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The map label for this gene is uppS1 [H]

Identifier: 86749805

GI number: 86749805

Start: 3072897

End: 3073616

Strand: Reverse

Name: uppS1 [H]

Synonym: RPB_2688

Alternate gene names: 86749805

Gene position: 3073616-3072897 (Counterclockwise)

Preceding gene: 86749806

Following gene: 86749804

Centisome position: 57.65

GC content: 63.89

Gene sequence:

>720_bases
ATGCAAAGCAATCTACATTCCAAACTACATGTCGGCATCATCATGGACGGCAACGGGCGATGGGCGACGAGGCGAGGGTT
GTCACGCCTGCGCGGGCATCAGGCCGGTGTCGAGGCGATCCGCCGCGTGATGGAAGCTGCGCCGGAGCAGGGCATCGGAA
CGCTGACGCTGTTCGCGTTCTCCAGCGACAATTGGCGACGCCCGAGATCCGAGGTCTCGGCGCTGATGGGGCTTTTTCGC
TCGTACCTGGTGAACGAGGTGAAGGGCCTCGTCGACAACGGAATCCGCCTCACGTTGATCGGACGTCGCGACCGCCTCCC
GGATGGCCTCGCCGAAACGATCGAACGTGCCGAAGCCGCGACCGCTGCAGGCGACGCGCTCGCCTTGCGTATCGCGGTCG
ACTACTCGGCTCGGGATACGATTGTCAACGCCGCTGTGCGCGCCGGCGGACTGCAGAGTTGCAGCCGCGAGACGTTTTCC
GACCTCATCACCGGATCGAAGCTGCGCGACGTCGACCTCATCATCCGCACCAGCGGCGAACGCCGACTGTCCGATTTCCT
GCTTTGGGAAAGCGCCTACGCCGAATTGTACTTCACCGACCGGATGTGGCCGGACTTCGATGCCAACGATCTCGCCGACG
CCATGGCGTCGTTCCATGGCCGTGAGCGCCGGTTCGGCGGCCTGCCATCGATGAAACCGGACGTCTCCATCAGCGCCTAG

Upstream 100 bases:

>100_bases
CCGGCAGTAGCGATCCGCTGCCGACCGGACTTCACACGCGTCCCGTCTGAAAGCACGTCTCGCCTGAACCACGTCCCCCT
TTTTGCACGGAGACTTTGTG

Downstream 100 bases:

>100_bases
GCGAAGGAAGTCCGTGATGCGTATCCTTCTGGTCAACGTTCCCCATCCCGCCATCGGCAGCCTGATTCCGAGCGATCACT
TGCCGCCGCTGGGCCTGCTG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 1; Di-trans,poly-cis-decaprenylcistransferase 1; Undecaprenyl diphosphate synthase 1; UDS 1 [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MQSNLHSKLHVGIIMDGNGRWATRRGLSRLRGHQAGVEAIRRVMEAAPEQGIGTLTLFAFSSDNWRRPRSEVSALMGLFR
SYLVNEVKGLVDNGIRLTLIGRRDRLPDGLAETIERAEAATAAGDALALRIAVDYSARDTIVNAAVRAGGLQSCSRETFS
DLITGSKLRDVDLIIRTSGERRLSDFLLWESAYAELYFTDRMWPDFDANDLADAMASFHGRERRFGGLPSMKPDVSISA

Sequences:

>Translated_239_residues
MQSNLHSKLHVGIIMDGNGRWATRRGLSRLRGHQAGVEAIRRVMEAAPEQGIGTLTLFAFSSDNWRRPRSEVSALMGLFR
SYLVNEVKGLVDNGIRLTLIGRRDRLPDGLAETIERAEAATAAGDALALRIAVDYSARDTIVNAAVRAGGLQSCSRETFS
DLITGSKLRDVDLIIRTSGERRLSDFLLWESAYAELYFTDRMWPDFDANDLADAMASFHGRERRFGGLPSMKPDVSISA
>Mature_239_residues
MQSNLHSKLHVGIIMDGNGRWATRRGLSRLRGHQAGVEAIRRVMEAAPEQGIGTLTLFAFSSDNWRRPRSEVSALMGLFR
SYLVNEVKGLVDNGIRLTLIGRRDRLPDGLAETIERAEAATAAGDALALRIAVDYSARDTIVNAAVRAGGLQSCSRETFS
DLITGSKLRDVDLIIRTSGERRLSDFLLWESAYAELYFTDRMWPDFDANDLADAMASFHGRERRFGGLPSMKPDVSISA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=221, Percent_Identity=33.0316742081448, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI45580738, Length=221, Percent_Identity=33.0316742081448, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI1786371, Length=230, Percent_Identity=48.695652173913, Blast_Score=208, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71993029, Length=224, Percent_Identity=32.1428571428571, Blast_Score=111, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319474, Length=218, Percent_Identity=33.0275229357798, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323748, Length=211, Percent_Identity=31.7535545023697, Blast_Score=105, Evalue=6e-24,
Organism=Drosophila melanogaster, GI18857969, Length=205, Percent_Identity=34.1463414634146, Blast_Score=118, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 26414; Mature: 26414

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSNLHSKLHVGIIMDGNGRWATRRGLSRLRGHQAGVEAIRRVMEAAPEQGIGTLTLFAF
CCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCEEEEEEE
SSDNWRRPRSEVSALMGLFRSYLVNEVKGLVDNGIRLTLIGRRDRLPDGLAETIERAEAA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHH
TAAGDALALRIAVDYSARDTIVNAAVRAGGLQSCSRETFSDLITGSKLRDVDLIIRTSGE
HCCCCEEEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCC
RRLSDFLLWESAYAELYFTDRMWPDFDANDLADAMASFHGRERRFGGLPSMKPDVSISA
HHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQSNLHSKLHVGIIMDGNGRWATRRGLSRLRGHQAGVEAIRRVMEAAPEQGIGTLTLFAF
CCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCEEEEEEE
SSDNWRRPRSEVSALMGLFRSYLVNEVKGLVDNGIRLTLIGRRDRLPDGLAETIERAEAA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHH
TAAGDALALRIAVDYSARDTIVNAAVRAGGLQSCSRETFSDLITGSKLRDVDLIIRTSGE
HCCCCEEEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCC
RRLSDFLLWESAYAELYFTDRMWPDFDANDLADAMASFHGRERRFGGLPSMKPDVSISA
HHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]