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The map label for this gene is serA [H]

Identifier: 86608852

GI number: 86608852

Start: 1454116

End: 1455696

Strand: Reverse

Name: serA [H]

Synonym: CYB_1383

Alternate gene names: 86608852

Gene position: 1455696-1454116 (Counterclockwise)

Preceding gene: 86608856

Following gene: 86608851

Centisome position: 47.78

GC content: 58.76

Gene sequence:

>1581_bases
ATGCCCAGAGTCATCGTCACAGATCCCATCGATCAGGCGGGGATCGACATTCTCTCCCAAGTCGCTCAGGTGGATGTGCA
AACCCAGCTCACCCCAGAGCAGTTGATCGCGGTCATCCCCAACTACGATGCCATCATGGTGCGCTCCGGTACACGGGTTA
CCCGAGAGGTAATCGAGGCGGGGACGAACTTAAAAATCATCGGGCGGGCGGGCGTTGGTGTCGATAACATCGATGTGCCT
GCCGCAACCAAAGCCGGGATCCTGGTGGTCAACTCCCCAGAGGGCAACACCATTGCCGCTGCCGAGCACGCCATTGCCTT
GATGATGGCCCTCTCCCGCCACATACCCGATGCCAATGCCTCTCTGAAGTCGGGCCTGTGGAATCGGCAAGAGTTTGTCG
GCGTAGAAGTCTACAAAAAAACGCTGGGGATTGTCGGATTGGGTCGGATTGGATCCCATGTGGCCCAGATTGCCAAGGCG
ATGGGGATGAAGCTGCTGGCCTATGACCCCTATCTATCCGTGGAGCGGGCCGAGCAACTGGGGGTACGCCTGGTGGACTT
CACAACTTTGGTCCAGGAATCCGACTACATCACCTTGCACATTCCCAAAACCCCTGAAACCACCAACCTGTTCAACGCCG
AAACCTTTCGCATGATGAAGCCGACCGCTCGCCTGATCAACTGCGCCCGCGGCGGTTTGGTGGATGAACAAGCCCTGTAC
GAAGCCCTGAAATCCGGCCAAATTGCCGGAGCGGCTTTGGATGTATTTGCCAATGAGCCCCTGAAGGACTCCCCGCTGTT
TTCCCTGGGCAAAGAAGTCCTGCTCACTCCCCACTTGGGGGCCTCCACCGAAGAAGCCCAAGTGAATGTGGCCATTGATG
TGGCCGAGCAGATCCGCGATGTGTTGCTGGGGCTGCCGGCCCGCTCTGCCGTGAACATCCCCGGCCTACAGGCAGAGGTG
CTGCAAAACCTCAGACCCTACCTGGACTTGGCCGAAACCCTAGGCAACTTGGTTGGCCAATTGGCGGGGGATCGCGTCAA
CCAGTTGGAGATCCGCCTGCAGGGAGATCTGGCGGAAAAAGATGGGCAGCCGATCGTCATTGCCGCTCTCAAAGGGCTTT
TGACGCTGGCGCTGCGGGAGCGGGTCAACTACGTCAACGCCTCCATCGAGGCCAAAGAACGGGGCATTCGGGTGGTGGAA
ACTCGAGATCCCTCTTTGAAAGATTATTCCGGATCCCTGACGTTGATTGCCCACGGCCCCAATGGGATCCGCTCGGTTTC
GGGGGCGTTGATTGGGGAGCGAGAGGTGCGGATTACCCAGATCGACGAGTTCCCGGTGAATGTGCCCCCTTCCGCCAACA
TGCTGATGACCCTGCACCGGGATATGCCGGGAATCATCGGACGGATTGGCACCTTGCTGGGAGCCTACAATGTCAACATC
GCCAGCATGCAGGTGGGGCGCAAGATCATCCGCGGCGATGCAGTCATGGTGCTCAGCTTGGACGATCCCCTGCCGGATGG
GATCCTGGAAGAGGTGCTCAAGCAGCCGGGCATCCGTGACGCTTTTGTAGTGAACCTCTAG

Upstream 100 bases:

>100_bases
GCGAACTGCGTAGCGGTAGGACGGAGCTTTAGACCCAATTTTTTGGGTAATCTGTTCCCCTACTTCTGTTGCCCTCCATC
CCACTGGACTAACGCTGCTT

Downstream 100 bases:

>100_bases
AATTGTTGATCCCTAGAAAAAATCCCAAATCTCACCTACCCTGGCAAGACGGAGTCTTTGCTTGAACCAGAGCAACTTGT
CCCTAACCCTGTCCCAGATC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MPRVIVTDPIDQAGIDILSQVAQVDVQTQLTPEQLIAVIPNYDAIMVRSGTRVTREVIEAGTNLKIIGRAGVGVDNIDVP
AATKAGILVVNSPEGNTIAAAEHAIALMMALSRHIPDANASLKSGLWNRQEFVGVEVYKKTLGIVGLGRIGSHVAQIAKA
MGMKLLAYDPYLSVERAEQLGVRLVDFTTLVQESDYITLHIPKTPETTNLFNAETFRMMKPTARLINCARGGLVDEQALY
EALKSGQIAGAALDVFANEPLKDSPLFSLGKEVLLTPHLGASTEEAQVNVAIDVAEQIRDVLLGLPARSAVNIPGLQAEV
LQNLRPYLDLAETLGNLVGQLAGDRVNQLEIRLQGDLAEKDGQPIVIAALKGLLTLALRERVNYVNASIEAKERGIRVVE
TRDPSLKDYSGSLTLIAHGPNGIRSVSGALIGEREVRITQIDEFPVNVPPSANMLMTLHRDMPGIIGRIGTLLGAYNVNI
ASMQVGRKIIRGDAVMVLSLDDPLPDGILEEVLKQPGIRDAFVVNL

Sequences:

>Translated_526_residues
MPRVIVTDPIDQAGIDILSQVAQVDVQTQLTPEQLIAVIPNYDAIMVRSGTRVTREVIEAGTNLKIIGRAGVGVDNIDVP
AATKAGILVVNSPEGNTIAAAEHAIALMMALSRHIPDANASLKSGLWNRQEFVGVEVYKKTLGIVGLGRIGSHVAQIAKA
MGMKLLAYDPYLSVERAEQLGVRLVDFTTLVQESDYITLHIPKTPETTNLFNAETFRMMKPTARLINCARGGLVDEQALY
EALKSGQIAGAALDVFANEPLKDSPLFSLGKEVLLTPHLGASTEEAQVNVAIDVAEQIRDVLLGLPARSAVNIPGLQAEV
LQNLRPYLDLAETLGNLVGQLAGDRVNQLEIRLQGDLAEKDGQPIVIAALKGLLTLALRERVNYVNASIEAKERGIRVVE
TRDPSLKDYSGSLTLIAHGPNGIRSVSGALIGEREVRITQIDEFPVNVPPSANMLMTLHRDMPGIIGRIGTLLGAYNVNI
ASMQVGRKIIRGDAVMVLSLDDPLPDGILEEVLKQPGIRDAFVVNL
>Mature_525_residues
PRVIVTDPIDQAGIDILSQVAQVDVQTQLTPEQLIAVIPNYDAIMVRSGTRVTREVIEAGTNLKIIGRAGVGVDNIDVPA
ATKAGILVVNSPEGNTIAAAEHAIALMMALSRHIPDANASLKSGLWNRQEFVGVEVYKKTLGIVGLGRIGSHVAQIAKAM
GMKLLAYDPYLSVERAEQLGVRLVDFTTLVQESDYITLHIPKTPETTNLFNAETFRMMKPTARLINCARGGLVDEQALYE
ALKSGQIAGAALDVFANEPLKDSPLFSLGKEVLLTPHLGASTEEAQVNVAIDVAEQIRDVLLGLPARSAVNIPGLQAEVL
QNLRPYLDLAETLGNLVGQLAGDRVNQLEIRLQGDLAEKDGQPIVIAALKGLLTLALRERVNYVNASIEAKERGIRVVET
RDPSLKDYSGSLTLIAHGPNGIRSVSGALIGEREVRITQIDEFPVNVPPSANMLMTLHRDMPGIIGRIGTLLGAYNVNIA
SMQVGRKIIRGDAVMVLSLDDPLPDGILEEVLKQPGIRDAFVVNL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=405, Percent_Identity=41.9753086419753, Blast_Score=311, Evalue=8e-85,
Organism=Homo sapiens, GI61743967, Length=280, Percent_Identity=38.5714285714286, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI4557497, Length=280, Percent_Identity=38.5714285714286, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI145580578, Length=317, Percent_Identity=35.6466876971609, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI4557499, Length=317, Percent_Identity=35.6466876971609, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI145580575, Length=308, Percent_Identity=35.7142857142857, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI6912396, Length=322, Percent_Identity=31.055900621118, Blast_Score=142, Evalue=8e-34,
Organism=Escherichia coli, GI1789279, Length=322, Percent_Identity=36.0248447204969, Blast_Score=184, Evalue=9e-48,
Organism=Escherichia coli, GI87082289, Length=300, Percent_Identity=36.6666666666667, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=41.8367346938776, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1788660, Length=265, Percent_Identity=31.6981132075472, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87081824, Length=245, Percent_Identity=29.7959183673469, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=45.3416149068323, Blast_Score=274, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI25147481, Length=300, Percent_Identity=31.6666666666667, Blast_Score=125, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6320925, Length=329, Percent_Identity=37.3860182370821, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6322116, Length=328, Percent_Identity=36.280487804878, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324055, Length=331, Percent_Identity=29.607250755287, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=291, Percent_Identity=27.4914089347079, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6321253, Length=294, Percent_Identity=27.5510204081633, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=176, Percent_Identity=26.7045454545455, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324980, Length=185, Percent_Identity=28.6486486486486, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19921140, Length=300, Percent_Identity=44.3333333333333, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=36.2179487179487, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI28574286, Length=251, Percent_Identity=35.4581673306773, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24585514, Length=319, Percent_Identity=31.974921630094, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI28574282, Length=319, Percent_Identity=31.974921630094, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646446, Length=291, Percent_Identity=36.0824742268041, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646448, Length=291, Percent_Identity=36.0824742268041, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646452, Length=291, Percent_Identity=36.0824742268041, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646450, Length=291, Percent_Identity=36.0824742268041, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45551003, Length=316, Percent_Identity=31.9620253164557, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI28574284, Length=319, Percent_Identity=31.974921630094, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45552429, Length=319, Percent_Identity=31.974921630094, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI62472511, Length=291, Percent_Identity=36.0824742268041, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24585516, Length=313, Percent_Identity=27.7955271565495, Blast_Score=131, Evalue=9e-31,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56569; Mature: 56438

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRVIVTDPIDQAGIDILSQVAQVDVQTQLTPEQLIAVIPNYDAIMVRSGTRVTREVIEA
CCCEEEECCCCHHHHHHHHHHHHHCHHCCCCHHHHEEECCCCCEEEEECCCHHHHHHHHC
GTNLKIIGRAGVGVDNIDVPAATKAGILVVNSPEGNTIAAAEHAIALMMALSRHIPDANA
CCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCC
SLKSGLWNRQEFVGVEVYKKTLGIVGLGRIGSHVAQIAKAMGMKLLAYDPYLSVERAEQL
HHHHCCCCCHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHC
GVRLVDFTTLVQESDYITLHIPKTPETTNLFNAETFRMMKPTARLINCARGGLVDEQALY
CCEEEEHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
EALKSGQIAGAALDVFANEPLKDSPLFSLGKEVLLTPHLGASTEEAQVNVAIDVAEQIRD
HHHHCCCCCCEEEHHHCCCCCCCCCHHHCCCCEEEECCCCCCCCCCEEEEEEEHHHHHHH
VLLGLPARSAVNIPGLQAEVLQNLRPYLDLAETLGNLVGQLAGDRVNQLEIRLQGDLAEK
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHCC
DGQPIVIAALKGLLTLALRERVNYVNASIEAKERGIRVVETRDPSLKDYSGSLTLIAHGP
CCCEEEHHHHHHHHHHHHHHHHHHHCCCEEHHHCCEEEEECCCCCCCCCCCCEEEEEECC
NGIRSVSGALIGEREVRITQIDEFPVNVPPSANMLMTLHRDMPGIIGRIGTLLGAYNVNI
CCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEHHCCCHHHHHHHHHHHHHCCEE
ASMQVGRKIIRGDAVMVLSLDDPLPDGILEEVLKQPGIRDAFVVNL
HHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure 
PRVIVTDPIDQAGIDILSQVAQVDVQTQLTPEQLIAVIPNYDAIMVRSGTRVTREVIEA
CCEEEECCCCHHHHHHHHHHHHHCHHCCCCHHHHEEECCCCCEEEEECCCHHHHHHHHC
GTNLKIIGRAGVGVDNIDVPAATKAGILVVNSPEGNTIAAAEHAIALMMALSRHIPDANA
CCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCC
SLKSGLWNRQEFVGVEVYKKTLGIVGLGRIGSHVAQIAKAMGMKLLAYDPYLSVERAEQL
HHHHCCCCCHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHC
GVRLVDFTTLVQESDYITLHIPKTPETTNLFNAETFRMMKPTARLINCARGGLVDEQALY
CCEEEEHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
EALKSGQIAGAALDVFANEPLKDSPLFSLGKEVLLTPHLGASTEEAQVNVAIDVAEQIRD
HHHHCCCCCCEEEHHHCCCCCCCCCHHHCCCCEEEECCCCCCCCCCEEEEEEEHHHHHHH
VLLGLPARSAVNIPGLQAEVLQNLRPYLDLAETLGNLVGQLAGDRVNQLEIRLQGDLAEK
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHCC
DGQPIVIAALKGLLTLALRERVNYVNASIEAKERGIRVVETRDPSLKDYSGSLTLIAHGP
CCCEEEHHHHHHHHHHHHHHHHHHHCCCEEHHHCCEEEEECCCCCCCCCCCCEEEEEECC
NGIRSVSGALIGEREVRITQIDEFPVNVPPSANMLMTLHRDMPGIIGRIGTLLGAYNVNI
CCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEHHCCCHHHHHHHHHHHHHCCEE
ASMQVGRKIIRGDAVMVLSLDDPLPDGILEEVLKQPGIRDAFVVNL
HHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]