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The map label for this gene is uppS [H]

Identifier: 86609106

GI number: 86609106

Start: 1718488

End: 1719234

Strand: Direct

Name: uppS [H]

Synonym: CYB_1646

Alternate gene names: 86609106

Gene position: 1718488-1719234 (Clockwise)

Preceding gene: 86609105

Following gene: 86609112

Centisome position: 56.41

GC content: 60.64

Gene sequence:

>747_bases
ATGACCCTTTCTCCTGCCCATCTTCTGCAGTTGCCTGCCGACCTAGATCCGCAGTTGTTGCCCCGCCATGTGGCGGTGGT
GATGGATGGCAACGGGCGTTGGGCGCAAAAACGGGGCTTACCCCGCAGTGTTGGGCATCAGCGAGGGGTAGCGGCCCTGA
AGGAGCTGCTGCGCTGTTGTGATGACTGGGGGATCCCAGCCCTTACCGCCTATGCCTTCTCCACCGAGAACTGGGGCCGG
GCCCGCGAGGAGGTGGATTTTCTCATGACTTTGTTCGAGCAGGTGCTGTGGCAGGAATTGGGGGAAATGGTGCAGCAGGG
GGTGCGCATCCAGTTTGCCGGCCAGTTGTCGGCTCTGCCCCACTCTCTGCAGGAAACCATCGTGCATGCGGTGGCCTGCA
CCCAGCACAACAAGGGCATTTGCCTGACGGTGGCCCTCAACTACGGGGGACGACAGGAGATCCTACAAGCCTGCCGCTCC
ATTGCCACCTTGGTGCAGCAGGGGCTGCTGCAGCCGGATCAGATTGACGAGGCCCTCTTTTCCCAATTTCTCTACACCAC
CGGCTTATCGGATCCTGATCTGCTGATCCGTACCAGCGGCGAGATGCGCATCAGCAACTTCCTGCTCTGGCAGATGGCCT
ACACCGAGCAGTATTTCACCCCCATCCTCTGGCCGGATTTCGACCGAGCCGCTTTTCACCAAGCCTTGCTTAGCTATCAG
TCGCGGCAGCGGCGGTTTGGCAGGTGA

Upstream 100 bases:

>100_bases
CCTGGTTTCGCAATGGGCCGCTGCGCTGGTGGGGATCCCTTGCCGATCTGACTAAACTCTTTCGCAAACCTGAGAAAACC
CTCCCGAAAGACTGATCCCC

Downstream 100 bases:

>100_bases
GGATGATCCCTGGTTGGATATCCGTTGCCAACCGGCAGCTAGCGCAGAAAGCTGGTCACCAACCACATCACCGTAAACGT
GATCCCCACCAACAGCGCAC

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase 1; Di-trans,poly-cis-decaprenylcistransferase 1; Undecaprenyl diphosphate synthase 1; UDS 1 [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MTLSPAHLLQLPADLDPQLLPRHVAVVMDGNGRWAQKRGLPRSVGHQRGVAALKELLRCCDDWGIPALTAYAFSTENWGR
AREEVDFLMTLFEQVLWQELGEMVQQGVRIQFAGQLSALPHSLQETIVHAVACTQHNKGICLTVALNYGGRQEILQACRS
IATLVQQGLLQPDQIDEALFSQFLYTTGLSDPDLLIRTSGEMRISNFLLWQMAYTEQYFTPILWPDFDRAAFHQALLSYQ
SRQRRFGR

Sequences:

>Translated_248_residues
MTLSPAHLLQLPADLDPQLLPRHVAVVMDGNGRWAQKRGLPRSVGHQRGVAALKELLRCCDDWGIPALTAYAFSTENWGR
AREEVDFLMTLFEQVLWQELGEMVQQGVRIQFAGQLSALPHSLQETIVHAVACTQHNKGICLTVALNYGGRQEILQACRS
IATLVQQGLLQPDQIDEALFSQFLYTTGLSDPDLLIRTSGEMRISNFLLWQMAYTEQYFTPILWPDFDRAAFHQALLSYQ
SRQRRFGR
>Mature_247_residues
TLSPAHLLQLPADLDPQLLPRHVAVVMDGNGRWAQKRGLPRSVGHQRGVAALKELLRCCDDWGIPALTAYAFSTENWGRA
REEVDFLMTLFEQVLWQELGEMVQQGVRIQFAGQLSALPHSLQETIVHAVACTQHNKGICLTVALNYGGRQEILQACRSI
ATLVQQGLLQPDQIDEALFSQFLYTTGLSDPDLLIRTSGEMRISNFLLWQMAYTEQYFTPILWPDFDRAAFHQALLSYQS
RQRRFGR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=43.3035714285714, Blast_Score=181, Evalue=6e-46,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=43.3035714285714, Blast_Score=181, Evalue=7e-46,
Organism=Escherichia coli, GI1786371, Length=226, Percent_Identity=49.5575221238938, Blast_Score=225, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=38.0530973451327, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319474, Length=237, Percent_Identity=37.9746835443038, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6323748, Length=229, Percent_Identity=32.7510917030568, Blast_Score=112, Evalue=4e-26,
Organism=Drosophila melanogaster, GI18857969, Length=224, Percent_Identity=39.2857142857143, Blast_Score=164, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28111; Mature: 27979

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSPAHLLQLPADLDPQLLPRHVAVVMDGNGRWAQKRGLPRSVGHQRGVAALKELLRCC
CCCCHHHHHHCCCCCCHHHCCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHH
DDWGIPALTAYAFSTENWGRAREEVDFLMTLFEQVLWQELGEMVQQGVRIQFAGQLSALP
CCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHH
HSLQETIVHAVACTQHNKGICLTVALNYGGRQEILQACRSIATLVQQGLLQPDQIDEALF
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
SQFLYTTGLSDPDLLIRTSGEMRISNFLLWQMAYTEQYFTPILWPDFDRAAFHQALLSYQ
HHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
SRQRRFGR
HHHHHCCC
>Mature Secondary Structure 
TLSPAHLLQLPADLDPQLLPRHVAVVMDGNGRWAQKRGLPRSVGHQRGVAALKELLRCC
CCCHHHHHHCCCCCCHHHCCCEEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHH
DDWGIPALTAYAFSTENWGRAREEVDFLMTLFEQVLWQELGEMVQQGVRIQFAGQLSALP
CCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHH
HSLQETIVHAVACTQHNKGICLTVALNYGGRQEILQACRSIATLVQQGLLQPDQIDEALF
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
SQFLYTTGLSDPDLLIRTSGEMRISNFLLWQMAYTEQYFTPILWPDFDRAAFHQALLSYQ
HHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
SRQRRFGR
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]