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The map label for this gene is prs [H]

Identifier: 86609112

GI number: 86609112

Start: 1729152

End: 1730150

Strand: Direct

Name: prs [H]

Synonym: CYB_1652

Alternate gene names: 86609112

Gene position: 1729152-1730150 (Clockwise)

Preceding gene: 86609106

Following gene: 86609113

Centisome position: 56.76

GC content: 58.46

Gene sequence:

>999_bases
GTGGTTCGCCCTGCCCCTCTTCTCCGCCCTTCTCCCCTGCCACCCATCTCGGATAGCAACCGCCTCAAAATCTTCTCAGG
CAGCGCCAACCCGGCTCTGGCTCAGGAGGTAGCGCGTTACCTGGGCATGGATCTGGGCCCGATGTTGCGCAAGCGCTTTG
CCGATGGCGAGCTGTACATCCAAATCCAAGAGTCGATCCGGGGTGCCGATGTCTACTTGGTGCAGCCCACCTGCCGCCCC
GTCAACGACCACCTAATGGAACTGCTGGTCATTATTGACGCCTGTCGCCGCGCCTCTGCCCGGCAGATCACCGCTGTCTT
GCCCTACTACGGCTACGCTCGCGCCGACCGCAAAACGGCAGGCCGAGAAGCGATCACCGCCAAGCTGGTGGCCAACATGA
TTACCCAGGCGGGAGCTCATCGCGTGCTGGCTATGGATCTGCACTCGGCCCAGATTCAAGGCTACTTCGACATTCCCCTC
GACCATGTCTACGCCCAGCCGGTATTACAGGCTTACCTCAAGGAAAAGGGCTTGCTCGACGAAGACATTGTGGTCGTCTC
TCCCGATGTGGGGGGCGTGGCTCGTGCCCGTGCCTTTGCCAAAAAACTCAAGGAAGCCCCTCTGGCAATCATTGACAAGC
GCCGCCAAGCCCACAACGATGTGGAAGTCATGAATCTGATTGGGGATGTGCGGGGGAAAACTGCCATCCTTGTGGATGAC
ATGATCGATACCGCAGGCACCATCTCGGAAGGGGCAAAATTGCTGCGCAAGCTGGGAGCCAAAGCGGTTTATGCCTGCGC
CATTCATCCTGTTTTTTCTGAGCCGGCCATTCAACGCCTGCGGGGTGGCCTGTTTGAAGAGGTGATCGTCACCAACACCA
TCCCTATCCCTCCAGAGCAGCACTTTCCCGAGTTAACCGTTCTCTCGGTAGCCAATGTGCTGGGGGAAGCGATCTGGCGC
ATCCATGAAGATAGCTCCGTCAGCAGCATGTTTCACTAA

Upstream 100 bases:

>100_bases
AAATCCCCAAGAATACAGTTGCTGAGGTTGCAAGTGCTGGTGCTACGATAGCGACAGCTCGCCGTTAGGCGTTGGCTACG
GACGAGTTCAGCATCGATCT

Downstream 100 bases:

>100_bases
AGTAAGTTTCAAAGTAAGTTTCTCCAGAGTATCGCTAGAGTAGAGTGGGTGCAGAATGGGTGCGCCTGCTCCTTTTCCCT
GTGGAGATCAGCCCAACCAG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MVRPAPLLRPSPLPPISDSNRLKIFSGSANPALAQEVARYLGMDLGPMLRKRFADGELYIQIQESIRGADVYLVQPTCRP
VNDHLMELLVIIDACRRASARQITAVLPYYGYARADRKTAGREAITAKLVANMITQAGAHRVLAMDLHSAQIQGYFDIPL
DHVYAQPVLQAYLKEKGLLDEDIVVVSPDVGGVARARAFAKKLKEAPLAIIDKRRQAHNDVEVMNLIGDVRGKTAILVDD
MIDTAGTISEGAKLLRKLGAKAVYACAIHPVFSEPAIQRLRGGLFEEVIVTNTIPIPPEQHFPELTVLSVANVLGEAIWR
IHEDSSVSSMFH

Sequences:

>Translated_332_residues
MVRPAPLLRPSPLPPISDSNRLKIFSGSANPALAQEVARYLGMDLGPMLRKRFADGELYIQIQESIRGADVYLVQPTCRP
VNDHLMELLVIIDACRRASARQITAVLPYYGYARADRKTAGREAITAKLVANMITQAGAHRVLAMDLHSAQIQGYFDIPL
DHVYAQPVLQAYLKEKGLLDEDIVVVSPDVGGVARARAFAKKLKEAPLAIIDKRRQAHNDVEVMNLIGDVRGKTAILVDD
MIDTAGTISEGAKLLRKLGAKAVYACAIHPVFSEPAIQRLRGGLFEEVIVTNTIPIPPEQHFPELTVLSVANVLGEAIWR
IHEDSSVSSMFH
>Mature_332_residues
MVRPAPLLRPSPLPPISDSNRLKIFSGSANPALAQEVARYLGMDLGPMLRKRFADGELYIQIQESIRGADVYLVQPTCRP
VNDHLMELLVIIDACRRASARQITAVLPYYGYARADRKTAGREAITAKLVANMITQAGAHRVLAMDLHSAQIQGYFDIPL
DHVYAQPVLQAYLKEKGLLDEDIVVVSPDVGGVARARAFAKKLKEAPLAIIDKRRQAHNDVEVMNLIGDVRGKTAILVDD
MIDTAGTISEGAKLLRKLGAKAVYACAIHPVFSEPAIQRLRGGLFEEVIVTNTIPIPPEQHFPELTVLSVANVLGEAIWR
IHEDSSVSSMFH

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=312, Percent_Identity=46.474358974359, Blast_Score=295, Evalue=3e-80,
Organism=Homo sapiens, GI4506129, Length=309, Percent_Identity=45.9546925566343, Blast_Score=291, Evalue=4e-79,
Organism=Homo sapiens, GI28557709, Length=312, Percent_Identity=45.8333333333333, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI84875539, Length=312, Percent_Identity=45.5128205128205, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI4506133, Length=344, Percent_Identity=31.9767441860465, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI194018537, Length=342, Percent_Identity=31.2865497076023, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=34.0277777777778, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=34.0277777777778, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=34.0277777777778, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=34.0277777777778, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1787458, Length=313, Percent_Identity=48.8817891373802, Blast_Score=315, Evalue=4e-87,
Organism=Caenorhabditis elegans, GI25149168, Length=312, Percent_Identity=44.2307692307692, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17554702, Length=312, Percent_Identity=44.2307692307692, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI71989924, Length=312, Percent_Identity=44.2307692307692, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=44.336569579288, Blast_Score=273, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI17570245, Length=340, Percent_Identity=30.2941176470588, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6319403, Length=314, Percent_Identity=41.0828025477707, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6321776, Length=315, Percent_Identity=41.2698412698413, Blast_Score=244, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6320946, Length=315, Percent_Identity=39.6825396825397, Blast_Score=240, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6322667, Length=205, Percent_Identity=40.9756097560976, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6324511, Length=114, Percent_Identity=39.4736842105263, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355239, Length=314, Percent_Identity=46.1783439490446, Blast_Score=288, Evalue=4e-78,
Organism=Drosophila melanogaster, GI45551540, Length=335, Percent_Identity=43.5820895522388, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI281362873, Length=373, Percent_Identity=30.8310991957105, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24651454, Length=373, Percent_Identity=30.8310991957105, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24651458, Length=358, Percent_Identity=30.1675977653631, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24651456, Length=358, Percent_Identity=30.1675977653631, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24651462, Length=377, Percent_Identity=28.6472148541114, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24651464, Length=377, Percent_Identity=28.6472148541114, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI45552010, Length=392, Percent_Identity=29.3367346938776, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 36451; Mature: 36451

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRPAPLLRPSPLPPISDSNRLKIFSGSANPALAQEVARYLGMDLGPMLRKRFADGELYI
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHCCCCEEEE
QIQESIRGADVYLVQPTCRPVNDHLMELLVIIDACRRASARQITAVLPYYGYARADRKTA
EEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHC
GREAITAKLVANMITQAGAHRVLAMDLHSAQIQGYFDIPLDHVYAQPVLQAYLKEKGLLD
CHHHHHHHHHHHHHHHHCCCEEEEEECHHHHCCEEECCCHHHHHHHHHHHHHHHHCCCCC
EDIVVVSPDVGGVARARAFAKKLKEAPLAIIDKRRQAHNDVEVMNLIGDVRGKTAILVDD
CCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEHH
MIDTAGTISEGAKLLRKLGAKAVYACAIHPVFSEPAIQRLRGGLFEEVIVTNTIPIPPEQ
HHHCCCCHHHHHHHHHHHCCHHEEHHHHCCHHCCHHHHHHHCCHHHHHHHHCCCCCCCCC
HFPELTVLSVANVLGEAIWRIHEDSSVSSMFH
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCC
>Mature Secondary Structure
MVRPAPLLRPSPLPPISDSNRLKIFSGSANPALAQEVARYLGMDLGPMLRKRFADGELYI
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHCCCCEEEE
QIQESIRGADVYLVQPTCRPVNDHLMELLVIIDACRRASARQITAVLPYYGYARADRKTA
EEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHC
GREAITAKLVANMITQAGAHRVLAMDLHSAQIQGYFDIPLDHVYAQPVLQAYLKEKGLLD
CHHHHHHHHHHHHHHHHCCCEEEEEECHHHHCCEEECCCHHHHHHHHHHHHHHHHCCCCC
EDIVVVSPDVGGVARARAFAKKLKEAPLAIIDKRRQAHNDVEVMNLIGDVRGKTAILVDD
CCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEHH
MIDTAGTISEGAKLLRKLGAKAVYACAIHPVFSEPAIQRLRGGLFEEVIVTNTIPIPPEQ
HHHCCCCHHHHHHHHHHHCCHHEEHHHHCCHHCCHHHHHHHCCHHHHHHHHCCCCCCCCC
HFPELTVLSVANVLGEAIWRIHEDSSVSSMFH
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]