Click here to switch to the map view.

The map label for this gene is lysA [H]

Identifier: 86747955

GI number: 86747955

Start: 942779

End: 944044

Strand: Direct

Name: lysA [H]

Synonym: RPB_0829

Alternate gene names: 86747955

Gene position: 942779-944044 (Clockwise)

Preceding gene: 86747954

Following gene: 86747957

Centisome position: 17.68

GC content: 65.96

Gene sequence:

>1266_bases
ATGCGTCATTTCGACTACCGCGACGGCGTGCTGCACGCCGAAGGCGTTGGCCTTGAAGTGCTCGCGCGCGAGGTCGGCAC
GCCGTTTTATTGCTACTCCACCGCGACGCTGGAGCGGCACTACCGCGTCTTCAGCGAAGCCTTCGCCGGCACCGACGCGC
TGGTCTGCTACGCGATGAAGGCGAACTCGAATCAATCGGTGTTGCGCACGCTGGCCAGGCTCGGCGCCGGTGCCGATGTT
GTTTCGGGCGGTGAATTGCAGCGCGCGCTGGCCGCGGGCATCCCGGCGAGCAAGATCGTGTTCTCCGGCGTCGGCAAGAC
CGAGGCCGAATTGCGCGCCGCGCTGGCGCACGACATCAAGTGCCTCAACGTCGAATCCGAGCCCGAGCTGGAATTGCTGT
CGCGGCTCGCGGTCGAGACCGGGCGGACCGCGCGGATTTCGATCCGGGTCAATCCGGACGTCGATTCCGGCACCCACGCC
AAGATCTCGACCGGCAAGTCGGAGAACAAATTCGGCATTCCGCTCGTGCATGCGCGTGAGGTCTATGCGCGCGCGGCGAA
GCTGCCCGGCATCCTGATATCGGGCGTCGACGTCCATATCGGCAGCCAGATCATCGATCTGGCGCCGATGGAGGCCGCGT
TCCGCCTCGTCGCCGAATTCGTGCACCAGTTGCGCGGCGATGGCCACACGATCAGTCACGTCGATTTCGGCGGCGGCCTC
GGCATTCCGTACTACGAGGATCGTGACGCGCCGCCGGAGCCGTTCGCCTATGCTCAGATGGTCAAGCGCGTCACCCACAA
TCTCGGCTGCGCGCTGCTGTTCGAGCCGGGCCGGATGATCGTCGGCAATGCCGGCATCCTGGTCGCGCGCGTGATCTATG
TGAAGCACGGCGACGGCAAGACCTTCGTGATCATCGATGCGGCGATGAACGATTTGATCCGGCCGACGCTGTACGAGGCC
TATCACGAAATTCTGCCGGTGGCGGCCCCCGCGCCCGGCGCCAAGCTGATCACCGCCGACGTCGTCGGCCCGGTCTGCGA
GACCGGCGATTACCTCGCGCTCGACCGCCAACTGCCGGAGCTGAAATCCGGCGACCTGATCGCGATCATGACGGCGGGCG
CCTATGGCGCGGTACAGGCGTGTACCTACAACACCCGCGCGCTGGTGCCCGAAGTGCTGGTCAAGGACGATCAGTACGCG
GTGGTGCGCCCGCGCATCGAGGTCGAGCAACTGATCGCGCTGGACCGGCCGGCGCCGTGGCTGTGA

Upstream 100 bases:

>100_bases
CGACGTGTTCGATTCGTCCTACGGCACCAACGCGCCGCCGGTCGCCGCCAAGGGCCAGAAGAAGCGCATCATCCTCGACC
CGCTGCTGGACTGATCCGCG

Downstream 100 bases:

>100_bases
GGCGCGGCCTTCCCCTTCGCTGATGCTGGAAGCGAGGGGTGGGACCGCCAGAACGCGGTGAACAAAAGCTGGCGGTCCCG
GATCGCGCATTGCAATCGTG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MRHFDYRDGVLHAEGVGLEVLAREVGTPFYCYSTATLERHYRVFSEAFAGTDALVCYAMKANSNQSVLRTLARLGAGADV
VSGGELQRALAAGIPASKIVFSGVGKTEAELRAALAHDIKCLNVESEPELELLSRLAVETGRTARISIRVNPDVDSGTHA
KISTGKSENKFGIPLVHAREVYARAAKLPGILISGVDVHIGSQIIDLAPMEAAFRLVAEFVHQLRGDGHTISHVDFGGGL
GIPYYEDRDAPPEPFAYAQMVKRVTHNLGCALLFEPGRMIVGNAGILVARVIYVKHGDGKTFVIIDAAMNDLIRPTLYEA
YHEILPVAAPAPGAKLITADVVGPVCETGDYLALDRQLPELKSGDLIAIMTAGAYGAVQACTYNTRALVPEVLVKDDQYA
VVRPRIEVEQLIALDRPAPWL

Sequences:

>Translated_421_residues
MRHFDYRDGVLHAEGVGLEVLAREVGTPFYCYSTATLERHYRVFSEAFAGTDALVCYAMKANSNQSVLRTLARLGAGADV
VSGGELQRALAAGIPASKIVFSGVGKTEAELRAALAHDIKCLNVESEPELELLSRLAVETGRTARISIRVNPDVDSGTHA
KISTGKSENKFGIPLVHAREVYARAAKLPGILISGVDVHIGSQIIDLAPMEAAFRLVAEFVHQLRGDGHTISHVDFGGGL
GIPYYEDRDAPPEPFAYAQMVKRVTHNLGCALLFEPGRMIVGNAGILVARVIYVKHGDGKTFVIIDAAMNDLIRPTLYEA
YHEILPVAAPAPGAKLITADVVGPVCETGDYLALDRQLPELKSGDLIAIMTAGAYGAVQACTYNTRALVPEVLVKDDQYA
VVRPRIEVEQLIALDRPAPWL
>Mature_421_residues
MRHFDYRDGVLHAEGVGLEVLAREVGTPFYCYSTATLERHYRVFSEAFAGTDALVCYAMKANSNQSVLRTLARLGAGADV
VSGGELQRALAAGIPASKIVFSGVGKTEAELRAALAHDIKCLNVESEPELELLSRLAVETGRTARISIRVNPDVDSGTHA
KISTGKSENKFGIPLVHAREVYARAAKLPGILISGVDVHIGSQIIDLAPMEAAFRLVAEFVHQLRGDGHTISHVDFGGGL
GIPYYEDRDAPPEPFAYAQMVKRVTHNLGCALLFEPGRMIVGNAGILVARVIYVKHGDGKTFVIIDAAMNDLIRPTLYEA
YHEILPVAAPAPGAKLITADVVGPVCETGDYLALDRQLPELKSGDLIAIMTAGAYGAVQACTYNTRALVPEVLVKDDQYA
VVRPRIEVEQLIALDRPAPWL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=353, Percent_Identity=26.3456090651558, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI16506287, Length=396, Percent_Identity=27.020202020202, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1789203, Length=413, Percent_Identity=32.9297820823245, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17562780, Length=368, Percent_Identity=23.3695652173913, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322664, Length=241, Percent_Identity=26.1410788381743, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24586472, Length=363, Percent_Identity=23.6914600550964, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24586474, Length=376, Percent_Identity=24.7340425531915, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45374; Mature: 45374

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHFDYRDGVLHAEGVGLEVLAREVGTPFYCYSTATLERHYRVFSEAFAGTDALVCYAMK
CCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEEE
ANSNQSVLRTLARLGAGADVVSGGELQRALAAGIPASKIVFSGVGKTEAELRAALAHDIK
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHEEECCCCCHHHHHHHHHHCEE
CLNVESEPELELLSRLAVETGRTARISIRVNPDVDSGTHAKISTGKSENKFGIPLVHARE
EECCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCCCCEEHHHH
VYARAAKLPGILISGVDVHIGSQIIDLAPMEAAFRLVAEFVHQLRGDGHTISHVDFGGGL
HHHHHHCCCCEEEECCEEECCCHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
GIPYYEDRDAPPEPFAYAQMVKRVTHNLGCALLFEPGRMIVGNAGILVARVIYVKHGDGK
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEEECCCEEEEEEEEEEECCCC
TFVIIDAAMNDLIRPTLYEAYHEILPVAAPAPGAKLITADVVGPVCETGDYLALDRQLPE
EEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHCCCHHCCCCEEEECCCCCC
LKSGDLIAIMTAGAYGAVQACTYNTRALVPEVLVKDDQYAVVRPRIEVEQLIALDRPAPW
CCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHCCCCCEEEECCCCCHHHHHHCCCCCCC
L
C
>Mature Secondary Structure
MRHFDYRDGVLHAEGVGLEVLAREVGTPFYCYSTATLERHYRVFSEAFAGTDALVCYAMK
CCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEEE
ANSNQSVLRTLARLGAGADVVSGGELQRALAAGIPASKIVFSGVGKTEAELRAALAHDIK
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHEEECCCCCHHHHHHHHHHCEE
CLNVESEPELELLSRLAVETGRTARISIRVNPDVDSGTHAKISTGKSENKFGIPLVHARE
EECCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCCCCEEHHHH
VYARAAKLPGILISGVDVHIGSQIIDLAPMEAAFRLVAEFVHQLRGDGHTISHVDFGGGL
HHHHHHCCCCEEEECCEEECCCHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
GIPYYEDRDAPPEPFAYAQMVKRVTHNLGCALLFEPGRMIVGNAGILVARVIYVKHGDGK
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEEECCCEEEEEEEEEEECCCC
TFVIIDAAMNDLIRPTLYEAYHEILPVAAPAPGAKLITADVVGPVCETGDYLALDRQLPE
EEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHCCCHHCCCCEEEECCCCCC
LKSGDLIAIMTAGAYGAVQACTYNTRALVPEVLVKDDQYAVVRPRIEVEQLIALDRPAPW
CCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHCCCCCEEEECCCCCHHHHHHCCCCCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA