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The map label for this gene is ahcY [H]

Identifier: 86609209

GI number: 86609209

Start: 1833865

End: 1835145

Strand: Direct

Name: ahcY [H]

Synonym: CYB_1751

Alternate gene names: 86609209

Gene position: 1833865-1835145 (Clockwise)

Preceding gene: 86609206

Following gene: 86609211

Centisome position: 60.19

GC content: 63.08

Gene sequence:

>1281_bases
ATGACCAGCGCTACCCTGTCTCTCCCGAAGCATGAAGTGAAAGATCTGAACCTCGCCCCCCTGGGCAAGCAACGGATCCA
GTGGGCGGCGCGGGAGATGCCGGTGCTGGCCCAGATCCGGGAGCGCTTTGCTCAAGAAAAGCCCTTTGCCGGGCTGCGCT
TGGTGGCCTGCTGCCACATTACGACCGAAACGGCCAACCTGGCCCTGGCTCTACAAGCAGGGGGGGCGGATAGCGTTCTC
ATTGCCAGCAATCCCCTTTCCACCCAAGACGATGTGGCCGCCAGCCTGGTGGCGGACCATGGCATTTCGGTGTTTGCCCT
CAAAGGAGAAGATGTGGCCACCTACCGCCGCCATGTCCAGATTGCCCTAGATCACCGCCCCAACCTGATTATCGACGATG
GCGGAGATGTGACGGCGGAGCTGGTGCAGCACCGTCAGGAGCAACTGTCGGAGCTCATCGGCACCACGGAAGAGACCACC
ACTGGCCTGGTGCGCCTTAGGGCCATGCTCAAGGCGGGGGTGCTCAGCTTCCCGGTGATGACCGTCAACGACGCCGAGAC
CAAACACCTGTTCGACAACCGCTACGGCACCGGCCAATCCACCCTGGACGGGATCCTGCGCTGTACCAACATCCTTCTGG
CCGGGAAGACGGTGGTGGTGGCTGGCTACGGCTGGTGCGCCAAGGGAGTGGCCATGCGGGCCCGCGGCATGGGATCCCAG
GTGATTGTCACGGAAGTCAACCCGGTGCGGGCTCTGGAGGCGGTGATGGACGGCTTCCGGGTGATGCCGATGGAAGAAGC
CGCTGCTCTGGGGGACATCTTCATCACCGTCACCGGCAACAAGCACGTGATTCGCGGCGAGCACTTCGACCGCATGAAGG
ATGGGGCGATGGTCTGCAACGCCGGCCACTTTGACATTGAAATCGACCTGGTGGCGCTGCAGGAGCGGGCCGTCTCCCGA
CAGACGGTGCGCCCCTTTGTGGAAGAATACCGTCTGCAGTCGGGCAAGTCAGTGGTGGTGCTGGGGGAAGGCCGCCTGAT
TAACTTGGCTGCTGCCGAAGGGCACCCCGCCAGCGTCATGGACATGAGCTTTGCCAACCAGGCCCTGGCCTGCGAATACC
TGGTGAAAAACCGGGGCCGCTTGGCCCCAGGGCTTCACCCCATTCCTCTCGAGGTGGACGAGGCCATCGCCCGCCTCAAG
CTCAAGGCCATGGGGATCCAAATCGACAGCCTCACCCCCGAGCAGATCGAGTACGGCAACACCTGGACTGCCGGGACTTG
A

Upstream 100 bases:

>100_bases
CGACATCCTTGCTGATCTTTATGGCTGCCTGGCCCCCTTTGGGGCTTGCAGTTTCCGTTCCCCTATCCTCTCTCGATGAC
CCTGTTTGGAGCAACACTCG

Downstream 100 bases:

>100_bases
GGGTGGGTGCTGGCGCTACGAACCTGAGATACATCCTAAAACCTGTCGCACCTGGGCCAACTCGTCAGCAGGGAGGCGAG
CTTTCAACTCCTTCTCCCAG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTSATLSLPKHEVKDLNLAPLGKQRIQWAAREMPVLAQIRERFAQEKPFAGLRLVACCHITTETANLALALQAGGADSVL
IASNPLSTQDDVAASLVADHGISVFALKGEDVATYRRHVQIALDHRPNLIIDDGGDVTAELVQHRQEQLSELIGTTEETT
TGLVRLRAMLKAGVLSFPVMTVNDAETKHLFDNRYGTGQSTLDGILRCTNILLAGKTVVVAGYGWCAKGVAMRARGMGSQ
VIVTEVNPVRALEAVMDGFRVMPMEEAAALGDIFITVTGNKHVIRGEHFDRMKDGAMVCNAGHFDIEIDLVALQERAVSR
QTVRPFVEEYRLQSGKSVVVLGEGRLINLAAAEGHPASVMDMSFANQALACEYLVKNRGRLAPGLHPIPLEVDEAIARLK
LKAMGIQIDSLTPEQIEYGNTWTAGT

Sequences:

>Translated_426_residues
MTSATLSLPKHEVKDLNLAPLGKQRIQWAAREMPVLAQIRERFAQEKPFAGLRLVACCHITTETANLALALQAGGADSVL
IASNPLSTQDDVAASLVADHGISVFALKGEDVATYRRHVQIALDHRPNLIIDDGGDVTAELVQHRQEQLSELIGTTEETT
TGLVRLRAMLKAGVLSFPVMTVNDAETKHLFDNRYGTGQSTLDGILRCTNILLAGKTVVVAGYGWCAKGVAMRARGMGSQ
VIVTEVNPVRALEAVMDGFRVMPMEEAAALGDIFITVTGNKHVIRGEHFDRMKDGAMVCNAGHFDIEIDLVALQERAVSR
QTVRPFVEEYRLQSGKSVVVLGEGRLINLAAAEGHPASVMDMSFANQALACEYLVKNRGRLAPGLHPIPLEVDEAIARLK
LKAMGIQIDSLTPEQIEYGNTWTAGT
>Mature_425_residues
TSATLSLPKHEVKDLNLAPLGKQRIQWAAREMPVLAQIRERFAQEKPFAGLRLVACCHITTETANLALALQAGGADSVLI
ASNPLSTQDDVAASLVADHGISVFALKGEDVATYRRHVQIALDHRPNLIIDDGGDVTAELVQHRQEQLSELIGTTEETTT
GLVRLRAMLKAGVLSFPVMTVNDAETKHLFDNRYGTGQSTLDGILRCTNILLAGKTVVVAGYGWCAKGVAMRARGMGSQV
IVTEVNPVRALEAVMDGFRVMPMEEAAALGDIFITVTGNKHVIRGEHFDRMKDGAMVCNAGHFDIEIDLVALQERAVSRQ
TVRPFVEEYRLQSGKSVVVLGEGRLINLAAAEGHPASVMDMSFANQALACEYLVKNRGRLAPGLHPIPLEVDEAIARLKL
KAMGIQIDSLTPEQIEYGNTWTAGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=415, Percent_Identity=42.6506024096386, Blast_Score=332, Evalue=3e-91,
Organism=Homo sapiens, GI239937451, Length=389, Percent_Identity=43.1876606683805, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI298286489, Length=410, Percent_Identity=40.4878048780488, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI195539349, Length=410, Percent_Identity=40.4878048780488, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI195539337, Length=410, Percent_Identity=40.4878048780488, Blast_Score=292, Evalue=5e-79,
Organism=Homo sapiens, GI24308043, Length=410, Percent_Identity=40.4878048780488, Blast_Score=291, Evalue=5e-79,
Organism=Homo sapiens, GI21361647, Length=410, Percent_Identity=39.0243902439024, Blast_Score=268, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI17506425, Length=419, Percent_Identity=41.7661097852029, Blast_Score=323, Evalue=9e-89,
Organism=Saccharomyces cerevisiae, GI6320882, Length=427, Percent_Identity=41.6861826697892, Blast_Score=324, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24642172, Length=417, Percent_Identity=42.6858513189448, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24656245, Length=402, Percent_Identity=38.3084577114428, Blast_Score=272, Evalue=4e-73,
Organism=Drosophila melanogaster, GI45553385, Length=409, Percent_Identity=37.1638141809291, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI45553387, Length=409, Percent_Identity=37.1638141809291, Blast_Score=253, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 46147; Mature: 46016

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00738 ADOHCYASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSATLSLPKHEVKDLNLAPLGKQRIQWAAREMPVLAQIRERFAQEKPFAGLRLVACCHI
CCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEEEE
TTETANLALALQAGGADSVLIASNPLSTQDDVAASLVADHGISVFALKGEDVATYRRHVQ
EECCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHEEEEE
IALDHRPNLIIDDGGDVTAELVQHRQEQLSELIGTTEETTTGLVRLRAMLKAGVLSFPVM
EEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHCCEE
TVNDAETKHLFDNRYGTGQSTLDGILRCTNILLAGKTVVVAGYGWCAKGVAMRARGMGSQ
EECCCHHHHHHCCCCCCCHHHHHHHHHHHHHHEECCEEEEEECCHHHHHHHHHHCCCCCE
VIVTEVNPVRALEAVMDGFRVMPMEEAAALGDIFITVTGNKHVIRGEHFDRMKDGAMVCN
EEEEECCHHHHHHHHHCCCEECCHHHHHCCCEEEEEEECCEEEECCCHHHHCCCCCEEEE
AGHFDIEIDLVALQERAVSRQTVRPFVEEYRLQSGKSVVVLGEGRLINLAAAEGHPASVM
CCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEECCCCCCCEE
DMSFANQALACEYLVKNRGRLAPGLHPIPLEVDEAIARLKLKAMGIQIDSLTPEQIEYGN
EHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEECCCHHHHHCCC
TWTAGT
EECCCC
>Mature Secondary Structure 
TSATLSLPKHEVKDLNLAPLGKQRIQWAAREMPVLAQIRERFAQEKPFAGLRLVACCHI
CCCCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEEEE
TTETANLALALQAGGADSVLIASNPLSTQDDVAASLVADHGISVFALKGEDVATYRRHVQ
EECCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHEEEEE
IALDHRPNLIIDDGGDVTAELVQHRQEQLSELIGTTEETTTGLVRLRAMLKAGVLSFPVM
EEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCHHHCCEE
TVNDAETKHLFDNRYGTGQSTLDGILRCTNILLAGKTVVVAGYGWCAKGVAMRARGMGSQ
EECCCHHHHHHCCCCCCCHHHHHHHHHHHHHHEECCEEEEEECCHHHHHHHHHHCCCCCE
VIVTEVNPVRALEAVMDGFRVMPMEEAAALGDIFITVTGNKHVIRGEHFDRMKDGAMVCN
EEEEECCHHHHHHHHHCCCEECCHHHHHCCCEEEEEEECCEEEECCCHHHHCCCCCEEEE
AGHFDIEIDLVALQERAVSRQTVRPFVEEYRLQSGKSVVVLGEGRLINLAAAEGHPASVM
CCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEECCCCCCCEE
DMSFANQALACEYLVKNRGRLAPGLHPIPLEVDEAIARLKLKAMGIQIDSLTPEQIEYGN
EHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEECCCHHHHHCCC
TWTAGT
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]