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The map label for this gene is nuoH1

Identifier: 86748478

GI number: 86748478

Start: 1542990

End: 1543949

Strand: Direct

Name: nuoH1

Synonym: RPB_1353

Alternate gene names: 86748478

Gene position: 1542990-1543949 (Clockwise)

Preceding gene: 86748477

Following gene: 86748479

Centisome position: 28.94

GC content: 67.08

Gene sequence:

>960_bases
ATGATCGGCCTCATCATCACCGCGATCATTTCGGCCGTGCTGATCATGGCGCTGCTGGTGGTCGCCGGCACGTTTACATG
GGTTGAGCGGCGGCTGCTCGGCTTCGTGCAGGAGCGCTACGGCCCCAACCGCGTCGGCCCGTTCGGCTCGCTGCAATGGG
TCGCCGACACCGTCAAGATTCTGACCAAGGAAGACCGGCCGCCGCCCGGCGCCGACAAGCTCACTTACATCCTCGCGCCA
GCCATCGCCGCGACGCCGGTGCTCGCCGGCTTCGGCGTCGTCGCCTTCGGCGACGGGCTGGTGCTCGCTCCCGTCGATGT
CGGCGTACTGTTTCTGCTCGGCATGATGGGGCTCACCGCCTACGCCGCGATGCTCGGTGCCTGGGCGTCGAACAACCGGT
TCTCGATGATGGGCGGCATGCGTGCGGCGGCACAGATGCTGGCCTACGAGGTGTTTCTCGGCCTGTCGCTGATGGGCGCG
GTGATGCTCGCAGGCTCGCTGTCGATGCACGCGATCGTCGAAGCACAGCGCGACGTCTGGTTCGTGGTGCTGCAGCCGCT
CGGCGCGGCGCTGTTCTGCATCGCCGGCGTCGCGGCCGCGCATCGTCTGCCGTTCGACCTGCCGGAATCCGAGAACGATC
TCGTCGCCGGCTTCATCACCGAATACACCGGCATGTCGTTCGGCCTGTTCTTCCTCGGCGAATATCTGGCGGTGCTGCTG
GTCTCGGCGCTGGCGGTCACGCTGTTCTTCGGCGGTTGGCTCGGGCCATGGTTGCCGGGGCCGATCTGGTTCGGCCTCAA
GACCGCGGTGATCGCCGTGGTGTTCGTCTGGCTGCGCGCGACGCTGCCGCGGCCACGTTACGATCAGTTGCTCGGCTTCG
CCTGGAAGATCGCGCTGCCGCTGTCGCTGCTCAACCTGCTGCTGACCGGCATCGTCGTGGTGGCGAGGAGCGCGCCATGA

Upstream 100 bases:

>100_bases
TTTCGCTCGACGCCTCGCTGCCGCGCGGCTGTGTGGCGATCAGCGCCGGCATCGACGCGCCGCGCGGGCCGCTGCGCCGG
GTGCGGCTGGAGGCTGCGCG

Downstream 100 bases:

>100_bases
TCGGCTGGCTGGAAGCGATGTTGCGGGTCGGCCGCAAGCTGTTCGTCAAGGCGGAGACGCAGCTTTATCCGGAAGAGAAG
CCGAAGCTGTTTCCGCGCAG

Product: respiratory-chain NADH dehydrogenase, subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H 1; NDH-1 subunit H 1

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MIGLIITAIISAVLIMALLVVAGTFTWVERRLLGFVQERYGPNRVGPFGSLQWVADTVKILTKEDRPPPGADKLTYILAP
AIAATPVLAGFGVVAFGDGLVLAPVDVGVLFLLGMMGLTAYAAMLGAWASNNRFSMMGGMRAAAQMLAYEVFLGLSLMGA
VMLAGSLSMHAIVEAQRDVWFVVLQPLGAALFCIAGVAAAHRLPFDLPESENDLVAGFITEYTGMSFGLFFLGEYLAVLL
VSALAVTLFFGGWLGPWLPGPIWFGLKTAVIAVVFVWLRATLPRPRYDQLLGFAWKIALPLSLLNLLLTGIVVVARSAP

Sequences:

>Translated_319_residues
MIGLIITAIISAVLIMALLVVAGTFTWVERRLLGFVQERYGPNRVGPFGSLQWVADTVKILTKEDRPPPGADKLTYILAP
AIAATPVLAGFGVVAFGDGLVLAPVDVGVLFLLGMMGLTAYAAMLGAWASNNRFSMMGGMRAAAQMLAYEVFLGLSLMGA
VMLAGSLSMHAIVEAQRDVWFVVLQPLGAALFCIAGVAAAHRLPFDLPESENDLVAGFITEYTGMSFGLFFLGEYLAVLL
VSALAVTLFFGGWLGPWLPGPIWFGLKTAVIAVVFVWLRATLPRPRYDQLLGFAWKIALPLSLLNLLLTGIVVVARSAP
>Mature_319_residues
MIGLIITAIISAVLIMALLVVAGTFTWVERRLLGFVQERYGPNRVGPFGSLQWVADTVKILTKEDRPPPGADKLTYILAP
AIAATPVLAGFGVVAFGDGLVLAPVDVGVLFLLGMMGLTAYAAMLGAWASNNRFSMMGGMRAAAQMLAYEVFLGLSLMGA
VMLAGSLSMHAIVEAQRDVWFVVLQPLGAALFCIAGVAAAHRLPFDLPESENDLVAGFITEYTGMSFGLFFLGEYLAVLL
VSALAVTLFFGGWLGPWLPGPIWFGLKTAVIAVVFVWLRATLPRPRYDQLLGFAWKIALPLSLLNLLLTGIVVVARSAP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=278, Percent_Identity=36.3309352517986, Blast_Score=185, Evalue=5e-47,
Organism=Escherichia coli, GI1788618, Length=311, Percent_Identity=53.6977491961415, Blast_Score=330, Evalue=5e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH1_RHOP2 (Q2J0E7)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_484974.1
- STRING:   Q2J0E7
- GeneID:   3908458
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_1353
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   MSWLTPE
- ProtClustDB:   CLSK827519
- BioCyc:   RPAL316058:RPB_1353-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 34072; Mature: 34072

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x19d59860)-; HASH(0x1b9de60c)-; HASH(0x1b63dd64)-; HASH(0x1aa3b710)-; HASH(0x1bd5b528)-; HASH(0x1a65c608)-; HASH(0x1c07c8f4)-; HASH(0x1bda4524)-; HASH(0x1b9fe5cc)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGLIITAIISAVLIMALLVVAGTFTWVERRLLGFVQERYGPNRVGPFGSLQWVADTVKI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LTKEDRPPPGADKLTYILAPAIAATPVLAGFGVVAFGDGLVLAPVDVGVLFLLGMMGLTA
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHEECCCEEECHHHHHHHHHHHHHHHHH
YAAMLGAWASNNRFSMMGGMRAAAQMLAYEVFLGLSLMGAVMLAGSLSMHAIVEAQRDVW
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHH
FVVLQPLGAALFCIAGVAAAHRLPFDLPESENDLVAGFITEYTGMSFGLFFLGEYLAVLL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
VSALAVTLFFGGWLGPWLPGPIWFGLKTAVIAVVFVWLRATLPRPRYDQLLGFAWKIALP
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LSLLNLLLTGIVVVARSAP
HHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure
MIGLIITAIISAVLIMALLVVAGTFTWVERRLLGFVQERYGPNRVGPFGSLQWVADTVKI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LTKEDRPPPGADKLTYILAPAIAATPVLAGFGVVAFGDGLVLAPVDVGVLFLLGMMGLTA
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHEECCCEEECHHHHHHHHHHHHHHHHH
YAAMLGAWASNNRFSMMGGMRAAAQMLAYEVFLGLSLMGAVMLAGSLSMHAIVEAQRDVW
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHH
FVVLQPLGAALFCIAGVAAAHRLPFDLPESENDLVAGFITEYTGMSFGLFFLGEYLAVLL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
VSALAVTLFFGGWLGPWLPGPIWFGLKTAVIAVVFVWLRATLPRPRYDQLLGFAWKIALP
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LSLLNLLLTGIVVVARSAP
HHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA