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The map label for this gene is dxs [H]

Identifier: 86609432

GI number: 86609432

Start: 2082996

End: 2084942

Strand: Direct

Name: dxs [H]

Synonym: CYB_1983

Alternate gene names: 86609432

Gene position: 2082996-2084942 (Clockwise)

Preceding gene: 86609430

Following gene: 86609436

Centisome position: 68.37

GC content: 60.86

Gene sequence:

>1947_bases
ATGCACCTGAGTGACATCACTCATCCCAACCAGCTCCGAAACCTGAACCTGAGCCAGTTGCGCAGCCTAGCCCGCCAGAT
TCGCGACAAACATCTGCAGACGGCTGCCAATTCCCCGGTCGGCTGTCATCTGGGGCCAGGGCTGGGGGTGGTGGAGCTGA
CCTTGGCCCTCTACAAGACCCTCGATCTGGATCGAGACAAGGTGATCTGGGATGTGGGGCACCAGGCTTATGCCCACAAA
ATGCTCACCGGCAGGTACCACAATTTCCACACATTGCGCCAGAAGGGGGGGATTTCCGGCTACCTGAAGCGCAGCGAGAG
CCGCTTCGATCACTTTGGGGCGGGGCACGCTTCCACCAGCATCTCGGCAGCTTTGGGCATGGCCATCGCTCGGGATCGGC
GGGGAGACAACTTCAAGGTGGTGGCCATCATTGGGGATGGTGCCCTGACCGGAGGCATGGCCTATGAAGCCATCAACCAC
GCCGGGCACCTGCCCAAGACCAACCTGATGGTGGTGCTCAACGACAACGGCATGTCTATTTCCCCCAATGTGGGGGCGAT
CCCTCGCTATTTAAACCGCCTGCGCCTCAGCCCGCCGGTGCAGTTTTTGGCCGACAGCCTAGAAGAGCAACTGAAGAACC
TGCCCCTACTGGGATCCAGCCTCAGCCCGGAAATTGACCGCCTCAAGGAAACGGTGAAGCTGGTTACCGCCGTGCAAAAC
AACAAGGCAGGCATCATCTTTGAGGAGCTGGGCTTTACCTACGTGGGGCCGGTGGACGGGCACAACCTGGCGGAGTTGTT
GGATGCCTTTGAGTTGGCCCACGGCATCTCCGGCCCGGTGCTGGTGCATGTAGCTACCGTCAAAGGCAAGGGCTACCCGC
CTGCCGAAGCGGAACAGGTGGGGTATCATGCCCAATCCCGCTTCGACCTGGCCACCGGCAAGCCCTACCCGCCCACCAAG
CCCAAGCCCCCCAGCTACAGCAAGGTCTTTGGCCATGCCCTCTGCAAGCTGGCCGAGCGGGATCCCCGCATCATCGGCAT
CACCGCCGCTATGGATACGGGCACTGGCCTGGATAAGCTCAAGGAAAAGCTGCCGGATCAGTTTGTGGATGTGGGGATCG
CCGAGCAGCACGCTGTAACGTTGGCGGCTGGCATGGCCTGTGAGGGAATGCGGCCAGTGGTGGCCATTTATTCCACCTTC
TTGCAGCGGGCCTACGACCAGATCATCCACGATGTCTGTATCCAAAAGTTGCCGGTCTTCTTTTGCTTGGATCGGGCGGG
AGTTGTAGGAGCCGATGGCCCCACCCACCAAGGCATGTACGACATCGCCTATCTGCGCTGCATTCCGGAAATGGTGCTAA
TGGCTCCCAAAGATGAAGCGGAGCTACAGCGCATGGTGGTGACCGGGATCCAGTACACCCAGGGCCCCATCGCCATGCGT
TACCCGCGCGGATCGGGTGTAGGGGTGCCTCTGGCAGAAGAGGGGTGGGAACCCCTGCCCATCGGCAAAGCCGAGGTGTT
GCGCAGCGGCGGCGAGGTGCTGATCCTGGCCTATGGGTCGATGGTGCATCCCAGCCTGCAGGCGGCGGAGATCTTGAAAG
AACACGGCATCTCAGCCACAGTGGTCAATGCCCGCTTCGCCAAGCCTTTGGATACCGAGCTGATCCTGCCTTTGGCCGAA
CAGAGCCGCTTGGTGGTGACGGTGGAAGAAGGTTGCCTCATGGGTGGGTTTGGCTCGGCAGTGGCCGAAGCCCTGCTCGA
CGCCGACCTGGCAGTGCCCTTGTTGCGCTTGGGGGTGCCGGATGTGTGGGTGGAGCACGCCACCCCCGAGGAATCCTTGG
CAGAACTAGGCTTGAACAGTGCCGGGATTGCCGAGCGGATTCGGGCCAAGTTTCAGGCACGAGTTCTCAAGGGATCCCCT
GCAGAACTTCCCACTGTCAATTCCTAA

Upstream 100 bases:

>100_bases
AGGGGGATCCCTGCATTCCTTGAAGTTTTGAGAGGGAGGGCTACAAAACCCCTCCTGAAAATGAATTAGAGTGAGATCAC
ACCGGAAGGACGAGTCCATT

Downstream 100 bases:

>100_bases
ATCTATCCTGAATCTATTCTGAGAGGCCCATCCGCCGGTTGAACTGCTCGATAGCGGCTTGCTGCAGAGCTTCTGCAACA
GGGCGGGTGCGCAGGAGGAT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 648; Mature: 648

Protein sequence:

>648_residues
MHLSDITHPNQLRNLNLSQLRSLARQIRDKHLQTAANSPVGCHLGPGLGVVELTLALYKTLDLDRDKVIWDVGHQAYAHK
MLTGRYHNFHTLRQKGGISGYLKRSESRFDHFGAGHASTSISAALGMAIARDRRGDNFKVVAIIGDGALTGGMAYEAINH
AGHLPKTNLMVVLNDNGMSISPNVGAIPRYLNRLRLSPPVQFLADSLEEQLKNLPLLGSSLSPEIDRLKETVKLVTAVQN
NKAGIIFEELGFTYVGPVDGHNLAELLDAFELAHGISGPVLVHVATVKGKGYPPAEAEQVGYHAQSRFDLATGKPYPPTK
PKPPSYSKVFGHALCKLAERDPRIIGITAAMDTGTGLDKLKEKLPDQFVDVGIAEQHAVTLAAGMACEGMRPVVAIYSTF
LQRAYDQIIHDVCIQKLPVFFCLDRAGVVGADGPTHQGMYDIAYLRCIPEMVLMAPKDEAELQRMVVTGIQYTQGPIAMR
YPRGSGVGVPLAEEGWEPLPIGKAEVLRSGGEVLILAYGSMVHPSLQAAEILKEHGISATVVNARFAKPLDTELILPLAE
QSRLVVTVEEGCLMGGFGSAVAEALLDADLAVPLLRLGVPDVWVEHATPEESLAELGLNSAGIAERIRAKFQARVLKGSP
AELPTVNS

Sequences:

>Translated_648_residues
MHLSDITHPNQLRNLNLSQLRSLARQIRDKHLQTAANSPVGCHLGPGLGVVELTLALYKTLDLDRDKVIWDVGHQAYAHK
MLTGRYHNFHTLRQKGGISGYLKRSESRFDHFGAGHASTSISAALGMAIARDRRGDNFKVVAIIGDGALTGGMAYEAINH
AGHLPKTNLMVVLNDNGMSISPNVGAIPRYLNRLRLSPPVQFLADSLEEQLKNLPLLGSSLSPEIDRLKETVKLVTAVQN
NKAGIIFEELGFTYVGPVDGHNLAELLDAFELAHGISGPVLVHVATVKGKGYPPAEAEQVGYHAQSRFDLATGKPYPPTK
PKPPSYSKVFGHALCKLAERDPRIIGITAAMDTGTGLDKLKEKLPDQFVDVGIAEQHAVTLAAGMACEGMRPVVAIYSTF
LQRAYDQIIHDVCIQKLPVFFCLDRAGVVGADGPTHQGMYDIAYLRCIPEMVLMAPKDEAELQRMVVTGIQYTQGPIAMR
YPRGSGVGVPLAEEGWEPLPIGKAEVLRSGGEVLILAYGSMVHPSLQAAEILKEHGISATVVNARFAKPLDTELILPLAE
QSRLVVTVEEGCLMGGFGSAVAEALLDADLAVPLLRLGVPDVWVEHATPEESLAELGLNSAGIAERIRAKFQARVLKGSP
AELPTVNS
>Mature_648_residues
MHLSDITHPNQLRNLNLSQLRSLARQIRDKHLQTAANSPVGCHLGPGLGVVELTLALYKTLDLDRDKVIWDVGHQAYAHK
MLTGRYHNFHTLRQKGGISGYLKRSESRFDHFGAGHASTSISAALGMAIARDRRGDNFKVVAIIGDGALTGGMAYEAINH
AGHLPKTNLMVVLNDNGMSISPNVGAIPRYLNRLRLSPPVQFLADSLEEQLKNLPLLGSSLSPEIDRLKETVKLVTAVQN
NKAGIIFEELGFTYVGPVDGHNLAELLDAFELAHGISGPVLVHVATVKGKGYPPAEAEQVGYHAQSRFDLATGKPYPPTK
PKPPSYSKVFGHALCKLAERDPRIIGITAAMDTGTGLDKLKEKLPDQFVDVGIAEQHAVTLAAGMACEGMRPVVAIYSTF
LQRAYDQIIHDVCIQKLPVFFCLDRAGVVGADGPTHQGMYDIAYLRCIPEMVLMAPKDEAELQRMVVTGIQYTQGPIAMR
YPRGSGVGVPLAEEGWEPLPIGKAEVLRSGGEVLILAYGSMVHPSLQAAEILKEHGISATVVNARFAKPLDTELILPLAE
QSRLVVTVEEGCLMGGFGSAVAEALLDADLAVPLLRLGVPDVWVEHATPEESLAELGLNSAGIAERIRAKFQARVLKGSP
AELPTVNS

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=565, Percent_Identity=25.8407079646018, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI4507521, Length=565, Percent_Identity=25.8407079646018, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI133778974, Length=639, Percent_Identity=24.5696400625978, Blast_Score=106, Evalue=8e-23,
Organism=Homo sapiens, GI225637463, Length=422, Percent_Identity=27.9620853080569, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI225637459, Length=422, Percent_Identity=27.9620853080569, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI225637461, Length=422, Percent_Identity=27.9620853080569, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI156564403, Length=285, Percent_Identity=22.8070175438596, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI291084858, Length=277, Percent_Identity=22.0216606498195, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786622, Length=627, Percent_Identity=46.88995215311, Blast_Score=549, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17539652, Length=383, Percent_Identity=31.5926892950392, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17538422, Length=294, Percent_Identity=26.1904761904762, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319698, Length=309, Percent_Identity=26.537216828479, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45551847, Length=629, Percent_Identity=27.027027027027, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI45550715, Length=629, Percent_Identity=27.027027027027, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24645119, Length=586, Percent_Identity=27.6450511945392, Blast_Score=149, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24666278, Length=526, Percent_Identity=26.8060836501901, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21358145, Length=296, Percent_Identity=25.3378378378378, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24650940, Length=296, Percent_Identity=25.3378378378378, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 69901; Mature: 69901

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLSDITHPNQLRNLNLSQLRSLARQIRDKHLQTAANSPVGCHLGPGLGVVELTLALYKT
CCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHH
LDLDRDKVIWDVGHQAYAHKMLTGRYHNFHTLRQKGGISGYLKRSESRFDHFGAGHASTS
HCCCCCCEEECCCHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHH
ISAALGMAIARDRRGDNFKVVAIIGDGALTGGMAYEAINHAGHLPKTNLMVVLNDNGMSI
HHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCEE
SPNVGAIPRYLNRLRLSPPVQFLADSLEEQLKNLPLLGSSLSPEIDRLKETVKLVTAVQN
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCC
NKAGIIFEELGFTYVGPVDGHNLAELLDAFELAHGISGPVLVHVATVKGKGYPPAEAEQV
CCCCEEEHHCCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHH
GYHAQSRFDLATGKPYPPTKPKPPSYSKVFGHALCKLAERDPRIIGITAAMDTGTGLDKL
CCCHHCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHH
KEKLPDQFVDVGIAEQHAVTLAAGMACEGMRPVVAIYSTFLQRAYDQIIHDVCIQKLPVF
HHHCCHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
FCLDRAGVVGADGPTHQGMYDIAYLRCIPEMVLMAPKDEAELQRMVVTGIQYTQGPIAMR
EEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEECCCCEEEE
YPRGSGVGVPLAEEGWEPLPIGKAEVLRSGGEVLILAYGSMVHPSLQAAEILKEHGISAT
CCCCCCCCCCCHHCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEE
VVNARFAKPLDTELILPLAEQSRLVVTVEEGCLMGGFGSAVAEALLDADLAVPLLRLGVP
EECCCCCCCCCCCEEEEECCCCEEEEEEECCCEECCHHHHHHHHHHHHHHHHHHHHHCCC
DVWVEHATPEESLAELGLNSAGIAERIRAKFQARVLKGSPAELPTVNS
HHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MHLSDITHPNQLRNLNLSQLRSLARQIRDKHLQTAANSPVGCHLGPGLGVVELTLALYKT
CCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHH
LDLDRDKVIWDVGHQAYAHKMLTGRYHNFHTLRQKGGISGYLKRSESRFDHFGAGHASTS
HCCCCCCEEECCCHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHH
ISAALGMAIARDRRGDNFKVVAIIGDGALTGGMAYEAINHAGHLPKTNLMVVLNDNGMSI
HHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCEE
SPNVGAIPRYLNRLRLSPPVQFLADSLEEQLKNLPLLGSSLSPEIDRLKETVKLVTAVQN
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCC
NKAGIIFEELGFTYVGPVDGHNLAELLDAFELAHGISGPVLVHVATVKGKGYPPAEAEQV
CCCCEEEHHCCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHH
GYHAQSRFDLATGKPYPPTKPKPPSYSKVFGHALCKLAERDPRIIGITAAMDTGTGLDKL
CCCHHCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHH
KEKLPDQFVDVGIAEQHAVTLAAGMACEGMRPVVAIYSTFLQRAYDQIIHDVCIQKLPVF
HHHCCHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
FCLDRAGVVGADGPTHQGMYDIAYLRCIPEMVLMAPKDEAELQRMVVTGIQYTQGPIAMR
EEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEECCCCEEEE
YPRGSGVGVPLAEEGWEPLPIGKAEVLRSGGEVLILAYGSMVHPSLQAAEILKEHGISAT
CCCCCCCCCCCHHCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEE
VVNARFAKPLDTELILPLAEQSRLVVTVEEGCLMGGFGSAVAEALLDADLAVPLLRLGVP
EECCCCCCCCCCCEEEEECCCCEEEEEEECCCEECCHHHHHHHHHHHHHHHHHHHHHCCC
DVWVEHATPEESLAELGLNSAGIAERIRAKFQARVLKGSPAELPTVNS
HHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA