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The map label for this gene is trpC [H]

Identifier: 86609783

GI number: 86609783

Start: 2450470

End: 2451390

Strand: Direct

Name: trpC [H]

Synonym: CYB_2343

Alternate gene names: 86609783

Gene position: 2450470-2451390 (Clockwise)

Preceding gene: 86609778

Following gene: 86609784

Centisome position: 80.43

GC content: 61.45

Gene sequence:

>921_bases
ATGGAGCTGCAAGGTGAGCCGCTTTCTATTCGTCGGCGTTCTCCTGCCCCGCCGGTGGTCGTAGCCTCTCAGGTGTACCA
GACAACAGCGCCGGAAGCCAAACCGCGCCACATTTTGGAAGCGATCGTCTGGCATAAAGAGCAGGAGGTGGAGCGCCAAC
GGGAGCAGCTTCCCCTCAAGGAATTGCAACGGCAACTGGATCAAGCCCCGCCGGTGCGGGATTTTGTGGCGGCCCTCACC
CAGTCGCCTCACCCTATCTCTGTGATTGCCGAGGTCAAAAAAGCCTCTCCCAGCCGCGGCGTTCTCCGGGATCCCTTTGA
CCCGGTGGCCATTGCCCAGAGCTATGAGGCCGGTGGGGCCAGTTGCCTCTCGGTGCTCACAGATGAGCGGTTCTTTCAGG
GCAGCGGCGAGTATCTGCGCCGGATCCGTCAGGCAGTAGGGATCCCCATCCTCTGCAAGGAGTTCATCCTCTACCCCTAC
CAAATCCTCTGGGCCCGCAGCCTGGGGGCAGATGCGGTGCTCTTGATTGCCGCCATTCTCTCCGATGCGGATTTGGGCTA
CTTTCTCAAGCTGATTCGGCAATTGGGCATGGCGGCTCTGCTGGAGGTGCACACCTCCCAAGAGTTGCAGCGGGTGTTGC
GTTTGCCCCAACTGCAAGACTCCAGGGGGCAGGTGCTCATTGGCATCAACAATCGCGATCTGAGAACCTTTGCGGTGGAC
TTAAACACAACGCGCAACCTGTTGGCCGCCCACTCGGAGCTCCTTGGCGATCTGCCTGTGGTCAGCGAGTCCGGCATCCA
TACCCCCGCCGATCTGCAGCAGTTGCGGGCCTGGGGGGTGCGCTCTGTGCTCGTGGGGGAAGCGCTGGTGACCCAGCCGG
ATCCCGGCCAAGCTGTGCGCCACCTGTTGTCATCTCAGTGA

Upstream 100 bases:

>100_bases
CGCCAGATGAGTTTTGGGGATGTCCGGGGTAGCTATTCAAACCGGTGGCGGAGCACTAAGGTAGTCTAGGGTGTGGTGTA
GGGTTCCGCTCAGGGTTTGT

Downstream 100 bases:

>100_bases
ATGAAAACCATTTATCAATGGATCTCTGCGAGAACAATTGATCTCTAAGGATTGCTTGGATCGATGAAACGTATTCCTGT
GCCGGCTCATATCCACTACG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MELQGEPLSIRRRSPAPPVVVASQVYQTTAPEAKPRHILEAIVWHKEQEVERQREQLPLKELQRQLDQAPPVRDFVAALT
QSPHPISVIAEVKKASPSRGVLRDPFDPVAIAQSYEAGGASCLSVLTDERFFQGSGEYLRRIRQAVGIPILCKEFILYPY
QILWARSLGADAVLLIAAILSDADLGYFLKLIRQLGMAALLEVHTSQELQRVLRLPQLQDSRGQVLIGINNRDLRTFAVD
LNTTRNLLAAHSELLGDLPVVSESGIHTPADLQQLRAWGVRSVLVGEALVTQPDPGQAVRHLLSSQ

Sequences:

>Translated_306_residues
MELQGEPLSIRRRSPAPPVVVASQVYQTTAPEAKPRHILEAIVWHKEQEVERQREQLPLKELQRQLDQAPPVRDFVAALT
QSPHPISVIAEVKKASPSRGVLRDPFDPVAIAQSYEAGGASCLSVLTDERFFQGSGEYLRRIRQAVGIPILCKEFILYPY
QILWARSLGADAVLLIAAILSDADLGYFLKLIRQLGMAALLEVHTSQELQRVLRLPQLQDSRGQVLIGINNRDLRTFAVD
LNTTRNLLAAHSELLGDLPVVSESGIHTPADLQQLRAWGVRSVLVGEALVTQPDPGQAVRHLLSSQ
>Mature_306_residues
MELQGEPLSIRRRSPAPPVVVASQVYQTTAPEAKPRHILEAIVWHKEQEVERQREQLPLKELQRQLDQAPPVRDFVAALT
QSPHPISVIAEVKKASPSRGVLRDPFDPVAIAQSYEAGGASCLSVLTDERFFQGSGEYLRRIRQAVGIPILCKEFILYPY
QILWARSLGADAVLLIAAILSDADLGYFLKLIRQLGMAALLEVHTSQELQRVLRLPQLQDSRGQVLIGINNRDLRTFAVD
LNTTRNLLAAHSELLGDLPVVSESGIHTPADLQQLRAWGVRSVLVGEALVTQPDPGQAVRHLLSSQ

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=266, Percent_Identity=40.9774436090226, Blast_Score=167, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6322638, Length=279, Percent_Identity=37.2759856630824, Blast_Score=148, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 33890; Mature: 33890

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELQGEPLSIRRRSPAPPVVVASQVYQTTAPEAKPRHILEAIVWHKEQEVERQREQLPLK
CCCCCCCCCCCCCCCCCCEEEHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHH
ELQRQLDQAPPVRDFVAALTQSPHPISVIAEVKKASPSRGVLRDPFDPVAIAQSYEAGGA
HHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCHH
SCLSVLTDERFFQGSGEYLRRIRQAVGIPILCKEFILYPYQILWARSLGADAVLLIAAIL
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SDADLGYFLKLIRQLGMAALLEVHTSQELQRVLRLPQLQDSRGQVLIGINNRDLRTFAVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEEEE
LNTTRNLLAAHSELLGDLPVVSESGIHTPADLQQLRAWGVRSVLVGEALVTQPDPGQAVR
CCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
HLLSSQ
HHHCCC
>Mature Secondary Structure
MELQGEPLSIRRRSPAPPVVVASQVYQTTAPEAKPRHILEAIVWHKEQEVERQREQLPLK
CCCCCCCCCCCCCCCCCCEEEHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHH
ELQRQLDQAPPVRDFVAALTQSPHPISVIAEVKKASPSRGVLRDPFDPVAIAQSYEAGGA
HHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCHH
SCLSVLTDERFFQGSGEYLRRIRQAVGIPILCKEFILYPYQILWARSLGADAVLLIAAIL
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SDADLGYFLKLIRQLGMAALLEVHTSQELQRVLRLPQLQDSRGQVLIGINNRDLRTFAVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEEEE
LNTTRNLLAAHSELLGDLPVVSESGIHTPADLQQLRAWGVRSVLVGEALVTQPDPGQAVR
CCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
HLLSSQ
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA