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The map label for this gene is emrK [H]

Identifier: 86749103

GI number: 86749103

Start: 2249198

End: 2250433

Strand: Direct

Name: emrK [H]

Synonym: RPB_1980

Alternate gene names: 86749103

Gene position: 2249198-2250433 (Clockwise)

Preceding gene: 86749101

Following gene: 86749104

Centisome position: 42.19

GC content: 70.15

Gene sequence:

>1236_bases
ATGTCCGGTCGCGACCAAGCTGCACGCGTTCTGAGGTCCGAGCCCGCCCAAGAGGCGGACCCGCGTGCCGCCGTGCCGCC
GCAAGCCGCGCGCCCGTTGCCGGACGATCCATCGACGCTGAAGCGCGCCGAGCCGGTGCAGCCCGACACCAAGTCCGAGC
CGGTCGCCCCGGCGACGGAGCCCGCGGCGGCGGCGAAGAAGCCGGGCCGGAAGCGGCTGGCGCTGATCGCGGTCGGCCTC
GCGGCGCTGGCGGCAGGCGCTTATTTCGGCACCGACTACATGCTGGTCGGCCGCTTCATGGTGTCGACCGACGACGCTTA
TGTGCGCGCCAACAACACCACGCTCGGCGCCCGCGTCGCCGGCCATATCGCCGCGATCGTCCCGCGCGACAACACGCTGG
TGAAGGCCGGCGACGTGGTGTTCCGGATCGACGACGGCGACTATCGGATCGCGGTCGATACCGCGCGCGCCAAGATCGCC
ACGCAGCAGGCGACCATCGAACGGATCGGCCGCCAGGTCACCGCGCAGGAAAGCGCGGTGGAGCAGGCGCAGGCGCAGCG
CGAATCCGCCGAAGCCTCGGCCAGGCGCGCCACGCTCGATTTCGACCGCCAGCAGGCGCTGAGCACCAAGGGCTTCGCCT
CCCGCGCGGTGTTCGAGACCTCGCAGGCGAGCCGCGACCAGGGCACCGCCTCGGTCGCCGCCGCCAAGGCGGCCTATGAC
GCCGCGCGCGACAATGTCGAGGTCACCAAGGCGCAGCAGAACGAGGCCCGCGCCCAACTCGTCGAACTGCAGAGCTCGCT
CGCCAAGGCCGAGCGCGATCTCGACTTCACCAATGTCCGCGCGCCGGTCGACGGCGTGTTCTCCAACCGCATGGTCAATA
CCGGCGATTACATCAACGCCGGCCAGCGCCTCGGCAACATCGTGCCGCTCAGCGGCGTGTACATCGACGCCAATTTCAAG
GAAACCCAGCTCGCCCGCCTGAAGCCCGGCCAGACCGTCGACATCTCGGTCGACGCTTACTCCGGCCGCAAGATCGAGGG
CACGGTGGACAGCCTGTCGCCCGCGGCGGGGCAGGTGTTCACGCTGCTGCCGCCCGACAACGCCACCGGCAATTTCACCA
AGGTCGTGCAGCGCGTGCCGGTCCGCATCCGCGTGCCCGCCGAGGTGGCACGCGAGGGCCTGCTGCGCGCCGGCATGTCG
GTCTATATCCGGGTCGACACAAGGACCGGGAAGTAA

Upstream 100 bases:

>100_bases
ATCTTGACCGAACCGTTCGGTCAATTTATTTGAGAATGGCTGTCAGGACGGGTGGTCCGGACAAGCGCTCATCCTTGTGA
GCCAGTCAGGAGAAAGCCCG

Downstream 100 bases:

>100_bases
GCGAAACCAATCACCGTCATTGCGAGGAGCGAAGCGACGAAGCAATCCAGCTCAGCGCACCGAGCCCTGGTTTGCTTCGC
TTCGCTCGCAATGACGGATA

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MSGRDQAARVLRSEPAQEADPRAAVPPQAARPLPDDPSTLKRAEPVQPDTKSEPVAPATEPAAAAKKPGRKRLALIAVGL
AALAAGAYFGTDYMLVGRFMVSTDDAYVRANNTTLGARVAGHIAAIVPRDNTLVKAGDVVFRIDDGDYRIAVDTARAKIA
TQQATIERIGRQVTAQESAVEQAQAQRESAEASARRATLDFDRQQALSTKGFASRAVFETSQASRDQGTASVAAAKAAYD
AARDNVEVTKAQQNEARAQLVELQSSLAKAERDLDFTNVRAPVDGVFSNRMVNTGDYINAGQRLGNIVPLSGVYIDANFK
ETQLARLKPGQTVDISVDAYSGRKIEGTVDSLSPAAGQVFTLLPPDNATGNFTKVVQRVPVRIRVPAEVAREGLLRAGMS
VYIRVDTRTGK

Sequences:

>Translated_411_residues
MSGRDQAARVLRSEPAQEADPRAAVPPQAARPLPDDPSTLKRAEPVQPDTKSEPVAPATEPAAAAKKPGRKRLALIAVGL
AALAAGAYFGTDYMLVGRFMVSTDDAYVRANNTTLGARVAGHIAAIVPRDNTLVKAGDVVFRIDDGDYRIAVDTARAKIA
TQQATIERIGRQVTAQESAVEQAQAQRESAEASARRATLDFDRQQALSTKGFASRAVFETSQASRDQGTASVAAAKAAYD
AARDNVEVTKAQQNEARAQLVELQSSLAKAERDLDFTNVRAPVDGVFSNRMVNTGDYINAGQRLGNIVPLSGVYIDANFK
ETQLARLKPGQTVDISVDAYSGRKIEGTVDSLSPAAGQVFTLLPPDNATGNFTKVVQRVPVRIRVPAEVAREGLLRAGMS
VYIRVDTRTGK
>Mature_410_residues
SGRDQAARVLRSEPAQEADPRAAVPPQAARPLPDDPSTLKRAEPVQPDTKSEPVAPATEPAAAAKKPGRKRLALIAVGLA
ALAAGAYFGTDYMLVGRFMVSTDDAYVRANNTTLGARVAGHIAAIVPRDNTLVKAGDVVFRIDDGDYRIAVDTARAKIAT
QQATIERIGRQVTAQESAVEQAQAQRESAEASARRATLDFDRQQALSTKGFASRAVFETSQASRDQGTASVAAAKAAYDA
ARDNVEVTKAQQNEARAQLVELQSSLAKAERDLDFTNVRAPVDGVFSNRMVNTGDYINAGQRLGNIVPLSGVYIDANFKE
TQLARLKPGQTVDISVDAYSGRKIEGTVDSLSPAAGQVFTLLPPDNATGNFTKVVQRVPVRIRVPAEVAREGLLRAGMSV
YIRVDTRTGK

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=340, Percent_Identity=32.6470588235294, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1789041, Length=352, Percent_Identity=31.8181818181818, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1790519, Length=289, Percent_Identity=29.757785467128, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87081951, Length=331, Percent_Identity=25.6797583081571, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789637, Length=314, Percent_Identity=27.7070063694268, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790012, Length=251, Percent_Identity=25.0996015936255, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790024, Length=243, Percent_Identity=23.4567901234568, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789900, Length=357, Percent_Identity=25.2100840336134, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43868; Mature: 43737

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGRDQAARVLRSEPAQEADPRAAVPPQAARPLPDDPSTLKRAEPVQPDTKSEPVAPATE
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCC
PAAAAKKPGRKRLALIAVGLAALAAGAYFGTDYMLVGRFMVSTDDAYVRANNTTLGARVA
CHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEECCCEEEEECCCEEHHHHH
GHIAAIVPRDNTLVKAGDVVFRIDDGDYRIAVDTARAKIATQQATIERIGRQVTAQESAV
CEEEEEEECCCCEEEECCEEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
EQAQAQRESAEASARRATLDFDRQQALSTKGFASRAVFETSQASRDQGTASVAAAKAAYD
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHH
AARDNVEVTKAQQNEARAQLVELQSSLAKAERDLDFTNVRAPVDGVFSNRMVNTGDYINA
HHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHCCEECCCCHHHH
GQRLGNIVPLSGVYIDANFKETQLARLKPGQTVDISVDAYSGRKIEGTVDSLSPAAGQVF
HHHHCCEEECCCEEEECCCCHHHHHHCCCCCEEEEEEECCCCCEEECCHHCCCCCCCCEE
TLLPPDNATGNFTKVVQRVPVRIRVPAEVAREGLLRAGMSVYIRVDTRTGK
EEECCCCCCCHHHHHHHHCCEEEECCHHHHHHHHHHCCCEEEEEEECCCCC
>Mature Secondary Structure 
SGRDQAARVLRSEPAQEADPRAAVPPQAARPLPDDPSTLKRAEPVQPDTKSEPVAPATE
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCC
PAAAAKKPGRKRLALIAVGLAALAAGAYFGTDYMLVGRFMVSTDDAYVRANNTTLGARVA
CHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEECCCEEEEECCCEEHHHHH
GHIAAIVPRDNTLVKAGDVVFRIDDGDYRIAVDTARAKIATQQATIERIGRQVTAQESAV
CEEEEEEECCCCEEEECCEEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
EQAQAQRESAEASARRATLDFDRQQALSTKGFASRAVFETSQASRDQGTASVAAAKAAYD
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHH
AARDNVEVTKAQQNEARAQLVELQSSLAKAERDLDFTNVRAPVDGVFSNRMVNTGDYINA
HHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHCCEECCCCHHHH
GQRLGNIVPLSGVYIDANFKETQLARLKPGQTVDISVDAYSGRKIEGTVDSLSPAAGQVF
HHHHCCEEECCCEEEECCCCHHHHHHCCCCCEEEEEEECCCCCEEECCHHCCCCCCCCEE
TLLPPDNATGNFTKVVQRVPVRIRVPAEVAREGLLRAGMSVYIRVDTRTGK
EEECCCCCCCHHHHHHHHCCEEEECCHHHHHHHHHHCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]