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The map label for this gene is guaA [H]

Identifier: 86608644

GI number: 86608644

Start: 1206389

End: 1207999

Strand: Direct

Name: guaA [H]

Synonym: CYB_1168

Alternate gene names: 86608644

Gene position: 1206389-1207999 (Clockwise)

Preceding gene: 86608640

Following gene: 86608650

Centisome position: 39.6

GC content: 58.78

Gene sequence:

>1611_bases
GTGATCCCTTCTGCATCTCCTCCCAGTTCCGGCCTTTCCCCCCTCGAAGTGCAGCGCCAGATGATCGTCATTCTCGATTT
TGGATCCCAGTACTCTGAGCTGATTGCCCGCCGCATTCGCGAAACCCACGTCTATTCGGAAATCCTTTCCTATCGCACCA
CTGCTGAGCAACTGCGGCAACTGCAACCGCAGGGCATTATCCTCTCCGGGGGCCCCAACTCGGTGTATGAGCCAGCCGCT
CCGGTGTGTGACCCCGAGATTTGGAACCTAGGGATCCCGGTTCTGGGGGTGTGCTACGGCATGCAACTCATGGTGCAGCA
GTTGGGGGGCAAGGTGGAAGCAGCCCAGAAGGGGGAATATGGCCGTGCCGCTCTGCACATTTTGGATCCCACCGACCTGC
TCACCAACCTGCCGGAAAACAGCATCATGTGGATGAGCCACGGGGATTCGGTTACCGAACTGCCGCCGGGCTTTCACACC
TTGGCCTCTACCGACAACACCCCCTGTGCCGCCATTGCCGATCCAAGGCGTCGTCTCTACGGGGTGCAATTTCATCCGGA
GGTGGCCCACTCAGAGGCTGGCGCCTTTCTCATCCGCAACTTTGTCTATCACATCTGCGGTTGCGAGCCCACCTGGACAA
CGGCAGCTTTTCTGGAGGAAGCCATTCGAGAGGTACGTGCCCGTGTGGGCAATAAGAAGGTGCTGTTGGCCCTCTCGGGG
GGGGTAGACAGCTCTACTTTGGCTTTTCTGCTGCACAAGGCCATCGGCGACCAGCTCACCTGCGTGTTCATCGACCAAGG
GTTTATGCGCAAGGACGAGCCCCAACGGCTGCTGCGCCTTTTCCAAGAGCAATTTCACATTCCCGTCCACTACGTGGATG
GCCAGGAGCGGTTTCTCCGGCAGTTGCAGGGGGTTACCGATCCCGAAGAAAAACGCAAACGAATTGGGGCAGAGTTTATT
CGCGTGTTTGAGGAAGAATCCCAGCGGCTGGGTCCTTTTGAGTACTTAGCCCAAGGCACTCTCTACCCAGACGTGATCGA
GTCTGCCAATACCCATGTGGATCCGGTTACTGGAGAACGCATTGCCGTCAAGATCAAAAGCCATCACAATGTCGGCGGCC
TGCCCGAAAATCTGCGCTTTAAGCTGGTAGAGCCTTTGCGCAAGCTCTTCAAAGACGAGGTGCGGCAACTGGCCCGCTCT
TTGGGGCTGCCGGAAGAGATTGTGGGCCGCCATCCTTTTCCGGGGCCGGGGCTGGCCATCCGCATTGTAGGCGAGGTTAC
CAAAGAACGGCTGGAAACCCTGCGAGAAGCGGACATGATCGTGCGGCAGGAGATCAACCGCTCCGGCTACTATCCCAAAC
TTTGGCAAGCCTTTGCCGTGCTGCTGCCAGAGGTGCGGTCGGTGGGGGTGATGGGGGATAAGCGCACCTATGCCTGCCCG
GTGGTGGTGCGGCTGGTTACCAGCGAAGACGGTATGACCGCCGATTGGGCGCGAGTTCCCTACGACCTCTTGGCCACCAT
TTCCAACCGCATCGTCAACGAGGTGCCCGGCATCAACCGCGTGGTTTACGACATCACCTCCAAGCCCCCTGGCACCATCG
AGTGGGAGTAG

Upstream 100 bases:

>100_bases
TACCATGGAAGAGCCCTTAATGTTTCTTTCGTATCCATCGTATCCATAGCCAAGCTAGTCTCTTGGACCGGCTTTTTTAT
TGTGCACTGCGCCAGGTTTT

Downstream 100 bases:

>100_bases
GCGGGATCCCTTGCGTCTGGCCTCGATTCCCGGCTGGATCGATGGCTACCTATGGCCAGCTTCCGGCAGGGAATAGGAAG
GGCTTGAGCTGAAGGGCTGA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MIPSASPPSSGLSPLEVQRQMIVILDFGSQYSELIARRIRETHVYSEILSYRTTAEQLRQLQPQGIILSGGPNSVYEPAA
PVCDPEIWNLGIPVLGVCYGMQLMVQQLGGKVEAAQKGEYGRAALHILDPTDLLTNLPENSIMWMSHGDSVTELPPGFHT
LASTDNTPCAAIADPRRRLYGVQFHPEVAHSEAGAFLIRNFVYHICGCEPTWTTAAFLEEAIREVRARVGNKKVLLALSG
GVDSSTLAFLLHKAIGDQLTCVFIDQGFMRKDEPQRLLRLFQEQFHIPVHYVDGQERFLRQLQGVTDPEEKRKRIGAEFI
RVFEEESQRLGPFEYLAQGTLYPDVIESANTHVDPVTGERIAVKIKSHHNVGGLPENLRFKLVEPLRKLFKDEVRQLARS
LGLPEEIVGRHPFPGPGLAIRIVGEVTKERLETLREADMIVRQEINRSGYYPKLWQAFAVLLPEVRSVGVMGDKRTYACP
VVVRLVTSEDGMTADWARVPYDLLATISNRIVNEVPGINRVVYDITSKPPGTIEWE

Sequences:

>Translated_536_residues
MIPSASPPSSGLSPLEVQRQMIVILDFGSQYSELIARRIRETHVYSEILSYRTTAEQLRQLQPQGIILSGGPNSVYEPAA
PVCDPEIWNLGIPVLGVCYGMQLMVQQLGGKVEAAQKGEYGRAALHILDPTDLLTNLPENSIMWMSHGDSVTELPPGFHT
LASTDNTPCAAIADPRRRLYGVQFHPEVAHSEAGAFLIRNFVYHICGCEPTWTTAAFLEEAIREVRARVGNKKVLLALSG
GVDSSTLAFLLHKAIGDQLTCVFIDQGFMRKDEPQRLLRLFQEQFHIPVHYVDGQERFLRQLQGVTDPEEKRKRIGAEFI
RVFEEESQRLGPFEYLAQGTLYPDVIESANTHVDPVTGERIAVKIKSHHNVGGLPENLRFKLVEPLRKLFKDEVRQLARS
LGLPEEIVGRHPFPGPGLAIRIVGEVTKERLETLREADMIVRQEINRSGYYPKLWQAFAVLLPEVRSVGVMGDKRTYACP
VVVRLVTSEDGMTADWARVPYDLLATISNRIVNEVPGINRVVYDITSKPPGTIEWE
>Mature_536_residues
MIPSASPPSSGLSPLEVQRQMIVILDFGSQYSELIARRIRETHVYSEILSYRTTAEQLRQLQPQGIILSGGPNSVYEPAA
PVCDPEIWNLGIPVLGVCYGMQLMVQQLGGKVEAAQKGEYGRAALHILDPTDLLTNLPENSIMWMSHGDSVTELPPGFHT
LASTDNTPCAAIADPRRRLYGVQFHPEVAHSEAGAFLIRNFVYHICGCEPTWTTAAFLEEAIREVRARVGNKKVLLALSG
GVDSSTLAFLLHKAIGDQLTCVFIDQGFMRKDEPQRLLRLFQEQFHIPVHYVDGQERFLRQLQGVTDPEEKRKRIGAEFI
RVFEEESQRLGPFEYLAQGTLYPDVIESANTHVDPVTGERIAVKIKSHHNVGGLPENLRFKLVEPLRKLFKDEVRQLARS
LGLPEEIVGRHPFPGPGLAIRIVGEVTKERLETLREADMIVRQEINRSGYYPKLWQAFAVLLPEVRSVGVMGDKRTYACP
VVVRLVTSEDGMTADWARVPYDLLATISNRIVNEVPGINRVVYDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=553, Percent_Identity=38.3363471971067, Blast_Score=322, Evalue=5e-88,
Organism=Escherichia coli, GI1788854, Length=529, Percent_Identity=50.4725897920605, Blast_Score=541, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI71992710, Length=578, Percent_Identity=37.0242214532872, Blast_Score=319, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI71992717, Length=578, Percent_Identity=37.0242214532872, Blast_Score=319, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI133901714, Length=576, Percent_Identity=37.1527777777778, Blast_Score=319, Evalue=3e-87,
Organism=Saccharomyces cerevisiae, GI6323873, Length=521, Percent_Identity=47.6007677543186, Blast_Score=496, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6322638, Length=152, Percent_Identity=29.6052631578947, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281365319, Length=556, Percent_Identity=38.6690647482014, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 60014; Mature: 60014

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPSASPPSSGLSPLEVQRQMIVILDFGSQYSELIARRIRETHVYSEILSYRTTAEQLRQ
CCCCCCCCCCCCCHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQPQGIILSGGPNSVYEPAAPVCDPEIWNLGIPVLGVCYGMQLMVQQLGGKVEAAQKGEY
CCCCCEEEECCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCEEHHHCCCC
GRAALHILDPTDLLTNLPENSIMWMSHGDSVTELPPGFHTLASTDNTPCAAIADPRRRLY
CCEEEEEECHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHC
GVQFHPEVAHSEAGAFLIRNFVYHICGCEPTWTTAAFLEEAIREVRARVGNKKVLLALSG
CCEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
GVDSSTLAFLLHKAIGDQLTCVFIDQGFMRKDEPQRLLRLFQEQFHIPVHYVDGQERFLR
CCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHH
QLQGVTDPEEKRKRIGAEFIRVFEEESQRLGPFEYLAQGTLYPDVIESANTHVDPVTGER
HHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHCCCCCCCCCCCCE
IAVKIKSHHNVGGLPENLRFKLVEPLRKLFKDEVRQLARSLGLPEEIVGRHPFPGPGLAI
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEE
RIVGEVTKERLETLREADMIVRQEINRSGYYPKLWQAFAVLLPEVRSVGVMGDKRTYACP
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECC
VVVRLVTSEDGMTADWARVPYDLLATISNRIVNEVPGINRVVYDITSKPPGTIEWE
EEEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MIPSASPPSSGLSPLEVQRQMIVILDFGSQYSELIARRIRETHVYSEILSYRTTAEQLRQ
CCCCCCCCCCCCCHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQPQGIILSGGPNSVYEPAAPVCDPEIWNLGIPVLGVCYGMQLMVQQLGGKVEAAQKGEY
CCCCCEEEECCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCEEHHHCCCC
GRAALHILDPTDLLTNLPENSIMWMSHGDSVTELPPGFHTLASTDNTPCAAIADPRRRLY
CCEEEEEECHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHC
GVQFHPEVAHSEAGAFLIRNFVYHICGCEPTWTTAAFLEEAIREVRARVGNKKVLLALSG
CCEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
GVDSSTLAFLLHKAIGDQLTCVFIDQGFMRKDEPQRLLRLFQEQFHIPVHYVDGQERFLR
CCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHH
QLQGVTDPEEKRKRIGAEFIRVFEEESQRLGPFEYLAQGTLYPDVIESANTHVDPVTGER
HHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHCCCCCCCCCCCCE
IAVKIKSHHNVGGLPENLRFKLVEPLRKLFKDEVRQLARSLGLPEEIVGRHPFPGPGLAI
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCEEE
RIVGEVTKERLETLREADMIVRQEINRSGYYPKLWQAFAVLLPEVRSVGVMGDKRTYACP
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECC
VVVRLVTSEDGMTADWARVPYDLLATISNRIVNEVPGINRVVYDITSKPPGTIEWE
EEEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]