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The map label for this gene is arsC [H]

Identifier: 86749094

GI number: 86749094

Start: 2237529

End: 2237969

Strand: Direct

Name: arsC [H]

Synonym: RPB_1971

Alternate gene names: 86749094

Gene position: 2237529-2237969 (Clockwise)

Preceding gene: 86749093

Following gene: 86749095

Centisome position: 41.97

GC content: 63.95

Gene sequence:

>441_bases
TTGAGAGGCCCCAAGATGGACGTCGTCATCTACCACAATCCCGCCTGCGGAACCTCGCGCAACACGCTCGGCCTGATCCG
CAATACCGGGATCGAGCCGCATGTGATCGAGTATCTCAAATGCCCGCCGAGCCGGGCGATGCTCGAACAGCTGATGGTTC
GCGCCGGGCTGACGCTGCGGCAATTGATCCGCGAAAAAGGCACGCCGTATCACGAGCTGAAGCTCGACGACCCCGAGCTG
AGCTATGACCAGCTGATGGATGCCGTGACGGCGCATCCGATCCTGATCAATCGCCCGCTGGTGGTGACGCCGAAAGGCGT
GCGGCTGTGCCGGCCGTCCGAAACCGTGCTCGACCTGCTGCCGCCGCAACGCGGCGAATTCCGCAAAGAGAACGGCGAAC
TCGTCGTCACCGCCACCGGCCGCCGCATGGCGACGGTGTAA

Upstream 100 bases:

>100_bases
GCAGCCCCGAACTATGTGCGCCGCTGATCGCCGATTTGCAGCCGCGCTGTGCGCCGCCAGCGAAGACCGCCGCGCGCAGC
CGCGCGCGCGCGGCATCGCG

Downstream 100 bases:

>100_bases
CAAGCGCAGACCGGTGATGGCAGACCAACGATGAAGGCAAGGCGAAGCAACGTTGCACGACGTCATCGCCCGGCTTGAAC
GGGCGACCCAGTATTCCAGC

Product: arsenate reductase

Products: NA

Alternate protein names: Arsenical pump modifier [H]

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MRGPKMDVVIYHNPACGTSRNTLGLIRNTGIEPHVIEYLKCPPSRAMLEQLMVRAGLTLRQLIREKGTPYHELKLDDPEL
SYDQLMDAVTAHPILINRPLVVTPKGVRLCRPSETVLDLLPPQRGEFRKENGELVVTATGRRMATV

Sequences:

>Translated_146_residues
MRGPKMDVVIYHNPACGTSRNTLGLIRNTGIEPHVIEYLKCPPSRAMLEQLMVRAGLTLRQLIREKGTPYHELKLDDPEL
SYDQLMDAVTAHPILINRPLVVTPKGVRLCRPSETVLDLLPPQRGEFRKENGELVVTATGRRMATV
>Mature_146_residues
MRGPKMDVVIYHNPACGTSRNTLGLIRNTGIEPHVIEYLKCPPSRAMLEQLMVRAGLTLRQLIREKGTPYHELKLDDPEL
SYDQLMDAVTAHPILINRPLVVTPKGVRLCRPSETVLDLLPPQRGEFRKENGELVVTATGRRMATV

Specific function: Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance [H]

COG id: COG1393

COG function: function code P; Arsenate reductase and related proteins, glutaredoxin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArsC family [H]

Homologues:

Organism=Escherichia coli, GI1789918, Length=138, Percent_Identity=54.3478260869565, Blast_Score=158, Evalue=2e-40,
Organism=Escherichia coli, GI1788841, Length=114, Percent_Identity=42.1052631578947, Blast_Score=92, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006659
- InterPro:   IPR006660
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF03960 ArsC [H]

EC number: =1.20.4.1 [H]

Molecular weight: Translated: 16407; Mature: 16407

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGPKMDVVIYHNPACGTSRNTLGLIRNTGIEPHVIEYLKCPPSRAMLEQLMVRAGLTLR
CCCCCEEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHH
QLIREKGTPYHELKLDDPELSYDQLMDAVTAHPILINRPLVVTPKGVRLCRPSETVLDLL
HHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCEEECCCEEECCCCCEEECCCHHHHHHC
PPQRGEFRKENGELVVTATGRRMATV
CCCCCCCCCCCCCEEEEECCCEECCC
>Mature Secondary Structure
MRGPKMDVVIYHNPACGTSRNTLGLIRNTGIEPHVIEYLKCPPSRAMLEQLMVRAGLTLR
CCCCCEEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHH
QLIREKGTPYHELKLDDPELSYDQLMDAVTAHPILINRPLVVTPKGVRLCRPSETVLDLL
HHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCEEECCCEEECCCCCEEECCCHHHHHHC
PPQRGEFRKENGELVVTATGRRMATV
CCCCCCCCCCCCCEEEEECCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3021763; 1703401; 1704144 [H]