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The map label for this gene is pmbA [H]

Identifier: 86609847

GI number: 86609847

Start: 2508113

End: 2509453

Strand: Direct

Name: pmbA [H]

Synonym: CYB_2411

Alternate gene names: 86609847

Gene position: 2508113-2509453 (Clockwise)

Preceding gene: 86609846

Following gene: 86609848

Centisome position: 82.32

GC content: 58.24

Gene sequence:

>1341_bases
ATGGTGCAAGTCGAGGTGTTGGCAGAACAGACACAAAGCTGTGCCCGGCGGCTGGGGATCCCTCAGTTTGATCTCTACGG
GGCTCAAGTGGATGAAACCAGCGTGCAGGTAGATCATGGGGAACCTCGCCAGGTCAAGGCTTCCCACCGCTGCAGCGTGA
CGGTGCGGGCCTGGAACGACCAAGGGCAGGTGGGAGTAACTTCCACCACCGATGTGGATGAGGCGGGGCTGGAACTGGCC
CTGCAAACGGCCTTTGAAGCCAGCCATTTTGGCGTGCGGGAACATGCCCCTCAATTCAGCCCGGAAGCCACTCTGCCCAT
TGCCCAGCCTTGTAACGACAAAGGGCCGTTGGCTTTGGCTGGCGACTTGTTGGAACAGTTGGTGGCTGCTGAAAAGGCAC
TCCTGGGATCCCATCCCGCCATTCAGGGGGTGCCCTACAACGGCCTAGCGCAGCGGCAAATCAACCGCTTCTACCTCAAC
AGCCACCAAGCCCTGCGACAAGAGGAGCATACCCTCGCTTCGGTTTTTCTCTACAGCAAGGCAGAGCAAGAAGGTCGCAA
ACCCCGCAGCGCCGGAGCCATGCGAGTGGCTCGCAGCCTGGATGAGTTGGATATCCAGGGTTGTGTGCAGGAAGCTGCTG
AGAAACTGATTAGCCATCTGGAGTACGAGCGGATCCCTTCTGGAAAATACACAGTGGTCTTTTCAGGAGAAGCCTTTTTG
AGTTTGTTGGGCGCCTTCTCCAATGTGTTCAATGCCCAAAACATTTTGGACAACCAAAGCCTGTCCACCCCAGAATCCCT
GGGCAAGACCATTGCCTCACCTCTTCTGTCGGTGTGTGACGATGCCCTGCACCCGACCAATGTGGGAGCGATCAGCTTTG
ATGGAGAAGGCACCCCCACCCGCCGTGTCCCTCTCATCACCAATGGGGTCTTGACCCACTTTTTGCACAGCGCCGGTACG
GCTAAGCGCCTAGGAGCCAAGCCCACTGGCCATGCCAACATCGGCGCCAAGGTCACAGTTGCCGCCCACTACTACCATGT
ATTTGCCGGGGCACCGCCGGAGAGCACCTATGACTTGGCTACGGCTGAAAATGTAGTTTGGATCGATGAGCTGCAAGCGC
TTCATGCCGGCGTTAAGCCCCTACAGGGATCCTTCTCGCTGCCGTTTCAGGGGTGGTGGGTACGCCAAGGAGAACGCATC
AGCATCGAAGCGGCCACGGTGGCCGGAGACTTCCTGGAGCTGTTGAAGTCGATTTTCTACGTCGAGCCCGAGCCGCAAGT
CACACCGGGTGGGCTGTGTCCCCGCATCTGGGTTGCCGATCTCTCCATTACCGGGCAATAA

Upstream 100 bases:

>100_bases
TGCACTCTTTCGCTTTAGCGGTGCGGAGCGCTCTGCGTCAGCATGAGTGCGGGTAGTTTACTAGAGGCGCTGGATGGCAA
CAGGAACTTGGGGAGTGGCA

Downstream 100 bases:

>100_bases
CCTCACTTCAAACTCATGCAACTGACCCGCATCGACCTCAACAGTTGGCTCATCCACACCCGGGAGCAAACCTTCCTATT
GGATCCGTGGCTGGTGGATC

Product: tldD/pmbA family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MVQVEVLAEQTQSCARRLGIPQFDLYGAQVDETSVQVDHGEPRQVKASHRCSVTVRAWNDQGQVGVTSTTDVDEAGLELA
LQTAFEASHFGVREHAPQFSPEATLPIAQPCNDKGPLALAGDLLEQLVAAEKALLGSHPAIQGVPYNGLAQRQINRFYLN
SHQALRQEEHTLASVFLYSKAEQEGRKPRSAGAMRVARSLDELDIQGCVQEAAEKLISHLEYERIPSGKYTVVFSGEAFL
SLLGAFSNVFNAQNILDNQSLSTPESLGKTIASPLLSVCDDALHPTNVGAISFDGEGTPTRRVPLITNGVLTHFLHSAGT
AKRLGAKPTGHANIGAKVTVAAHYYHVFAGAPPESTYDLATAENVVWIDELQALHAGVKPLQGSFSLPFQGWWVRQGERI
SIEAATVAGDFLELLKSIFYVEPEPQVTPGGLCPRIWVADLSITGQ

Sequences:

>Translated_446_residues
MVQVEVLAEQTQSCARRLGIPQFDLYGAQVDETSVQVDHGEPRQVKASHRCSVTVRAWNDQGQVGVTSTTDVDEAGLELA
LQTAFEASHFGVREHAPQFSPEATLPIAQPCNDKGPLALAGDLLEQLVAAEKALLGSHPAIQGVPYNGLAQRQINRFYLN
SHQALRQEEHTLASVFLYSKAEQEGRKPRSAGAMRVARSLDELDIQGCVQEAAEKLISHLEYERIPSGKYTVVFSGEAFL
SLLGAFSNVFNAQNILDNQSLSTPESLGKTIASPLLSVCDDALHPTNVGAISFDGEGTPTRRVPLITNGVLTHFLHSAGT
AKRLGAKPTGHANIGAKVTVAAHYYHVFAGAPPESTYDLATAENVVWIDELQALHAGVKPLQGSFSLPFQGWWVRQGERI
SIEAATVAGDFLELLKSIFYVEPEPQVTPGGLCPRIWVADLSITGQ
>Mature_446_residues
MVQVEVLAEQTQSCARRLGIPQFDLYGAQVDETSVQVDHGEPRQVKASHRCSVTVRAWNDQGQVGVTSTTDVDEAGLELA
LQTAFEASHFGVREHAPQFSPEATLPIAQPCNDKGPLALAGDLLEQLVAAEKALLGSHPAIQGVPYNGLAQRQINRFYLN
SHQALRQEEHTLASVFLYSKAEQEGRKPRSAGAMRVARSLDELDIQGCVQEAAEKLISHLEYERIPSGKYTVVFSGEAFL
SLLGAFSNVFNAQNILDNQSLSTPESLGKTIASPLLSVCDDALHPTNVGAISFDGEGTPTRRVPLITNGVLTHFLHSAGT
AKRLGAKPTGHANIGAKVTVAAHYYHVFAGAPPESTYDLATAENVVWIDELQALHAGVKPLQGSFSLPFQGWWVRQGERI
SIEAATVAGDFLELLKSIFYVEPEPQVTPGGLCPRIWVADLSITGQ

Specific function: May facilitate the secretion of the peptide antibiotic microcin B17 (MccB17) by completing its maturation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA) [H]

COG id: COG0312

COG function: function code R; Predicted Zn-dependent proteases and their inactivated homologs

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase U62 family [H]

Homologues:

Organism=Escherichia coli, GI1790682, Length=420, Percent_Identity=23.3333333333333, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002510 [H]

Pfam domain/function: PF01523 PmbA_TldD [H]

EC number: NA

Molecular weight: Translated: 48159; Mature: 48159

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQVEVLAEQTQSCARRLGIPQFDLYGAQVDETSVQVDHGEPRQVKASHRCSVTVRAWND
CEEEHHHHHHHHHHHHHCCCCCEECCCCEECCCEEEECCCCCCCCCCCCCEEEEEEEECC
QGQVGVTSTTDVDEAGLELALQTAFEASHFGVREHAPQFSPEATLPIAQPCNDKGPLALA
CCCEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCCCEEHH
GDLLEQLVAAEKALLGSHPAIQGVPYNGLAQRQINRFYLNSHQALRQEEHTLASVFLYSK
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEQEGRKPRSAGAMRVARSLDELDIQGCVQEAAEKLISHLEYERIPSGKYTVVFSGEAFL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHH
SLLGAFSNVFNAQNILDNQSLSTPESLGKTIASPLLSVCDDALHPTNVGAISFDGEGTPT
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
RRVPLITNGVLTHFLHSAGTAKRLGAKPTGHANIGAKVTVAAHYYHVFAGAPPESTYDLA
CCCCEEHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEEEEEEEEEEEEEECCCCCCCEECC
TAENVVWIDELQALHAGVKPLQGSFSLPFQGWWVRQGERISIEAATVAGDFLELLKSIFY
CCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHE
VEPEPQVTPGGLCPRIWVADLSITGQ
ECCCCCCCCCCCCCEEEEEEEEECCC
>Mature Secondary Structure
MVQVEVLAEQTQSCARRLGIPQFDLYGAQVDETSVQVDHGEPRQVKASHRCSVTVRAWND
CEEEHHHHHHHHHHHHHCCCCCEECCCCEECCCEEEECCCCCCCCCCCCCEEEEEEEECC
QGQVGVTSTTDVDEAGLELALQTAFEASHFGVREHAPQFSPEATLPIAQPCNDKGPLALA
CCCEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCCCEEHH
GDLLEQLVAAEKALLGSHPAIQGVPYNGLAQRQINRFYLNSHQALRQEEHTLASVFLYSK
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEQEGRKPRSAGAMRVARSLDELDIQGCVQEAAEKLISHLEYERIPSGKYTVVFSGEAFL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHH
SLLGAFSNVFNAQNILDNQSLSTPESLGKTIASPLLSVCDDALHPTNVGAISFDGEGTPT
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
RRVPLITNGVLTHFLHSAGTAKRLGAKPTGHANIGAKVTVAAHYYHVFAGAPPESTYDLA
CCCCEEHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEEEEEEEEEEEEEECCCCCCCEECC
TAENVVWIDELQALHAGVKPLQGSFSLPFQGWWVRQGERISIEAATVAGDFLELLKSIFY
CCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHE
VEPEPQVTPGGLCPRIWVADLSITGQ
ECCCCCCCCCCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]