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The map label for this gene is pdxH

Identifier: 86748330

GI number: 86748330

Start: 1378920

End: 1379558

Strand: Reverse

Name: pdxH

Synonym: RPB_1205

Alternate gene names: 86748330

Gene position: 1379558-1378920 (Counterclockwise)

Preceding gene: 86748333

Following gene: 86748329

Centisome position: 25.87

GC content: 64.48

Gene sequence:

>639_bases
ATGAGCGATACCTCCATCAAACAACAGAGTCAGTTAACGTCGGGTGATTTCACCGCGGCGGAGAATCCGTTTGAGTTGTT
TGCTGAATGGCTTGCAGAGGCGGATCGGTCCGAGCCCAACGACCCGAACGCGATGGCGCTCGCGACGGTGGATTCCGACG
GCCTGCCCGACGTCCGGATGGTGCTGATGAAGGGCTACGACGCCGACGGCTTCGTCTTCTACAGCCACATCGCCAGCCAG
AAGGGCCGCGAACTCACCGCCAACCCCAAGGCGGCGCTGCTGTTTCACTGGAAGTCGCTGCGTCGGCAGGTGCGGATCCG
GGGCACGGTGACGCCGGTGAGCGACGCCGAGGCGGATGCCTATTTCGCCACGAGGCCGAAGCAGGCCCAGATCGGCGCCT
GGGCCAGCAAACAGTCACAACCGCTCGAAAGCCGTTTCGCGTTCGAGCAGGCGATCGCCAAGGTCGCCGCGCGCTATCTG
ATCGGCGAGGTTCCCCGCCCGCCGGGCTGGAGCGGATGGCGGATCACGCCGTCGCGGGTCGAATTCTGGCACGATCGCCC
GTTCCGGCTGCACGACCGCATCGAATTCAACCGGGACACCCCGGCCCAACCCTGGACCAAGACAAGGCTGTATCCATGA

Upstream 100 bases:

>100_bases
TCGATAGGCCAACGCAATTGCGTGCCCTATATAGGTCTGGCCTATACAGAGCTGCCAGCGCGTTCCGGATGGCGGCGAAG
CACAAGTCGGATTCCCTCGC

Downstream 100 bases:

>100_bases
GCCCCGACACCCCGAAGCCACGCGCGCAGGATAGCAATGCGCAGCGCCGGACCATGATTCTGACCGGCGCGAGCCGTGGA
ATCGGCCATGCCACCGTGAT

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MSDTSIKQQSQLTSGDFTAAENPFELFAEWLAEADRSEPNDPNAMALATVDSDGLPDVRMVLMKGYDADGFVFYSHIASQ
KGRELTANPKAALLFHWKSLRRQVRIRGTVTPVSDAEADAYFATRPKQAQIGAWASKQSQPLESRFAFEQAIAKVAARYL
IGEVPRPPGWSGWRITPSRVEFWHDRPFRLHDRIEFNRDTPAQPWTKTRLYP

Sequences:

>Translated_212_residues
MSDTSIKQQSQLTSGDFTAAENPFELFAEWLAEADRSEPNDPNAMALATVDSDGLPDVRMVLMKGYDADGFVFYSHIASQ
KGRELTANPKAALLFHWKSLRRQVRIRGTVTPVSDAEADAYFATRPKQAQIGAWASKQSQPLESRFAFEQAIAKVAARYL
IGEVPRPPGWSGWRITPSRVEFWHDRPFRLHDRIEFNRDTPAQPWTKTRLYP
>Mature_211_residues
SDTSIKQQSQLTSGDFTAAENPFELFAEWLAEADRSEPNDPNAMALATVDSDGLPDVRMVLMKGYDADGFVFYSHIASQK
GRELTANPKAALLFHWKSLRRQVRIRGTVTPVSDAEADAYFATRPKQAQIGAWASKQSQPLESRFAFEQAIAKVAARYLI
GEVPRPPGWSGWRITPSRVEFWHDRPFRLHDRIEFNRDTPAQPWTKTRLYP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=201, Percent_Identity=40.7960199004975, Blast_Score=157, Evalue=9e-39,
Organism=Escherichia coli, GI1787926, Length=191, Percent_Identity=40.8376963350785, Blast_Score=162, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17553712, Length=197, Percent_Identity=38.5786802030457, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319509, Length=210, Percent_Identity=36.6666666666667, Blast_Score=142, Evalue=3e-35,
Organism=Drosophila melanogaster, GI45551845, Length=197, Percent_Identity=39.5939086294416, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24644901, Length=197, Percent_Identity=39.5939086294416, Blast_Score=137, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24644903, Length=188, Percent_Identity=29.2553191489362, Blast_Score=84, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_RHOP2 (Q2J0U5)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_484826.1
- ProteinModelPortal:   Q2J0U5
- SMR:   Q2J0U5
- STRING:   Q2J0U5
- GeneID:   3910140
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_1205
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   HWSGFRI
- ProtClustDB:   PRK05679
- BioCyc:   RPAL316058:RPB_1205-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24055; Mature: 23924

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 59-59 BINDING 62-62 BINDING 64-64 BINDING 81-81 BINDING 121-121 BINDING 125-125

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTSIKQQSQLTSGDFTAAENPFELFAEWLAEADRSEPNDPNAMALATVDSDGLPDVRM
CCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHH
VLMKGYDADGFVFYSHIASQKGRELTANPKAALLFHWKSLRRQVRIRGTVTPVSDAEADA
HHHHCCCCCCEEHHHHHHHCCCCEEECCCCEEEEHHHHHHHHHEEEEEECCCCCCCCCCC
YFATRPKQAQIGAWASKQSQPLESRFAFEQAIAKVAARYLIGEVPRPPGWSGWRITPSRV
EECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHHH
EFWHDRPFRLHDRIEFNRDTPAQPWTKTRLYP
HHHCCCCCEECCEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDTSIKQQSQLTSGDFTAAENPFELFAEWLAEADRSEPNDPNAMALATVDSDGLPDVRM
CCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHH
VLMKGYDADGFVFYSHIASQKGRELTANPKAALLFHWKSLRRQVRIRGTVTPVSDAEADA
HHHHCCCCCCEEHHHHHHHCCCCEEECCCCEEEEHHHHHHHHHEEEEEECCCCCCCCCCC
YFATRPKQAQIGAWASKQSQPLESRFAFEQAIAKVAARYLIGEVPRPPGWSGWRITPSRV
EECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHHH
EFWHDRPFRLHDRIEFNRDTPAQPWTKTRLYP
HHHCCCCCEECCEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA