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The map label for this gene is lpxC [H]

Identifier: 86610210

GI number: 86610210

Start: 2881309

End: 2882163

Strand: Direct

Name: lpxC [H]

Synonym: CYB_2785

Alternate gene names: 86610210

Gene position: 2881309-2882163 (Clockwise)

Preceding gene: 86610209

Following gene: 86610211

Centisome position: 94.57

GC content: 61.99

Gene sequence:

>855_bases
ATGAGAGGCCGGCAACACACCTTAGCCAGCTCTATTGCCCTAGAAGGCGTTGGCCTGCACACCGGCCTGCCAATTGGCTG
CAGTCTGCATCCAGCTCCTGCCGGCAGCGGTCGGGTGTTTGTGCGGGTGGATCAACCGGGATCCCCTGAGATCCCGGCTC
GGTTGGGATCCCTGGCCCCTGCCCATCTCTGCACCCTGTTGCAGCAGGGATCCCCCTCTGTTCAAGTGCAGACGGTGGAA
CACCTGCTGGCCGCCCTTTACATCCTGGGCATTGACAACTGCCGCATCGAGGTGGAGGGGCCGGAGCTGCCGATTCTGGA
TGGCTCTGCCCTGCCCTTTGTAGAGGCCATTGCCCAGGCCGGGATCCAGGCCCAAGATCAGCCAGCCCTGCTGGGGGTGA
TCCAAGAACCGGTCACTGTCTGGGCGGGGGAAGCCTTTGTCAGCGCCCTCCCCCATCCTACAGCCCGCTTTACCTATGGC
ATCGATTTTGCCGATTGCCCGATTGGAGAACAGTGGCTGAGCTGGAGGGAGAACAGGCCGGATTTTGTCCAGTCCATTGC
GCCGGCCCGCACCTTCGCCCGCCAGCAGGATGTGGAGCTGGCCCGGGAACGGGGGCTAATCCAGGGGGGCAGCCTGGAAA
ATGCCATTGTCTGTAGCCAAACCGAGTGGTTGGGGCCATTGCGCTACCCAGATGAGCCGGTGCGCCATAAGCTGATAGAT
TTACTAGGAGATCTCAGCCTCCTGGGCTGCCGACTGCAGGGGCACATTGTGGCCTACAAGGCGGGCCATGCCCTGCACCA
CCGTTTGGCCGAGCAGTTGCTCAAGAGTGGATCCCTGCTGATCCATGAAGAGTGA

Upstream 100 bases:

>100_bases
TGGCAGATGCCAGCAGCAACCTGCGCGTGGGCTATCGGGAGCTGTATTACCGCGTTTTCGACCAGGGCCAAGAGCGTTTG
CACTAGCGCTGCGGAGCACG

Downstream 100 bases:

>100_bases
GGGGGAGCAAGGGATCCGGTTGCGCAGCAACAACCCTGCCATCCTCAGTTGCGAGAGCGGTGCGGAGCACTTGTCTTCAA
GGGGATCCCCAGGGTGGGAT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MRGRQHTLASSIALEGVGLHTGLPIGCSLHPAPAGSGRVFVRVDQPGSPEIPARLGSLAPAHLCTLLQQGSPSVQVQTVE
HLLAALYILGIDNCRIEVEGPELPILDGSALPFVEAIAQAGIQAQDQPALLGVIQEPVTVWAGEAFVSALPHPTARFTYG
IDFADCPIGEQWLSWRENRPDFVQSIAPARTFARQQDVELARERGLIQGGSLENAIVCSQTEWLGPLRYPDEPVRHKLID
LLGDLSLLGCRLQGHIVAYKAGHALHHRLAEQLLKSGSLLIHEE

Sequences:

>Translated_284_residues
MRGRQHTLASSIALEGVGLHTGLPIGCSLHPAPAGSGRVFVRVDQPGSPEIPARLGSLAPAHLCTLLQQGSPSVQVQTVE
HLLAALYILGIDNCRIEVEGPELPILDGSALPFVEAIAQAGIQAQDQPALLGVIQEPVTVWAGEAFVSALPHPTARFTYG
IDFADCPIGEQWLSWRENRPDFVQSIAPARTFARQQDVELARERGLIQGGSLENAIVCSQTEWLGPLRYPDEPVRHKLID
LLGDLSLLGCRLQGHIVAYKAGHALHHRLAEQLLKSGSLLIHEE
>Mature_284_residues
MRGRQHTLASSIALEGVGLHTGLPIGCSLHPAPAGSGRVFVRVDQPGSPEIPARLGSLAPAHLCTLLQQGSPSVQVQTVE
HLLAALYILGIDNCRIEVEGPELPILDGSALPFVEAIAQAGIQAQDQPALLGVIQEPVTVWAGEAFVSALPHPTARFTYG
IDFADCPIGEQWLSWRENRPDFVQSIAPARTFARQQDVELARERGLIQGGSLENAIVCSQTEWLGPLRYPDEPVRHKLID
LLGDLSLLGCRLQGHIVAYKAGHALHHRLAEQLLKSGSLLIHEE

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=275, Percent_Identity=39.2727272727273, Blast_Score=181, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 30643; Mature: 30643

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGRQHTLASSIALEGVGLHTGLPIGCSLHPAPAGSGRVFVRVDQPGSPEIPARLGSLAP
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCH
AHLCTLLQQGSPSVQVQTVEHLLAALYILGIDNCRIEVEGPELPILDGSALPFVEAIAQA
HHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCCEEEECCCCCCEECCCCCHHHHHHHHC
GIQAQDQPALLGVIQEPVTVWAGEAFVSALPHPTARFTYGIDFADCPIGEQWLSWRENRP
CCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHCCCCH
DFVQSIAPARTFARQQDVELARERGLIQGGSLENAIVCSQTEWLGPLRYPDEPVRHKLID
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHCCCCCCCCHHHHHHHHH
LLGDLSLLGCRLQGHIVAYKAGHALHHRLAEQLLKSGSLLIHEE
HHHCHHHHEEEEECEEEEEECCHHHHHHHHHHHHHCCCEEEECC
>Mature Secondary Structure
MRGRQHTLASSIALEGVGLHTGLPIGCSLHPAPAGSGRVFVRVDQPGSPEIPARLGSLAP
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCH
AHLCTLLQQGSPSVQVQTVEHLLAALYILGIDNCRIEVEGPELPILDGSALPFVEAIAQA
HHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCCEEEECCCCCCEECCCCCHHHHHHHHC
GIQAQDQPALLGVIQEPVTVWAGEAFVSALPHPTARFTYGIDFADCPIGEQWLSWRENRP
CCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHCCCCH
DFVQSIAPARTFARQQDVELARERGLIQGGSLENAIVCSQTEWLGPLRYPDEPVRHKLID
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHCCCCCCCCHHHHHHHHH
LLGDLSLLGCRLQGHIVAYKAGHALHHRLAEQLLKSGSLLIHEE
HHHCHHHHEEEEECEEEEEECCHHHHHHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]