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The map label for this gene is pyrC [H]

Identifier: 86609956

GI number: 86609956

Start: 2621229

End: 2622539

Strand: Direct

Name: pyrC [H]

Synonym: CYB_2522

Alternate gene names: 86609956

Gene position: 2621229-2622539 (Clockwise)

Preceding gene: 86609955

Following gene: 86609957

Centisome position: 86.04

GC content: 61.86

Gene sequence:

>1311_bases
TTGCTGATCCGAAATGCTGAGCTGCTGGTGCCGGAAGGGGATCCCTGGCGGGGAGATGTGCTGGTGCGGGAGGGGCGCAT
TGCCCAAATCGGCCCAAACCTCTCGCCAGAAGGGGTGGCCAAGGTCATCGACGCCGAGGGCCATACCCTGATGCCGGGGG
TTATCGATCCCCAAGTTCACTTTCGCGAGCCTGGCCGCGAGCACAAAGAAGACCTCCAGACGGGATCCTGGGCCTGTGCC
CGGGGCGGGGTGACCAGCTTTTTGGAGATGCCCAACACCGACCCGCTGACGATTGACCAAGCGACGCTGGATGACAAGCT
GGCCCGTGCGGCCAGCAAGTGTGTGGTCAATTACGGCTTTTTTATCGGGGCCACTGCCGATAACTTAGAAGAGTTGCAAA
CGGTGCAGGGAGCCTGTGGCATCAAAATCTTCATGGGATCCATGCATGGGCCCCTGTTGGTGGATGATCAGGCGGCGCTG
GAGCGGATTTTCGGGGAAACGGATCCCAACTTTTTAATTGCCGTCCATGCCGAAGATTTGTCTCGCATCACAGCTCGTAA
GGCCCTGTTTGCCGGACGCACAGACGTAGCTGTTCACTCGCAAATTCAGGACGAGGAATCGGCCCTGATCGCCTCACGGC
GGGCTTTGGACTTGGCCACCCGCTACCGCCATCGCCTACACATTTTGCACCTTTCCACCGGCCTAGAGGTCGAGCTGCTG
CGCCAGCACAAGCCGGCCTGGGTGACGGCAGAGGTGACCCCCCAACACCTACTGCTCAGCACCGCCGATTACGCTCGTCT
GGGATCCCTGGCCCAGATGAACCCCCCCCTGCGGGATCCCGCTAACCTGGCCCAACTGTGGCAGGGGCTGCAGGACGGGA
TCCTGGATTGCATTGCCACCGACCATGCCCCCCATACTCTGGAAGAAAAGGCTCAGCCCTATCCCCACTCCCCTTCCGGT
ATGCCCGGCGTGGAAACCGCTTTGCCTCTGATGTTGACGGCAGCCCAGCAGGGGCGTTGTACGCTGGCGCAGGTGGTGCG
GTGGATGTGTGAGGCACCGGCCCGCCTCTACGGGATCCCCAACAAAGGGCGGCTGCAGGTGGGCTACGACGCCGACCTGG
TGCTGGTGGATCGCCACACACCCAAACCGGTGCGGCGGGAAGAGCTGCTGACCAAATGCGGCTGGAGTCCCTTCGAGGGC
TGGGAATTGGTGGGCTGGCCCCTAGTCACGATCGTGGGCGGACAGATTGCCTTTCAAAACGGCCAGGTGGATCCCTCGGT
GCGGGGAAAGGCTCTTCAGTTTCAGCGCTAG

Upstream 100 bases:

>100_bases
GTAGTTTACTGGATCCAGATGCGGCTGTGCTGGCGGAGCCAAGTCAATAGTCTTTATCTTGAGAGCGCCTTTGGGGGAGG
GCGGAGCTTTGTCTGGAGAT

Downstream 100 bases:

>100_bases
CCAGGGATCCCTGCTATCCCGCAAGGGCTTCCGATAGCAGCAGGACAGAAGTGGCGCAGTAGCCTATCCTAGCTTCCCTC
TCCCTTTGTGGGAGAGAAGC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MLIRNAELLVPEGDPWRGDVLVREGRIAQIGPNLSPEGVAKVIDAEGHTLMPGVIDPQVHFREPGREHKEDLQTGSWACA
RGGVTSFLEMPNTDPLTIDQATLDDKLARAASKCVVNYGFFIGATADNLEELQTVQGACGIKIFMGSMHGPLLVDDQAAL
ERIFGETDPNFLIAVHAEDLSRITARKALFAGRTDVAVHSQIQDEESALIASRRALDLATRYRHRLHILHLSTGLEVELL
RQHKPAWVTAEVTPQHLLLSTADYARLGSLAQMNPPLRDPANLAQLWQGLQDGILDCIATDHAPHTLEEKAQPYPHSPSG
MPGVETALPLMLTAAQQGRCTLAQVVRWMCEAPARLYGIPNKGRLQVGYDADLVLVDRHTPKPVRREELLTKCGWSPFEG
WELVGWPLVTIVGGQIAFQNGQVDPSVRGKALQFQR

Sequences:

>Translated_436_residues
MLIRNAELLVPEGDPWRGDVLVREGRIAQIGPNLSPEGVAKVIDAEGHTLMPGVIDPQVHFREPGREHKEDLQTGSWACA
RGGVTSFLEMPNTDPLTIDQATLDDKLARAASKCVVNYGFFIGATADNLEELQTVQGACGIKIFMGSMHGPLLVDDQAAL
ERIFGETDPNFLIAVHAEDLSRITARKALFAGRTDVAVHSQIQDEESALIASRRALDLATRYRHRLHILHLSTGLEVELL
RQHKPAWVTAEVTPQHLLLSTADYARLGSLAQMNPPLRDPANLAQLWQGLQDGILDCIATDHAPHTLEEKAQPYPHSPSG
MPGVETALPLMLTAAQQGRCTLAQVVRWMCEAPARLYGIPNKGRLQVGYDADLVLVDRHTPKPVRREELLTKCGWSPFEG
WELVGWPLVTIVGGQIAFQNGQVDPSVRGKALQFQR
>Mature_436_residues
MLIRNAELLVPEGDPWRGDVLVREGRIAQIGPNLSPEGVAKVIDAEGHTLMPGVIDPQVHFREPGREHKEDLQTGSWACA
RGGVTSFLEMPNTDPLTIDQATLDDKLARAASKCVVNYGFFIGATADNLEELQTVQGACGIKIFMGSMHGPLLVDDQAAL
ERIFGETDPNFLIAVHAEDLSRITARKALFAGRTDVAVHSQIQDEESALIASRRALDLATRYRHRLHILHLSTGLEVELL
RQHKPAWVTAEVTPQHLLLSTADYARLGSLAQMNPPLRDPANLAQLWQGLQDGILDCIATDHAPHTLEEKAQPYPHSPSG
MPGVETALPLMLTAAQQGRCTLAQVVRWMCEAPARLYGIPNKGRLQVGYDADLVLVDRHTPKPVRREELLTKCGWSPFEG
WELVGWPLVTIVGGQIAFQNGQVDPSVRGKALQFQR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=405, Percent_Identity=33.0864197530864, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI4503051, Length=428, Percent_Identity=25.4672897196262, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI62422571, Length=428, Percent_Identity=25.4672897196262, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4503379, Length=446, Percent_Identity=25.5605381165919, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI19923821, Length=428, Percent_Identity=25.7009345794392, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI4503377, Length=443, Percent_Identity=25.2821670428894, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI190194363, Length=446, Percent_Identity=25.7847533632287, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI4503375, Length=431, Percent_Identity=25.5220417633411, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1786722, Length=437, Percent_Identity=28.8329519450801, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI87082175, Length=458, Percent_Identity=30.3493449781659, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI193204318, Length=376, Percent_Identity=31.1170212765957, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17539558, Length=446, Percent_Identity=27.1300448430493, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71989490, Length=448, Percent_Identity=25.8928571428571, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322218, Length=421, Percent_Identity=27.3159144893112, Blast_Score=138, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24642586, Length=379, Percent_Identity=34.0369393139842, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI18859883, Length=407, Percent_Identity=29.2383292383292, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI221377917, Length=451, Percent_Identity=25.7206208425721, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17137462, Length=446, Percent_Identity=25.7847533632287, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24644287, Length=300, Percent_Identity=26, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 47895; Mature: 47895

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIRNAELLVPEGDPWRGDVLVREGRIAQIGPNLSPEGVAKVIDAEGHTLMPGVIDPQVH
CEEECCEEEECCCCCCCCCEEEECCEEEEECCCCCHHHHHHHCCCCCCEECCCCCCCCCC
FREPGREHKEDLQTGSWACARGGVTSFLEMPNTDPLTIDQATLDDKLARAASKCVVNYGF
CCCCCHHHHHHHCCCCCCHHCCCHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHEECCE
FIGATADNLEELQTVQGACGIKIFMGSMHGPLLVDDQAALERIFGETDPNFLIAVHAEDL
EEECCHHHHHHHHHHHCCCCEEEEECCCCCCEEECCHHHHHHHHCCCCCCEEEEEEHHHH
SRITARKALFAGRTDVAVHSQIQDEESALIASRRALDLATRYRHRLHILHLSTGLEVELL
HHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHH
RQHKPAWVTAEVTPQHLLLSTADYARLGSLAQMNPPLRDPANLAQLWQGLQDGILDCIAT
HCCCCCEEEEECCHHHHEEECCHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
DHAPHTLEEKAQPYPHSPSGMPGVETALPLMLTAAQQGRCTLAQVVRWMCEAPARLYGIP
CCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHEECCC
NKGRLQVGYDADLVLVDRHTPKPVRREELLTKCGWSPFEGWELVGWPLVTIVGGQIAFQN
CCCEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCEEECCEEEEEECCEEEEEC
GQVDPSVRGKALQFQR
CCCCCCCCCCEEECCC
>Mature Secondary Structure
MLIRNAELLVPEGDPWRGDVLVREGRIAQIGPNLSPEGVAKVIDAEGHTLMPGVIDPQVH
CEEECCEEEECCCCCCCCCEEEECCEEEEECCCCCHHHHHHHCCCCCCEECCCCCCCCCC
FREPGREHKEDLQTGSWACARGGVTSFLEMPNTDPLTIDQATLDDKLARAASKCVVNYGF
CCCCCHHHHHHHCCCCCCHHCCCHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHEECCE
FIGATADNLEELQTVQGACGIKIFMGSMHGPLLVDDQAALERIFGETDPNFLIAVHAEDL
EEECCHHHHHHHHHHHCCCCEEEEECCCCCCEEECCHHHHHHHHCCCCCCEEEEEEHHHH
SRITARKALFAGRTDVAVHSQIQDEESALIASRRALDLATRYRHRLHILHLSTGLEVELL
HHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHH
RQHKPAWVTAEVTPQHLLLSTADYARLGSLAQMNPPLRDPANLAQLWQGLQDGILDCIAT
HCCCCCEEEEECCHHHHEEECCHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHC
DHAPHTLEEKAQPYPHSPSGMPGVETALPLMLTAAQQGRCTLAQVVRWMCEAPARLYGIP
CCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHEECCC
NKGRLQVGYDADLVLVDRHTPKPVRREELLTKCGWSPFEGWELVGWPLVTIVGGQIAFQN
CCCEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCEEECCEEEEEECCEEEEEC
GQVDPSVRGKALQFQR
CCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]