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The map label for this gene is thrB [H]

Identifier: 86609358

GI number: 86609358

Start: 1987414

End: 1988340

Strand: Reverse

Name: thrB [H]

Synonym: CYB_1902

Alternate gene names: 86609358

Gene position: 1988340-1987414 (Counterclockwise)

Preceding gene: 86609362

Following gene: 86609354

Centisome position: 65.26

GC content: 60.84

Gene sequence:

>927_bases
TTGGTCAAAGAACGCGTAGAGGTGATCGTCCCGGCCACCACCGCCAACTTGGGGCCAGGGTTCGACTGCATCGGTGCAGC
CCTAGAGCTCTACAATCACTTCTATTTTCGCGAGATCCCTTCTGGCCTCAGCATCCACTACCGCGGCAGCGACCACATCA
GCCAAAGCAAGGACAACCTGGTGTACCGGGCTTTTTGCCGCGCCTTTGAGTTGCTGAGTAAGCCTGTGCCGGGGGTAGAA
ATCGAAATTACCCTCAACGTGCCCCTGGCGCGGGGGTTGGGCAGTTCTGCCACCGCCATTGTCGGCGGCTTGCTGGGGGC
CAATGCCATTGGAGCACTCAACTTAGCTCCCGAAACCCTTCTACAACTGGCTATTGCCTTGGAGGGCCACCCAGACAATG
TGGTGCCCGCCCTGCAGGGCAGTTGTCAGCTTTGTGTGCAGGGACAGCAGGGGCAATGGGTGTTCTGTCCGGTGGAGTGG
CATGAGAGCATTGGCATCCTGGCCGTAGTGCCCAACTTTAAGCTTTCCACCCAAGCGGCCCGCGAGATCCTGCCCAAATC
CGTCAGCTTGGCGGATGCAGTTTTTTCCAGCAGCCATCTGGGCCTACTCATCCGCAGCCTGCAGTCGGGGCGGGTGGACT
GGCTGAAGGTGGCCCTGCAGGATCGGCTGCACCAGCCGGCGCGTATGGAGCTGATCACCGGGTTCAAAACGGTTCAAGCT
GCAGCCATGGCTGCCGGAGCCTATGGAGTGGTGATCAGCGGAGCCGGCCCCACTCTTCTGGCCCTCTGTGCTCCCGAGAA
TCGGGAACGGGTGGGATCCGCGATGGTCAGCGCTTGGGCGCAGTTGGATATTGAAGCGGAGGCCAAACTGCTCAACCTGG
ACCGGCAGGGAGGACGGGTGGTGATCCACTCCCAGCCGTCTGGATAG

Upstream 100 bases:

>100_bases
GAATATCCAAGGTCTGGCCATCGTTCGTAGGATAATGGGAGCCCGCAGGCACTAACCCGCAAACATTGAGTTACCCACCG
TTCACTGAGGAGTTGTCCCC

Downstream 100 bases:

>100_bases
GAAACTTCCTGTCCAATCGGGGAGCTACCCTGCTGCCGGGAAGCCATCTTGCAGCAGCAACACCAAGGGCGGAAGAAATA
GCCAAGCCGCCACCATCAAG

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MVKERVEVIVPATTANLGPGFDCIGAALELYNHFYFREIPSGLSIHYRGSDHISQSKDNLVYRAFCRAFELLSKPVPGVE
IEITLNVPLARGLGSSATAIVGGLLGANAIGALNLAPETLLQLAIALEGHPDNVVPALQGSCQLCVQGQQGQWVFCPVEW
HESIGILAVVPNFKLSTQAAREILPKSVSLADAVFSSSHLGLLIRSLQSGRVDWLKVALQDRLHQPARMELITGFKTVQA
AAMAAGAYGVVISGAGPTLLALCAPENRERVGSAMVSAWAQLDIEAEAKLLNLDRQGGRVVIHSQPSG

Sequences:

>Translated_308_residues
MVKERVEVIVPATTANLGPGFDCIGAALELYNHFYFREIPSGLSIHYRGSDHISQSKDNLVYRAFCRAFELLSKPVPGVE
IEITLNVPLARGLGSSATAIVGGLLGANAIGALNLAPETLLQLAIALEGHPDNVVPALQGSCQLCVQGQQGQWVFCPVEW
HESIGILAVVPNFKLSTQAAREILPKSVSLADAVFSSSHLGLLIRSLQSGRVDWLKVALQDRLHQPARMELITGFKTVQA
AAMAAGAYGVVISGAGPTLLALCAPENRERVGSAMVSAWAQLDIEAEAKLLNLDRQGGRVVIHSQPSG
>Mature_308_residues
MVKERVEVIVPATTANLGPGFDCIGAALELYNHFYFREIPSGLSIHYRGSDHISQSKDNLVYRAFCRAFELLSKPVPGVE
IEITLNVPLARGLGSSATAIVGGLLGANAIGALNLAPETLLQLAIALEGHPDNVVPALQGSCQLCVQGQQGQWVFCPVEW
HESIGILAVVPNFKLSTQAAREILPKSVSLADAVFSSSHLGLLIRSLQSGRVDWLKVALQDRLHQPARMELITGFKTVQA
AAMAAGAYGVVISGAGPTLLALCAPENRERVGSAMVSAWAQLDIEAEAKLLNLDRQGGRVVIHSQPSG

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=313, Percent_Identity=32.5878594249201, Blast_Score=122, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321814, Length=351, Percent_Identity=28.7749287749288, Blast_Score=133, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 32755; Mature: 32755

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKERVEVIVPATTANLGPGFDCIGAALELYNHFYFREIPSGLSIHYRGSDHISQSKDNL
CCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCH
VYRAFCRAFELLSKPVPGVEIEITLNVPLARGLGSSATAIVGGLLGANAIGALNLAPETL
HHHHHHHHHHHHHCCCCCEEEEEEECCCHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHHH
LQLAIALEGHPDNVVPALQGSCQLCVQGQQGQWVFCPVEWHESIGILAVVPNFKLSTQAA
HHHHHHCCCCCCCCCHHCCCCEEEEEECCCCCEEEEEEHHCCCCCEEEEECCCCCCHHHH
REILPKSVSLADAVFSSSHLGLLIRSLQSGRVDWLKVALQDRLHQPARMELITGFKTVQA
HHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AAMAAGAYGVVISGAGPTLLALCAPENRERVGSAMVSAWAQLDIEAEAKLLNLDRQGGRV
HHHHCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEE
VIHSQPSG
EEECCCCC
>Mature Secondary Structure
MVKERVEVIVPATTANLGPGFDCIGAALELYNHFYFREIPSGLSIHYRGSDHISQSKDNL
CCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCH
VYRAFCRAFELLSKPVPGVEIEITLNVPLARGLGSSATAIVGGLLGANAIGALNLAPETL
HHHHHHHHHHHHHCCCCCEEEEEEECCCHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHHH
LQLAIALEGHPDNVVPALQGSCQLCVQGQQGQWVFCPVEWHESIGILAVVPNFKLSTQAA
HHHHHHCCCCCCCCCHHCCCCEEEEEECCCCCEEEEEEHHCCCCCEEEEECCCCCCHHHH
REILPKSVSLADAVFSSSHLGLLIRSLQSGRVDWLKVALQDRLHQPARMELITGFKTVQA
HHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AAMAAGAYGVVISGAGPTLLALCAPENRERVGSAMVSAWAQLDIEAEAKLLNLDRQGGRV
HHHHCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEE
VIHSQPSG
EEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA