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The map label for this gene is ggt [H]

Identifier: 86609539

GI number: 86609539

Start: 2187221

End: 2188864

Strand: Reverse

Name: ggt [H]

Synonym: CYB_2091

Alternate gene names: 86609539

Gene position: 2188864-2187221 (Counterclockwise)

Preceding gene: 86609540

Following gene: 86609537

Centisome position: 71.84

GC content: 64.23

Gene sequence:

>1644_bases
ATGCCAGCACCCACTTTTTTGCGGCAGGCCCTGGATCGCTATCCGTTTGCTTCGCGGCGACGGGTGGTGATGGGCAGACA
GGGATCCGTGGCCACCAGCCAACCTTTGGCGGCAATGGCGGGCATGGAGATGTTCTGGGCGGGCGGCAATGCTGTGGATG
CAGCCGTGGCAATGGCGGTGGCTTTGACGGTGGTGGAGCCAACCTCCAATGGCATTGGCGGCGATGCCTTTGCTCTGGTG
TGGGAGGGGGGGGAGGAGGGTCAGCTGTACGGGTTGAATGCTTCCGGTCGCAGCCCAGCCGCCCTGACGCCGGAGCGGTA
CCGGGACCATGGGCGGATCCCCCCCTACGATTGGTTAGCGGTGACGGTGCCGGGGGCAGTTTCCGCTTGGCAGACCTTGC
ACCGGCGCTGGGGAAAGCTGCCGTTCGAGCGTCTGTTTGTGCCTGCCCTTCGTCTGGCGCAAGAGGGATTTCCGGTCTCT
CCCCGGGTGGCCCAACTGTGGCAGGCGGCGGAGTCCATCTATTTGCCCCTGCCGGATCCGCGCCACGAGGCCTTCAAGGC
CGTTTTCTTTCCCCAAGGGCGTGCCCCACGGGCTGGAGAGCGCTGGAGCAGCCCCCTGCATGCTCAAACCCTAGAAGAGA
TTGCCCGTAGCGGTGGGGAGAGTTTTTACCGGGGGGAGCTGGCGGAGAAGTTGCTGGCTTTCTCGGAGGCCACGGGCGGC
TTCCTGTCCCCCGCCGACTTGGCTGAGCACCGGGCCGATTGGGTGGAACCCATCCATACGGATTACCGCGGCTACACCGT
CTGGGAGATCCCCCCCAACGGGCAGGGCATTGCCGCTTTGATGGCGCTCAACCTTTTGGAGGGTTTTGAGCTGGGTCGGA
TCTCCTACGATGCCGGCGAGCGCTATCACCTGCAGATTGAGGCAATGAAGCTGGCCTTTGCCGATGTGAGCCGACAGGTG
GCGGATCCGGAGTATGTGCGGGTCAGTCCTGCCCAGATGCTGGATAAGGCTTATGCACAGCGGCGGCGGCAGTTGATCGG
GAGGGAGGCGATCCCCCTGGCCCAGCCAGGGCTGCCGGAGGGGGGAACGGTTTACCTGGCTGCAGCTGATGGTGAGTTGA
TGGTGTCTTTGATTCAGTCGAATTTCGATGGCTTCGGCAGTGGTCTGCTGGTTCCGGGCACGGGCATTGCTCTCCACAAC
CGCGGCACGGGTTTCACCCTGGAGCCCGGCCATCCCAACCAGGTGGGCCCCCGCAAGCGCCCCTACCACACGATTATCCC
CGCCTTTCTATCTAAAGAAGGGATCCCCCTCGGCCCTTTTGGTGTCATGGGGGGGGCAATGCAGCCCCAAGGCCATGTGC
AGGTGGTGGTGAATTTGGTGGATTACGGCCTGAACCCCCAGGCGGCTCTGGATGCGCCCCGCTGGCGAGTGCTGTGGGAT
CAGGGGATCCCGCAGGTGGCGCTGGAGAGCACGGTGCCGCCCCAGGTGGTGCGCGAACTCTCCGCCCGCGGCCATGCAGT
GCAGGTGGTGGACGCAGAAGAGGATTGCGGTCTTTTTGGCCGGGGACAGATCCTCTTGCGGGATGGGGATCACTTCATTG
CGGCTTCCGAACCCCGTGCCGATGGCCTAGCCCTGGCGTGGTAG

Upstream 100 bases:

>100_bases
TTTGCGGAGTTGGCCACACTCCTGTTCGCGAGAGCGTCGCGTAGCGATAACCTGCCTGTGTAGGGAGCCCAGCCCATTCG
CGAGAGCGTCGCGTAGCGAT

Downstream 100 bases:

>100_bases
AGTGCCTAGCTCATCACCATGCCACCATCGATGGCAAAAACCTGTCCCGTGATGTAGGCCGCCGCCGGATCTGCCGCCAA
AAAACGCACCAGCCCCGCCA

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MPAPTFLRQALDRYPFASRRRVVMGRQGSVATSQPLAAMAGMEMFWAGGNAVDAAVAMAVALTVVEPTSNGIGGDAFALV
WEGGEEGQLYGLNASGRSPAALTPERYRDHGRIPPYDWLAVTVPGAVSAWQTLHRRWGKLPFERLFVPALRLAQEGFPVS
PRVAQLWQAAESIYLPLPDPRHEAFKAVFFPQGRAPRAGERWSSPLHAQTLEEIARSGGESFYRGELAEKLLAFSEATGG
FLSPADLAEHRADWVEPIHTDYRGYTVWEIPPNGQGIAALMALNLLEGFELGRISYDAGERYHLQIEAMKLAFADVSRQV
ADPEYVRVSPAQMLDKAYAQRRRQLIGREAIPLAQPGLPEGGTVYLAAADGELMVSLIQSNFDGFGSGLLVPGTGIALHN
RGTGFTLEPGHPNQVGPRKRPYHTIIPAFLSKEGIPLGPFGVMGGAMQPQGHVQVVVNLVDYGLNPQAALDAPRWRVLWD
QGIPQVALESTVPPQVVRELSARGHAVQVVDAEEDCGLFGRGQILLRDGDHFIAASEPRADGLALAW

Sequences:

>Translated_547_residues
MPAPTFLRQALDRYPFASRRRVVMGRQGSVATSQPLAAMAGMEMFWAGGNAVDAAVAMAVALTVVEPTSNGIGGDAFALV
WEGGEEGQLYGLNASGRSPAALTPERYRDHGRIPPYDWLAVTVPGAVSAWQTLHRRWGKLPFERLFVPALRLAQEGFPVS
PRVAQLWQAAESIYLPLPDPRHEAFKAVFFPQGRAPRAGERWSSPLHAQTLEEIARSGGESFYRGELAEKLLAFSEATGG
FLSPADLAEHRADWVEPIHTDYRGYTVWEIPPNGQGIAALMALNLLEGFELGRISYDAGERYHLQIEAMKLAFADVSRQV
ADPEYVRVSPAQMLDKAYAQRRRQLIGREAIPLAQPGLPEGGTVYLAAADGELMVSLIQSNFDGFGSGLLVPGTGIALHN
RGTGFTLEPGHPNQVGPRKRPYHTIIPAFLSKEGIPLGPFGVMGGAMQPQGHVQVVVNLVDYGLNPQAALDAPRWRVLWD
QGIPQVALESTVPPQVVRELSARGHAVQVVDAEEDCGLFGRGQILLRDGDHFIAASEPRADGLALAW
>Mature_546_residues
PAPTFLRQALDRYPFASRRRVVMGRQGSVATSQPLAAMAGMEMFWAGGNAVDAAVAMAVALTVVEPTSNGIGGDAFALVW
EGGEEGQLYGLNASGRSPAALTPERYRDHGRIPPYDWLAVTVPGAVSAWQTLHRRWGKLPFERLFVPALRLAQEGFPVSP
RVAQLWQAAESIYLPLPDPRHEAFKAVFFPQGRAPRAGERWSSPLHAQTLEEIARSGGESFYRGELAEKLLAFSEATGGF
LSPADLAEHRADWVEPIHTDYRGYTVWEIPPNGQGIAALMALNLLEGFELGRISYDAGERYHLQIEAMKLAFADVSRQVA
DPEYVRVSPAQMLDKAYAQRRRQLIGREAIPLAQPGLPEGGTVYLAAADGELMVSLIQSNFDGFGSGLLVPGTGIALHNR
GTGFTLEPGHPNQVGPRKRPYHTIIPAFLSKEGIPLGPFGVMGGAMQPQGHVQVVVNLVDYGLNPQAALDAPRWRVLWDQ
GIPQVALESTVPPQVVRELSARGHAVQVVDAEEDCGLFGRGQILLRDGDHFIAASEPRADGLALAW

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=543, Percent_Identity=26.1510128913444, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI73915090, Length=543, Percent_Identity=26.1510128913444, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI73915096, Length=543, Percent_Identity=26.1510128913444, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI73915094, Length=543, Percent_Identity=26.1510128913444, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI109148539, Length=510, Percent_Identity=30.3921568627451, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI113429324, Length=528, Percent_Identity=26.3257575757576, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI113429326, Length=529, Percent_Identity=26.2759924385633, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI153266885, Length=525, Percent_Identity=26.4761904761905, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI153266901, Length=526, Percent_Identity=26.425855513308, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI153266907, Length=523, Percent_Identity=25.4302103250478, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI1789856, Length=545, Percent_Identity=30.6422018348624, Blast_Score=234, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI72000294, Length=440, Percent_Identity=25.4545454545455, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI212646519, Length=498, Percent_Identity=24.2971887550201, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17506189, Length=537, Percent_Identity=26.6294227188082, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI193208245, Length=516, Percent_Identity=24.8062015503876, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI193208247, Length=516, Percent_Identity=24.8062015503876, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17542894, Length=554, Percent_Identity=22.7436823104693, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24642670, Length=520, Percent_Identity=25.1923076923077, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24642666, Length=520, Percent_Identity=25.1923076923077, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI161077880, Length=517, Percent_Identity=25.3384912959381, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI161077878, Length=517, Percent_Identity=25.3384912959381, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI45551474, Length=520, Percent_Identity=25.1923076923077, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI18859893, Length=525, Percent_Identity=26.4761904761905, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI18859741, Length=517, Percent_Identity=24.9516441005803, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI161077496, Length=520, Percent_Identity=24.6153846153846, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 59387; Mature: 59256

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPTFLRQALDRYPFASRRRVVMGRQGSVATSQPLAAMAGMEMFWAGGNAVDAAVAMAV
CCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHCCCEEECCCCHHHHHHHHHH
ALTVVEPTSNGIGGDAFALVWEGGEEGQLYGLNASGRSPAALTPERYRDHGRIPPYDWLA
HHEEECCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCCCEEE
VTVPGAVSAWQTLHRRWGKLPFERLFVPALRLAQEGFPVSPRVAQLWQAAESIYLPLPDP
EECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEECCCCC
RHEAFKAVFFPQGRAPRAGERWSSPLHAQTLEEIARSGGESFYRGELAEKLLAFSEATGG
HHHHEEEEECCCCCCCCCCHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
FLSPADLAEHRADWVEPIHTDYRGYTVWEIPPNGQGIAALMALNLLEGFELGRISYDAGE
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCC
RYHLQIEAMKLAFADVSRQVADPEYVRVSPAQMLDKAYAQRRRQLIGREAIPLAQPGLPE
EEEEEEEEHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GGTVYLAAADGELMVSLIQSNFDGFGSGLLVPGTGIALHNRGTGFTLEPGHPNQVGPRKR
CCEEEEEECCCHHHHHHHHHCCCCCCCCEEECCCCEEEECCCCCEEECCCCCCCCCCCCC
PYHTIIPAFLSKEGIPLGPFGVMGGAMQPQGHVQVVVNLVDYGLNPQAALDAPRWRVLWD
CHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCHHEEEEEHHHCCCCCHHHCCCCCEEEEEC
QGIPQVALESTVPPQVVRELSARGHAVQVVDAEEDCGLFGRGQILLRDGDHFIAASEPRA
CCCCCEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEECCCEEEEECCCCC
DGLALAW
CCCEECC
>Mature Secondary Structure 
PAPTFLRQALDRYPFASRRRVVMGRQGSVATSQPLAAMAGMEMFWAGGNAVDAAVAMAV
CCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHCCCEEECCCCHHHHHHHHHH
ALTVVEPTSNGIGGDAFALVWEGGEEGQLYGLNASGRSPAALTPERYRDHGRIPPYDWLA
HHEEECCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCCCEEE
VTVPGAVSAWQTLHRRWGKLPFERLFVPALRLAQEGFPVSPRVAQLWQAAESIYLPLPDP
EECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEECCCCC
RHEAFKAVFFPQGRAPRAGERWSSPLHAQTLEEIARSGGESFYRGELAEKLLAFSEATGG
HHHHEEEEECCCCCCCCCCHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
FLSPADLAEHRADWVEPIHTDYRGYTVWEIPPNGQGIAALMALNLLEGFELGRISYDAGE
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCC
RYHLQIEAMKLAFADVSRQVADPEYVRVSPAQMLDKAYAQRRRQLIGREAIPLAQPGLPE
EEEEEEEEHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GGTVYLAAADGELMVSLIQSNFDGFGSGLLVPGTGIALHNRGTGFTLEPGHPNQVGPRKR
CCEEEEEECCCHHHHHHHHHCCCCCCCCEEECCCCEEEECCCCCEEECCCCCCCCCCCCC
PYHTIIPAFLSKEGIPLGPFGVMGGAMQPQGHVQVVVNLVDYGLNPQAALDAPRWRVLWD
CHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCHHEEEEEHHHCCCCCHHHCCCCCEEEEEC
QGIPQVALESTVPPQVVRELSARGHAVQVVDAEEDCGLFGRGQILLRDGDHFIAASEPRA
CCCCCEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEECCCEEEEECCCCC
DGLALAW
CCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]