGGCCGAGTTCAACAAGGAG
CCGCACGTTCGCGGCACGACCTCGATGGCGCGCGCCGCCAGCCCGGATTCCGGCGACAGCCAGTTCTTCATCTGCTTCGA
CGACGCCCGCTTCCTCGACAACCAGTACACGGTGTGGGGCAAGGTGATCGAGGGCATGGAGAACGTCGACAAGATCAAGC
GCGGCGAACCGGTGCAGAACCCCGACAAGATCGTCAAGGCGACGATGGCCGCCGACGCGGCGGCTTGA

Upstream 100 bases:

>100_bases
TGCCGTTCACGCAAAGCATGGGCAACGCAGTTGCCGGACGTCCCTTCACGCTGCGGTTCGACGATCGCAGAACATTCCCC
CAACCGAACGAGAAGAGAGC

Downstream 100 bases:

>100_bases
GCTGCCGAGGTCGGCTCCTGACGCCGACGGCGCCACATAGAAGGTGTCATGCCCGGGCTTGACCCGGGCATCCATCTTTC
GAAGAGGATGGATCGCCGGA

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 155; Mature: 154

Protein sequence:

>155_residues
MADNDNILILETTQGDVKIEMRPDLAPNHVARIKELVREGFYDGIVFHRVIEGFMAQTGCPQGTGTGGSGKKLKAEFNKE
PHVRGTTSMARAASPDSGDSQFFICFDDARFLDNQYTVWGKVIEGMENVDKIKRGEPVQNPDKIVKATMAADAAA

Sequences:

>Translated_155_residues
MADNDNILILETTQGDVKIEMRPDLAPNHVARIKELVREGFYDGIVFHRVIEGFMAQTGCPQGTGTGGSGKKLKAEFNKE
PHVRGTTSMARAASPDSGDSQFFICFDDARFLDNQYTVWGKVIEGMENVDKIKRGEPVQNPDKIVKATMAADAAA
>Mature_154_residues
ADNDNILILETTQGDVKIEMRPDLAPNHVARIKELVREGFYDGIVFHRVIEGFMAQTGCPQGTGTGGSGKKLKAEFNKEP
HVRGTTSMARAASPDSGDSQFFICFDDARFLDNQYTVWGKVIEGMENVDKIKRGEPVQNPDKIVKATMAADAAA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=132, Percent_Identity=41.6666666666667, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI24308049, Length=129, Percent_Identity=43.4108527131783, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI7706339, Length=129, Percent_Identity=36.4341085271318, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI64276486, Length=120, Percent_Identity=41.6666666666667, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI22547212, Length=132, Percent_Identity=41.6666666666667, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI7657473, Length=132, Percent_Identity=41.6666666666667, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI22547215, Length=132, Percent_Identity=41.6666666666667, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI5031987, Length=127, Percent_Identity=39.3700787401575, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI10863927, Length=128, Percent_Identity=39.0625, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI20911035, Length=138, Percent_Identity=34.0579710144928, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1789763, Length=143, Percent_Identity=38.4615384615385, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1786736, Length=137, Percent_Identity=37.956204379562, Blast_Score=85, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=131, Percent_Identity=40.4580152671756, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71980590, Length=131, Percent_Identity=40.4580152671756, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17506311, Length=133, Percent_Identity=39.0977443609023, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17539496, Length=136, Percent_Identity=33.8235294117647, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71997782, Length=122, Percent_Identity=40.9836065573771, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17539498, Length=141, Percent_Identity=38.2978723404255, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532641, Length=138, Percent_Identity=32.6086956521739, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32563659, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17559074, Length=164, Percent_Identity=31.7073170731707, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17566266, Length=143, Percent_Identity=32.8671328671329, Blast_Score=66, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=149, Percent_Identity=35.5704697986577, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17506307, Length=119, Percent_Identity=42.0168067226891, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17552782, Length=134, Percent_Identity=35.0746268656716, Blast_Score=63, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=143, Percent_Identity=36.3636363636364, Blast_Score=62, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17986117, Length=154, Percent_Identity=39.6103896103896, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI19922376, Length=144, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24652460, Length=132, Percent_Identity=37.8787878787879, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17647301, Length=128, Percent_Identity=39.84375, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357249, Length=134, Percent_Identity=35.8208955223881, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45549139, Length=127, Percent_Identity=39.3700787401575, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19922912, Length=129, Percent_Identity=41.8604651162791, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24664125, Length=127, Percent_Identity=39.3700787401575, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357783, Length=127, Percent_Identity=39.3700787401575, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16975; Mature: 16844

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNDNILILETTQGDVKIEMRPDLAPNHVARIKELVREGFYDGIVFHRVIEGFMAQTGC
CCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
PQGTGTGGSGKKLKAEFNKEPHVRGTTSMARAASPDSGDSQFFICFDDARFLDNQYTVWG
CCCCCCCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCHHHCCCHHHHH
KVIEGMENVDKIKRGEPVQNPDKIVKATMAADAAA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ADNDNILILETTQGDVKIEMRPDLAPNHVARIKELVREGFYDGIVFHRVIEGFMAQTGC
CCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
PQGTGTGGSGKKLKAEFNKEPHVRGTTSMARAASPDSGDSQFFICFDDARFLDNQYTVWG
CCCCCCCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCCCCEEEEEECCCHHHCCCHHHHH
KVIEGMENVDKIKRGEPVQNPDKIVKATMAADAAA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA