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The map label for this gene is accC [H]

Identifier: 86608860

GI number: 86608860

Start: 1462919

End: 1464274

Strand: Direct

Name: accC [H]

Synonym: CYB_1391

Alternate gene names: 86608860

Gene position: 1462919-1464274 (Clockwise)

Preceding gene: 86608859

Following gene: 86608861

Centisome position: 48.02

GC content: 61.65

Gene sequence:

>1356_bases
ATGCCGCCCATCACCAAGATCCTGATCGCCAACCGGGGTGAGATTGCCCTGCGCATCATCCGCACCTGTCAGGAAATGGG
GATCCGAACGGTGGCCGTTTACTCCACTGCGGATCAGAACTCCCTGCACGTCCAACTGGCGGACGAGGCTGTTTGCGTAG
GAGATGCCCCGGTGGCCAAAAGCTACCTCAACATTCCCAACATCATCTCGGCAGCCCTCACCCGCGGGGCCACTGCCATT
CATCCGGGCTATGGGTTCTTGGCGGAGAATGCCAAATTTGCCGAGATGTGTGCCGACCACAACTTGATCTTCATCGGCCC
CTCGCCAGAGGCGATGCGCAAGATGGGCGACAAGGCCACGGCCCGCGAGACCATGCAAGCGGTGGGGGTGCCGACGGTGC
CGGGCAGCCGCGGGTTGATCACCTCTGAGGAGGAGGCAGTGAAGCTGGCGGAGAAAATCGGCTACCCCGTGATCATCAAA
GCCACCGCCGGTGGCGGGGGGCGGGGTATGCGGGTGGCGCGGGATGCCCAGGAGCTGCTGAAGATGCTGCGCACCGCTCA
GGGGGAAGCCCAAGCAGCCTTTGGCAACGGCGGGGTTTACTTGGAGAAGTTCATCGAGCGCCCCCGTCATGTGGAGTTTC
AGATCTTGGCGGATAGCCAGGGCAATGTGGTGCATCTGTACGAGCGGGATTGCTCCATTCAACGGCGGCATCAAAAGCTG
TTGGAAGAGGCCCCCAGCCCGGCTTTGACTGCAAGCTTGCGCGCCCGCATGGGAGCAGCGGCGGTGAAAGCGGCCAAGGT
GGTGAATTACGTGGGAGCGGGCACGGTGGAGTTTTTGCTGGACAAAAATGGCCAGTTCTACTTCATCGAGATGAACACCC
GCATCCAGGTGGAGCACCCGGTTACCGAGATGGTGACAGGGCTGGATCTGATTGCCGAGCAGATTCGCATTGCCCAAGGT
CAACCCCTCACCTTTCGCCAGAAGGATGTGGAGTTGCGGGGCCATGCTATCGAATGCCGCATCAACGCCGAGGATCCCAA
GCAGCAGTTTCGGCCTTGCGCTGGCACGATCAGCGCCTATTTGCCCCCTGGGGGGCCGGGGGTGCGCATGGATTCCCACA
TCTACACCGACTACACCATTCCCCCCTACTACGATTCGCTGTTGGGCAAGCTGATCGTCTGGGGGCCTAACCGGGCGGCA
GCCATCCGCCGCATGCAGCGGGCTTTGGGGGAATGTGCCATCACCGGGGTGCCCACCACGATCCCTTTCCACCAGCAGAT
CCTGCGCCACGAGGCTTTTTTGCGGGGCGAGGTGTACACGGATTTCATCACCCAACACCTGCTGCCCGGCCAGTAG

Upstream 100 bases:

>100_bases
CCTCTGGTTGGCATAGTAGGATGAGCACCTAAACTTAACCTTGCGTTCACAGACTGCTGGCTTTAGCGGTCAAGTTATCT
CTCTGCTCTGAACCTCCCTC

Downstream 100 bases:

>100_bases
CCATCGACTCTCAGGTCGGGATCCCTCTCTGGACAGCAGCTGGCCACAAGTTGAGGATAAAGTTAAGGGCTAGCAGAGGG
ATGGAGGTGGCAGGATGAGG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MPPITKILIANRGEIALRIIRTCQEMGIRTVAVYSTADQNSLHVQLADEAVCVGDAPVAKSYLNIPNIISAALTRGATAI
HPGYGFLAENAKFAEMCADHNLIFIGPSPEAMRKMGDKATARETMQAVGVPTVPGSRGLITSEEEAVKLAEKIGYPVIIK
ATAGGGGRGMRVARDAQELLKMLRTAQGEAQAAFGNGGVYLEKFIERPRHVEFQILADSQGNVVHLYERDCSIQRRHQKL
LEEAPSPALTASLRARMGAAAVKAAKVVNYVGAGTVEFLLDKNGQFYFIEMNTRIQVEHPVTEMVTGLDLIAEQIRIAQG
QPLTFRQKDVELRGHAIECRINAEDPKQQFRPCAGTISAYLPPGGPGVRMDSHIYTDYTIPPYYDSLLGKLIVWGPNRAA
AIRRMQRALGECAITGVPTTIPFHQQILRHEAFLRGEVYTDFITQHLLPGQ

Sequences:

>Translated_451_residues
MPPITKILIANRGEIALRIIRTCQEMGIRTVAVYSTADQNSLHVQLADEAVCVGDAPVAKSYLNIPNIISAALTRGATAI
HPGYGFLAENAKFAEMCADHNLIFIGPSPEAMRKMGDKATARETMQAVGVPTVPGSRGLITSEEEAVKLAEKIGYPVIIK
ATAGGGGRGMRVARDAQELLKMLRTAQGEAQAAFGNGGVYLEKFIERPRHVEFQILADSQGNVVHLYERDCSIQRRHQKL
LEEAPSPALTASLRARMGAAAVKAAKVVNYVGAGTVEFLLDKNGQFYFIEMNTRIQVEHPVTEMVTGLDLIAEQIRIAQG
QPLTFRQKDVELRGHAIECRINAEDPKQQFRPCAGTISAYLPPGGPGVRMDSHIYTDYTIPPYYDSLLGKLIVWGPNRAA
AIRRMQRALGECAITGVPTTIPFHQQILRHEAFLRGEVYTDFITQHLLPGQ
>Mature_450_residues
PPITKILIANRGEIALRIIRTCQEMGIRTVAVYSTADQNSLHVQLADEAVCVGDAPVAKSYLNIPNIISAALTRGATAIH
PGYGFLAENAKFAEMCADHNLIFIGPSPEAMRKMGDKATARETMQAVGVPTVPGSRGLITSEEEAVKLAEKIGYPVIIKA
TAGGGGRGMRVARDAQELLKMLRTAQGEAQAAFGNGGVYLEKFIERPRHVEFQILADSQGNVVHLYERDCSIQRRHQKLL
EEAPSPALTASLRARMGAAAVKAAKVVNYVGAGTVEFLLDKNGQFYFIEMNTRIQVEHPVTEMVTGLDLIAEQIRIAQGQ
PLTFRQKDVELRGHAIECRINAEDPKQQFRPCAGTISAYLPPGGPGVRMDSHIYTDYTIPPYYDSLLGKLIVWGPNRAAA
IRRMQRALGECAITGVPTTIPFHQQILRHEAFLRGEVYTDFITQHLLPGQ

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=444, Percent_Identity=49.7747747747748, Blast_Score=470, Evalue=1e-132,
Organism=Homo sapiens, GI189095269, Length=447, Percent_Identity=49.4407158836689, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=50, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=50, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI106049528, Length=450, Percent_Identity=50.4444444444444, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI106049295, Length=450, Percent_Identity=50.4444444444444, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI106049292, Length=450, Percent_Identity=50.4444444444444, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI38679960, Length=507, Percent_Identity=32.9388560157791, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI38679977, Length=507, Percent_Identity=32.9388560157791, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI38679967, Length=507, Percent_Identity=32.9388560157791, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI38679974, Length=507, Percent_Identity=32.9388560157791, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI38679971, Length=507, Percent_Identity=32.9388560157791, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI134142062, Length=508, Percent_Identity=33.2677165354331, Blast_Score=275, Evalue=6e-74,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=57.5280898876405, Blast_Score=496, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI71987519, Length=445, Percent_Identity=49.438202247191, Blast_Score=447, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17567343, Length=444, Percent_Identity=49.0990990990991, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=47.7678571428571, Blast_Score=411, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=29.9412915851272, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=29.9412915851272, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=29.038854805726, Blast_Score=216, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=46.3087248322148, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319685, Length=441, Percent_Identity=44.2176870748299, Blast_Score=375, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=47.427293064877, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6324343, Length=522, Percent_Identity=32.183908045977, Blast_Score=254, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6323863, Length=485, Percent_Identity=31.9587628865979, Blast_Score=238, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24651757, Length=448, Percent_Identity=49.1071428571429, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=50.3340757238307, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=50.3340757238307, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=50.3340757238307, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=50.3340757238307, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=50.3340757238307, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=50.3340757238307, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=50.3340757238307, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=50.3340757238307, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=50.3340757238307, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=50.3340757238307, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24651759, Length=409, Percent_Identity=47.6772616136919, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI161076407, Length=502, Percent_Identity=32.8685258964143, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24586460, Length=502, Percent_Identity=32.8685258964143, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI161076409, Length=502, Percent_Identity=32.8685258964143, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24586458, Length=502, Percent_Identity=32.8685258964143, Blast_Score=266, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49348; Mature: 49216

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPITKILIANRGEIALRIIRTCQEMGIRTVAVYSTADQNSLHVQLADEAVCVGDAPVAK
CCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCEEEECCCHHHH
SYLNIPNIISAALTRGATAIHPGYGFLAENAKFAEMCADHNLIFIGPSPEAMRKMGDKAT
HHCCCHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHCCCCEEEECCCHHHHHHCCCHHH
ARETMQAVGVPTVPGSRGLITSEEEAVKLAEKIGYPVIIKATAGGGGRGMRVARDAQELL
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHH
KMLRTAQGEAQAAFGNGGVYLEKFIERPRHVEFQILADSQGNVVHLYERDCSIQRRHQKL
HHHHHCCCCCEEEECCCCHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCHHHHHHHHH
LEEAPSPALTASLRARMGAAAVKAAKVVNYVGAGTVEFLLDKNGQFYFIEMNTRIQVEHP
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCEEEECCC
VTEMVTGLDLIAEQIRIAQGQPLTFRQKDVELRGHAIECRINAEDPKQQFRPCAGTISAY
HHHHHHHHHHHHHHHHHCCCCCCEEECCCCEECCEEEEEEECCCCCHHHHCCCCCCCEEE
LPPGGPGVRMDSHIYTDYTIPPYYDSLLGKLIVWGPNRAAAIRRMQRALGECAITGVPTT
CCCCCCCCEECCEEEECCCCCHHHHHHHCCEEEECCCHHHHHHHHHHHHHHEEECCCCCC
IPFHQQILRHEAFLRGEVYTDFITQHLLPGQ
CCHHHHHHHHHHHHCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PPITKILIANRGEIALRIIRTCQEMGIRTVAVYSTADQNSLHVQLADEAVCVGDAPVAK
CCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCEEEECCCHHHH
SYLNIPNIISAALTRGATAIHPGYGFLAENAKFAEMCADHNLIFIGPSPEAMRKMGDKAT
HHCCCHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHCCCCEEEECCCHHHHHHCCCHHH
ARETMQAVGVPTVPGSRGLITSEEEAVKLAEKIGYPVIIKATAGGGGRGMRVARDAQELL
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHH
KMLRTAQGEAQAAFGNGGVYLEKFIERPRHVEFQILADSQGNVVHLYERDCSIQRRHQKL
HHHHHCCCCCEEEECCCCHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCHHHHHHHHH
LEEAPSPALTASLRARMGAAAVKAAKVVNYVGAGTVEFLLDKNGQFYFIEMNTRIQVEHP
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCEEEECCC
VTEMVTGLDLIAEQIRIAQGQPLTFRQKDVELRGHAIECRINAEDPKQQFRPCAGTISAY
HHHHHHHHHHHHHHHHHCCCCCCEEECCCCEECCEEEEEEECCCCCHHHHCCCCCCCEEE
LPPGGPGVRMDSHIYTDYTIPPYYDSLLGKLIVWGPNRAAAIRRMQRALGECAITGVPTT
CCCCCCCCEECCEEEECCCCCHHHHHHHCCEEEECCCHHHHHHHHHHHHHHEEECCCCCC
IPFHQQILRHEAFLRGEVYTDFITQHLLPGQ
CCHHHHHHHHHHHHCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]