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The map label for this gene is cpg2 [H]

Identifier: 86748350

GI number: 86748350

Start: 1401931

End: 1403061

Strand: Reverse

Name: cpg2 [H]

Synonym: RPB_1225

Alternate gene names: 86748350

Gene position: 1403061-1401931 (Counterclockwise)

Preceding gene: 86748352

Following gene: 86748349

Centisome position: 26.32

GC content: 68.79

Gene sequence:

>1131_bases
ATGAACCCAGCAAATCTGCCGTTTGATTCCGAAGCCATGCTGCAAGGCCTGCGCGCCTGGGTCGAGTGCGAAAGCCCGAC
CTGGGACAAAGCCGCCGTCGAGCGCATGCTCGACCTCGCCGCGCGCGACATGGCGGTGATGGGTGCGTCGATCGAACGCA
TCGCCGGACGGCAGGGCTTCGCCGGCTGTGTTCGCGCACGCTTTCCGCACCCGCGGCAGGGCGAGCCCGGCATCCTGATC
GCCGGCCATCTCGACACCGTGCATCCGGTCGGCACGATCGAGAAACTGCAATGGCGCCGCGACGGCAACAAATGCTACGG
CCCGGGCATCTTCGACATGAAGGGCGGCAACTATCTGACGCTCGAAGCCATCCGCCAGCTCGCGCGCGCGTCGTTCACGA
CGCCGCTGCCGGTCACCGTGCTGTTCACGCCGGACGAGGAAGTCGGCACGCCCTCGACCCGGGACATCATCGAGGCGGAG
GCCGCCCGCAACAAATACGTGCTGGTGCCGGAGCCCGGCCGCCCCGACAACGGCGTCGTCACCGGCCGCTACGCGATCGC
GCGATTCAATCTGACGGCGACCGGCAAGCCCAGCCACGCCGGCGCGACGCTGTCCTCGGGACGTTCCGCGATCCGGGAAA
TGGCGCGGCAGATATTGGCGATCGACGCGATGACGACGGAGGACTGCACGTTCAGCGTCGGCATCGTGCACGGCGGACAA
TGGGTCAATTGCGTCGCCACCACCTGCACCGGCGAGGCGCTCAGCATGGCGAAGCGGCAGGCCGATCTCGACCGCGGCGT
CGAACGGATGCTGGCGCTGTCCGGCACCAGCAACGACGTCGGCTTCGAAGTGACGCGCGGCGTGACGCGGCCGGTCTGGG
AGCCCGACGCCGGCACCATGGCGCTGTACCAGAAGGCGGCCGCGATCGCCGACCAGCTCGGGCTGAAGCTGCCGCACGGC
AGCGCCGGCGGCGGTTCCGACGGCAACTTCACCGGCGCGATGGGGATCCCGACTCTCGACGGCCTCGGCGTGCGTGGCGC
CGACGCCCACACGCTGAACGAGCATATCGAAGTCGATAGTCTGGCGGAACGCGGGCGCCTGATGGCCGGGCTGCTCGCGA
CTCTCGCATGA

Upstream 100 bases:

>100_bases
GCAGCATGCAGCCGGTCGGGATGGCCGTTCGCGCATCTTTCACTTTACAAACTCGCGCGCAGTCAGTCTCGTAGCTGTGC
CCCGAACCGTGAGTGTACGA

Downstream 100 bases:

>100_bases
GGTTGCGGACGACAGGGCCTTCATCCCATGCCACACTCCGTGGCATGGGAATTGCTGACCACTCTGCCGTAAAGATCACC
GAACTTCGGTCACCGCAGGT

Product: carboxypeptidase

Products: NA

Alternate protein names: CPDG2; Folate hydrolase G2; Glutamate carboxypeptidase; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MNPANLPFDSEAMLQGLRAWVECESPTWDKAAVERMLDLAARDMAVMGASIERIAGRQGFAGCVRARFPHPRQGEPGILI
AGHLDTVHPVGTIEKLQWRRDGNKCYGPGIFDMKGGNYLTLEAIRQLARASFTTPLPVTVLFTPDEEVGTPSTRDIIEAE
AARNKYVLVPEPGRPDNGVVTGRYAIARFNLTATGKPSHAGATLSSGRSAIREMARQILAIDAMTTEDCTFSVGIVHGGQ
WVNCVATTCTGEALSMAKRQADLDRGVERMLALSGTSNDVGFEVTRGVTRPVWEPDAGTMALYQKAAAIADQLGLKLPHG
SAGGGSDGNFTGAMGIPTLDGLGVRGADAHTLNEHIEVDSLAERGRLMAGLLATLA

Sequences:

>Translated_376_residues
MNPANLPFDSEAMLQGLRAWVECESPTWDKAAVERMLDLAARDMAVMGASIERIAGRQGFAGCVRARFPHPRQGEPGILI
AGHLDTVHPVGTIEKLQWRRDGNKCYGPGIFDMKGGNYLTLEAIRQLARASFTTPLPVTVLFTPDEEVGTPSTRDIIEAE
AARNKYVLVPEPGRPDNGVVTGRYAIARFNLTATGKPSHAGATLSSGRSAIREMARQILAIDAMTTEDCTFSVGIVHGGQ
WVNCVATTCTGEALSMAKRQADLDRGVERMLALSGTSNDVGFEVTRGVTRPVWEPDAGTMALYQKAAAIADQLGLKLPHG
SAGGGSDGNFTGAMGIPTLDGLGVRGADAHTLNEHIEVDSLAERGRLMAGLLATLA
>Mature_376_residues
MNPANLPFDSEAMLQGLRAWVECESPTWDKAAVERMLDLAARDMAVMGASIERIAGRQGFAGCVRARFPHPRQGEPGILI
AGHLDTVHPVGTIEKLQWRRDGNKCYGPGIFDMKGGNYLTLEAIRQLARASFTTPLPVTVLFTPDEEVGTPSTRDIIEAE
AARNKYVLVPEPGRPDNGVVTGRYAIARFNLTATGKPSHAGATLSSGRSAIREMARQILAIDAMTTEDCTFSVGIVHGGQ
WVNCVATTCTGEALSMAKRQADLDRGVERMLALSGTSNDVGFEVTRGVTRPVWEPDAGTMALYQKAAAIADQLGLKLPHG
SAGGGSDGNFTGAMGIPTLDGLGVRGADAHTLNEHIEVDSLAERGRLMAGLLATLA

Specific function: Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity [H]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR017150
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.17.11 [H]

Molecular weight: Translated: 39977; Mature: 39977

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPANLPFDSEAMLQGLRAWVECESPTWDKAAVERMLDLAARDMAVMGASIERIAGRQGF
CCCCCCCCCHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCH
AGCVRARFPHPRQGEPGILIAGHLDTVHPVGTIEKLQWRRDGNKCYGPGIFDMKGGNYLT
HHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHCCCCEEECCCEEEECCCCEEE
LEAIRQLARASFTTPLPVTVLFTPDEEVGTPSTRDIIEAEAARNKYVLVPEPGRPDNGVV
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCEE
TGRYAIARFNLTATGKPSHAGATLSSGRSAIREMARQILAIDAMTTEDCTFSVGIVHGGQ
EEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCC
WVNCVATTCTGEALSMAKRQADLDRGVERMLALSGTSNDVGFEVTRGVTRPVWEPDAGTM
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCHH
ALYQKAAAIADQLGLKLPHGSAGGGSDGNFTGAMGIPTLDGLGVRGADAHTLNEHIEVDS
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHCCHHH
LAERGRLMAGLLATLA
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPANLPFDSEAMLQGLRAWVECESPTWDKAAVERMLDLAARDMAVMGASIERIAGRQGF
CCCCCCCCCHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCH
AGCVRARFPHPRQGEPGILIAGHLDTVHPVGTIEKLQWRRDGNKCYGPGIFDMKGGNYLT
HHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHCCCCEEECCCEEEECCCCEEE
LEAIRQLARASFTTPLPVTVLFTPDEEVGTPSTRDIIEAEAARNKYVLVPEPGRPDNGVV
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCEE
TGRYAIARFNLTATGKPSHAGATLSSGRSAIREMARQILAIDAMTTEDCTFSVGIVHGGQ
EEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCC
WVNCVATTCTGEALSMAKRQADLDRGVERMLALSGTSNDVGFEVTRGVTRPVWEPDAGTM
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCHH
ALYQKAAAIADQLGLKLPHGSAGGGSDGNFTGAMGIPTLDGLGVRGADAHTLNEHIEVDS
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHCCHHH
LAERGRLMAGLLATLA
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6396165; 3838935; 9083113 [H]