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The map label for this gene is lldD [H]

Identifier: 86748430

GI number: 86748430

Start: 1486929

End: 1488068

Strand: Reverse

Name: lldD [H]

Synonym: RPB_1305

Alternate gene names: 86748430

Gene position: 1488068-1486929 (Counterclockwise)

Preceding gene: 86748444

Following gene: 86748429

Centisome position: 27.91

GC content: 64.74

Gene sequence:

>1140_bases
ATGAAATACATCACCTGCATCGAGGACCTTCGCCAGATTCACAAGCGGCGGGTGCCGAAGATGTTCTTCGACTATGTCGA
CCACGGCTCCTATGCCGAGGAGACGCTCCGCGCCAATGTCGACGACCTGAAGCGGATCAAGTTCCGCCAGCGCATCCTGG
TCGACATCTCCAAGCGCGATCTGTCCACCACCATCATCGGCGAGAAGTCGGCGATGCCGCTGATCCTGGCGCCGGTCGGC
TCCACCGGGATGCAATATGGCGACGGCGAGATCCACGCCTGCCGCGCCGCCCAGGCCGCCGGCATCCCCTACACGTTGTC
GACGATGTCGATCTGCTCGATCGAGGACGTCGCGGCGAATGTCGACAAGCCGTTCTGGTTTCAGCTCTACGTCATGAAGG
ACCGCGGCTTCGTCAAGGCGCTGATCGAGCGCGCGATCGCGGCCAAATGCAGCGCGCTGGTGCTGACCGTCGACCTGCAG
GTGATCGGCCAGCGCCATCAGGACATCAAGAACGGCATGACGGTGCCGCCGGAGATCTTCCGGCCGAAGAACCTGCTCGA
CATCGCCACCAAGCCCGGCTGGGTGAAGGGCATCCTCGGCGCCAAGCAGCGCAATTTCGGCAACATCGCCGGGCACCTGC
CCGGCTCCAAGGATCTGGAATCGGTGTCGGCCTGGGTGGCGTCGCAATTCGACGCCTCGCTGAACTGGAAGGACATCGAC
TGGATCCGCTCGATCTGGCCGGGCAAGCTGATCATCAAGGGCATCCTCGACGTCGAGGATGCCCGCGAGGCGGTGAAGGT
CGGCGCCGAGGCGCTGGTGGTGTCGAACCATGGCGGCCGCCAGCTCGACGGCGCGCCGTCGTCGATCGAGGTGCTGCCGG
AGATCGTCCACACCGTCGGCTCACATATCGAGGTGATGTTCGACGGCGGCATCCGCTCCGGCCAGGACGTGATGCGAGCG
CTGGCGCTCGGCGCGCGCAGCTGCATGATCGGCCGCGCCTACATCTACGGCCTCGGCGCCTATGGCGGCCCCGGCGTCGC
CAAGGCGATCGACATCATCGGCAAGGAGCTGTCGACCACCATGGGCCTGTGCGGCGTCAATGCGATCAACCAGATCGACG
AGAAGGTGCTGGCGGAGTAA

Upstream 100 bases:

>100_bases
CCCCGGCAAGGCATCGGCCGTGTTCCGCACCATGTTGCAGGCCGCGCCGGCGTGCTAGAGGACGCGACGCGCTGACAATG
CACCAGGGGCGGCACCGTTC

Downstream 100 bases:

>100_bases
GCACCAGCAACAATTCCTTCGTCATTGCGAGCGCAGCGAAGCAATCCAGAGCGCAGTGCACGGCGCCCCTGGATTGCTTC
GTCGGCTTCGCCTCCTCGCA

Product: L-lactate dehydrogenase (cytochrome)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MKYITCIEDLRQIHKRRVPKMFFDYVDHGSYAEETLRANVDDLKRIKFRQRILVDISKRDLSTTIIGEKSAMPLILAPVG
STGMQYGDGEIHACRAAQAAGIPYTLSTMSICSIEDVAANVDKPFWFQLYVMKDRGFVKALIERAIAAKCSALVLTVDLQ
VIGQRHQDIKNGMTVPPEIFRPKNLLDIATKPGWVKGILGAKQRNFGNIAGHLPGSKDLESVSAWVASQFDASLNWKDID
WIRSIWPGKLIIKGILDVEDAREAVKVGAEALVVSNHGGRQLDGAPSSIEVLPEIVHTVGSHIEVMFDGGIRSGQDVMRA
LALGARSCMIGRAYIYGLGAYGGPGVAKAIDIIGKELSTTMGLCGVNAINQIDEKVLAE

Sequences:

>Translated_379_residues
MKYITCIEDLRQIHKRRVPKMFFDYVDHGSYAEETLRANVDDLKRIKFRQRILVDISKRDLSTTIIGEKSAMPLILAPVG
STGMQYGDGEIHACRAAQAAGIPYTLSTMSICSIEDVAANVDKPFWFQLYVMKDRGFVKALIERAIAAKCSALVLTVDLQ
VIGQRHQDIKNGMTVPPEIFRPKNLLDIATKPGWVKGILGAKQRNFGNIAGHLPGSKDLESVSAWVASQFDASLNWKDID
WIRSIWPGKLIIKGILDVEDAREAVKVGAEALVVSNHGGRQLDGAPSSIEVLPEIVHTVGSHIEVMFDGGIRSGQDVMRA
LALGARSCMIGRAYIYGLGAYGGPGVAKAIDIIGKELSTTMGLCGVNAINQIDEKVLAE
>Mature_379_residues
MKYITCIEDLRQIHKRRVPKMFFDYVDHGSYAEETLRANVDDLKRIKFRQRILVDISKRDLSTTIIGEKSAMPLILAPVG
STGMQYGDGEIHACRAAQAAGIPYTLSTMSICSIEDVAANVDKPFWFQLYVMKDRGFVKALIERAIAAKCSALVLTVDLQ
VIGQRHQDIKNGMTVPPEIFRPKNLLDIATKPGWVKGILGAKQRNFGNIAGHLPGSKDLESVSAWVASQFDASLNWKDID
WIRSIWPGKLIIKGILDVEDAREAVKVGAEALVVSNHGGRQLDGAPSSIEVLPEIVHTVGSHIEVMFDGGIRSGQDVMRA
LALGARSCMIGRAYIYGLGAYGGPGVAKAIDIIGKELSTTMGLCGVNAINQIDEKVLAE

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=375, Percent_Identity=37.3333333333333, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI54234014, Length=375, Percent_Identity=36.2666666666667, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI7705393, Length=375, Percent_Identity=36.2666666666667, Blast_Score=229, Evalue=2e-60,
Organism=Escherichia coli, GI1790033, Length=377, Percent_Identity=45.8885941644562, Blast_Score=352, Evalue=3e-98,
Organism=Caenorhabditis elegans, GI193208036, Length=375, Percent_Identity=34.1333333333333, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI32566217, Length=292, Percent_Identity=33.2191780821918, Blast_Score=154, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6323587, Length=385, Percent_Identity=30.6493506493506, Blast_Score=173, Evalue=4e-44,
Organism=Drosophila melanogaster, GI78707188, Length=370, Percent_Identity=38.1081081081081, Blast_Score=247, Evalue=8e-66,
Organism=Drosophila melanogaster, GI281363140, Length=370, Percent_Identity=38.1081081081081, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI78707190, Length=370, Percent_Identity=38.1081081081081, Blast_Score=247, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41372; Mature: 41372

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYITCIEDLRQIHKRRVPKMFFDYVDHGSYAEETLRANVDDLKRIKFRQRILVDISKRD
CCHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHEECCCC
LSTTIIGEKSAMPLILAPVGSTGMQYGDGEIHACRAAQAAGIPYTLSTMSICSIEDVAAN
CEEEEECCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCEEECHHHHHHHHHHHHC
VDKPFWFQLYVMKDRGFVKALIERAIAAKCSALVLTVDLQVIGQRHQDIKNGMTVPPEIF
CCCCEEEEEEEEECCCHHHHHHHHHHHHHHCEEEEEEEHHHHHHHHHHHHCCCCCCHHHC
RPKNLLDIATKPGWVKGILGAKQRNFGNIAGHLPGSKDLESVSAWVASQFDASLNWKDID
CCCCHHECCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHH
WIRSIWPGKLIIKGILDVEDAREAVKVGAEALVVSNHGGRQLDGAPSSIEVLPEIVHTVG
HHHHHCCCHHHHHHHHCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCC
SHIEVMFDGGIRSGQDVMRALALGARSCMIGRAYIYGLGAYGGPGVAKAIDIIGKELSTT
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHH
MGLCGVNAINQIDEKVLAE
HHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKYITCIEDLRQIHKRRVPKMFFDYVDHGSYAEETLRANVDDLKRIKFRQRILVDISKRD
CCHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHEECCCC
LSTTIIGEKSAMPLILAPVGSTGMQYGDGEIHACRAAQAAGIPYTLSTMSICSIEDVAAN
CEEEEECCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCEEECHHHHHHHHHHHHC
VDKPFWFQLYVMKDRGFVKALIERAIAAKCSALVLTVDLQVIGQRHQDIKNGMTVPPEIF
CCCCEEEEEEEEECCCHHHHHHHHHHHHHHCEEEEEEEHHHHHHHHHHHHCCCCCCHHHC
RPKNLLDIATKPGWVKGILGAKQRNFGNIAGHLPGSKDLESVSAWVASQFDASLNWKDID
CCCCHHECCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHH
WIRSIWPGKLIIKGILDVEDAREAVKVGAEALVVSNHGGRQLDGAPSSIEVLPEIVHTVG
HHHHHCCCHHHHHHHHCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCC
SHIEVMFDGGIRSGQDVMRALALGARSCMIGRAYIYGLGAYGGPGVAKAIDIIGKELSTT
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHH
MGLCGVNAINQIDEKVLAE
HHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA