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The map label for this gene is tuaD [H]

Identifier: 86609386

GI number: 86609386

Start: 2013648

End: 2015054

Strand: Reverse

Name: tuaD [H]

Synonym: CYB_1930

Alternate gene names: 86609386

Gene position: 2015054-2013648 (Counterclockwise)

Preceding gene: 86609388

Following gene: 86609385

Centisome position: 66.14

GC content: 61.05

Gene sequence:

>1407_bases
ATGCACGTTGCTGTGGTAGGCGCTGGCTATGTGGGCCTGGTAACAGGGGCTTGCCTGGCTCACCTAGGAAATAGCGTTAT
CTGTGTGGACAACAACCCCGCCAAGATTGAAGGGCTGCAGCGGGGTTGCCTGCCCATCTACGAGCCCGGCCTGGAAGAGC
TGGTGCGGGAGGGAACTGCGGCGGGTCGGCTGCACTTTACCACCGATCTGGGCCTTGGGATCCAGGCCAGCGAGGTGGTG
TTTATTGCCGTGGGCACCCCGGCCCTGCCCAGCGGGGATCCCGATCTGCGCTACGTGGAAGCAGTGGCGCGGGAAATTGG
CCAGCATCTGGACGAGCACTATCGAGTCATTGTCAACAAATCCACTGTGCCCATTGGCTCTGGGGACTGGGTGCGCATGC
TCATTTTGGACGGGGCCGCCGAAGCCGCCAAGCAGCGGCTGAGCAGCCGAGAAGTGGGGAGGGATCCTGAGGCCAGATCT
CTCACCTTAGAGCTCTCCCCTTGGACGCCGCAGTTTGACGTGGTGAGCAACCCCGAGTTTCTGCGGGAGGGCAGTGCCAT
CCAAGATACCTTCTACCCGGATCGCATTGTGATTGGCTCCAACAGCCCCCGCGCCATTGAAATCATGCGGCAGCTGTATG
AACCCATCCTCAACCGCCAGCAGGGCCTGCAAGGGGATCCCGTGCCTTTGCTGGTGACCGACCTGGCTTCTGCCGAAATG
ATCAAGTATGCCGCCAACGCCTTCCTGGCCACCAAGATTAGCTTCATCAACGAAATGGCCAACATCTGTGAGCGCACCGG
CGCCGACATCACCCAGGTGGCAGAAGGGATCGGCCTAGATAGGCGCATTGGCCGCGCCTTTCTCAACGCCGGCATAGGGT
GGGGCGGAAGCTGCTTCCCCAAAGATCTGGCGGCTCTTATCCAAACCGCTGCTGACTACGGCTATGAGGCCAAGCTGTTG
CAGGCCACGGTGGAGGTTAACCGAGAACAGCGGCAGCGCCTGGTGGAAAAGCTGCAGCAGGCCCTCAAGGTGCTCAAGGG
AAAAACCGTTGGCCTACTGGGTCTGACGTTTAAACCCCACACCGACGACCTGCGGGATGCCCCTTCCCTGACCTTAATCG
AGCAGCTCCACCGCCTTGGGGCAAAGGTGAAGGCGTATGATCCCGTTGTGTCCGCCTCGGGGATGCGGGAGGGGCTAGCC
CATGTGGTGGTGGAAACGGATGTGTTTCGCCTGGCCCAAGATTGCGATGCCCTGGTGCTGGTGACGGAGTGGCCGGAGTT
TTTGTCGCTGGATTACCGACGGATTGCAGAGCTGATGCGGCGGCCCTTGCTCATCGATGGCCGTAACTGTCTGGATCGGG
AGGCAGTGCGGCAGGCGGGCATAACCCTCATCGGAGTGGGCTGGTAG

Upstream 100 bases:

>100_bases
TATTCTGTCACCGACCTCAATAGGGGTAAGGGAGGGTACCCTAAAAGCAAGCTGCTAAGGCTTAGTCAAGTGGCCGCCGA
TTGGGGAGCGAACTCTGAGT

Downstream 100 bases:

>100_bases
GCGCTGGGGAAATCAGGGGAAATCATGAAGATCCTGGTTACAGGTGGCCTGGGATTTATTGGATCCCACTTGGTAACCCG
CCTTCTGCAAGAAGGCCACT

Product: UDP-glucose dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MHVAVVGAGYVGLVTGACLAHLGNSVICVDNNPAKIEGLQRGCLPIYEPGLEELVREGTAAGRLHFTTDLGLGIQASEVV
FIAVGTPALPSGDPDLRYVEAVAREIGQHLDEHYRVIVNKSTVPIGSGDWVRMLILDGAAEAAKQRLSSREVGRDPEARS
LTLELSPWTPQFDVVSNPEFLREGSAIQDTFYPDRIVIGSNSPRAIEIMRQLYEPILNRQQGLQGDPVPLLVTDLASAEM
IKYAANAFLATKISFINEMANICERTGADITQVAEGIGLDRRIGRAFLNAGIGWGGSCFPKDLAALIQTAADYGYEAKLL
QATVEVNREQRQRLVEKLQQALKVLKGKTVGLLGLTFKPHTDDLRDAPSLTLIEQLHRLGAKVKAYDPVVSASGMREGLA
HVVVETDVFRLAQDCDALVLVTEWPEFLSLDYRRIAELMRRPLLIDGRNCLDREAVRQAGITLIGVGW

Sequences:

>Translated_468_residues
MHVAVVGAGYVGLVTGACLAHLGNSVICVDNNPAKIEGLQRGCLPIYEPGLEELVREGTAAGRLHFTTDLGLGIQASEVV
FIAVGTPALPSGDPDLRYVEAVAREIGQHLDEHYRVIVNKSTVPIGSGDWVRMLILDGAAEAAKQRLSSREVGRDPEARS
LTLELSPWTPQFDVVSNPEFLREGSAIQDTFYPDRIVIGSNSPRAIEIMRQLYEPILNRQQGLQGDPVPLLVTDLASAEM
IKYAANAFLATKISFINEMANICERTGADITQVAEGIGLDRRIGRAFLNAGIGWGGSCFPKDLAALIQTAADYGYEAKLL
QATVEVNREQRQRLVEKLQQALKVLKGKTVGLLGLTFKPHTDDLRDAPSLTLIEQLHRLGAKVKAYDPVVSASGMREGLA
HVVVETDVFRLAQDCDALVLVTEWPEFLSLDYRRIAELMRRPLLIDGRNCLDREAVRQAGITLIGVGW
>Mature_468_residues
MHVAVVGAGYVGLVTGACLAHLGNSVICVDNNPAKIEGLQRGCLPIYEPGLEELVREGTAAGRLHFTTDLGLGIQASEVV
FIAVGTPALPSGDPDLRYVEAVAREIGQHLDEHYRVIVNKSTVPIGSGDWVRMLILDGAAEAAKQRLSSREVGRDPEARS
LTLELSPWTPQFDVVSNPEFLREGSAIQDTFYPDRIVIGSNSPRAIEIMRQLYEPILNRQQGLQGDPVPLLVTDLASAEM
IKYAANAFLATKISFINEMANICERTGADITQVAEGIGLDRRIGRAFLNAGIGWGGSCFPKDLAALIQTAADYGYEAKLL
QATVEVNREQRQRLVEKLQQALKVLKGKTVGLLGLTFKPHTDDLRDAPSLTLIEQLHRLGAKVKAYDPVVSASGMREGLA
HVVVETDVFRLAQDCDALVLVTEWPEFLSLDYRRIAELMRRPLLIDGRNCLDREAVRQAGITLIGVGW

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=477, Percent_Identity=35.0104821802935, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI296040438, Length=378, Percent_Identity=34.6560846560847, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI296040443, Length=299, Percent_Identity=37.123745819398, Blast_Score=186, Evalue=3e-47,
Organism=Escherichia coli, GI1788340, Length=425, Percent_Identity=27.5294117647059, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI48994968, Length=387, Percent_Identity=28.9405684754522, Blast_Score=118, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17560350, Length=491, Percent_Identity=35.8452138492872, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI17136908, Length=495, Percent_Identity=33.9393939393939, Blast_Score=267, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 51061; Mature: 51061

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVAVVGAGYVGLVTGACLAHLGNSVICVDNNPAKIEGLQRGCLPIYEPGLEELVREGTA
CEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCCCCCCCCCCHHHHHHCCCC
AGRLHFTTDLGLGIQASEVVFIAVGTPALPSGDPDLRYVEAVAREIGQHLDEHYRVIVNK
CCEEEEEECCCCCCEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEC
STVPIGSGDWVRMLILDGAAEAAKQRLSSREVGRDPEARSLTLELSPWTPQFDVVSNPEF
CCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHH
LREGSAIQDTFYPDRIVIGSNSPRAIEIMRQLYEPILNRQQGLQGDPVPLLVTDLASAEM
HHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHH
IKYAANAFLATKISFINEMANICERTGADITQVAEGIGLDRRIGRAFLNAGIGWGGSCFP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCH
KDLAALIQTAADYGYEAKLLQATVEVNREQRQRLVEKLQQALKVLKGKTVGLLGLTFKPH
HHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCC
TDDLRDAPSLTLIEQLHRLGAKVKAYDPVVSASGMREGLAHVVVETDVFRLAQDCDALVL
CCHHHCCCCHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
VTEWPEFLSLDYRRIAELMRRPLLIDGRNCLDREAVRQAGITLIGVGW
EECCHHHHCCCHHHHHHHHHCCEEECCCCHHHHHHHHHCCCEEEEECC
>Mature Secondary Structure
MHVAVVGAGYVGLVTGACLAHLGNSVICVDNNPAKIEGLQRGCLPIYEPGLEELVREGTA
CEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCCCCCCCCCCHHHHHHCCCC
AGRLHFTTDLGLGIQASEVVFIAVGTPALPSGDPDLRYVEAVAREIGQHLDEHYRVIVNK
CCEEEEEECCCCCCEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEC
STVPIGSGDWVRMLILDGAAEAAKQRLSSREVGRDPEARSLTLELSPWTPQFDVVSNPEF
CCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHH
LREGSAIQDTFYPDRIVIGSNSPRAIEIMRQLYEPILNRQQGLQGDPVPLLVTDLASAEM
HHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHH
IKYAANAFLATKISFINEMANICERTGADITQVAEGIGLDRRIGRAFLNAGIGWGGSCFP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCH
KDLAALIQTAADYGYEAKLLQATVEVNREQRQRLVEKLQQALKVLKGKTVGLLGLTFKPH
HHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCC
TDDLRDAPSLTLIEQLHRLGAKVKAYDPVVSASGMREGLAHVVVETDVFRLAQDCDALVL
CCHHHCCCCHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
VTEWPEFLSLDYRRIAELMRRPLLIDGRNCLDREAVRQAGITLIGVGW
EECCHHHHCCCHHHHHHHHHCCEEECCCCHHHHHHHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]