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The map label for this gene is purM

Identifier: 86609116

GI number: 86609116

Start: 1735696

End: 1736760

Strand: Direct

Name: purM

Synonym: CYB_1656

Alternate gene names: 86609116

Gene position: 1735696-1736760 (Clockwise)

Preceding gene: 86609114

Following gene: 86609117

Centisome position: 56.97

GC content: 63.29

Gene sequence:

>1065_bases
TTGGACTACCGCTCAGCAGGGGTTGACATCGATCTGGGCCAGGCCTTTGTCAGGGGGATCCGCGAGCGCGTTGAACGGAT
TCAAGTTCCGTCTTCAGGTTCTTCAGAAACCTTGGGTGGCATCGGCGGCTTTGCCGGCCTGTTTGAGCTGCCGACAGGGT
ATCAAGCGCCGGTGTTGGTGGCGGGCACCGATGGGGTGGGGACAAAGCTGGACATTGCCCAGCAGTGGGGTCAGCACCAG
GGGGTGGGCGTCGATCTGGTGGCGATGTGTGCCAACGATGTGCTGACGGTGGGGGCCCGGCCGCTGTTTTTCTTGGACTA
TGTGGCCACTGGCAAGCTGGAGCCAGAAGCCCTGTGGCAGGTGATCGATGGCATCTTGGCGGGCTGCCAGGAAGCGGGCT
GCCAACTGCTGGGCGGGGAAACGGCGGAGATGCCGGGGTTTTATCCCCCTGGGAAGTACGACCTGGCCGGGTTTTGTATC
GGAATTGTGGAAAAAACGGCCATTCTGGATGGGTCGCGGGTACAGCTTGGGGATCGGTTGTTGGCTTTGCCCAGCAGCGG
CCTACACAGCAACGGCTACAGCTTGGTGCGGCGGATTGTGGCCGACCGGGGTTGGCGCTGGGATCACCGGCCACCCGGCT
GGGATCGGCCTTTGGCGGAAGTATTCCTCACCCCCACCCGCATCTACGTGCAGGCGGTGCAGCGGCTGCAGGCAGCAGGG
ATCGCCATCCACGGCATGGCCCACATCACTGGCGGCGGGATCCCGGAAAACTTGCCCCGCTGTTTGGCCCCGAACCAAGC
GGCGCGGCTGCAGCCCCATAGCTGGCCCATCCCACAGGAGTTTCTCTGGCTCCAAGAACAGGGCCAGGTGGAGACCTTGG
AGATGTTCCGCACCTTCAACCTGGGGGTGGGCTATGTGCTGGTGATCCCCCCTGAGGCAGAAAATCAGGTGAGATCCCTG
CTCCCCGAAGCCTTCCCCATTGGGGAGGTGGTGGCGGCCTGTCCAGGGGAAAGCCGCGTTCTGGGACTGGAACAGTGGGG
ATCCCTCACAAGCCCTGCCGACTAG

Upstream 100 bases:

>100_bases
GTTAAAACAGAAGTTAATGTACCATAGGTTTCTGAGTTGACCCGTTTGTACGGTCGGACACAGGAGCTCAAGTCTTGATA
GCATAAGGGGTTTCGGCATC

Downstream 100 bases:

>100_bases
CCAACCGATGGATCCCCACCAAAAGGGGGAAAGGGATCCCAGTTCCCTCGACTCATCCTCGCCGTCGCTATGCTAAGTTG
GCATGTGGCCTCAGCGCTGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MDYRSAGVDIDLGQAFVRGIRERVERIQVPSSGSSETLGGIGGFAGLFELPTGYQAPVLVAGTDGVGTKLDIAQQWGQHQ
GVGVDLVAMCANDVLTVGARPLFFLDYVATGKLEPEALWQVIDGILAGCQEAGCQLLGGETAEMPGFYPPGKYDLAGFCI
GIVEKTAILDGSRVQLGDRLLALPSSGLHSNGYSLVRRIVADRGWRWDHRPPGWDRPLAEVFLTPTRIYVQAVQRLQAAG
IAIHGMAHITGGGIPENLPRCLAPNQAARLQPHSWPIPQEFLWLQEQGQVETLEMFRTFNLGVGYVLVIPPEAENQVRSL
LPEAFPIGEVVAACPGESRVLGLEQWGSLTSPAD

Sequences:

>Translated_354_residues
MDYRSAGVDIDLGQAFVRGIRERVERIQVPSSGSSETLGGIGGFAGLFELPTGYQAPVLVAGTDGVGTKLDIAQQWGQHQ
GVGVDLVAMCANDVLTVGARPLFFLDYVATGKLEPEALWQVIDGILAGCQEAGCQLLGGETAEMPGFYPPGKYDLAGFCI
GIVEKTAILDGSRVQLGDRLLALPSSGLHSNGYSLVRRIVADRGWRWDHRPPGWDRPLAEVFLTPTRIYVQAVQRLQAAG
IAIHGMAHITGGGIPENLPRCLAPNQAARLQPHSWPIPQEFLWLQEQGQVETLEMFRTFNLGVGYVLVIPPEAENQVRSL
LPEAFPIGEVVAACPGESRVLGLEQWGSLTSPAD
>Mature_354_residues
MDYRSAGVDIDLGQAFVRGIRERVERIQVPSSGSSETLGGIGGFAGLFELPTGYQAPVLVAGTDGVGTKLDIAQQWGQHQ
GVGVDLVAMCANDVLTVGARPLFFLDYVATGKLEPEALWQVIDGILAGCQEAGCQLLGGETAEMPGFYPPGKYDLAGFCI
GIVEKTAILDGSRVQLGDRLLALPSSGLHSNGYSLVRRIVADRGWRWDHRPPGWDRPLAEVFLTPTRIYVQAVQRLQAAG
IAIHGMAHITGGGIPENLPRCLAPNQAARLQPHSWPIPQEFLWLQEQGQVETLEMFRTFNLGVGYVLVIPPEAENQVRSL
LPEAFPIGEVVAACPGESRVLGLEQWGSLTSPAD

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=348, Percent_Identity=45.6896551724138, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI209869995, Length=348, Percent_Identity=45.6896551724138, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI209869993, Length=348, Percent_Identity=45.6896551724138, Blast_Score=286, Evalue=2e-77,
Organism=Escherichia coli, GI1788845, Length=346, Percent_Identity=49.4219653179191, Blast_Score=317, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI17567511, Length=350, Percent_Identity=40.5714285714286, Blast_Score=236, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6321203, Length=343, Percent_Identity=43.4402332361516, Blast_Score=258, Evalue=8e-70,
Organism=Drosophila melanogaster, GI24582400, Length=301, Percent_Identity=43.5215946843854, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_SYNJB (Q2JL07)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_477878.1
- ProteinModelPortal:   Q2JL07
- SMR:   Q2JL07
- STRING:   Q2JL07
- GeneID:   3901871
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_1656
- TIGR:   CYB_1656
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- PhylomeDB:   Q2JL07
- ProtClustDB:   PRK05385
- BioCyc:   SSP321332:CYB_1656-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 38085; Mature: 38085

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYRSAGVDIDLGQAFVRGIRERVERIQVPSSGSSETLGGIGGFAGLFELPTGYQAPVLV
CCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEE
AGTDGVGTKLDIAQQWGQHQGVGVDLVAMCANDVLTVGARPLFFLDYVATGKLEPEALWQ
ECCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHEEEHHHHCCCCCHHHHHH
VIDGILAGCQEAGCQLLGGETAEMPGFYPPGKYDLAGFCIGIVEKTAILDGSRVQLGDRL
HHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCEE
LALPSSGLHSNGYSLVRRIVADRGWRWDHRPPGWDRPLAEVFLTPTRIYVQAVQRLQAAG
EECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCC
IAIHGMAHITGGGIPENLPRCLAPNQAARLQPHSWPIPQEFLWLQEQGQVETLEMFRTFN
EEEEEEEEECCCCCHHHCHHHCCCCCHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHC
LGVGYVLVIPPEAENQVRSLLPEAFPIGEVVAACPGESRVLGLEQWGSLTSPAD
CCCCEEEEECCCCHHHHHHHCCCCCCHHHHHHHCCCCCEEEEHHHCCCCCCCCC
>Mature Secondary Structure
MDYRSAGVDIDLGQAFVRGIRERVERIQVPSSGSSETLGGIGGFAGLFELPTGYQAPVLV
CCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEE
AGTDGVGTKLDIAQQWGQHQGVGVDLVAMCANDVLTVGARPLFFLDYVATGKLEPEALWQ
ECCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHEEEHHHHCCCCCHHHHHH
VIDGILAGCQEAGCQLLGGETAEMPGFYPPGKYDLAGFCIGIVEKTAILDGSRVQLGDRL
HHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCEE
LALPSSGLHSNGYSLVRRIVADRGWRWDHRPPGWDRPLAEVFLTPTRIYVQAVQRLQAAG
EECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCC
IAIHGMAHITGGGIPENLPRCLAPNQAARLQPHSWPIPQEFLWLQEQGQVETLEMFRTFN
EEEEEEEEECCCCCHHHCHHHCCCCCHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHC
LGVGYVLVIPPEAENQVRSLLPEAFPIGEVVAACPGESRVLGLEQWGSLTSPAD
CCCCEEEEECCCCHHHHHHHCCCCCCHHHHHHHCCCCCEEEEHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA