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The map label for this gene is srrA [H]

Identifier: 86608817

GI number: 86608817

Start: 1411475

End: 1412218

Strand: Reverse

Name: srrA [H]

Synonym: CYB_1343

Alternate gene names: 86608817

Gene position: 1412218-1411475 (Counterclockwise)

Preceding gene: 86608818

Following gene: 86608815

Centisome position: 46.35

GC content: 61.96

Gene sequence:

>744_bases
ATGGCCTCTTCTCCCCCAGCCAAACCCGAACCCCCTGCTGCCAGTCCAGCAGCCCGCATTCTGCTAGTAGATGATGAACC
CGGCTTACGGGAAGCGGTGCAAGCCTACCTCGAGGACAGCGGCTTTGAGGTGATCCCGGCGGCCAACGCCCAGCAGGCTC
TGCAACTGCTCAGCACGGCCCAGCCTCAGTTGATCATCTCCGACATCATGATGCCGGGCATGGATGGCTATCAATTTTTG
GCCCAACTGCGAAAACTCGAGCCCTACAGCCATCTGCCGGTGGTGTTCCTCACCGCCAAGGGGATGACCGCCGACCGCAT
CCAGGGTTACCGGGCCGGTGTCGATGCCTATTTGCCCAAGCCCTTCGATCCGGAGGAGCTGGTGGCCATTGTCTCCAATC
TCATTGAGCGATCCCGCGCTGCCAGCCCTTCGGAGGTGGTGGCCCGCGAGCTGGCCTCGATTCGCGCCCTGCTGTCGGAG
CGCACCCTTGCCACAGCCACGCCTGCCCAGACCTCTGCCCCCACCCCCCTGCCCCCACCCATCAAGGTAGAGCTGACGCC
GCGGGAACAACAGGTGTTGGAGAAGGTGGCAGAAGGGCTGATGAACAAGGAGATTGCCAAGCAGCTGCAAACCAGCGTGC
GCAACGTGGAAAAATACGTGACCCGCCTGCTGAACAAGACGGGCACCAGCAGCCGCACCGAGCTGGTTCGCTATGCCCTT
ACCTATGGCCTAATTCGGCTATAG

Upstream 100 bases:

>100_bases
CCTGTTTTCGCCTGAGATTGCCCACAGGTTAGTAGGAAGATTGTAGAGATATGGGATGGCAGGTGCCGCCAAACGCTTGA
ACGCTACCCAGGAGCTGCAG

Downstream 100 bases:

>100_bases
CCCTCACCCCCAACCCCTAGGAAGACTGAAGAACGTGAGACACGGTTTTATCGCTGGGGCTTTGGTGGCACAGTAACCAG
CAGCTCCAACCCAAAGGCGT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MASSPPAKPEPPAASPAARILLVDDEPGLREAVQAYLEDSGFEVIPAANAQQALQLLSTAQPQLIISDIMMPGMDGYQFL
AQLRKLEPYSHLPVVFLTAKGMTADRIQGYRAGVDAYLPKPFDPEELVAIVSNLIERSRAASPSEVVARELASIRALLSE
RTLATATPAQTSAPTPLPPPIKVELTPREQQVLEKVAEGLMNKEIAKQLQTSVRNVEKYVTRLLNKTGTSSRTELVRYAL
TYGLIRL

Sequences:

>Translated_247_residues
MASSPPAKPEPPAASPAARILLVDDEPGLREAVQAYLEDSGFEVIPAANAQQALQLLSTAQPQLIISDIMMPGMDGYQFL
AQLRKLEPYSHLPVVFLTAKGMTADRIQGYRAGVDAYLPKPFDPEELVAIVSNLIERSRAASPSEVVARELASIRALLSE
RTLATATPAQTSAPTPLPPPIKVELTPREQQVLEKVAEGLMNKEIAKQLQTSVRNVEKYVTRLLNKTGTSSRTELVRYAL
TYGLIRL
>Mature_246_residues
ASSPPAKPEPPAASPAARILLVDDEPGLREAVQAYLEDSGFEVIPAANAQQALQLLSTAQPQLIISDIMMPGMDGYQFLA
QLRKLEPYSHLPVVFLTAKGMTADRIQGYRAGVDAYLPKPFDPEELVAIVSNLIERSRAASPSEVVARELASIRALLSER
TLATATPAQTSAPTPLPPPIKVELTPREQQVLEKVAEGLMNKEIAKQLQTSVRNVEKYVTRLLNKTGTSSRTELVRYALT
YGLIRL

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=216, Percent_Identity=32.4074074074074, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1789809, Length=120, Percent_Identity=41.6666666666667, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788394, Length=130, Percent_Identity=33.8461538461538, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790299, Length=116, Percent_Identity=35.3448275862069, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1788521, Length=224, Percent_Identity=32.1428571428571, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1788550, Length=113, Percent_Identity=37.1681415929204, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790863, Length=120, Percent_Identity=34.1666666666667, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI87082012, Length=113, Percent_Identity=38.0530973451327, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788905, Length=121, Percent_Identity=35.5371900826446, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1786911, Length=123, Percent_Identity=35.7723577235772, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI2367329, Length=123, Percent_Identity=40.650406504065, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789402, Length=128, Percent_Identity=33.59375, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790860, Length=132, Percent_Identity=34.8484848484849, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1790552, Length=133, Percent_Identity=33.8345864661654, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1786784, Length=123, Percent_Identity=35.7723577235772, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1786747, Length=228, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787375, Length=130, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787473, Length=226, Percent_Identity=31.4159292035398, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788713, Length=136, Percent_Identity=33.8235294117647, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788222, Length=229, Percent_Identity=25.3275109170306, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI145693157, Length=143, Percent_Identity=27.972027972028, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787229, Length=128, Percent_Identity=31.25, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26911; Mature: 26780

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSPPAKPEPPAASPAARILLVDDEPGLREAVQAYLEDSGFEVIPAANAQQALQLLSTA
CCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCC
QPQLIISDIMMPGMDGYQFLAQLRKLEPYSHLPVVFLTAKGMTADRIQGYRAGVDAYLPK
CCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHCCCC
PFDPEELVAIVSNLIERSRAASPSEVVARELASIRALLSERTLATATPAQTSAPTPLPPP
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
IKVELTPREQQVLEKVAEGLMNKEIAKQLQTSVRNVEKYVTRLLNKTGTSSRTELVRYAL
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TYGLIRL
HHHHHCC
>Mature Secondary Structure 
ASSPPAKPEPPAASPAARILLVDDEPGLREAVQAYLEDSGFEVIPAANAQQALQLLSTA
CCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCC
QPQLIISDIMMPGMDGYQFLAQLRKLEPYSHLPVVFLTAKGMTADRIQGYRAGVDAYLPK
CCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHCCCC
PFDPEELVAIVSNLIERSRAASPSEVVARELASIRALLSERTLATATPAQTSAPTPLPPP
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
IKVELTPREQQVLEKVAEGLMNKEIAKQLQTSVRNVEKYVTRLLNKTGTSSRTELVRYAL
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TYGLIRL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA