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The map label for this gene is argH [H]

Identifier: 86747953

GI number: 86747953

Start: 941031

End: 942428

Strand: Direct

Name: argH [H]

Synonym: RPB_0827

Alternate gene names: 86747953

Gene position: 941031-942428 (Clockwise)

Preceding gene: 86747950

Following gene: 86747954

Centisome position: 17.65

GC content: 66.67

Gene sequence:

>1398_bases
ATGAGCAACAAAATGTGGGGCGGCCGGTTCACGGATCGCCCCGATGCGATCATGGAAGAGATCAACGTCTCGATCGACGT
CGACCGGCATCTTTACGCCCAGGATATCGCCGCGTCCAAGGCCCATGCCGCCATGCTTGCCGCGCAGGGCATCATCACCG
CGAACGATGCGAAAAATATCGGCAAGGGTCTAGACACGATTCTGTCAGAGATCGGCGCCGGCAAGTTCACCTTCAAGCGC
GCGCTCGAAGACATCCATATGAATGTCGAGAGCCGGCTCGCCGAGTTGATCGGCCCCGCCGCCGGGCGGCTGCACACCGC
GCGCTCGCGCAACGATCAGGTCGCGACCGATTTCCGGCTCTACGTCCGCGACGTGCTCGACGAGACCGATGCGGCGCTGG
CGGCGTTTCAATTCGCGCTGGCGGAGCGGGCGCTGGAGCAGGCCGACACCGTGATGCCCGGCTTCACCCATCTGCAGACC
GCCCAGCCGGTCACCTTCGGTCATCATCTGATGGCCTATGTGGAGATGGCAGCGCGCGATCGCGGCCGTTTCCAGGATGC
CCGCAAGCGGCTCAACGAAAGCCCGCTCGGCGCCGCGGCGCTGGCCGGCACCTCGTTCCCGATCGATCGCCATGCCACCG
CGCAGAAGCTCGGCTTCGTCCGGCCGATGGCGAATTCGCTGGATGCGGTGTCGGACCGCGATTTCGTGCTGGAGACGCTG
TCGGCGGCGTCGATCTGCGCGGTGCATCTGTCGCGCTTCGCCGAGGAGATCGTGATCTGGACCTCGCCGCTGGTCGGCCT
GATCCGGCTGTCGGACAAGTTCACCACCGGCTCCTCGATCATGCCGCAGAAGCGCAATCCGGACGCCGCCGAGCTGGTCC
GCGCCAAGACCGGCCGGGTGATCGGCGCGCTCAACGGCCTGTTGATCGTGATGAAGGGCCTGCCGCTGGCCTATCAAAAG
GACATGCAGGAAGACAAGCAGGGCGCGATGGAGGGCTTCGCGGCGCTGTCGCTGGCGATCCGGGCGATGACCGGCATGGT
CCGCGACCTCGTGCCGGAGCACGACCGGATGCGGGCGGCCGCCGGCGAGGGCTACGCCACCGCCACGGACCTCGCCGACT
GGCTGGTGCGGACGCTGAAGATGCCGTTCCGCGACGCGCACCATGTCACCGGCCGGATCGTCGGCCTCGCCGCCAAGCAG
GGCCTGGCGCTGCACGAACTGCCGCTCGCCGAGATGCAGGCGGTGGAAAAGCGCATCACCAGGGATGCGCTGGCGGTGCT
CAGCGTCGAATCCTCGGTGAAGAGCCGCACCTCTTACGGCGGCACGGCGCCGAAGAACGTCCGCGCGCAGGCCAAGGCGT
GGCTCAAGCGACTGGAAAAAGAGCGGAAATTGGGCTGA

Upstream 100 bases:

>100_bases
GTCATCAGGCACTCAACACCGGATAGCTGCGCAGGCTCGCAGGCGGCTGCTGGCGGGTTCGAACAAAGGCAAAGGCGGGC
ATGATCGTGAGCGGCACACT

Downstream 100 bases:

>100_bases
ACCGGGAAGCCGCGGGATAATTCTCTGCCGCGCCGGGTCTCGCCAGACCGCGGCAATCTCTGTAGGATGCGGCCGCAATT
GGGGATTTCGACGTGAACCG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSNKMWGGRFTDRPDAIMEEINVSIDVDRHLYAQDIAASKAHAAMLAAQGIITANDAKNIGKGLDTILSEIGAGKFTFKR
ALEDIHMNVESRLAELIGPAAGRLHTARSRNDQVATDFRLYVRDVLDETDAALAAFQFALAERALEQADTVMPGFTHLQT
AQPVTFGHHLMAYVEMAARDRGRFQDARKRLNESPLGAAALAGTSFPIDRHATAQKLGFVRPMANSLDAVSDRDFVLETL
SAASICAVHLSRFAEEIVIWTSPLVGLIRLSDKFTTGSSIMPQKRNPDAAELVRAKTGRVIGALNGLLIVMKGLPLAYQK
DMQEDKQGAMEGFAALSLAIRAMTGMVRDLVPEHDRMRAAAGEGYATATDLADWLVRTLKMPFRDAHHVTGRIVGLAAKQ
GLALHELPLAEMQAVEKRITRDALAVLSVESSVKSRTSYGGTAPKNVRAQAKAWLKRLEKERKLG

Sequences:

>Translated_465_residues
MSNKMWGGRFTDRPDAIMEEINVSIDVDRHLYAQDIAASKAHAAMLAAQGIITANDAKNIGKGLDTILSEIGAGKFTFKR
ALEDIHMNVESRLAELIGPAAGRLHTARSRNDQVATDFRLYVRDVLDETDAALAAFQFALAERALEQADTVMPGFTHLQT
AQPVTFGHHLMAYVEMAARDRGRFQDARKRLNESPLGAAALAGTSFPIDRHATAQKLGFVRPMANSLDAVSDRDFVLETL
SAASICAVHLSRFAEEIVIWTSPLVGLIRLSDKFTTGSSIMPQKRNPDAAELVRAKTGRVIGALNGLLIVMKGLPLAYQK
DMQEDKQGAMEGFAALSLAIRAMTGMVRDLVPEHDRMRAAAGEGYATATDLADWLVRTLKMPFRDAHHVTGRIVGLAAKQ
GLALHELPLAEMQAVEKRITRDALAVLSVESSVKSRTSYGGTAPKNVRAQAKAWLKRLEKERKLG
>Mature_464_residues
SNKMWGGRFTDRPDAIMEEINVSIDVDRHLYAQDIAASKAHAAMLAAQGIITANDAKNIGKGLDTILSEIGAGKFTFKRA
LEDIHMNVESRLAELIGPAAGRLHTARSRNDQVATDFRLYVRDVLDETDAALAAFQFALAERALEQADTVMPGFTHLQTA
QPVTFGHHLMAYVEMAARDRGRFQDARKRLNESPLGAAALAGTSFPIDRHATAQKLGFVRPMANSLDAVSDRDFVLETLS
AASICAVHLSRFAEEIVIWTSPLVGLIRLSDKFTTGSSIMPQKRNPDAAELVRAKTGRVIGALNGLLIVMKGLPLAYQKD
MQEDKQGAMEGFAALSLAIRAMTGMVRDLVPEHDRMRAAAGEGYATATDLADWLVRTLKMPFRDAHHVTGRIVGLAAKQG
LALHELPLAEMQAVEKRITRDALAVLSVESSVKSRTSYGGTAPKNVRAQAKAWLKRLEKERKLG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=451, Percent_Identity=41.6851441241685, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI68303542, Length=451, Percent_Identity=41.6851441241685, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI68303549, Length=451, Percent_Identity=39.4678492239468, Blast_Score=328, Evalue=7e-90,
Organism=Homo sapiens, GI68303547, Length=451, Percent_Identity=39.2461197339246, Blast_Score=325, Evalue=7e-89,
Organism=Escherichia coli, GI1790398, Length=452, Percent_Identity=47.5663716814159, Blast_Score=400, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6321806, Length=452, Percent_Identity=42.2566371681416, Blast_Score=355, Evalue=9e-99,
Organism=Drosophila melanogaster, GI221473854, Length=453, Percent_Identity=38.8520971302428, Blast_Score=322, Evalue=5e-88,
Organism=Drosophila melanogaster, GI78706858, Length=453, Percent_Identity=38.8520971302428, Blast_Score=322, Evalue=5e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 50715; Mature: 50584

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKMWGGRFTDRPDAIMEEINVSIDVDRHLYAQDIAASKAHAAMLAAQGIITANDAKNI
CCCCCCCCCCCCCHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHH
GKGLDTILSEIGAGKFTFKRALEDIHMNVESRLAELIGPAAGRLHTARSRNDQVATDFRL
HHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHH
YVRDVLDETDAALAAFQFALAERALEQADTVMPGFTHLQTAQPVTFGHHLMAYVEMAARD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHH
RGRFQDARKRLNESPLGAAALAGTSFPIDRHATAQKLGFVRPMANSLDAVSDRDFVLETL
CHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SAASICAVHLSRFAEEIVIWTSPLVGLIRLSDKFTTGSSIMPQKRNPDAAELVRAKTGRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCH
IGALNGLLIVMKGLPLAYQKDMQEDKQGAMEGFAALSLAIRAMTGMVRDLVPEHDRMRAA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AGEGYATATDLADWLVRTLKMPFRDAHHVTGRIVGLAAKQGLALHELPLAEMQAVEKRIT
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHH
RDALAVLSVESSVKSRTSYGGTAPKNVRAQAKAWLKRLEKERKLG
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNKMWGGRFTDRPDAIMEEINVSIDVDRHLYAQDIAASKAHAAMLAAQGIITANDAKNI
CCCCCCCCCCCCHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHH
GKGLDTILSEIGAGKFTFKRALEDIHMNVESRLAELIGPAAGRLHTARSRNDQVATDFRL
HHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHH
YVRDVLDETDAALAAFQFALAERALEQADTVMPGFTHLQTAQPVTFGHHLMAYVEMAARD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHH
RGRFQDARKRLNESPLGAAALAGTSFPIDRHATAQKLGFVRPMANSLDAVSDRDFVLETL
CHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SAASICAVHLSRFAEEIVIWTSPLVGLIRLSDKFTTGSSIMPQKRNPDAAELVRAKTGRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCH
IGALNGLLIVMKGLPLAYQKDMQEDKQGAMEGFAALSLAIRAMTGMVRDLVPEHDRMRAA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AGEGYATATDLADWLVRTLKMPFRDAHHVTGRIVGLAAKQGLALHELPLAEMQAVEKRIT
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHH
RDALAVLSVESSVKSRTSYGGTAPKNVRAQAKAWLKRLEKERKLG
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA