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The map label for this gene is lysA [H]

Identifier: 86609104

GI number: 86609104

Start: 1715961

End: 1717340

Strand: Direct

Name: lysA [H]

Synonym: CYB_1644

Alternate gene names: 86609104

Gene position: 1715961-1717340 (Clockwise)

Preceding gene: 86609100

Following gene: 86609105

Centisome position: 56.32

GC content: 61.74

Gene sequence:

>1380_bases
ATGATTTCGACCCTCGGCACTCCCACCCATCCAGAGCAGACCCTTTCCCCCAACCAGTCTTTGCGCCCCTTGACCAGCCG
TATCAACAGCCGGGGGCACTTGGAAATTGGGGGGTGCGACGTGGTGGAGCTGGTGCGCCAGTTTGGATCCCCTCTCTACA
TCCTGGACGAATGGACGCTGCGCCGCGCCTGCCAGCTTTACCGTGACACCTGGGCCCGCTGCTACGCCGGGGGATCCCGG
GTTTTGTACGCCACGAAAGCCTGGAATTGCCTGGCCATCTGTGCATTGGCGCTGCAAGAAGGGCTGGGGTTGGATGTGGC
TTCTGGCGGGGAGCTGTACACGGCCCTGCAGGCGGGGGCCAAAGGTGAAGATCTCTATCTGCACGGCAACGCCAAGTCTC
TCGACGAGCTGAACTTGGCCCTGGAGACGGGCTGTACTTTGGTGGTCGATAGCCTGTACGAACTGCAGCAGGTGTCGGCC
CTGACCACGCCCGCACGGCCAGCGCGGCTGCTCCTGCGGGTTAACCCTGGTATTGACGTCCACACCCACGAGTACATCCG
CACCGGACAAACCGACAGCAAATTCGGCATCGGCCAATGGCAACTGCCGGAAGTGTTTGACTTTTTGGCAGCCCATCCCC
AACTGCAGTGCGTTGGGCTCCATGCCCACATTGGGTCACAGATTTTTGATCTACAGGGCCACCGCGACCTGGCGGGGGTG
CTGGCCCAGATCTGGCGGCAAGGGCTGGGCAGAGGGTTGCCCCTACAAGAGCTGAATGTGGGTGGGGGCCTGGGGATCCG
CTATATCGAATCCGATGATCCCCCCTCCATCCCGGAGTGGGTGGAAACTGTGGCAACGGCGGTGCAACAAGCCTTTGCCC
AGTCCGGGATCCCTTTGCCCAAGGTGCTCTGCGAGCCCGGACGATCTGTGATTGGGCCGGCTGCCGTGACCGCCTACACC
CTGGGAGGGCAAAAGCGGATCCCTCCCAGCGATGACCTGCCCCAAGGACGCACCTACATCACCATCGACGGTGGTATGTC
CGACAACCCCCGCCCGATCACCTATCAAGCCCGCTATACCGCCCTTCTGGCCAACCGACCAGAGGCAGAGGCCACGCAGC
GGGTAACGGTGGCCGGCAAGCACTGCGAGTCGGGGGATGTGCTGTTGAAGGATGTGCTTCTGCCCGCCCCAATGGCAGGA
GAAGTGTTGGTGGTTTTGGCGACGGGGGCCTACAACTACAGCATGGCTTCCAATTACAATCGCTTCCCTCGGCCAGCCGC
GGTGCTGGTCAACGAGGGAGAGGCCCAGTTGATTGTGCGGCGAGAAACTTATGCCGACTTAATCCGTCAAGATGTCTTGC
CAGAGCGGTTGCTGCGTTGA

Upstream 100 bases:

>100_bases
AGAGCTGGGTATAAAGGGATCGGGTTAGAGCTGGGCACTTTTCAAGACAAACTGAATAAGGAACTTGATATCGTTTAAGA
CAGTTTTCTGACTCCTGACC

Downstream 100 bases:

>100_bases
AGGGGAAGTTTGCCCATACCCATCTGGTCAGTAGAGGCACAGCCTTTCCTGGCAGCGCCGACCGCAGCCAACGCACCTCA
TGCGAGAAAGACTGGAAGAC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MISTLGTPTHPEQTLSPNQSLRPLTSRINSRGHLEIGGCDVVELVRQFGSPLYILDEWTLRRACQLYRDTWARCYAGGSR
VLYATKAWNCLAICALALQEGLGLDVASGGELYTALQAGAKGEDLYLHGNAKSLDELNLALETGCTLVVDSLYELQQVSA
LTTPARPARLLLRVNPGIDVHTHEYIRTGQTDSKFGIGQWQLPEVFDFLAAHPQLQCVGLHAHIGSQIFDLQGHRDLAGV
LAQIWRQGLGRGLPLQELNVGGGLGIRYIESDDPPSIPEWVETVATAVQQAFAQSGIPLPKVLCEPGRSVIGPAAVTAYT
LGGQKRIPPSDDLPQGRTYITIDGGMSDNPRPITYQARYTALLANRPEAEATQRVTVAGKHCESGDVLLKDVLLPAPMAG
EVLVVLATGAYNYSMASNYNRFPRPAAVLVNEGEAQLIVRRETYADLIRQDVLPERLLR

Sequences:

>Translated_459_residues
MISTLGTPTHPEQTLSPNQSLRPLTSRINSRGHLEIGGCDVVELVRQFGSPLYILDEWTLRRACQLYRDTWARCYAGGSR
VLYATKAWNCLAICALALQEGLGLDVASGGELYTALQAGAKGEDLYLHGNAKSLDELNLALETGCTLVVDSLYELQQVSA
LTTPARPARLLLRVNPGIDVHTHEYIRTGQTDSKFGIGQWQLPEVFDFLAAHPQLQCVGLHAHIGSQIFDLQGHRDLAGV
LAQIWRQGLGRGLPLQELNVGGGLGIRYIESDDPPSIPEWVETVATAVQQAFAQSGIPLPKVLCEPGRSVIGPAAVTAYT
LGGQKRIPPSDDLPQGRTYITIDGGMSDNPRPITYQARYTALLANRPEAEATQRVTVAGKHCESGDVLLKDVLLPAPMAG
EVLVVLATGAYNYSMASNYNRFPRPAAVLVNEGEAQLIVRRETYADLIRQDVLPERLLR
>Mature_459_residues
MISTLGTPTHPEQTLSPNQSLRPLTSRINSRGHLEIGGCDVVELVRQFGSPLYILDEWTLRRACQLYRDTWARCYAGGSR
VLYATKAWNCLAICALALQEGLGLDVASGGELYTALQAGAKGEDLYLHGNAKSLDELNLALETGCTLVVDSLYELQQVSA
LTTPARPARLLLRVNPGIDVHTHEYIRTGQTDSKFGIGQWQLPEVFDFLAAHPQLQCVGLHAHIGSQIFDLQGHRDLAGV
LAQIWRQGLGRGLPLQELNVGGGLGIRYIESDDPPSIPEWVETVATAVQQAFAQSGIPLPKVLCEPGRSVIGPAAVTAYT
LGGQKRIPPSDDLPQGRTYITIDGGMSDNPRPITYQARYTALLANRPEAEATQRVTVAGKHCESGDVLLKDVLLPAPMAG
EVLVVLATGAYNYSMASNYNRFPRPAAVLVNEGEAQLIVRRETYADLIRQDVLPERLLR

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=425, Percent_Identity=30.5882352941176, Blast_Score=145, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 49944; Mature: 49944

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISTLGTPTHPEQTLSPNQSLRPLTSRINSRGHLEIGGCDVVELVRQFGSPLYILDEWTL
CCCCCCCCCCCHHHCCCCCCCCHHHHHCCCCCCEEECCCHHHHHHHHHCCCEEEECHHHH
RRACQLYRDTWARCYAGGSRVLYATKAWNCLAICALALQEGLGLDVASGGELYTALQAGA
HHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCEECCCCCEEHHHHCCC
KGEDLYLHGNAKSLDELNLALETGCTLVVDSLYELQQVSALTTPARPARLLLRVNPGIDV
CCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
HTHEYIRTGQTDSKFGIGQWQLPEVFDFLAAHPQLQCVGLHAHIGSQIFDLQGHRDLAGV
CCHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEHHHCCEEEECCCCHHHHHH
LAQIWRQGLGRGLPLQELNVGGGLGIRYIESDDPPSIPEWVETVATAVQQAFAQSGIPLP
HHHHHHHHCCCCCCHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
KVLCEPGRSVIGPAAVTAYTLGGQKRIPPSDDLPQGRTYITIDGGMSDNPRPITYQARYT
HHHHCCCCCCCCCHHHEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEHHEE
ALLANRPEAEATQRVTVAGKHCESGDVLLKDVLLPAPMAGEVLVVLATGAYNYSMASNYN
EEECCCCCHHHHCEEEEECCCCCCCCEEHHHHHCCCCCCCCEEEEEEECCCCCHHHCCCC
RFPRPAAVLVNEGEAQLIVRRETYADLIRQDVLPERLLR
CCCCCEEEEEECCCEEEEEEHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure
MISTLGTPTHPEQTLSPNQSLRPLTSRINSRGHLEIGGCDVVELVRQFGSPLYILDEWTL
CCCCCCCCCCCHHHCCCCCCCCHHHHHCCCCCCEEECCCHHHHHHHHHCCCEEEECHHHH
RRACQLYRDTWARCYAGGSRVLYATKAWNCLAICALALQEGLGLDVASGGELYTALQAGA
HHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCEECCCCCEEHHHHCCC
KGEDLYLHGNAKSLDELNLALETGCTLVVDSLYELQQVSALTTPARPARLLLRVNPGIDV
CCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
HTHEYIRTGQTDSKFGIGQWQLPEVFDFLAAHPQLQCVGLHAHIGSQIFDLQGHRDLAGV
CCHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEHHHCCEEEECCCCHHHHHH
LAQIWRQGLGRGLPLQELNVGGGLGIRYIESDDPPSIPEWVETVATAVQQAFAQSGIPLP
HHHHHHHHCCCCCCHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
KVLCEPGRSVIGPAAVTAYTLGGQKRIPPSDDLPQGRTYITIDGGMSDNPRPITYQARYT
HHHHCCCCCCCCCHHHEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEHHEE
ALLANRPEAEATQRVTVAGKHCESGDVLLKDVLLPAPMAGEVLVVLATGAYNYSMASNYN
EEECCCCCHHHHCEEEEECCCCCCCCEEHHHHHCCCCCCCCEEEEEEECCCCCHHHCCCC
RFPRPAAVLVNEGEAQLIVRRETYADLIRQDVLPERLLR
CCCCCEEEEEECCCEEEEEEHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]