Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 86609206

GI number: 86609206

Start: 1831100

End: 1831903

Strand: Direct

Name: proC [H]

Synonym: CYB_1749

Alternate gene names: 86609206

Gene position: 1831100-1831903 (Clockwise)

Preceding gene: 86609205

Following gene: 86609209

Centisome position: 60.1

GC content: 63.68

Gene sequence:

>804_bases
ATGGAGCGGCCACTGCTAAGTGTTATCGGGGGTGGAGCCATGGGATCCGCCCTGCTGCGGCGTTGGGTAGCTGTGGGAGT
TTATCCCGCAGCGCAGGTGGCCTTGCGGGAGCCTGATCTGGATAAGGCTGTGGCCCTGCAGCAGGAGCTGGGTATCCGAT
TGTTGGCGGATCCATCCCAGGCGGGAGAGTCTGAGATTCTGTTTCTGGCCGTTAAACCGCAGCTCTTCCCGACGGTGGTG
GCTGAGATGGGCCGGCTGTCCGCCACAGAGCTGGTGATCTCGATTATGGCCGGGATCCCCTTGCAGCAGTTGCAGCAGGC
TTTTCCCAAGCAAAAGGTGGTGCGCACGATGCCCAACACGCCGGCGCTGGTGGGGGCGGGCATAACGGCCATCAGCTACG
GGCCAGGGGTGACGCCTATGCAGGTGGAGCAGGTGGAGAAGCTGTTTCGCGCGGTGGGCGAGGTGGTGACGGTGGCCGAA
AGCCAGATGGATGCGGTGACGGCACTTTCGGGTTCCGGGCCGGGGTATCTGGCGGTGATTCTGGAAGGGCTGATCGACGG
AGGGGTACAGGTGGGGCTGCCGCGTCCCATTGCTACCCAGTTGGCCCTGCAGACCTTGGCGGGTACTGCTGCCCTCTTGC
AGCAAGAAAATCTGCACCCTGCCGTTCTCAAAGACCGGGTCACCAGTCCAGGGGGGACGACCATTGCCGGGATCCAAGCC
TTGGAGCAGGCGGGGGTGCGGGGAGCCCTGATGCAGGCAGTGCGAGCGGCCTACGAGCGCTCTTGCCAGTTACAGGGATC
CTAG

Upstream 100 bases:

>100_bases
GCCAAGTGGTGCAGCCGCTGCAGCGCCCTTTGCAAAGCCCTACCCCCCTCTGGCCCAGCACCTATGAGCATCTGCAGGCA
GTAGGTCAGCACTAGTTGCT

Downstream 100 bases:

>100_bases
CGGGCCAGCAGCCCTTGCCACAGGGGGCGGGTGATCCAATTCCATCCCACCTTGAGCTGGTGTTCCAGTGTGGGCAGGCG
CACCAAATAGGCAGTTCGCC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MERPLLSVIGGGAMGSALLRRWVAVGVYPAAQVALREPDLDKAVALQQELGIRLLADPSQAGESEILFLAVKPQLFPTVV
AEMGRLSATELVISIMAGIPLQQLQQAFPKQKVVRTMPNTPALVGAGITAISYGPGVTPMQVEQVEKLFRAVGEVVTVAE
SQMDAVTALSGSGPGYLAVILEGLIDGGVQVGLPRPIATQLALQTLAGTAALLQQENLHPAVLKDRVTSPGGTTIAGIQA
LEQAGVRGALMQAVRAAYERSCQLQGS

Sequences:

>Translated_267_residues
MERPLLSVIGGGAMGSALLRRWVAVGVYPAAQVALREPDLDKAVALQQELGIRLLADPSQAGESEILFLAVKPQLFPTVV
AEMGRLSATELVISIMAGIPLQQLQQAFPKQKVVRTMPNTPALVGAGITAISYGPGVTPMQVEQVEKLFRAVGEVVTVAE
SQMDAVTALSGSGPGYLAVILEGLIDGGVQVGLPRPIATQLALQTLAGTAALLQQENLHPAVLKDRVTSPGGTTIAGIQA
LEQAGVRGALMQAVRAAYERSCQLQGS
>Mature_267_residues
MERPLLSVIGGGAMGSALLRRWVAVGVYPAAQVALREPDLDKAVALQQELGIRLLADPSQAGESEILFLAVKPQLFPTVV
AEMGRLSATELVISIMAGIPLQQLQQAFPKQKVVRTMPNTPALVGAGITAISYGPGVTPMQVEQVEKLFRAVGEVVTVAE
SQMDAVTALSGSGPGYLAVILEGLIDGGVQVGLPRPIATQLALQTLAGTAALLQQENLHPAVLKDRVTSPGGTTIAGIQA
LEQAGVRGALMQAVRAAYERSCQLQGS

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=267, Percent_Identity=39.3258426966292, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI24797095, Length=267, Percent_Identity=39.3258426966292, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI21361454, Length=264, Percent_Identity=38.2575757575758, Blast_Score=167, Evalue=6e-42,
Organism=Homo sapiens, GI198041662, Length=259, Percent_Identity=35.5212355212355, Blast_Score=148, Evalue=5e-36,
Organism=Escherichia coli, GI1786585, Length=270, Percent_Identity=37.4074074074074, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17569021, Length=260, Percent_Identity=41.9230769230769, Blast_Score=185, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17540664, Length=278, Percent_Identity=32.0143884892086, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320861, Length=279, Percent_Identity=32.6164874551971, Blast_Score=139, Evalue=7e-34,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=37.5, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24648116, Length=271, Percent_Identity=36.90036900369, Blast_Score=167, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=42.3529411764706, Blast_Score=134, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27787; Mature: 27787

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERPLLSVIGGGAMGSALLRRWVAVGVYPAAQVALREPDLDKAVALQQELGIRLLADPSQ
CCCCHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHCCEEEEECCCC
AGESEILFLAVKPQLFPTVVAEMGRLSATELVISIMAGIPLQQLQQAFPKQKVVRTMPNT
CCCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHCCCC
PALVGAGITAISYGPGVTPMQVEQVEKLFRAVGEVVTVAESQMDAVTALSGSGPGYLAVI
CCHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LEGLIDGGVQVGLPRPIATQLALQTLAGTAALLQQENLHPAVLKDRVTSPGGTTIAGIQA
HHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHH
LEQAGVRGALMQAVRAAYERSCQLQGS
HHHHCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MERPLLSVIGGGAMGSALLRRWVAVGVYPAAQVALREPDLDKAVALQQELGIRLLADPSQ
CCCCHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHCCEEEEECCCC
AGESEILFLAVKPQLFPTVVAEMGRLSATELVISIMAGIPLQQLQQAFPKQKVVRTMPNT
CCCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHCCCC
PALVGAGITAISYGPGVTPMQVEQVEKLFRAVGEVVTVAESQMDAVTALSGSGPGYLAVI
CCHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LEGLIDGGVQVGLPRPIATQLALQTLAGTAALLQQENLHPAVLKDRVTSPGGTTIAGIQA
HHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHH
LEQAGVRGALMQAVRAAYERSCQLQGS
HHHHCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]