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The map label for this gene is lpxC [H]

Identifier: 86749128

GI number: 86749128

Start: 2279263

End: 2280225

Strand: Direct

Name: lpxC [H]

Synonym: RPB_2005

Alternate gene names: 86749128

Gene position: 2279263-2280225 (Clockwise)

Preceding gene: 86749127

Following gene: 86749129

Centisome position: 42.75

GC content: 67.29

Gene sequence:

>963_bases
ATGAAATTCAGCCGGCAGACAACGCTGCGATCGCAAGCCACGGTCACTGGCGTCGGTGTCCACTCCGGTCGTCCGGCCAC
GCTCTCCATCGGACCCGCCTCCATCGACGCGGGTTATATTTTTGTCCGCAGCGGTCTCGACGGCGGTGACCGCGAAATCC
AGGCCAATGCCAAATCGGTGGTCGCCACCGAACTCGCCACCGTGCTGGGCGATAGCGACGGCCCGCTGGTTTCGACGGCC
GAGCACGTCCTTGCCGCGCTGCGCGGCATGGGCATCGACAATGCCACCATCGAAGTCGACGGCCCCGAAGTGCCGATCAT
GGACGGCAGCGCCGCGCCTTTCGTTGCCGCGATCGACCAGGCCGGCATCCGCGAGCAATCGGCGCCGCGCCGCTTCATCC
AGGTTCTCAAGCCGGTCCGCGTGTCGCACGGCGACTCGTTCGGCGAGCTTCGCCCCTATACCGGTGGTTTCCGCGTCGAG
GTCGACATCGACTTCGCCAATCCGGTCATCGGTCAGCAGAATTACAGCCTCGGCGTCGAGCCGGAAGCCTTCCGCCGCGA
AATCGCCCGCGCCCGCACCTTCGGCTGCATGAGCGACGTCGCCCGGCTGTGGGAAATGGGCTACGCGCTCGGCGCGTCGT
TCGAGAATTCGGTGGTGTTCGACGACGAGCGGCTGCTCAACGCCGAAGGCCTGCGCTATGCCGACGAATGCGCCCGCCAC
AAGCTGCTCGACGCGATCGGCGATCTGGCGCTGGCGGGTCTGCCGATTCTGGGCGCCTATCGCTCGATGCGGGGTGGCCA
CAAGCTCAACCATTCGGTGCTGACCGCGCTTCTGGCCGATCGCACCAACTTCCGAGTGATCGAAGCCGAGCCGGCGCGCC
GCGCGGTGCGGGGCCACGCCGAAGCCGTCACCCGCCTGGCCGGCGGCATGGTCGCCCCGGCCTACGGTCCGGATATGTCC
TGA

Upstream 100 bases:

>100_bases
GCAGTGCTATGGTTTCTTGGACTTGGGGACACACGGTCGAGTCGCCTGGACGTTATGTCCGGGAAACGACGGACTGGTGG
TCATTGGTGGGCACTAGCGC

Downstream 100 bases:

>100_bases
TCCGACGGGGCACGACATCGACCGCCTTCGCGACCACGACTGGCGGCCCGTCATCTCCATATCCCGCCGCTTTTCCCCGT
CTGCCAGCCGCCGCCGCCCG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MKFSRQTTLRSQATVTGVGVHSGRPATLSIGPASIDAGYIFVRSGLDGGDREIQANAKSVVATELATVLGDSDGPLVSTA
EHVLAALRGMGIDNATIEVDGPEVPIMDGSAAPFVAAIDQAGIREQSAPRRFIQVLKPVRVSHGDSFGELRPYTGGFRVE
VDIDFANPVIGQQNYSLGVEPEAFRREIARARTFGCMSDVARLWEMGYALGASFENSVVFDDERLLNAEGLRYADECARH
KLLDAIGDLALAGLPILGAYRSMRGGHKLNHSVLTALLADRTNFRVIEAEPARRAVRGHAEAVTRLAGGMVAPAYGPDMS

Sequences:

>Translated_320_residues
MKFSRQTTLRSQATVTGVGVHSGRPATLSIGPASIDAGYIFVRSGLDGGDREIQANAKSVVATELATVLGDSDGPLVSTA
EHVLAALRGMGIDNATIEVDGPEVPIMDGSAAPFVAAIDQAGIREQSAPRRFIQVLKPVRVSHGDSFGELRPYTGGFRVE
VDIDFANPVIGQQNYSLGVEPEAFRREIARARTFGCMSDVARLWEMGYALGASFENSVVFDDERLLNAEGLRYADECARH
KLLDAIGDLALAGLPILGAYRSMRGGHKLNHSVLTALLADRTNFRVIEAEPARRAVRGHAEAVTRLAGGMVAPAYGPDMS
>Mature_320_residues
MKFSRQTTLRSQATVTGVGVHSGRPATLSIGPASIDAGYIFVRSGLDGGDREIQANAKSVVATELATVLGDSDGPLVSTA
EHVLAALRGMGIDNATIEVDGPEVPIMDGSAAPFVAAIDQAGIREQSAPRRFIQVLKPVRVSHGDSFGELRPYTGGFRVE
VDIDFANPVIGQQNYSLGVEPEAFRREIARARTFGCMSDVARLWEMGYALGASFENSVVFDDERLLNAEGLRYADECARH
KLLDAIGDLALAGLPILGAYRSMRGGHKLNHSVLTALLADRTNFRVIEAEPARRAVRGHAEAVTRLAGGMVAPAYGPDMS

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=285, Percent_Identity=44.5614035087719, Blast_Score=248, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 34117; Mature: 34117

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFSRQTTLRSQATVTGVGVHSGRPATLSIGPASIDAGYIFVRSGLDGGDREIQANAKSV
CCCCCHHHHHCCCEEEEEECCCCCCCEEEECCCCCCCCEEEEECCCCCCCCEECCCHHHH
VATELATVLGDSDGPLVSTAEHVLAALRGMGIDNATIEVDGPEVPIMDGSAAPFVAAIDQ
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEECCCCCCHHHHHHH
AGIREQSAPRRFIQVLKPVRVSHGDSFGELRPYTGGFRVEVDIDFANPVIGQQNYSLGVE
HCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCC
PEAFRREIARARTFGCMSDVARLWEMGYALGASFENSVVFDDERLLNAEGLRYADECARH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHCCCCCCHHHHHHHH
KLLDAIGDLALAGLPILGAYRSMRGGHKLNHSVLTALLADRTNFRVIEAEPARRAVRGHA
HHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
EAVTRLAGGMVAPAYGPDMS
HHHHHHHCCEECCCCCCCCC
>Mature Secondary Structure
MKFSRQTTLRSQATVTGVGVHSGRPATLSIGPASIDAGYIFVRSGLDGGDREIQANAKSV
CCCCCHHHHHCCCEEEEEECCCCCCCEEEECCCCCCCCEEEEECCCCCCCCEECCCHHHH
VATELATVLGDSDGPLVSTAEHVLAALRGMGIDNATIEVDGPEVPIMDGSAAPFVAAIDQ
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEECCCCCCHHHHHHH
AGIREQSAPRRFIQVLKPVRVSHGDSFGELRPYTGGFRVEVDIDFANPVIGQQNYSLGVE
HCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCC
PEAFRREIARARTFGCMSDVARLWEMGYALGASFENSVVFDDERLLNAEGLRYADECARH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHCCCCCCHHHHHHHH
KLLDAIGDLALAGLPILGAYRSMRGGHKLNHSVLTALLADRTNFRVIEAEPARRAVRGHA
HHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
EAVTRLAGGMVAPAYGPDMS
HHHHHHHCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA