Click here to switch to the map view.

The map label for this gene is adk [H]

Identifier: 86749436

GI number: 86749436

Start: 2665080

End: 2666105

Strand: Direct

Name: adk [H]

Synonym: RPB_2316

Alternate gene names: 86749436

Gene position: 2665080-2666105 (Clockwise)

Preceding gene: 86749435

Following gene: 86749437

Centisome position: 49.99

GC content: 66.28

Gene sequence:

>1026_bases
ATGAGACTGATCCTTCTCGGGCCGCCGGGGGCGGGCAAGGGAACGCAAGCGGCCCGCCTGGTTCAGCAATACGGACTGGT
GCAGCTTTCCACCGGAGACATGCTGCGCGCCGCGGTCGCGGCCGGCACGCCGGTCGGGCTGAAGGCCAAGGACATCATGG
CGAGCGGCGGCCTGGTGCCGGACGAGGTGGTGATCGGCATCATCTCCGACCGCATCGAGCAGCCCGACGCCACCAACGGC
TTCATCCTCGACGGCTTTCCGCGCACCGTGCCGCAGGCCGAGGCGCTCGACGCGCTGCTCAAGGACAAGAAGCTCGGCCT
CGATGCCGTGGTCGAATTGCGGGTCAACGAAAGCGCGCTGCTGGCCCGGGTCGAGACCCGCGTCGCGGAGATGCGCGAGC
GGGGCGAGGAGCCCCGCGCCGACGACAACGCCGAGGCGCTGGCGAAGCGCCTGACCGCGTATCGCCTGCAGACCGAGCCG
CTGGTCGAGTATTATTCGGACAAGCGCAAGCTGCTGACCGTCGACGGCATGATGACCATCGACGAGGTCACCCGCGAGAT
CGGCCGGATCCTTGAGGCGCTCGGCGAGGCCAACGCCAAGAAGGCTGCCAAGACCGCCGCTGCCAAGCGCGCGGTCAAAA
AGAGCGCGAAGCCGGCCAAGGCTTCCGGCAAGCCCAAGGCTTCCGGCAAGGCGAAAGCTCCCGGCAAGGCTCCGGCCAAG
AAAGCTTCGGCCAAGAAGGCAGTTAGCGGAAAATCTTCGAGCAAGGCGGAATCCGCCAAGACGGCTTCGGCCGGTCTGAA
GAAGCCGGCGAAAGCCACGAAGAAGACTGGCAAAAAGGCCGCCAAGGTCGCGAGCAAGGCGCCCGCCAAGGCGGCCAAGA
CGGCCGGCAAGAAAGCAAACAAATCGAAGGCCAAATCGGCCGCCAAGGCGCCGAAACGCGGCGCCAAGGTGACGAAGAAG
GCGGCCAAGAAGGCGGGGACGCCCTCCGCCCAAAAGGCCAGGAAAGTCAACAAAAAGCGAGCTTGA

Upstream 100 bases:

>100_bases
TCAGCGTCACGATGGACACGGTCGCCCAGGTGCAGGGCTATCTGCTGGCGCATCAGTATGAAGGCCTGATCCGGAAGTCG
AAGTTGAGGGGCCGTAAGAA

Downstream 100 bases:

>100_bases
ACCTGGATTCGGTTGACGAACAGAAACGGAATCCTTTAATAAGGCCCGATATCCCGTCGGATAGGTTTCAGACGATGCCG
GGCCCCAGAACGACCGAGGG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MRLILLGPPGAGKGTQAARLVQQYGLVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVIGIISDRIEQPDATNG
FILDGFPRTVPQAEALDALLKDKKLGLDAVVELRVNESALLARVETRVAEMRERGEEPRADDNAEALAKRLTAYRLQTEP
LVEYYSDKRKLLTVDGMMTIDEVTREIGRILEALGEANAKKAAKTAAAKRAVKKSAKPAKASGKPKASGKAKAPGKAPAK
KASAKKAVSGKSSSKAESAKTASAGLKKPAKATKKTGKKAAKVASKAPAKAAKTAGKKANKSKAKSAAKAPKRGAKVTKK
AAKKAGTPSAQKARKVNKKRA

Sequences:

