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The map label for this gene is zwf [H]

Identifier: 86609434

GI number: 86609434

Start: 2086061

End: 2087614

Strand: Reverse

Name: zwf [H]

Synonym: CYB_1985

Alternate gene names: 86609434

Gene position: 2087614-2086061 (Counterclockwise)

Preceding gene: 86609435

Following gene: 86609433

Centisome position: 68.52

GC content: 62.03

Gene sequence:

>1554_bases
ATGGTAACCCTGGCAGAAAACCCCCTTCGCGTTGGTCTCAACCAAGAACGCACCCCGGATCCCTGCATTGTGGTGCAGTT
TGGCGCTTCTGGGGATCTGGCCGCCCGCAAGCTGCTCCCGGCCTACTATCGGCTGTTTGGGCAGCGGCGGCTGCCGCCGG
AGTTTACTTTGGTGGGGGTGGCCCGCCGCGATTGGACTCACGAGGTTTATCGGGAAAAGATGCGGGCTGCCGTGCAGGAG
TTTGCCCCCCAGGACTTGGGGCCGGAGGCCCTCTGGCAGGACTTCGCCAGCCGCCTGTTCTATTGCCGCCTCGATATCGG
AGATGCTGAGAGCTATCTGCGCCTAAAGCAGCTGCTCAGCCAGCTGGACGAAGAGCGGGGCACCCGCGGCAACCGAGTGT
TCTATCTGGCGGTGGCGCCGGACTTCTATGCCCAGGCCATCCAACAGCTGGGGGCAGCTGGCATGGTGGCCGATCCGACC
AAAACGCGGGTGGTGATCGAAAAGCCCTTTGGCCACGACCTCACCTCGGCCCAGGAACTCAACCGCCTTGTGCAGCGAAT
TTGCCAGGAAGAGCAGATCTACCGCATTGATCACTACTTGGGCAAAGAGACGGTGCAAAACCTGCTGGTCTTCCGCTTTG
CCAACGCCATTTTCGAGCCTCTCTGGAACCGCAACTACATCGACCATGTGCAGATCACCGTGGCGGAGACGGTGGGGGTG
GAGGATCGGGCCGGCTACTACGACACTGCCGGCGCCCTGCGAGACATGGTGCAAAACCACCTAATGCAGATCTATTGCCT
GACGGCCATGGAGCCACCTGTCTCACTGCGCAGCGATGGGGTGCGTAACGAAAAAACCAAGGTGCTGCAGGCCACCCGCC
TAGCGGATCCCCGCAATGTGGCAGCCGCAGCGGTGCGGGCGCAGTACGGCCCTGGCTGGATTGCCGGCAAGCCGGTGCTG
GGCTATCGGCAGGAGCCCAATGTCAATCCCCAGTCCAAAACCCCCACCTACGTCGCTCTGAAACTGGAGTGTGATACTTG
GCGGTGGAAGGGGGTGCCCTTCTACTTGCGCACTGGGAAACGCCTGCCCAAGAAGGTTTCGGAGGTGGCCATTCACTTTA
AGCAGGTGCCCCTTTCCCTGTTCCAATCGGCAGCTCGGGAGGTGAGCCCCAATATCCTGGTGCTGCGTATCCAACCCAAT
GAGGGCATCTCGTTGCGCTTTGAGGCCAAGATGCCGGGGCCAGAGATCCGCACCCGCTCGGTGGATATGGATTTCCGCTA
TGGGACTGCCTTTGGAGCGAGTACACCGGATGCTTACGATCGCCTGCTCCTGGATTGTCTGCTGGGGGATCCAACGCTGT
TTACCCGTGCCGATGAGGTTGAAGCGGCCTGGCGGGTGGTGACGCCGGTGTTATCGGCCTGGGAGTCTGAGCCCGGCAGC
GGCAATGGCGGCGGTGCTGCACCGCCTCTGTTCACCTATGAGGCCGGCACTTGGGGGCCAAAGGCTGCCGAAGATCTGCT
CACCCAATCGGGGCGGCGGTGGCGGCGCCTCTGA

Upstream 100 bases:

>100_bases
ATCGGCAGCCGCGAGAACGTGGAAGAAGTGCTGCGCTGCCTAGAGGGTTCTCTGGTGCCCTAGGTTCTTCCCAATCCTTC
TCTTTGAGCCAAGCTGGCCT

Downstream 100 bases:

>100_bases
TTTGGCTGCTCTCGGCTGGTAAACCATGGCCTATCCACCTCTGTGTAAGCCGGGGCACCCTCAGCAACAGGCAGAAGAGC
ATGAGCAGCTCAAGAGCCCT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MVTLAENPLRVGLNQERTPDPCIVVQFGASGDLAARKLLPAYYRLFGQRRLPPEFTLVGVARRDWTHEVYREKMRAAVQE
FAPQDLGPEALWQDFASRLFYCRLDIGDAESYLRLKQLLSQLDEERGTRGNRVFYLAVAPDFYAQAIQQLGAAGMVADPT
KTRVVIEKPFGHDLTSAQELNRLVQRICQEEQIYRIDHYLGKETVQNLLVFRFANAIFEPLWNRNYIDHVQITVAETVGV
EDRAGYYDTAGALRDMVQNHLMQIYCLTAMEPPVSLRSDGVRNEKTKVLQATRLADPRNVAAAAVRAQYGPGWIAGKPVL
GYRQEPNVNPQSKTPTYVALKLECDTWRWKGVPFYLRTGKRLPKKVSEVAIHFKQVPLSLFQSAAREVSPNILVLRIQPN
EGISLRFEAKMPGPEIRTRSVDMDFRYGTAFGASTPDAYDRLLLDCLLGDPTLFTRADEVEAAWRVVTPVLSAWESEPGS
GNGGGAAPPLFTYEAGTWGPKAAEDLLTQSGRRWRRL

Sequences:

>Translated_517_residues
MVTLAENPLRVGLNQERTPDPCIVVQFGASGDLAARKLLPAYYRLFGQRRLPPEFTLVGVARRDWTHEVYREKMRAAVQE
FAPQDLGPEALWQDFASRLFYCRLDIGDAESYLRLKQLLSQLDEERGTRGNRVFYLAVAPDFYAQAIQQLGAAGMVADPT
KTRVVIEKPFGHDLTSAQELNRLVQRICQEEQIYRIDHYLGKETVQNLLVFRFANAIFEPLWNRNYIDHVQITVAETVGV
EDRAGYYDTAGALRDMVQNHLMQIYCLTAMEPPVSLRSDGVRNEKTKVLQATRLADPRNVAAAAVRAQYGPGWIAGKPVL
GYRQEPNVNPQSKTPTYVALKLECDTWRWKGVPFYLRTGKRLPKKVSEVAIHFKQVPLSLFQSAAREVSPNILVLRIQPN
EGISLRFEAKMPGPEIRTRSVDMDFRYGTAFGASTPDAYDRLLLDCLLGDPTLFTRADEVEAAWRVVTPVLSAWESEPGS
GNGGGAAPPLFTYEAGTWGPKAAEDLLTQSGRRWRRL
>Mature_517_residues
MVTLAENPLRVGLNQERTPDPCIVVQFGASGDLAARKLLPAYYRLFGQRRLPPEFTLVGVARRDWTHEVYREKMRAAVQE
FAPQDLGPEALWQDFASRLFYCRLDIGDAESYLRLKQLLSQLDEERGTRGNRVFYLAVAPDFYAQAIQQLGAAGMVADPT
KTRVVIEKPFGHDLTSAQELNRLVQRICQEEQIYRIDHYLGKETVQNLLVFRFANAIFEPLWNRNYIDHVQITVAETVGV
EDRAGYYDTAGALRDMVQNHLMQIYCLTAMEPPVSLRSDGVRNEKTKVLQATRLADPRNVAAAAVRAQYGPGWIAGKPVL
GYRQEPNVNPQSKTPTYVALKLECDTWRWKGVPFYLRTGKRLPKKVSEVAIHFKQVPLSLFQSAAREVSPNILVLRIQPN
EGISLRFEAKMPGPEIRTRSVDMDFRYGTAFGASTPDAYDRLLLDCLLGDPTLFTRADEVEAAWRVVTPVLSAWESEPGS
GNGGGAAPPLFTYEAGTWGPKAAEDLLTQSGRRWRRL

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=497, Percent_Identity=38.430583501006, Blast_Score=319, Evalue=5e-87,
Organism=Homo sapiens, GI108773793, Length=497, Percent_Identity=38.430583501006, Blast_Score=318, Evalue=6e-87,
Organism=Homo sapiens, GI52145310, Length=492, Percent_Identity=29.6747967479675, Blast_Score=172, Evalue=9e-43,
Organism=Escherichia coli, GI1788158, Length=504, Percent_Identity=43.6507936507937, Blast_Score=422, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17538218, Length=493, Percent_Identity=37.9310344827586, Blast_Score=340, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6324088, Length=510, Percent_Identity=34.1176470588235, Blast_Score=295, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24643350, Length=491, Percent_Identity=36.4562118126273, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24643352, Length=491, Percent_Identity=36.4562118126273, Blast_Score=289, Evalue=3e-78,
Organism=Drosophila melanogaster, GI221513548, Length=484, Percent_Identity=29.9586776859504, Blast_Score=205, Evalue=5e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 58261; Mature: 58261

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTLAENPLRVGLNQERTPDPCIVVQFGASGDLAARKLLPAYYRLFGQRRLPPEFTLVGV
CCEECCCCEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEE
ARRDWTHEVYREKMRAAVQEFAPQDLGPEALWQDFASRLFYCRLDIGDAESYLRLKQLLS
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHH
QLDEERGTRGNRVFYLAVAPDFYAQAIQQLGAAGMVADPTKTRVVIEKPFGHDLTSAQEL
HHHHHHCCCCCEEEEEEECCHHHHHHHHHHCCCCEECCCCCCEEEEECCCCCCCCCHHHH
NRLVQRICQEEQIYRIDHYLGKETVQNLLVFRFANAIFEPLWNRNYIDHVQITVAETVGV
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCC
EDRAGYYDTAGALRDMVQNHLMQIYCLTAMEPPVSLRSDGVRNEKTKVLQATRLADPRNV
CCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHH
AAAAVRAQYGPGWIAGKPVLGYRQEPNVNPQSKTPTYVALKLECDTWRWKGVPFYLRTGK
HHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCEEECCCCEEECCCC
RLPKKVSEVAIHFKQVPLSLFQSAAREVSPNILVLRIQPNEGISLRFEAKMPGPEIRTRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCCCCCEEEE
VDMDFRYGTAFGASTPDAYDRLLLDCLLGDPTLFTRADEVEAAWRVVTPVLSAWESEPGS
ECCCEECCCCCCCCCCHHHHHHHHHHHCCCCHHEECCHHHHHHHHHHHHHHHHHCCCCCC
GNGGGAAPPLFTYEAGTWGPKAAEDLLTQSGRRWRRL
CCCCCCCCCEEEECCCCCCCHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MVTLAENPLRVGLNQERTPDPCIVVQFGASGDLAARKLLPAYYRLFGQRRLPPEFTLVGV
CCEECCCCEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEE
ARRDWTHEVYREKMRAAVQEFAPQDLGPEALWQDFASRLFYCRLDIGDAESYLRLKQLLS
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHH
QLDEERGTRGNRVFYLAVAPDFYAQAIQQLGAAGMVADPTKTRVVIEKPFGHDLTSAQEL
HHHHHHCCCCCEEEEEEECCHHHHHHHHHHCCCCEECCCCCCEEEEECCCCCCCCCHHHH
NRLVQRICQEEQIYRIDHYLGKETVQNLLVFRFANAIFEPLWNRNYIDHVQITVAETVGV
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCC
EDRAGYYDTAGALRDMVQNHLMQIYCLTAMEPPVSLRSDGVRNEKTKVLQATRLADPRNV
CCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHH
AAAAVRAQYGPGWIAGKPVLGYRQEPNVNPQSKTPTYVALKLECDTWRWKGVPFYLRTGK
HHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCEEECCCCEEECCCC
RLPKKVSEVAIHFKQVPLSLFQSAAREVSPNILVLRIQPNEGISLRFEAKMPGPEIRTRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCCCCCEEEE
VDMDFRYGTAFGASTPDAYDRLLLDCLLGDPTLFTRADEVEAAWRVVTPVLSAWESEPGS
ECCCEECCCCCCCCCCHHHHHHHHHHHCCCCHHEECCHHHHHHHHHHHHHHHHHCCCCCC
GNGGGAAPPLFTYEAGTWGPKAAEDLLTQSGRRWRRL
CCCCCCCCCEEEECCCCCCCHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]