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The map label for this gene is acdA [H]

Identifier: 86748287

GI number: 86748287

Start: 1331347

End: 1332561

Strand: Direct

Name: acdA [H]

Synonym: RPB_1162

Alternate gene names: 86748287

Gene position: 1331347-1332561 (Clockwise)

Preceding gene: 86748286

Following gene: 86748288

Centisome position: 24.97

GC content: 65.68

Gene sequence:

>1215_bases
ATGAGCGTTCGCGCGCAAACCAAGGACAAGCCGGCTCCCGCGAGTTTCAAGTGGGACGACCCGCTGCTCCTGGAAGATCA
GCTCACCGAAGACGAGCGGATGATCCGCGACACCGCGCGCGCCTACGCGCAGGACAAGCTGCTGCCGCGTGTCAGCCAGG
CCTATCTCGAAGAGAAGACCGATCGCGAGATCTTCAACGAGATGGGCTCGCTCGGCCTGATCGGCATCACGCTGCCCGAG
GATTACGGCTGCGCCAATGCCAGCTACGTCGCCTACGGCCTCGTGGCGCGCGAGATCGAGCGCGTCGATAGCGGCTATCG
CTCGATGAATTCGGTGCAGTCGTCGCTGGTGATGTATCCGATCTACGCCTATGGCGACGAGACCCAGCGTAAGAAATATC
TGCCCAAGCTCGCCTCCGGCGAATGGGTCGGCTGCTTCGGCCTGACCGAGCCCGACGCCGGCTCCGATCCCGGCGGCATG
AAGACCCGCGCCGAGAAGGTCGCCGACGGCTATCGCCTCACCGGCACCAAGATGTGGATCTCCAACGCGCCGATCGCCGA
CGTGTTCGTGGTGTGGGCGAAGTCGGCCGCGCACGACAACCAGATCCGCGGCTTCATCCTCGAGAAGGGCATGAAGGGCC
TGTCGGCGCCGAAGATCGGCGGCAAGCTCTCGTTGCGCGCCTCGATCACCGGCGAGATCGTGATGGACGGCGTCGTGGTG
CCCGAAGAGGCGCTGCTGCCCAACGTGTCGGGCCTCAAGGGTCCGTTCGGCTGTCTCAACCGCGCCCGCTACGGCATCTC
CTGGGGCGTGCTCGGCGCCGCCGAGGATTGCTTCCAGCGCGCCCGGCAGTACACGCTCGACCGCAAGCAGTTCAACCGGC
CGCTCGCCGCCACCCAGCTGGTGCAGAAGAAGCTCGCCGACATGGAGACCGAGATCACGCTCGGCCTGCAGGCGTCGTTG
CGCGTCGGCCGGCTGATGGACGAAGGCCGGGTCGCGCCGGAAATGATCTCGATCGTCAAGCGCAACAATTGCGGCAAGGC
GCTCGACATCGCCCGCGTCGCCCGCGACATGCACGGCGGCAACGGCATCCAGATCGAGTACCACGTGATGCGCCACGCCC
AGAACCTCGAGACGGTCAACACCTACGAGGGCACCCACGACGTCCACGCTTTGATCATCGGCCGCGCCATCACCGGGCTG
CAGGCGTTTTCGTAA

Upstream 100 bases:

>100_bases
CGGCATCGAGATCGTCGGCAACGAGCACCTTGAAGGCACCTGACCAACGTTTTACCTTGCTGCTGTCGCACCATGCGGCA
GCGTCCCGAAAGGATGATCG

Downstream 100 bases:

>100_bases
GCTCTGTGTCCCGGACGCGATGCAGCGCGCTTGCGCTGCTTCGCAGAGCCGGGACCGCAACAGGCTATTCCGTCGCGACG
GTCCCGGTTCTGCGGCGCAT

Product: Acyl-CoA dehydrogenase-like

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSVRAQTKDKPAPASFKWDDPLLLEDQLTEDERMIRDTARAYAQDKLLPRVSQAYLEEKTDREIFNEMGSLGLIGITLPE
DYGCANASYVAYGLVAREIERVDSGYRSMNSVQSSLVMYPIYAYGDETQRKKYLPKLASGEWVGCFGLTEPDAGSDPGGM
KTRAEKVADGYRLTGTKMWISNAPIADVFVVWAKSAAHDNQIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVVV
PEEALLPNVSGLKGPFGCLNRARYGISWGVLGAAEDCFQRARQYTLDRKQFNRPLAATQLVQKKLADMETEITLGLQASL
RVGRLMDEGRVAPEMISIVKRNNCGKALDIARVARDMHGGNGIQIEYHVMRHAQNLETVNTYEGTHDVHALIIGRAITGL
QAFS

Sequences:

>Translated_404_residues
MSVRAQTKDKPAPASFKWDDPLLLEDQLTEDERMIRDTARAYAQDKLLPRVSQAYLEEKTDREIFNEMGSLGLIGITLPE
DYGCANASYVAYGLVAREIERVDSGYRSMNSVQSSLVMYPIYAYGDETQRKKYLPKLASGEWVGCFGLTEPDAGSDPGGM
KTRAEKVADGYRLTGTKMWISNAPIADVFVVWAKSAAHDNQIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVVV
PEEALLPNVSGLKGPFGCLNRARYGISWGVLGAAEDCFQRARQYTLDRKQFNRPLAATQLVQKKLADMETEITLGLQASL
RVGRLMDEGRVAPEMISIVKRNNCGKALDIARVARDMHGGNGIQIEYHVMRHAQNLETVNTYEGTHDVHALIIGRAITGL
QAFS
>Mature_403_residues
SVRAQTKDKPAPASFKWDDPLLLEDQLTEDERMIRDTARAYAQDKLLPRVSQAYLEEKTDREIFNEMGSLGLIGITLPED
YGCANASYVAYGLVAREIERVDSGYRSMNSVQSSLVMYPIYAYGDETQRKKYLPKLASGEWVGCFGLTEPDAGSDPGGMK
TRAEKVADGYRLTGTKMWISNAPIADVFVVWAKSAAHDNQIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVVVP
EEALLPNVSGLKGPFGCLNRARYGISWGVLGAAEDCFQRARQYTLDRKQFNRPLAATQLVQKKLADMETEITLGLQASLR
VGRLMDEGRVAPEMISIVKRNNCGKALDIARVARDMHGGNGIQIEYHVMRHAQNLETVNTYEGTHDVHALIIGRAITGLQ
AFS

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=397, Percent_Identity=66.7506297229219, Blast_Score=547, Evalue=1e-156,
Organism=Homo sapiens, GI7669494, Length=376, Percent_Identity=65.9574468085106, Blast_Score=508, Evalue=1e-144,
Organism=Homo sapiens, GI226958412, Length=378, Percent_Identity=32.5396825396825, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI226958414, Length=348, Percent_Identity=32.7586206896552, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=30.9973045822102, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=31.3672922252011, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4557235, Length=429, Percent_Identity=29.1375291375291, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=29.0666666666667, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=29.0666666666667, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI21361497, Length=392, Percent_Identity=29.3367346938776, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI76496475, Length=362, Percent_Identity=29.8342541436464, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4501857, Length=382, Percent_Identity=27.7486910994764, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI7656849, Length=382, Percent_Identity=27.2251308900524, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1786223, Length=353, Percent_Identity=22.0963172804533, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87081958, Length=350, Percent_Identity=24.5714285714286, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17534353, Length=392, Percent_Identity=66.0714285714286, Blast_Score=541, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17538396, Length=391, Percent_Identity=33.2480818414322, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=30.4812834224599, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=30.0268096514745, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=30.0791556728232, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71985184, Length=401, Percent_Identity=28.1795511221945, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=29.1005291005291, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71990804, Length=244, Percent_Identity=37.7049180327869, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=27.5590551181102, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71985192, Length=304, Percent_Identity=29.6052631578947, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=34.6320346320346, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71982178, Length=269, Percent_Identity=30.1115241635688, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17533517, Length=385, Percent_Identity=24.6753246753247, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17551932, Length=273, Percent_Identity=26.007326007326, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17505929, Length=249, Percent_Identity=23.2931726907631, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19920834, Length=404, Percent_Identity=61.8811881188119, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=31.6353887399464, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=30.6666666666667, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=32.4538258575198, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=31.4814814814815, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=29.9465240641711, Blast_Score=164, Evalue=8e-41,
Organism=Drosophila melanogaster, GI281363737, Length=378, Percent_Identity=29.1005291005291, Blast_Score=146, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 44512; Mature: 44380

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRAQTKDKPAPASFKWDDPLLLEDQLTEDERMIRDTARAYAQDKLLPRVSQAYLEEKT
CCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DREIFNEMGSLGLIGITLPEDYGCANASYVAYGLVAREIERVDSGYRSMNSVQSSLVMYP
HHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
IYAYGDETQRKKYLPKLASGEWVGCFGLTEPDAGSDPGGMKTRAEKVADGYRLTGTKMWI
EEECCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCEEEECEEEEE
SNAPIADVFVVWAKSAAHDNQIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVVV
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEECCEEC
PEEALLPNVSGLKGPFGCLNRARYGISWGVLGAAEDCFQRARQYTLDRKQFNRPLAATQL
CHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
VQKKLADMETEITLGLQASLRVGRLMDEGRVAPEMISIVKRNNCGKALDIARVARDMHGG
HHHHHHCCHHHEEECHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCC
NGIQIEYHVMRHAQNLETVNTYEGTHDVHALIIGRAITGLQAFS
CCEEEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVRAQTKDKPAPASFKWDDPLLLEDQLTEDERMIRDTARAYAQDKLLPRVSQAYLEEKT
CCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DREIFNEMGSLGLIGITLPEDYGCANASYVAYGLVAREIERVDSGYRSMNSVQSSLVMYP
HHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
IYAYGDETQRKKYLPKLASGEWVGCFGLTEPDAGSDPGGMKTRAEKVADGYRLTGTKMWI
EEECCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCEEEECEEEEE
SNAPIADVFVVWAKSAAHDNQIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVVV
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEECCEEC
PEEALLPNVSGLKGPFGCLNRARYGISWGVLGAAEDCFQRARQYTLDRKQFNRPLAATQL
CHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
VQKKLADMETEITLGLQASLRVGRLMDEGRVAPEMISIVKRNNCGKALDIARVARDMHGG
HHHHHHCCHHHEEECHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCC
NGIQIEYHVMRHAQNLETVNTYEGTHDVHALIIGRAITGLQAFS
CCEEEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]