>Translated_341_residues
MRLILLGPPGAGKGTQAARLVQQYGLVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVIGIISDRIEQPDATNG
FILDGFPRTVPQAEALDALLKDKKLGLDAVVELRVNESALLARVETRVAEMRERGEEPRADDNAEALAKRLTAYRLQTEP
LVEYYSDKRKLLTVDGMMTIDEVTREIGRILEALGEANAKKAAKTAAAKRAVKKSAKPAKASGKPKASGKAKAPGKAPAK
KASAKKAVSGKSSSKAESAKTASAGLKKPAKATKKTGKKAAKVASKAPAKAAKTAGKKANKSKAKSAAKAPKRGAKVTKK
AAKKAGTPSAQKARKVNKKRA
>Mature_341_residues
MRLILLGPPGAGKGTQAARLVQQYGLVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVIGIISDRIEQPDATNG
FILDGFPRTVPQAEALDALLKDKKLGLDAVVELRVNESALLARVETRVAEMRERGEEPRADDNAEALAKRLTAYRLQTEP
LVEYYSDKRKLLTVDGMMTIDEVTREIGRILEALGEANAKKAAKTAAAKRAVKKSAKPAKASGKPKASGKAKAPGKAPAK
KASAKKAVSGKSSSKAESAKTASAGLKKPAKATKKTGKKAAKVASKAPAKAAKTAGKKANKSKAKSAAKAPKRGAKVTKK
AAKKAGTPSAQKARKVNKKRA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=221, Percent_Identity=42.5339366515837, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI7524346, Length=220, Percent_Identity=42.2727272727273, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI4502011, Length=198, Percent_Identity=35.3535353535354, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI19923437, Length=200, Percent_Identity=34, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI310110345, Length=200, Percent_Identity=33.5, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI53832003, Length=200, Percent_Identity=33.5, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI8051579, Length=200, Percent_Identity=33.5, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI53832001, Length=200, Percent_Identity=33.5, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI7706497, Length=199, Percent_Identity=31.6582914572864, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI28144899, Length=193, Percent_Identity=30.5699481865285, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI28144897, Length=193, Percent_Identity=30.5699481865285, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI22749187, Length=129, Percent_Identity=34.8837209302326, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=42.8571428571429, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17552384, Length=212, Percent_Identity=39.622641509434, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17567503, Length=185, Percent_Identity=36.7567567567568, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17550688, Length=195, Percent_Identity=29.7435897435897, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17533833, Length=192, Percent_Identity=28.6458333333333, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17537943, Length=199, Percent_Identity=28.1407035175879, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI25147457, Length=194, Percent_Identity=24.7422680412371, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=187, Percent_Identity=45.9893048128342, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6321018, Length=186, Percent_Identity=38.1720430107527, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322828, Length=189, Percent_Identity=31.7460317460317, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=46.448087431694, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI17647141, Length=208, Percent_Identity=31.7307692307692, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24663208, Length=208, Percent_Identity=31.7307692307692, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17737899, Length=215, Percent_Identity=33.4883720930233, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24645822, Length=215, Percent_Identity=33.4883720930233, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221459597, Length=194, Percent_Identity=27.319587628866, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21356893, Length=194, Percent_Identity=27.319587628866, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 35467; Mature: 35467

Theoretical pI: Translated: 11.14; Mature: 11.14

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGPPGAGKGTQAARLVQQYGLVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVP
CEEEEECCCCCCCCHHHHHHHHHHCCEEECCCHHHHHHHHCCCCCCCCHHHHHHCCCCCH
DEVVIGIISDRIEQPDATNGFILDGFPRTVPQAEALDALLKDKKLGLDAVVELRVNESAL
HHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHH
LARVETRVAEMRERGEEPRADDNAEALAKRLTAYRLQTEPLVEYYSDKRKLLTVDGMMTI
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEECCCHHH
DEVTREIGRILEALGEANAKKAAKTAAAKRAVKKSAKPAKASGKPKASGKAKAPGKAPAK
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHH
KASAKKAVSGKSSSKAESAKTASAGLKKPAKATKKTGKKAAKVASKAPAKAAKTAGKKAN
HHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCH
KSKAKSAAKAPKRGAKVTKKAAKKAGTPSAQKARKVNKKRA
HHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MRLILLGPPGAGKGTQAARLVQQYGLVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVP
CEEEEECCCCCCCCHHHHHHHHHHCCEEECCCHHHHHHHHCCCCCCCCHHHHHHCCCCCH
DEVVIGIISDRIEQPDATNGFILDGFPRTVPQAEALDALLKDKKLGLDAVVELRVNESAL
HHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHH
LARVETRVAEMRERGEEPRADDNAEALAKRLTAYRLQTEPLVEYYSDKRKLLTVDGMMTI
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEECCCHHH
DEVTREIGRILEALGEANAKKAAKTAAAKRAVKKSAKPAKASGKPKASGKAKAPGKAPAK
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHH
KASAKKAVSGKSSSKAESAKTASAGLKKPAKATKKTGKKAAKVASKAPAKAAKTAGKKAN
HHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCH
KSKAKSAAKAPKRGAKVTKKAAKKAGTPSAQKARKVNKKRA
HHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA