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The map label for this gene is nuoI1

Identifier: 86748479

GI number: 86748479

Start: 1543946

End: 1544461

Strand: Direct

Name: nuoI1

Synonym: RPB_1354

Alternate gene names: 86748479

Gene position: 1543946-1544461 (Clockwise)

Preceding gene: 86748478

Following gene: 86748480

Centisome position: 28.96

GC content: 65.89

Gene sequence:

>516_bases
ATGATCGGCTGGCTGGAAGCGATGTTGCGGGTCGGCCGCAAGCTGTTCGTCAAGGCGGAGACGCAGCTTTATCCGGAAGA
GAAGCCGAAGCTGTTTCCGCGCAGCCGCGGCCGCATCGTGCTGACGCGCGATCCGGACGGCCAGGAGCGCTGCGTCGCCT
GCAACCTGTGCGCGGCGGTGTGCCCGGTCGGCTGCATCGATCTTTCCAAGGCGGTCGCCGACGACGGCCGCTGGTATCCG
GAGCATTTCCGCATCAATTTCGCGCGCTGCATCTTCTGCGGCTTCTGCGAGGAGGCGTGTCCGACCGCGGCGATCCAGCT
CACGCCGGATTTCGAACTCGGCGAATGGCGCCGCGACGCGCTGGTCTACGAGAAGCACGATCTGCTGATTGCAGGCGAGG
GCAAGGTGCGCGGCTATCGCTACTGGTCGGTCGCCGGCAAGGCGATCGACGGCAAGGACAAGGGCTGCGCCGAGAACGAA
TCCCCGCCGGTCGATCTGAAGGGGCTGCTGCCATGA

Upstream 100 bases:

>100_bases
GTTACGATCAGTTGCTCGGCTTCGCCTGGAAGATCGCGCTGCCGCTGTCGCTGCTCAACCTGCTGCTGACCGGCATCGTC
GTGGTGGCGAGGAGCGCGCC

Downstream 100 bases:

>100_bases
GCCTGTGGCTGGCGATCTATGCCGGCGGCTTCGCGCTGGTGTCCGCGGCGATCGCGGTGACGCGGCCGAATGCCGTGCAC
GCGCTGCTGTATCTGGTGGT

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I 1; NDH-1 subunit I 1

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MIGWLEAMLRVGRKLFVKAETQLYPEEKPKLFPRSRGRIVLTRDPDGQERCVACNLCAAVCPVGCIDLSKAVADDGRWYP
EHFRINFARCIFCGFCEEACPTAAIQLTPDFELGEWRRDALVYEKHDLLIAGEGKVRGYRYWSVAGKAIDGKDKGCAENE
SPPVDLKGLLP

Sequences:

>Translated_171_residues
MIGWLEAMLRVGRKLFVKAETQLYPEEKPKLFPRSRGRIVLTRDPDGQERCVACNLCAAVCPVGCIDLSKAVADDGRWYP
EHFRINFARCIFCGFCEEACPTAAIQLTPDFELGEWRRDALVYEKHDLLIAGEGKVRGYRYWSVAGKAIDGKDKGCAENE
SPPVDLKGLLP
>Mature_171_residues
MIGWLEAMLRVGRKLFVKAETQLYPEEKPKLFPRSRGRIVLTRDPDGQERCVACNLCAAVCPVGCIDLSKAVADDGRWYP
EHFRINFARCIFCGFCEEACPTAAIQLTPDFELGEWRRDALVYEKHDLLIAGEGKVRGYRYWSVAGKAIDGKDKGCAENE
SPPVDLKGLLP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=119, Percent_Identity=42.8571428571429, Blast_Score=101, Evalue=3e-22,
Organism=Escherichia coli, GI1788617, Length=167, Percent_Identity=67.6646706586826, Blast_Score=238, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17555194, Length=120, Percent_Identity=40, Blast_Score=99, Evalue=8e-22,
Organism=Drosophila melanogaster, GI17864306, Length=119, Percent_Identity=42.0168067226891, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NUOI1_RHOP2 (Q2J0E6)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_484975.1
- ProteinModelPortal:   Q2J0E6
- SMR:   Q2J0E6
- STRING:   Q2J0E6
- GeneID:   3908459
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_1354
- eggNOG:   COG1143
- HOGENOM:   HBG724359
- OMA:   RYWSVAG
- ProtClustDB:   PRK05888
- BioCyc:   RPAL316058:RPB_1354-MONOMER
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226
- Gene3D:   G3DSA:1.10.1060.10
- TIGRFAMs:   TIGR01971

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 19194; Mature: 19194

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
5.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGWLEAMLRVGRKLFVKAETQLYPEEKPKLFPRSRGRIVLTRDPDGQERCVACNLCAAV
CCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
CPVGCIDLSKAVADDGRWYPEHFRINFARCIFCGFCEEACPTAAIQLTPDFELGEWRRDA
CCCCHHHHHHHHHCCCCCCCHHEEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHCC
LVYEKHDLLIAGEGKVRGYRYWSVAGKAIDGKDKGCAENESPPVDLKGLLP
EEEECCCEEEECCCCCCEEEEEEECCCEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIGWLEAMLRVGRKLFVKAETQLYPEEKPKLFPRSRGRIVLTRDPDGQERCVACNLCAAV
CCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
CPVGCIDLSKAVADDGRWYPEHFRINFARCIFCGFCEEACPTAAIQLTPDFELGEWRRDA
CCCCHHHHHHHHHCCCCCCCHHEEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHCC
LVYEKHDLLIAGEGKVRGYRYWSVAGKAIDGKDKGCAENESPPVDLKGLLP
EEEECCCEEEECCCCCCEEEEEEECCCEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA