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The map label for this gene is ahcY [H]

Identifier: 86748714

GI number: 86748714

Start: 1790547

End: 1791962

Strand: Direct

Name: ahcY [H]

Synonym: RPB_1589

Alternate gene names: 86748714

Gene position: 1790547-1791962 (Clockwise)

Preceding gene: 86748713

Following gene: 86748715

Centisome position: 33.58

GC content: 63.77

Gene sequence:

>1416_bases
ATGACCGCCAAGTTCACCGATTACATCGTCAAGGACATCGGCCTCGCCGAGTTCGGCCGCAAGGAGATCTCGCTGGCCGA
GACCGAAATGCCCGGCCTGATGGCGACGCGCGAGGAATACGGCCCCAAGCAGCCCCTGAAGGGCGCGCGGATCGCCGGCT
CGCTGCACATGACGATCCAGACCGCGGTGCTGATCGAGACGCTGGTCGCGCTCGGCGCCGACGTGCGCTGGGTGTCGTGC
AACATCTATTCGACCCAGGACCACGCCGCCGCGGCGATCGCCGCCGCCGGCATTCCGGTGTTCGCCATCAAGGGCGAGAG
CCTGGAAGACTATTGGGACTACACCGCCCGGATGTTCGACTGGCACGGCGGCGGCACCCCGAACATGATCCTCGATGACG
GCGGCGACGCCACCATGTACGTCCATCTCGGCCTGCGCGCCGAGAACGGCGACACCGCCTTCCTCGACAAGCCCGGCTCC
GACGAGGAGGTGATCTTCTTCGCGCTCTTGAAGAAGCAGCTCAAGGAGAAGCCGAAGGGCTACTTCGCCGAGATCGCCAA
GAACATCCGGGGCGTCTCCGAAGAGACCACCACGGGCGTGCACCGGCTCTACGACATGCAGAAGGCCGGCACGCTGCTGT
GGCCGGCCATCAACGTCAACGACTCGGTCACCAAGTCGAAATTCGACAACCTCTATGGCTGCCGTGAGTCGCTGGTCGAC
GGCATCCGCCGCGGCACCGACGTGATGCTGTCCGGCAAGGTGGCGATGGTCGCGGGCTTCGGCGACGTCGGCAAGGGCTC
GGCCGCCTCGCTGCGCCAGGCCGGCTGCCGTGTGATGGTGTCCGAAGTCGATCCGATCTGCGCGCTGCAGGCGGCGATGG
AAGGCTATCAGGTCGTGACCATGGAAGACGCGGCGCCGCTCGCCGACATCTTCGTCACCGCCACCGGCAACAAGGACATC
ATCACCATCGAGCACATGCGCGCGATGAAGGATCGCGCCATCGTCTGCAACATCGGCCATTTCGACAACGAGATCCAGAT
CGCGCATCTCAAGAACCTGAAGTGGGACAACATCAAGCCGCAGGTCGACGAGATCACCTTCCCGGACGGCAAGCGCATGA
TCCTGCTGTCCGAAGGCCGCCTCGTGAACCTCGGCAACGCGATGGGGCATCCGTCCTTCGTGATGTCGGCCTCCTTCACC
AACCAGACGCTGGCGCAGATCGAACTGTTCGCCAACAACAAGGACGGCAAGTACAAGAAGGAAGTCTACGTCCTGCCGAA
GTCGCTGGATGAGAAGGTCGCCCGCCTGCACCTCGCCAAGATCGGCGTCAAGCTCACCGAACTGCGCAAGGACCAGGCCG
ACTACATCGGCGTCAAGGTCGAGGGGCCGTTCAAGGCGGATCATTACCGGTATTGA

Upstream 100 bases:

>100_bases
CACCTCAGGATGACGCTGAGCCTGCAGGACCGCCTCGAAATGCCCCAATCAGTTTGTAGTGCTCAGTTCGACTGACACAG
ACATCAGGAAACCCATCCGC

Downstream 100 bases:

>100_bases
GATTCATCGTAATACGGAAATGGCCGGGGGATTCCCCGGCCATTTTTTTTGCTAGCATTTCTCTATTTTCAAGTGTGATT
GCGTCTGGGTGCAAATTCAG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTAKFTDYIVKDIGLAEFGRKEISLAETEMPGLMATREEYGPKQPLKGARIAGSLHMTIQTAVLIETLVALGADVRWVSC
NIYSTQDHAAAAIAAAGIPVFAIKGESLEDYWDYTARMFDWHGGGTPNMILDDGGDATMYVHLGLRAENGDTAFLDKPGS
DEEVIFFALLKKQLKEKPKGYFAEIAKNIRGVSEETTTGVHRLYDMQKAGTLLWPAINVNDSVTKSKFDNLYGCRESLVD
GIRRGTDVMLSGKVAMVAGFGDVGKGSAASLRQAGCRVMVSEVDPICALQAAMEGYQVVTMEDAAPLADIFVTATGNKDI
ITIEHMRAMKDRAIVCNIGHFDNEIQIAHLKNLKWDNIKPQVDEITFPDGKRMILLSEGRLVNLGNAMGHPSFVMSASFT
NQTLAQIELFANNKDGKYKKEVYVLPKSLDEKVARLHLAKIGVKLTELRKDQADYIGVKVEGPFKADHYRY

Sequences:

>Translated_471_residues
MTAKFTDYIVKDIGLAEFGRKEISLAETEMPGLMATREEYGPKQPLKGARIAGSLHMTIQTAVLIETLVALGADVRWVSC
NIYSTQDHAAAAIAAAGIPVFAIKGESLEDYWDYTARMFDWHGGGTPNMILDDGGDATMYVHLGLRAENGDTAFLDKPGS
DEEVIFFALLKKQLKEKPKGYFAEIAKNIRGVSEETTTGVHRLYDMQKAGTLLWPAINVNDSVTKSKFDNLYGCRESLVD
GIRRGTDVMLSGKVAMVAGFGDVGKGSAASLRQAGCRVMVSEVDPICALQAAMEGYQVVTMEDAAPLADIFVTATGNKDI
ITIEHMRAMKDRAIVCNIGHFDNEIQIAHLKNLKWDNIKPQVDEITFPDGKRMILLSEGRLVNLGNAMGHPSFVMSASFT
NQTLAQIELFANNKDGKYKKEVYVLPKSLDEKVARLHLAKIGVKLTELRKDQADYIGVKVEGPFKADHYRY
>Mature_470_residues
TAKFTDYIVKDIGLAEFGRKEISLAETEMPGLMATREEYGPKQPLKGARIAGSLHMTIQTAVLIETLVALGADVRWVSCN
IYSTQDHAAAAIAAAGIPVFAIKGESLEDYWDYTARMFDWHGGGTPNMILDDGGDATMYVHLGLRAENGDTAFLDKPGSD
EEVIFFALLKKQLKEKPKGYFAEIAKNIRGVSEETTTGVHRLYDMQKAGTLLWPAINVNDSVTKSKFDNLYGCRESLVDG
IRRGTDVMLSGKVAMVAGFGDVGKGSAASLRQAGCRVMVSEVDPICALQAAMEGYQVVTMEDAAPLADIFVTATGNKDII
TIEHMRAMKDRAIVCNIGHFDNEIQIAHLKNLKWDNIKPQVDEITFPDGKRMILLSEGRLVNLGNAMGHPSFVMSASFTN
QTLAQIELFANNKDGKYKKEVYVLPKSLDEKVARLHLAKIGVKLTELRKDQADYIGVKVEGPFKADHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=467, Percent_Identity=57.8158458244111, Blast_Score=499, Evalue=1e-141,
Organism=Homo sapiens, GI239937451, Length=445, Percent_Identity=57.752808988764, Blast_Score=474, Evalue=1e-134,
Organism=Homo sapiens, GI298286489, Length=468, Percent_Identity=48.7179487179487, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI195539337, Length=468, Percent_Identity=48.7179487179487, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI24308043, Length=468, Percent_Identity=48.7179487179487, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI195539349, Length=468, Percent_Identity=48.7179487179487, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI21361647, Length=471, Percent_Identity=48.1953290870488, Blast_Score=435, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17506425, Length=467, Percent_Identity=60.1713062098501, Blast_Score=534, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6320882, Length=486, Percent_Identity=59.6707818930041, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24642172, Length=466, Percent_Identity=61.1587982832618, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24656245, Length=472, Percent_Identity=48.9406779661017, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45553387, Length=468, Percent_Identity=50, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45553385, Length=467, Percent_Identity=49.8929336188437, Blast_Score=429, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51797; Mature: 51666

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKFTDYIVKDIGLAEFGRKEISLAETEMPGLMATREEYGPKQPLKGARIAGSLHMTIQ
CCCCHHHHHHHHCCHHHCCCCCEEEECCCCCCCCHHHHHCCCCCCCCCCEEECEEEEHHH
TAVLIETLVALGADVRWVSCNIYSTQDHAAAAIAAAGIPVFAIKGESLEDYWDYTARMFD
HHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHEEE
WHGGGTPNMILDDGGDATMYVHLGLRAENGDTAFLDKPGSDEEVIFFALLKKQLKEKPKG
ECCCCCCCEEEECCCCEEEEEEEEEEECCCCEEEECCCCCCCCEEHHHHHHHHHHHCCCH
YFAEIAKNIRGVSEETTTGVHRLYDMQKAGTLLWPAINVNDSVTKSKFDNLYGCRESLVD
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
GIRRGTDVMLSGKVAMVAGFGDVGKGSAASLRQAGCRVMVSEVDPICALQAAMEGYQVVT
HHHCCCCEEEECCEEEEEECCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHCCEEEEE
MEDAAPLADIFVTATGNKDIITIEHMRAMKDRAIVCNIGHFDNEIQIAHLKNLKWDNIKP
ECCCCCEEEEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCCCCC
QVDEITFPDGKRMILLSEGRLVNLGNAMGHPSFVMSASFTNQTLAQIELFANNKDGKYKK
CCCEEECCCCCEEEEEECCCEEECCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCEEE
EVYVLPKSLDEKVARLHLAKIGVKLTELRKDQADYIGVKVEGPFKADHYRY
EEEEECCHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
TAKFTDYIVKDIGLAEFGRKEISLAETEMPGLMATREEYGPKQPLKGARIAGSLHMTIQ
CCCHHHHHHHHCCHHHCCCCCEEEECCCCCCCCHHHHHCCCCCCCCCCEEECEEEEHHH
TAVLIETLVALGADVRWVSCNIYSTQDHAAAAIAAAGIPVFAIKGESLEDYWDYTARMFD
HHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHEEE
WHGGGTPNMILDDGGDATMYVHLGLRAENGDTAFLDKPGSDEEVIFFALLKKQLKEKPKG
ECCCCCCCEEEECCCCEEEEEEEEEEECCCCEEEECCCCCCCCEEHHHHHHHHHHHCCCH
YFAEIAKNIRGVSEETTTGVHRLYDMQKAGTLLWPAINVNDSVTKSKFDNLYGCRESLVD
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
GIRRGTDVMLSGKVAMVAGFGDVGKGSAASLRQAGCRVMVSEVDPICALQAAMEGYQVVT
HHHCCCCEEEECCEEEEEECCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHCCEEEEE
MEDAAPLADIFVTATGNKDIITIEHMRAMKDRAIVCNIGHFDNEIQIAHLKNLKWDNIKP
ECCCCCEEEEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCCCCC
QVDEITFPDGKRMILLSEGRLVNLGNAMGHPSFVMSASFTNQTLAQIELFANNKDGKYKK
CCCEEECCCCCEEEEEECCCEEECCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCEEE
EVYVLPKSLDEKVARLHLAKIGVKLTELRKDQADYIGVKVEGPFKADHYRY
EEEEECCHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]