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The map label for this gene is hemG [H]

Identifier: 86608892

GI number: 86608892

Start: 1493069

End: 1494565

Strand: Reverse

Name: hemG [H]

Synonym: CYB_1424

Alternate gene names: 86608892

Gene position: 1494565-1493069 (Counterclockwise)

Preceding gene: 86608893

Following gene: 86608891

Centisome position: 49.06

GC content: 65.26

Gene sequence:

>1497_bases
TTGCAGGCCGAGGTGGTGGTGGTGGGGGCGGGCATCAGCGGCCTAACGTTGGCCTTGCGATTACAACAGGGCTTATCCCC
CAAGGATGAATCCACCCAGCCGCTGCTCCTGGCCGAGGCCAGCTCCCGCGTGGGGGGCTGTATCTCCACCCAATCCAAAG
ACAGCTATCGCTGGGAAGAGGGCCCCAACAGCTTTACCCCCGTCCCCGCCCTGCTTAACCTCATTGCCGAGGTGGGCTTG
GCGGAGCACCTGGTGCTGGCCGATGCCAAGCTGCCCCGCTACATCTACTGGGAAAAAGAGCTGCTGCCGGTGCCCCTGAG
CCCTTCTGCAGCCATTGGCTCGCGGCTGTTGAGCGTGGGCGGCAAGTTGCGGGCCTTACGTGGGTTGTTGGGGTTTGTCG
CGCCGCCGCCAGGCGGAGAGGAAACGGTGCGGCAATTCTTCCGGCGGCAACTGGGATCCGAGGTGGTGGAACGGCTGGTC
GAACCTTTCACCTCAGGGGTGTATGCCGGGGATCCGGATCAGCTCAGCGCCTTGGCAGCCTTCCCCCGCATTGCCGGCTT
GGAAGAACGCTACGGCAGCCTCTTTGCCGGTGCTGTGCAGGCTTTGCGCAGCCGTTATCGCTACGCGACGCTCCCGCGAA
CCCGTCACCAGGACAGCGCCAACTCCCCCATCCAGCCTCCTCCCAAGCGGGGCCAACTGGGTAACCTGCGGCAGGGGTTG
CAGCAGCTACCTGAGGCGATTGCCCAGAAACTGGGCAGTGCGCTGCGGCTGGGCTGGCGGGCTGTGCATCTCAAGCGGGA
TGAGACGGGCTACCGGGTGGGCTTCGTCATACACGACAGCGGCGCGGAGCACACGGCCCCAGAAGAAATCCACTGGGTGG
CGGCTCAACAGGTGGTGCTCACCCTCCCTGCCTACGCTGCTGCCACCCTCCTGCAGGATCTCAACCCCCAGGCCAGCCGG
CTGCTGAGGGAAATCCCCTACCCGCCTGTGGCGGTGGTGGCTTTGGCCTATCCAGAAGAAGCCCTCCCCCAACCGCTGCG
AGGGTTTGGCCATCTGATCCCTCGCTCTCAGGGCCTGCGCACCCTGGGCACCATCTGGGCCTCCTCCCTCTTCCCAGAGC
GGGCTCCTCAGGGCTATCACTGCCTGATCAGCTTCATCGGGGGAGCTACCGATGCGGCTTTTGCCCGCCAGAAAGGGATC
CCGCCCATTACGGCGCTCTCCCCTGACGAGCGGGCCCAAATTGTGCATGCAGAACTCAGCCAGATCCTGCTCACCCGCCC
TGTCGAACCCATCCGCCTGGGAGAGCGCCTGTGGCCCCAGGCTATCCCGCAATATACGCTTGGCCACCGGCAGCGGATTG
CCCAATTGCAGGCCAGCCTGGCCGACCAAACCCCAGGGGTGTGGGTGTGTGCCAACTACCTGGATGGCGTGGCCTTGGGA
GATTGTGTGCGGCGGGCCGAGGCCCTAGCCCAGCAGATCCTGTCCGTCCGGCGTTAG

Upstream 100 bases:

>100_bases
AGCGGCTCAGAGCATAATTGTTTGACTCTTGAGGATTGAAAACCCCGTTGGAACCCAAAAGATGAACTCTTCTGTTGAGC
ACTTTAGCGGGACGCAGTCC

Downstream 100 bases:

>100_bases
CGGTGCGGTTCCCGTTCGCGTGTAGCAGCATAGAGTGCTGTAGACATAGCAGCATGAGCCATCCCTACACCAGCCTCCTG
CTCATCCCCACCGGCATTGG

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MQAEVVVVGAGISGLTLALRLQQGLSPKDESTQPLLLAEASSRVGGCISTQSKDSYRWEEGPNSFTPVPALLNLIAEVGL
AEHLVLADAKLPRYIYWEKELLPVPLSPSAAIGSRLLSVGGKLRALRGLLGFVAPPPGGEETVRQFFRRQLGSEVVERLV
EPFTSGVYAGDPDQLSALAAFPRIAGLEERYGSLFAGAVQALRSRYRYATLPRTRHQDSANSPIQPPPKRGQLGNLRQGL
QQLPEAIAQKLGSALRLGWRAVHLKRDETGYRVGFVIHDSGAEHTAPEEIHWVAAQQVVLTLPAYAAATLLQDLNPQASR
LLREIPYPPVAVVALAYPEEALPQPLRGFGHLIPRSQGLRTLGTIWASSLFPERAPQGYHCLISFIGGATDAAFARQKGI
PPITALSPDERAQIVHAELSQILLTRPVEPIRLGERLWPQAIPQYTLGHRQRIAQLQASLADQTPGVWVCANYLDGVALG
DCVRRAEALAQQILSVRR

Sequences:

>Translated_498_residues
MQAEVVVVGAGISGLTLALRLQQGLSPKDESTQPLLLAEASSRVGGCISTQSKDSYRWEEGPNSFTPVPALLNLIAEVGL
AEHLVLADAKLPRYIYWEKELLPVPLSPSAAIGSRLLSVGGKLRALRGLLGFVAPPPGGEETVRQFFRRQLGSEVVERLV
EPFTSGVYAGDPDQLSALAAFPRIAGLEERYGSLFAGAVQALRSRYRYATLPRTRHQDSANSPIQPPPKRGQLGNLRQGL
QQLPEAIAQKLGSALRLGWRAVHLKRDETGYRVGFVIHDSGAEHTAPEEIHWVAAQQVVLTLPAYAAATLLQDLNPQASR
LLREIPYPPVAVVALAYPEEALPQPLRGFGHLIPRSQGLRTLGTIWASSLFPERAPQGYHCLISFIGGATDAAFARQKGI
PPITALSPDERAQIVHAELSQILLTRPVEPIRLGERLWPQAIPQYTLGHRQRIAQLQASLADQTPGVWVCANYLDGVALG
DCVRRAEALAQQILSVRR
>Mature_498_residues
MQAEVVVVGAGISGLTLALRLQQGLSPKDESTQPLLLAEASSRVGGCISTQSKDSYRWEEGPNSFTPVPALLNLIAEVGL
AEHLVLADAKLPRYIYWEKELLPVPLSPSAAIGSRLLSVGGKLRALRGLLGFVAPPPGGEETVRQFFRRQLGSEVVERLV
EPFTSGVYAGDPDQLSALAAFPRIAGLEERYGSLFAGAVQALRSRYRYATLPRTRHQDSANSPIQPPPKRGQLGNLRQGL
QQLPEAIAQKLGSALRLGWRAVHLKRDETGYRVGFVIHDSGAEHTAPEEIHWVAAQQVVLTLPAYAAATLLQDLNPQASR
LLREIPYPPVAVVALAYPEEALPQPLRGFGHLIPRSQGLRTLGTIWASSLFPERAPQGYHCLISFIGGATDAAFARQKGI
PPITALSPDERAQIVHAELSQILLTRPVEPIRLGERLWPQAIPQYTLGHRQRIAQLQASLADQTPGVWVCANYLDGVALG
DCVRRAEALAQQILSVRR

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. May have an essential extracellular function during development, possibly as a pheromone [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=523, Percent_Identity=29.6367112810707, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI4506001, Length=523, Percent_Identity=29.6367112810707, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24649745, Length=479, Percent_Identity=25.8872651356994, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 54132; Mature: 54132

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.2 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAEVVVVGAGISGLTLALRLQQGLSPKDESTQPLLLAEASSRVGGCISTQSKDSYRWEE
CCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
GPNSFTPVPALLNLIAEVGLAEHLVLADAKLPRYIYWEKELLPVPLSPSAAIGSRLLSVG
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEECCCCCCCHHHHHHHHHHC
GKLRALRGLLGFVAPPPGGEETVRQFFRRQLGSEVVERLVEPFTSGVYAGDPDQLSALAA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
FPRIAGLEERYGSLFAGAVQALRSRYRYATLPRTRHQDSANSPIQPPPKRGQLGNLRQGL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
QQLPEAIAQKLGSALRLGWRAVHLKRDETGYRVGFVIHDSGAEHTAPEEIHWVAAQQVVL
HHHHHHHHHHHHHHHHHCHHEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHH
TLPAYAAATLLQDLNPQASRLLREIPYPPVAVVALAYPEEALPQPLRGFGHLIPRSQGLR
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCHHHCCHHHHHHHHHCCCCCCHH
TLGTIWASSLFPERAPQGYHCLISFIGGATDAAFARQKGIPPITALSPDERAQIVHAELS
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
QILLTRPVEPIRLGERLWPQAIPQYTLGHRQRIAQLQASLADQTPGVWVCANYLDGVALG
HHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCHHHH
DCVRRAEALAQQILSVRR
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQAEVVVVGAGISGLTLALRLQQGLSPKDESTQPLLLAEASSRVGGCISTQSKDSYRWEE
CCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
GPNSFTPVPALLNLIAEVGLAEHLVLADAKLPRYIYWEKELLPVPLSPSAAIGSRLLSVG
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEECCCCCCCHHHHHHHHHHC
GKLRALRGLLGFVAPPPGGEETVRQFFRRQLGSEVVERLVEPFTSGVYAGDPDQLSALAA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
FPRIAGLEERYGSLFAGAVQALRSRYRYATLPRTRHQDSANSPIQPPPKRGQLGNLRQGL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
QQLPEAIAQKLGSALRLGWRAVHLKRDETGYRVGFVIHDSGAEHTAPEEIHWVAAQQVVL
HHHHHHHHHHHHHHHHHCHHEEEEEECCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHH
TLPAYAAATLLQDLNPQASRLLREIPYPPVAVVALAYPEEALPQPLRGFGHLIPRSQGLR
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCHHHCCHHHHHHHHHCCCCCCHH
TLGTIWASSLFPERAPQGYHCLISFIGGATDAAFARQKGIPPITALSPDERAQIVHAELS
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
QILLTRPVEPIRLGERLWPQAIPQYTLGHRQRIAQLQASLADQTPGVWVCANYLDGVALG
HHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCHHHH
DCVRRAEALAQQILSVRR
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1372277; 8621504 [H]