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The map label for this gene is hom [H]

Identifier: 86608893

GI number: 86608893

Start: 1494723

End: 1496033

Strand: Reverse

Name: hom [H]

Synonym: CYB_1425

Alternate gene names: 86608893

Gene position: 1496033-1494723 (Counterclockwise)

Preceding gene: 86608894

Following gene: 86608892

Centisome position: 49.1

GC content: 63.54

Gene sequence:

>1311_bases
ATGCGCCGCTACCGCGAACGAGTTGGGCTATTGGGGCTGGGCACGGTTGGCACGGGTGTTGTGCAAATTCTGCAGCAACC
CCGGCATCCTCTCTTGCAGTCAGTTGAGATTGCGGCGGTGGGGGTGCGCTCTTTGGATAAGCCGCGGCAAGTGCGGATCC
CACCTGAGCGCCTGACCACCAATCTGGAGCAAATCGTGTCGGATCCGGAAATCGACGTGGTCATCGAGCTGATGGGGGGC
TTGGAGCCGGCCCGCACCTTGATCTTAAAAGCCCTTGACCACGGCAAACCGGTGATCACAGCCAACAAAGCGGTGATCGC
CCGCCACGGGGAGGAGATCTTTCAGGCGGCAGCCCAAGCCAAAGTCTCGGTGCTCTTGGAAGCGGCAGTCGGGGGCGGGA
TCCCGATTCTGCAGCCCTTGCAACAGTCCCTGCAGGCCAGCCACATCCAGGCGGTCTGGGGCATTGTGAACGGCACCACC
AACTTCATCCTCAGCCAGATGACCCAGGCGGCCAGCTCGTTTGAGGAAGCCCTGGCCCTGGCCCAGGCCCACGGCTACGC
CGAGGCGGATCCCAGCGCCGATGTGGAAGGGTGGGATGCCGCCGACAAGATCGCCATTTTGGCCAGCCTTGCTTTCGGGG
TGTCTGTGAAGCGGGAAGCCATCCCCTGCGAAGGGATCCGCGGCATCAGCCCCACCGACATTCGCTATGCCCGCGAGTGG
GGCTACACCTTCAAGCTCTTGGCCATCGCCCAAAGGGCCAACTCTGGCGGGGAGGCAGCGAAGATGGCTTTGGATATCCG
GGTTCACCCCACCCTTCTGCCCTCTACCCACCCCTTGGCCAACATCAACGGTGTGGACAATGCCGTCCTGGTGCAGGGGG
ATCCCTTGGGGCAGGTGGTGCTGTCGGGGCCGGGGGCGGGGCGGGGGCCGACTGCCAGTGCCGTTGTTGGCGATCTGCTG
ACCCTGATTGCCCACCGGCAAACGGGGGCTGATGCCCCCAATCCGCTGTGGGGATTCTCCTGCTTCCCCGCTGCCGCCTC
TTTGATCCCTCTCTCGGAATTGGAGTCGGAGTTTTACGTGCGGGTGTTGGCTCAGGATCAGCCGGGGGTAATGGGGGCGA
TTGGCACCTGCTTCGGTCGCCACCGGGTTAGCCTGGAGAGCATTACCCAAAAGGAATGTCACCAAGAGCAGGCGGAGATC
GTCATCCTCACCCACACCGTCCGCGAGGCCGATTGCCGACAGGCGCTGGCCGAGATCCAACAACTGCCCCAGGTGGCCGG
GATCCCCAGCCTATTTCGGGTGCTGCGCTAG

Upstream 100 bases:

>100_bases
TTCCTGTTTGCATTGGCGAGGCGGAGCCCTCACAGGGCAAAGGACTCCGTCCCGCTAACGGGAACAGCAGGCAAAAGGAA
GAGTTGTGGTCTAAAGCGCT

Downstream 100 bases:

>100_bases
CTGCTATAGATCCAAAATGCTCCGCACCGCTGACGCGAACGCGCTGGTGGGACGGGGAGCGGCTCAGAGCATAATTGTTT
GACTCTTGAGGATTGAAAAC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MRRYRERVGLLGLGTVGTGVVQILQQPRHPLLQSVEIAAVGVRSLDKPRQVRIPPERLTTNLEQIVSDPEIDVVIELMGG
LEPARTLILKALDHGKPVITANKAVIARHGEEIFQAAAQAKVSVLLEAAVGGGIPILQPLQQSLQASHIQAVWGIVNGTT
NFILSQMTQAASSFEEALALAQAHGYAEADPSADVEGWDAADKIAILASLAFGVSVKREAIPCEGIRGISPTDIRYAREW
GYTFKLLAIAQRANSGGEAAKMALDIRVHPTLLPSTHPLANINGVDNAVLVQGDPLGQVVLSGPGAGRGPTASAVVGDLL
TLIAHRQTGADAPNPLWGFSCFPAAASLIPLSELESEFYVRVLAQDQPGVMGAIGTCFGRHRVSLESITQKECHQEQAEI
VILTHTVREADCRQALAEIQQLPQVAGIPSLFRVLR

Sequences:

>Translated_436_residues
MRRYRERVGLLGLGTVGTGVVQILQQPRHPLLQSVEIAAVGVRSLDKPRQVRIPPERLTTNLEQIVSDPEIDVVIELMGG
LEPARTLILKALDHGKPVITANKAVIARHGEEIFQAAAQAKVSVLLEAAVGGGIPILQPLQQSLQASHIQAVWGIVNGTT
NFILSQMTQAASSFEEALALAQAHGYAEADPSADVEGWDAADKIAILASLAFGVSVKREAIPCEGIRGISPTDIRYAREW
GYTFKLLAIAQRANSGGEAAKMALDIRVHPTLLPSTHPLANINGVDNAVLVQGDPLGQVVLSGPGAGRGPTASAVVGDLL
TLIAHRQTGADAPNPLWGFSCFPAAASLIPLSELESEFYVRVLAQDQPGVMGAIGTCFGRHRVSLESITQKECHQEQAEI
VILTHTVREADCRQALAEIQQLPQVAGIPSLFRVLR
>Mature_436_residues
MRRYRERVGLLGLGTVGTGVVQILQQPRHPLLQSVEIAAVGVRSLDKPRQVRIPPERLTTNLEQIVSDPEIDVVIELMGG
LEPARTLILKALDHGKPVITANKAVIARHGEEIFQAAAQAKVSVLLEAAVGGGIPILQPLQQSLQASHIQAVWGIVNGTT
NFILSQMTQAASSFEEALALAQAHGYAEADPSADVEGWDAADKIAILASLAFGVSVKREAIPCEGIRGISPTDIRYAREW
GYTFKLLAIAQRANSGGEAAKMALDIRVHPTLLPSTHPLANINGVDNAVLVQGDPLGQVVLSGPGAGRGPTASAVVGDLL
TLIAHRQTGADAPNPLWGFSCFPAAASLIPLSELESEFYVRVLAQDQPGVMGAIGTCFGRHRVSLESITQKECHQEQAEI
VILTHTVREADCRQALAEIQQLPQVAGIPSLFRVLR

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=262, Percent_Identity=27.0992366412214, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790376, Length=255, Percent_Identity=27.843137254902, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46466; Mature: 46466

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRYRERVGLLGLGTVGTGVVQILQQPRHPLLQSVEIAAVGVRSLDKPRQVRIPPERLTT
CCCHHHHCCEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHH
NLEQIVSDPEIDVVIELMGGLEPARTLILKALDHGKPVITANKAVIARHGEEIFQAAAQA
HHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCHHHHHCCHHHHHHHHHH
KVSVLLEAAVGGGIPILQPLQQSLQASHIQAVWGIVNGTTNFILSQMTQAASSFEEALAL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
AQAHGYAEADPSADVEGWDAADKIAILASLAFGVSVKREAIPCEGIRGISPTDIRYAREW
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHC
GYTFKLLAIAQRANSGGEAAKMALDIRVHPTLLPSTHPLANINGVDNAVLVQGDPLGQVV
CCHHHHHHHHHHCCCCCCEEEEEEEEEECCEECCCCCCCCCCCCCCCEEEEECCCCCEEE
LSGPGAGRGPTASAVVGDLLTLIAHRQTGADAPNPLWGFSCFPAAASLIPLSELESEFYV
EECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHEE
RVLAQDQPGVMGAIGTCFGRHRVSLESITQKECHQEQAEIVILTHTVREADCRQALAEIQ
EEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHH
QLPQVAGIPSLFRVLR
HCHHHCCCHHHHHHHC
>Mature Secondary Structure
MRRYRERVGLLGLGTVGTGVVQILQQPRHPLLQSVEIAAVGVRSLDKPRQVRIPPERLTT
CCCHHHHCCEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHH
NLEQIVSDPEIDVVIELMGGLEPARTLILKALDHGKPVITANKAVIARHGEEIFQAAAQA
HHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCHHHHHCCHHHHHHHHHH
KVSVLLEAAVGGGIPILQPLQQSLQASHIQAVWGIVNGTTNFILSQMTQAASSFEEALAL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
AQAHGYAEADPSADVEGWDAADKIAILASLAFGVSVKREAIPCEGIRGISPTDIRYAREW
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHC
GYTFKLLAIAQRANSGGEAAKMALDIRVHPTLLPSTHPLANINGVDNAVLVQGDPLGQVV
CCHHHHHHHHHHCCCCCCEEEEEEEEEECCEECCCCCCCCCCCCCCCEEEEECCCCCEEE
LSGPGAGRGPTASAVVGDLLTLIAHRQTGADAPNPLWGFSCFPAAASLIPLSELESEFYV
EECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHEE
RVLAQDQPGVMGAIGTCFGRHRVSLESITQKECHQEQAEIVILTHTVREADCRQALAEIQ
EEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHH
QLPQVAGIPSLFRVLR
HCHHHCCCHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]