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The map label for this gene is fabG [H]

Identifier: 86748807

GI number: 86748807

Start: 1917524

End: 1918282

Strand: Direct

Name: fabG [H]

Synonym: RPB_1684

Alternate gene names: 86748807

Gene position: 1917524-1918282 (Clockwise)

Preceding gene: 86748806

Following gene: 86748808

Centisome position: 35.96

GC content: 67.33

Gene sequence:

>759_bases
ATGCAGTTGAAAGACGTCTCCGTTCTCATCACCGGCGGAGGGTCGGGGCTCGGCGCCGCGACGGCGCAAGCGATGGCCGC
CAAGGGCGCCAAGGTCGCGGTGCTCGACATGAACAAGGACAATGCCGAGAAGGTCGCGGCCGAGATCGGCGGCGTCGCCT
GTGTCGGTGACGTGTCGCAGGAAGCGCCGGTCAAGGAAGCGATCGCCAAGGCCGAAGCCGCGCACGGCATCGTCCGCGTG
CTGGTGAACTGCGCCGGCATCGGCGGCGCAGTGAAGACCGTCGGCAAGAACGGCGCCTATCCGCTCGATCATTTCTCGCG
CATCATCAACGTCAATCTGATCGGCAGCTTCAACTGCATCCGGCTCGTCGCCGAGCGGATGCAGAACGCGCCGACCATCG
GCGAAGAGCGCGGCGTCTGCATCAACACCGCCTCTGTGGCGGCGTTCGACGGCCAGATCGGCCAGGCGGCTTATTCGGCG
TCGAAGGGCGGCATCGTCGGCATGACCTTGCCGGTGGCGCGCGACCTCGCCTCGATGAACATCCGCGTCATGACGATCGC
GCCCGGCCTGTTCCTGACGCCGCTGCTGATGGGCCTGTCGGAAGAAGCCCGCAAGAGCCTCGGCTCGCAGGTGCCGCATC
CGGCCCGCCTCGGCGATCCGTCGGAGTACGCGTCGCTCGCGGTGCAGATCGTCGAGAACCCGATGCTGAACGGCGAGACC
ATCCGTCTCGACGGCGCGATCCGCATGGCGCCGCGGTAG

Upstream 100 bases:

>100_bases
ACGCCGAAGGACCCGTCCGAGGTTCGTTGAACAGTTCAGGAAACGCCCAGGGACGGGCCCAAAGACAAGCTTCAAGAAGC
GCCCAAGGAAAGGATTTACG

Downstream 100 bases:

>100_bases
TCACTTCAACCCTCTCCCCTCGTGGGGGAGGGTGGCGGCCGAAGGCTGCCGGGTGAGGCGCGCGGCGAGTTCCGCCCCCT
CTCCCTGCAGCACGCGACGT

Product: Short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MQLKDVSVLITGGGSGLGAATAQAMAAKGAKVAVLDMNKDNAEKVAAEIGGVACVGDVSQEAPVKEAIAKAEAAHGIVRV
LVNCAGIGGAVKTVGKNGAYPLDHFSRIINVNLIGSFNCIRLVAERMQNAPTIGEERGVCINTASVAAFDGQIGQAAYSA
SKGGIVGMTLPVARDLASMNIRVMTIAPGLFLTPLLMGLSEEARKSLGSQVPHPARLGDPSEYASLAVQIVENPMLNGET
IRLDGAIRMAPR

Sequences:

>Translated_252_residues
MQLKDVSVLITGGGSGLGAATAQAMAAKGAKVAVLDMNKDNAEKVAAEIGGVACVGDVSQEAPVKEAIAKAEAAHGIVRV
LVNCAGIGGAVKTVGKNGAYPLDHFSRIINVNLIGSFNCIRLVAERMQNAPTIGEERGVCINTASVAAFDGQIGQAAYSA
SKGGIVGMTLPVARDLASMNIRVMTIAPGLFLTPLLMGLSEEARKSLGSQVPHPARLGDPSEYASLAVQIVENPMLNGET
IRLDGAIRMAPR
>Mature_252_residues
MQLKDVSVLITGGGSGLGAATAQAMAAKGAKVAVLDMNKDNAEKVAAEIGGVACVGDVSQEAPVKEAIAKAEAAHGIVRV
LVNCAGIGGAVKTVGKNGAYPLDHFSRIINVNLIGSFNCIRLVAERMQNAPTIGEERGVCINTASVAAFDGQIGQAAYSA
SKGGIVGMTLPVARDLASMNIRVMTIAPGLFLTPLLMGLSEEARKSLGSQVPHPARLGDPSEYASLAVQIVENPMLNGET
IRLDGAIRMAPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=57.6470588235294, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI83715985, Length=255, Percent_Identity=54.5098039215686, Blast_Score=241, Evalue=3e-64,
Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=33.0612244897959, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI15277342, Length=272, Percent_Identity=27.2058823529412, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI31542939, Length=255, Percent_Identity=25.8823529411765, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4504505, Length=194, Percent_Identity=36.5979381443299, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI59889578, Length=212, Percent_Identity=27.3584905660377, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI4503817, Length=208, Percent_Identity=30.7692307692308, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI32483357, Length=251, Percent_Identity=25.4980079681275, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=256, Percent_Identity=30.859375, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI87082160, Length=254, Percent_Identity=31.496062992126, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790717, Length=252, Percent_Identity=29.3650793650794, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1787905, Length=234, Percent_Identity=32.9059829059829, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI87082100, Length=260, Percent_Identity=29.6153846153846, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789057, Length=217, Percent_Identity=33.6405529953917, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789378, Length=238, Percent_Identity=27.7310924369748, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786812, Length=229, Percent_Identity=29.2576419213974, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=252, Percent_Identity=50.3968253968254, Blast_Score=232, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17555706, Length=247, Percent_Identity=30.7692307692308, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25147288, Length=250, Percent_Identity=28, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560332, Length=220, Percent_Identity=28.6363636363636, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=259, Percent_Identity=27.027027027027, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562910, Length=271, Percent_Identity=26.9372693726937, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567345, Length=200, Percent_Identity=28.5, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=27.843137254902, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=200, Percent_Identity=35.5, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=52.755905511811, Blast_Score=250, Evalue=8e-67,
Organism=Drosophila melanogaster, GI24639444, Length=252, Percent_Identity=30.5555555555556, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24644339, Length=261, Percent_Identity=31.4176245210728, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357041, Length=264, Percent_Identity=28.7878787878788, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI23397609, Length=236, Percent_Identity=30.9322033898305, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571526, Length=264, Percent_Identity=26.8939393939394, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=27.5303643724696, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356301, Length=212, Percent_Identity=28.7735849056604, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 25857; Mature: 25857

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLKDVSVLITGGGSGLGAATAQAMAAKGAKVAVLDMNKDNAEKVAAEIGGVACVGDVSQ
CCCCEEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCEEEECCCCC
EAPVKEAIAKAEAAHGIVRVLVNCAGIGGAVKTVGKNGAYPLDHFSRIINVNLIGSFNCI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHEEEEEEECCHHHH
RLVAERMQNAPTIGEERGVCINTASVAAFDGQIGQAAYSASKGGIVGMTLPVARDLASMN
HHHHHHHHCCCCCCCCCCEEEECCCEEEECCCHHHHHHHCCCCCEEEEEHHHHHHHHHCC
IRVMTIAPGLFLTPLLMGLSEEARKSLGSQVPHPARLGDPSEYASLAVQIVENPMLNGET
EEEEEECCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCE
IRLDGAIRMAPR
EEECCEEEECCC
>Mature Secondary Structure
MQLKDVSVLITGGGSGLGAATAQAMAAKGAKVAVLDMNKDNAEKVAAEIGGVACVGDVSQ
CCCCEEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCEEEECCCCC
EAPVKEAIAKAEAAHGIVRVLVNCAGIGGAVKTVGKNGAYPLDHFSRIINVNLIGSFNCI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHEEEEEEECCHHHH
RLVAERMQNAPTIGEERGVCINTASVAAFDGQIGQAAYSASKGGIVGMTLPVARDLASMN
HHHHHHHHCCCCCCCCCCEEEECCCEEEECCCHHHHHHHCCCCCEEEEEHHHHHHHHHCC
IRVMTIAPGLFLTPLLMGLSEEARKSLGSQVPHPARLGDPSEYASLAVQIVENPMLNGET
EEEEEECCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCE
IRLDGAIRMAPR
EEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]