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The map label for this gene is ilvD [H]

Identifier: 86609436

GI number: 86609436

Start: 2089024

End: 2090721

Strand: Direct

Name: ilvD [H]

Synonym: CYB_1987

Alternate gene names: 86609436

Gene position: 2089024-2090721 (Clockwise)

Preceding gene: 86609432

Following gene: 86609440

Centisome position: 68.57

GC content: 62.78

Gene sequence:

>1698_bases
ATGGCCAATTCCCCTTTCCCGCTGCGCAGCCAAGTGGTTACCCAGGGAGTACAGCGCTCCCCCAACCGCGCCATGCTCAG
GGCCGTAGGCTTTCGCGACGAAGACTTCGGCAAGCCCATTGTCGGCATTGCCAACGCCCACAGCACCCTCACCCCCTGCA
ACATGGGGATCCAAACTCTGGCGGAGCGGGCGGAGGCGGCTTTGAGAACGGCGGGCTGTATGCCCCAGGTGTTCGGCACC
ATCACCATTAGCGACGGCATCTCGATGGGCACGGAGGGGATGAAATACTCCCTGGTGTCGCGGGAAGTGATTGCCGATTC
CATCGAGACGGTGGTCAACGGCCAGAGCATGGATGGCCTCTTGGCCATTGGCGGCTGCGACAAGAACATGCCGGGGGCGA
TGATCGCCATGGCCCGCCTCAATGTGCCCTCCATCTTCGTCTACGGCGGCACCATCAAGCCGGGTCACTACAATGGCCGC
GACCTCACCATCGTCAGCGCCTTTGAAGCGGTGGGGGAGTTCAGTGCCGGGCGCATCTCCGAGGAAGAGCTGCTGGCGGT
GGAGCGCCATGCCTGTCCCGGTGCCGGATCCTGCGGCGGCATGTACACGGCCAACACCATGTCCAGCGCGTTTGAGGCTA
TGGGGATGAGTCTGCCCTACTCCTCCACCATGGCTGCAGAAGACGAAGAGAAAGCCGAAAGTGCCGCCCAATCGGCCAAG
GTCTTGGCAGAGGCCATCAAAGCCAACATCCGCCCCCGCGACATCATCACCCGTAAAAGCATTGAAAATGCCATCTCGGT
GATCATGGCCGTAGGGGGATCCACCAACGCCGTGCTCCACTTTCTGGCCATTGCCCATGCGGCAGAAGTGCCCCTGACGC
TAGATGATTTCGAGACCATTCGTGCTCGCGTGCCTGTCCTCTGCGATCTCAAGCCTTCAGGGCGGTTTGTGGCCACCGAC
CTGCACCGGGCCGGTGGGATCCCCCAGGTGATGAAAATGCTGCTCAACCACGGCCTGCTGCACGGGGACTGCCTCACCAT
CTCCGGCCAGACCATCGTCGAAGTCCTGCGGGATGTGCCGGACGAGCCTAGCCCGGATCAGGAGGTGATCCGCCCTTGGC
ACAGCCCCCTGTATCCCCAAGGGCATCTGGCCATCCTCAAGGGGAATCTGGCTCCCGAAGGAGCAGTAGCCAAGATTACC
GGCGTCAAGAACCCGCAAATTACCGGGCCGGCGCGGGTCTTCGATTCAGAGGAGTCCTGCCTGCAGGCCATCCTCTCCGG
CCAGATCCGAGCAGGGGATGTGGTGGTGATCCGCTACGAAGGCCCCAAAGGTGGCCCCGGCATGCGGGAGATGCTCTCGC
CCACTTCGGCCATCATCGGCGCCGGCTTGGGGGATAGCGTTGGCCTGATCACCGATGGCCGCTTCTCCGGCGGCACCTAC
GGCATGGTAGTGGGCCATGTGGCTCCCGAAGCCTATGTGGGGGGCACGATTGCCCTGGTGGAGGAAGGGGATCTCATCAC
CATTGATGCCCCGGCTCGCCAGTTGCACTTGCATGTGAGCGAAGAAGAGCTGGCCCGCCGCCGCGCCCGCTGGTCTCCTC
CTGAGCCTCGCTACAAACGGGGCACCCTAGCCAAGTACGCCAAGCTGGTCTCCAGCAGCAGCCTGGGGGCAGTGACGGAT
TTAAACCTGTGGGATTAA

Upstream 100 bases:

>100_bases
CTCTTTCCGGGAAAGCTCATGTTCCCCCGAAGAAACGCGGTAGGATGAGTTCTACCCCTTTTCTCCTCTCCCTACTTCGT
CCCGGTTTCCTCTTGCAATG

Downstream 100 bases:

>100_bases
TTTCCCTCACCCCCGGCTCGTCTCCCAGAGGGAGAATTGGTACTTGAGAGATAGCTCCAGATTCCTGACCCTGCAGGGAT
CAGCCTTGCTGGGTTAAGTG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MANSPFPLRSQVVTQGVQRSPNRAMLRAVGFRDEDFGKPIVGIANAHSTLTPCNMGIQTLAERAEAALRTAGCMPQVFGT
ITISDGISMGTEGMKYSLVSREVIADSIETVVNGQSMDGLLAIGGCDKNMPGAMIAMARLNVPSIFVYGGTIKPGHYNGR
DLTIVSAFEAVGEFSAGRISEEELLAVERHACPGAGSCGGMYTANTMSSAFEAMGMSLPYSSTMAAEDEEKAESAAQSAK
VLAEAIKANIRPRDIITRKSIENAISVIMAVGGSTNAVLHFLAIAHAAEVPLTLDDFETIRARVPVLCDLKPSGRFVATD
LHRAGGIPQVMKMLLNHGLLHGDCLTISGQTIVEVLRDVPDEPSPDQEVIRPWHSPLYPQGHLAILKGNLAPEGAVAKIT
GVKNPQITGPARVFDSEESCLQAILSGQIRAGDVVVIRYEGPKGGPGMREMLSPTSAIIGAGLGDSVGLITDGRFSGGTY
GMVVGHVAPEAYVGGTIALVEEGDLITIDAPARQLHLHVSEEELARRRARWSPPEPRYKRGTLAKYAKLVSSSSLGAVTD
LNLWD

Sequences:

>Translated_565_residues
MANSPFPLRSQVVTQGVQRSPNRAMLRAVGFRDEDFGKPIVGIANAHSTLTPCNMGIQTLAERAEAALRTAGCMPQVFGT
ITISDGISMGTEGMKYSLVSREVIADSIETVVNGQSMDGLLAIGGCDKNMPGAMIAMARLNVPSIFVYGGTIKPGHYNGR
DLTIVSAFEAVGEFSAGRISEEELLAVERHACPGAGSCGGMYTANTMSSAFEAMGMSLPYSSTMAAEDEEKAESAAQSAK
VLAEAIKANIRPRDIITRKSIENAISVIMAVGGSTNAVLHFLAIAHAAEVPLTLDDFETIRARVPVLCDLKPSGRFVATD
LHRAGGIPQVMKMLLNHGLLHGDCLTISGQTIVEVLRDVPDEPSPDQEVIRPWHSPLYPQGHLAILKGNLAPEGAVAKIT
GVKNPQITGPARVFDSEESCLQAILSGQIRAGDVVVIRYEGPKGGPGMREMLSPTSAIIGAGLGDSVGLITDGRFSGGTY
GMVVGHVAPEAYVGGTIALVEEGDLITIDAPARQLHLHVSEEELARRRARWSPPEPRYKRGTLAKYAKLVSSSSLGAVTD
LNLWD
>Mature_564_residues
ANSPFPLRSQVVTQGVQRSPNRAMLRAVGFRDEDFGKPIVGIANAHSTLTPCNMGIQTLAERAEAALRTAGCMPQVFGTI
TISDGISMGTEGMKYSLVSREVIADSIETVVNGQSMDGLLAIGGCDKNMPGAMIAMARLNVPSIFVYGGTIKPGHYNGRD
LTIVSAFEAVGEFSAGRISEEELLAVERHACPGAGSCGGMYTANTMSSAFEAMGMSLPYSSTMAAEDEEKAESAAQSAKV
LAEAIKANIRPRDIITRKSIENAISVIMAVGGSTNAVLHFLAIAHAAEVPLTLDDFETIRARVPVLCDLKPSGRFVATDL
HRAGGIPQVMKMLLNHGLLHGDCLTISGQTIVEVLRDVPDEPSPDQEVIRPWHSPLYPQGHLAILKGNLAPEGAVAKITG
VKNPQITGPARVFDSEESCLQAILSGQIRAGDVVVIRYEGPKGGPGMREMLSPTSAIIGAGLGDSVGLITDGRFSGGTYG
MVVGHVAPEAYVGGTIALVEEGDLITIDAPARQLHLHVSEEELARRRARWSPPEPRYKRGTLAKYAKLVSSSSLGAVTDL
NLWD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=606, Percent_Identity=39.1089108910891, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1788157, Length=507, Percent_Identity=31.9526627218935, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI2367371, Length=532, Percent_Identity=34.3984962406015, Blast_Score=209, Evalue=5e-55,
Organism=Escherichia coli, GI1786464, Length=461, Percent_Identity=35.5748373101952, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6322476, Length=559, Percent_Identity=49.0161001788909, Blast_Score=545, Evalue=1e-156,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59804; Mature: 59673

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANSPFPLRSQVVTQGVQRSPNRAMLRAVGFRDEDFGKPIVGIANAHSTLTPCNMGIQTL
CCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHH
AERAEAALRTAGCMPQVFGTITISDGISMGTEGMKYSLVSREVIADSIETVVNGQSMDGL
HHHHHHHHHHHCCCHHHHEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCE
LAIGGCDKNMPGAMIAMARLNVPSIFVYGGTIKPGHYNGRDLTIVSAFEAVGEFSAGRIS
EEEECCCCCCCCCEEEEECCCCCEEEEECCEECCCCCCCCCEEEEEHHHHHCCCCCCCCC
EEELLAVERHACPGAGSCGGMYTANTMSSAFEAMGMSLPYSSTMAAEDEEKAESAAQSAK
HHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
VLAEAIKANIRPRDIITRKSIENAISVIMAVGGSTNAVLHFLAIAHAAEVPLTLDDFETI
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEHHHHHHH
RARVPVLCDLKPSGRFVATDLHRAGGIPQVMKMLLNHGLLHGDCLTISGQTIVEVLRDVP
HHCCCEEEECCCCCCEEEECHHHHCCCHHHHHHHHHCCCEECCEEEECCHHHHHHHHHCC
DEPSPDQEVIRPWHSPLYPQGHLAILKGNLAPEGAVAKITGVKNPQITGPARVFDSEESC
CCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCHHHCCCHHHH
LQAILSGQIRAGDVVVIRYEGPKGGPGMREMLSPTSAIIGAGLGDSVGLITDGRFSGGTY
HHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCCCEEECCCCCCCEE
GMVVGHVAPEAYVGGTIALVEEGDLITIDAPARQLHLHVSEEELARRRARWSPPEPRYKR
EEEEECCCCCHHCCCEEEEEECCCEEEEECCCEEEEEEECHHHHHHHHHCCCCCCCCCCC
GTLAKYAKLVSSSSLGAVTDLNLWD
CHHHHHHHHHCCCCCCCEECCCCCC
>Mature Secondary Structure 
ANSPFPLRSQVVTQGVQRSPNRAMLRAVGFRDEDFGKPIVGIANAHSTLTPCNMGIQTL
CCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHH
AERAEAALRTAGCMPQVFGTITISDGISMGTEGMKYSLVSREVIADSIETVVNGQSMDGL
HHHHHHHHHHHCCCHHHHEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCE
LAIGGCDKNMPGAMIAMARLNVPSIFVYGGTIKPGHYNGRDLTIVSAFEAVGEFSAGRIS
EEEECCCCCCCCCEEEEECCCCCEEEEECCEECCCCCCCCCEEEEEHHHHHCCCCCCCCC
EEELLAVERHACPGAGSCGGMYTANTMSSAFEAMGMSLPYSSTMAAEDEEKAESAAQSAK
HHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
VLAEAIKANIRPRDIITRKSIENAISVIMAVGGSTNAVLHFLAIAHAAEVPLTLDDFETI
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEHHHHHHH
RARVPVLCDLKPSGRFVATDLHRAGGIPQVMKMLLNHGLLHGDCLTISGQTIVEVLRDVP
HHCCCEEEECCCCCCEEEECHHHHCCCHHHHHHHHHCCCEECCEEEECCHHHHHHHHHCC
DEPSPDQEVIRPWHSPLYPQGHLAILKGNLAPEGAVAKITGVKNPQITGPARVFDSEESC
CCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCHHHCCCHHHH
LQAILSGQIRAGDVVVIRYEGPKGGPGMREMLSPTSAIIGAGLGDSVGLITDGRFSGGTY
HHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCCCEEECCCCCCCEE
GMVVGHVAPEAYVGGTIALVEEGDLITIDAPARQLHLHVSEEELARRRARWSPPEPRYKR
EEEEECCCCCHHCCCEEEEEECCCEEEEECCCEEEEEEECHHHHHHHHHCCCCCCCCCCC
GTLAKYAKLVSSSSLGAVTDLNLWD
CHHHHHHHHHCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA