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The map label for this gene is uppS2 [H]

Identifier: 86749941

GI number: 86749941

Start: 3218806

End: 3219564

Strand: Reverse

Name: uppS2 [H]

Synonym: RPB_2824

Alternate gene names: 86749941

Gene position: 3219564-3218806 (Counterclockwise)

Preceding gene: 86749942

Following gene: 86749940

Centisome position: 60.39

GC content: 66.27

Gene sequence:

>759_bases
ATGTCGAAAGCTGCCGCCACCGCGACTGACCGGTCGGATCCTCCCGTCATCCCGGCGCATGTCGCGATCATCATGGACGG
CAACGGCCGCTGGGCCGCAGCCCGCGGCCTGCCGCGTGCCGAGGGGCATCGCCGCGGCGTCGAGGCGCTTCGCCGCGTCG
TCCGGGCGGCGAACGACATCGGCATCCAGTATCTGACGATCTTCTCGTTCAGTTCGGAGAACTGGACCCGGCCGAAGAGC
GAGATCGGCGATCTTTTCGGCCTGCTGCGCCGCTTCATCCGCAACGATCTCGCCTCTCTGCATCGCGACGGCGTTCGCGT
CCGGGTGATCGGCGAGCGCGACCGCCTCGAGCGCGATCTGTGCGCGATGCTCGACGAGGCCCAGGAACTGACCCGCGACA
ACACCAAGCTGAACCTCGTGGTCGCCTTCAACTACGGCTCCCGGCAGGAAATCGCCAACGCCGCGCAGCGGCTGGCGCGC
GAGGTCGCCGAGGGTAAGCGCGATCCGGCGACGATCGATATCGAGACGCTGGGCCGCTATCTCGACGCCCCCGACATTCC
CGATCCCGACCTGATCATCCGCACCAGCGGAGAGCAACGATTGTCGAATTTTCTGATGTGGCAGGCGGCGTACAGTGAAC
TGGTGTTCGTGCCCATTCACTGGCCGGACTTCGACAAGGCCGCGCTGGAAGGCGCGATCGCCGAATATGCCCGACGCGAG
CGCCGTTTCGGCGGCTTGGCCGCGAAAACAGGATCGTGA

Upstream 100 bases:

>100_bases
TCCAGTCTTGTGATCGAAGCTGTCATAACTTATTGATCTGGAAATATTTCTGGCAGCGAACGGGTACGTCTTCGCGGGAT
GACGCTTCGGGAATTGGCCT

Downstream 100 bases:

>100_bases
CGCGCGTGAGCCAGGACAACGCGGCGCCAGCGCCGGCAGCCGAGCAGGGCTCCCGCAATTTCTGGCAGCGTGTCGGCGCC
GCCCTCGTGCTTGCGCCGGG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 2; Di-trans,poly-cis-decaprenylcistransferase 2; Undecaprenyl diphosphate synthase 2; UDS 2 [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSKAAATATDRSDPPVIPAHVAIIMDGNGRWAAARGLPRAEGHRRGVEALRRVVRAANDIGIQYLTIFSFSSENWTRPKS
EIGDLFGLLRRFIRNDLASLHRDGVRVRVIGERDRLERDLCAMLDEAQELTRDNTKLNLVVAFNYGSRQEIANAAQRLAR
EVAEGKRDPATIDIETLGRYLDAPDIPDPDLIIRTSGEQRLSNFLMWQAAYSELVFVPIHWPDFDKAALEGAIAEYARRE
RRFGGLAAKTGS

Sequences:

>Translated_252_residues
MSKAAATATDRSDPPVIPAHVAIIMDGNGRWAAARGLPRAEGHRRGVEALRRVVRAANDIGIQYLTIFSFSSENWTRPKS
EIGDLFGLLRRFIRNDLASLHRDGVRVRVIGERDRLERDLCAMLDEAQELTRDNTKLNLVVAFNYGSRQEIANAAQRLAR
EVAEGKRDPATIDIETLGRYLDAPDIPDPDLIIRTSGEQRLSNFLMWQAAYSELVFVPIHWPDFDKAALEGAIAEYARRE
RRFGGLAAKTGS
>Mature_251_residues
SKAAATATDRSDPPVIPAHVAIIMDGNGRWAAARGLPRAEGHRRGVEALRRVVRAANDIGIQYLTIFSFSSENWTRPKSE
IGDLFGLLRRFIRNDLASLHRDGVRVRVIGERDRLERDLCAMLDEAQELTRDNTKLNLVVAFNYGSRQEIANAAQRLARE
VAEGKRDPATIDIETLGRYLDAPDIPDPDLIIRTSGEQRLSNFLMWQAAYSELVFVPIHWPDFDKAALEGAIAEYARRER
RFGGLAAKTGS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=39.9103139013453, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=39.9103139013453, Blast_Score=164, Evalue=9e-41,
Organism=Escherichia coli, GI1786371, Length=226, Percent_Identity=46.4601769911504, Blast_Score=214, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=34.2222222222222, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=34.7222222222222, Blast_Score=118, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=228, Percent_Identity=28.0701754385965, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18857969, Length=227, Percent_Identity=40.9691629955947, Blast_Score=151, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28180; Mature: 28049

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAAATATDRSDPPVIPAHVAIIMDGNGRWAAARGLPRAEGHRRGVEALRRVVRAANDI
CCCCCCCCCCCCCCCCCEEEEEEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHC
GIQYLTIFSFSSENWTRPKSEIGDLFGLLRRFIRNDLASLHRDGVRVRVIGERDRLERDL
CEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHH
CAMLDEAQELTRDNTKLNLVVAFNYGSRQEIANAAQRLAREVAEGKRDPATIDIETLGRY
HHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHH
LDAPDIPDPDLIIRTSGEQRLSNFLMWQAAYSELVFVPIHWPDFDKAALEGAIAEYARRE
CCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHH
RRFGGLAAKTGS
HHHCCCCCCCCC
>Mature Secondary Structure 
SKAAATATDRSDPPVIPAHVAIIMDGNGRWAAARGLPRAEGHRRGVEALRRVVRAANDI
CCCCCCCCCCCCCCCCEEEEEEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHC
GIQYLTIFSFSSENWTRPKSEIGDLFGLLRRFIRNDLASLHRDGVRVRVIGERDRLERDL
CEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHH
CAMLDEAQELTRDNTKLNLVVAFNYGSRQEIANAAQRLAREVAEGKRDPATIDIETLGRY
HHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHH
LDAPDIPDPDLIIRTSGEQRLSNFLMWQAAYSELVFVPIHWPDFDKAALEGAIAEYARRE
CCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHH
RRFGGLAAKTGS
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]