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The map label for this gene is acdA [H]

Identifier: 86748872

GI number: 86748872

Start: 1998993

End: 2000183

Strand: Direct

Name: acdA [H]

Synonym: RPB_1749

Alternate gene names: 86748872

Gene position: 1998993-2000183 (Clockwise)

Preceding gene: 86748871

Following gene: 86748873

Centisome position: 37.49

GC content: 62.97

Gene sequence:

>1191_bases
ATGGATCTGAACTTCAGCAAGGAAGAAATCGCGTTTCGCGACGAGGTGCGGCAGTTCTTCAAGGACAACGTGCCGGCGAA
GACGCGGCAGAAGCTGGTCGAGGGCCGGCATCCGTCGAAGGACGACATGGTGGAGTGGTATCGCATCCTCCACAAGAAGG
GCTGGGGCGTCACCCACTGGCCGAAGGAATATGGCGGCACCGGTTGGAGCAGCGTGCAGCACTACATCTTCAACGAGGAG
CTGCAGGCCGCCCCCGCGCCGCAGCCGCTCGCTTTCGGCGTGTCGATGGTGGGACCTGTGATCTACACTTTCGGCAGTGA
AGAGCAGAAGAAGCGCTTCCTGCCGCGCATCGCCAGCGTCGAGGATTGGTGGTGCCAGGGCTTCTCCGAGCCCGGCTCCG
GCTCCGATCTCGCCTCGCTCAAGACCAAGGCCGAGAAGCGCGGCGACAAGTGGATCATCAACGGCCAGAAGACCTGGACC
ACGCTGGCGCAATACGCCGACTGGATCTTCTGCCTGTGCCGCACCGACCCCGCCGCCAAGAAGCAGTCGGGCATTTCCTT
CATCCTGGTCGACATGAAGACCAAGGGCATCACGGTGCGCCCGATCCAGACCATCGACGGCGGCAAGGAAGTCAACGAAG
TGTTCTTCGACGACGTCGAGGTGCCGCTCGAAAATCTGGTCGGCGAGGAGAACAAGGGCTGGGACTACGCCAAATTCCTG
CTCGGCAACGAGCGCACCGGCATTGCCCGGGTCGGCATGTCGAAGGAGCGCATCCGCCGCATCAAGGAACTGGCCGCCTC
GGTCGAATCCGGCGGCAAGCCGGTGATCGAGAACCCCAAGTTCCGCGACAAGCTCGCCGCGGTCGAGATCGAGCTGAAGG
CGCTCGAACTGACGCAGCTCCGCGTCGTCGCCGATGAAGGCAAGCACGGCAAGGGCAAGCCGAACCCGGCGTCGTCGGTG
CTGAAGATCAAGGGCTCCGAGATCCAGCAGGCGACCACCGAGCTGTTGATGGAAGTGATCGGCCCGTTCGCCGCGCCCTA
CGATGTGCACGGCGACGACGACAGCAACGAGACGATGGACTGGACCGCGCAGATCGCGCCGAGCTACTTCAACAACCGCA
AGGTGTCGATCTACGGCGGCTCGAACGAGATCCAGCGCAACATCATCACCAAGGCGGTGCTCGGGCTGTAA

Upstream 100 bases:

>100_bases
TCACCCCAACCCTCTCCCCGCAAGAGCGGGGCGAGGGAGGATGCTGCCGGTGTCGCGGGCGACGAGTTGAAACTGATTTG
ATTGACCCAAGGAGGATCCG

Downstream 100 bases:

>100_bases
GCGCGACGCGCGCTCCTTCACCTCTCCCCGTGTGCGGGGAGAGGTCGCCCGGCGAAGCCGGGCGGGTGAGGGGGCGTATC
AGCGCAGCCGAGAGTCAGCG

Product: Acyl-CoA dehydrogenase-like

Products: 6-carboxyhex-2-enoyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MDLNFSKEEIAFRDEVRQFFKDNVPAKTRQKLVEGRHPSKDDMVEWYRILHKKGWGVTHWPKEYGGTGWSSVQHYIFNEE
LQAAPAPQPLAFGVSMVGPVIYTFGSEEQKKRFLPRIASVEDWWCQGFSEPGSGSDLASLKTKAEKRGDKWIINGQKTWT
TLAQYADWIFCLCRTDPAAKKQSGISFILVDMKTKGITVRPIQTIDGGKEVNEVFFDDVEVPLENLVGEENKGWDYAKFL
LGNERTGIARVGMSKERIRRIKELAASVESGGKPVIENPKFRDKLAAVEIELKALELTQLRVVADEGKHGKGKPNPASSV
LKIKGSEIQQATTELLMEVIGPFAAPYDVHGDDDSNETMDWTAQIAPSYFNNRKVSIYGGSNEIQRNIITKAVLGL

Sequences:

>Translated_396_residues
MDLNFSKEEIAFRDEVRQFFKDNVPAKTRQKLVEGRHPSKDDMVEWYRILHKKGWGVTHWPKEYGGTGWSSVQHYIFNEE
LQAAPAPQPLAFGVSMVGPVIYTFGSEEQKKRFLPRIASVEDWWCQGFSEPGSGSDLASLKTKAEKRGDKWIINGQKTWT
TLAQYADWIFCLCRTDPAAKKQSGISFILVDMKTKGITVRPIQTIDGGKEVNEVFFDDVEVPLENLVGEENKGWDYAKFL
LGNERTGIARVGMSKERIRRIKELAASVESGGKPVIENPKFRDKLAAVEIELKALELTQLRVVADEGKHGKGKPNPASSV
LKIKGSEIQQATTELLMEVIGPFAAPYDVHGDDDSNETMDWTAQIAPSYFNNRKVSIYGGSNEIQRNIITKAVLGL
>Mature_396_residues
MDLNFSKEEIAFRDEVRQFFKDNVPAKTRQKLVEGRHPSKDDMVEWYRILHKKGWGVTHWPKEYGGTGWSSVQHYIFNEE
LQAAPAPQPLAFGVSMVGPVIYTFGSEEQKKRFLPRIASVEDWWCQGFSEPGSGSDLASLKTKAEKRGDKWIINGQKTWT
TLAQYADWIFCLCRTDPAAKKQSGISFILVDMKTKGITVRPIQTIDGGKEVNEVFFDDVEVPLENLVGEENKGWDYAKFL
LGNERTGIARVGMSKERIRRIKELAASVESGGKPVIENPKFRDKLAAVEIELKALELTQLRVVADEGKHGKGKPNPASSV
LKIKGSEIQQATTELLMEVIGPFAAPYDVHGDDDSNETMDWTAQIAPSYFNNRKVSIYGGSNEIQRNIITKAVLGL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557231, Length=409, Percent_Identity=26.6503667481663, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI187960098, Length=409, Percent_Identity=26.6503667481663, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI4501857, Length=400, Percent_Identity=27.75, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI4557233, Length=341, Percent_Identity=27.5659824046921, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI226958412, Length=235, Percent_Identity=30.6382978723404, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI7656849, Length=357, Percent_Identity=26.3305322128852, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI4501859, Length=414, Percent_Identity=26.5700483091787, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI226958414, Length=178, Percent_Identity=34.2696629213483, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI76496475, Length=349, Percent_Identity=28.6532951289398, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI4557235, Length=349, Percent_Identity=28.6532951289398, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4503943, Length=262, Percent_Identity=31.2977099236641, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI7669494, Length=262, Percent_Identity=31.2977099236641, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI21361497, Length=285, Percent_Identity=28.7719298245614, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI211971008, Length=212, Percent_Identity=28.3018867924528, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI48976061, Length=212, Percent_Identity=28.3018867924528, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI87081958, Length=330, Percent_Identity=26.969696969697, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786223, Length=251, Percent_Identity=25.4980079681275, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17570075, Length=411, Percent_Identity=27.007299270073, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17534899, Length=353, Percent_Identity=28.8951841359773, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17569725, Length=405, Percent_Identity=27.6543209876543, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17538396, Length=257, Percent_Identity=32.6848249027237, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17506239, Length=299, Percent_Identity=30.1003344481605, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17508101, Length=342, Percent_Identity=28.0701754385965, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI32563615, Length=195, Percent_Identity=34.3589743589744, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17551932, Length=254, Percent_Identity=25.5905511811024, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71990804, Length=245, Percent_Identity=29.3877551020408, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17505929, Length=225, Percent_Identity=27.1111111111111, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71985184, Length=253, Percent_Identity=29.6442687747036, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71985192, Length=253, Percent_Identity=29.6442687747036, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17533517, Length=235, Percent_Identity=25.9574468085106, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17534353, Length=261, Percent_Identity=27.9693486590038, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71982178, Length=209, Percent_Identity=31.1004784688995, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562446, Length=220, Percent_Identity=25.4545454545455, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21356377, Length=341, Percent_Identity=27.2727272727273, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24660351, Length=408, Percent_Identity=26.7156862745098, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI21355753, Length=290, Percent_Identity=29.3103448275862, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI281363737, Length=252, Percent_Identity=28.968253968254, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24666513, Length=242, Percent_Identity=29.7520661157025, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI19920834, Length=412, Percent_Identity=25.7281553398058, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646207, Length=398, Percent_Identity=24.3718592964824, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.1.62

Molecular weight: Translated: 44455; Mature: 44455

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLNFSKEEIAFRDEVRQFFKDNVPAKTRQKLVEGRHPSKDDMVEWYRILHKKGWGVTHW
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCC
PKEYGGTGWSSVQHYIFNEELQAAPAPQPLAFGVSMVGPVIYTFGSEEQKKRFLPRIASV
CHHHCCCCHHHHHHHHHCHHHHCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHCCC
EDWWCQGFSEPGSGSDLASLKTKAEKRGDKWIINGQKTWTTLAQYADWIFCLCRTDPAAK
HHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHEEEEECCCCCHH
KQSGISFILVDMKTKGITVRPIQTIDGGKEVNEVFFDDVEVPLENLVGEENKGWDYAKFL
HHCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHCCHHCCHHHHCCCCCCCCHHHHHH
LGNERTGIARVGMSKERIRRIKELAASVESGGKPVIENPKFRDKLAAVEIELKALELTQL
HCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEEEEEEEEEEEEEEE
RVVADEGKHGKGKPNPASSVLKIKGSEIQQATTELLMEVIGPFAAPYDVHGDDDSNETMD
EEEECCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
WTAQIAPSYFNNRKVSIYGGSNEIQRNIITKAVLGL
HHHEECHHHHCCCEEEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDLNFSKEEIAFRDEVRQFFKDNVPAKTRQKLVEGRHPSKDDMVEWYRILHKKGWGVTHW
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCC
PKEYGGTGWSSVQHYIFNEELQAAPAPQPLAFGVSMVGPVIYTFGSEEQKKRFLPRIASV
CHHHCCCCHHHHHHHHHCHHHHCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHCCC
EDWWCQGFSEPGSGSDLASLKTKAEKRGDKWIINGQKTWTTLAQYADWIFCLCRTDPAAK
HHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHEEEEECCCCCHH
KQSGISFILVDMKTKGITVRPIQTIDGGKEVNEVFFDDVEVPLENLVGEENKGWDYAKFL
HHCCCEEEEEEECCCCEEEEEECCCCCCHHHHHHHHCCHHCCHHHHCCCCCCCCHHHHHH
LGNERTGIARVGMSKERIRRIKELAASVESGGKPVIENPKFRDKLAAVEIELKALELTQL
HCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEEEEEEEEEEEEEEE
RVVADEGKHGKGKPNPASSVLKIKGSEIQQATTELLMEVIGPFAAPYDVHGDDDSNETMD
EEEECCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
WTAQIAPSYFNNRKVSIYGGSNEIQRNIITKAVLGL
HHHEECHHHHCCCEEEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pimeloyl-CoA; NAD+

Specific reaction: pimeloyl-CoA + NAD+ = 6-carboxyhex-2-enoyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]