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The map label for this gene is napA [H]

Identifier: 86608209

GI number: 86608209

Start: 742695

End: 744182

Strand: Reverse

Name: napA [H]

Synonym: CYB_0724

Alternate gene names: 86608209

Gene position: 744182-742695 (Counterclockwise)

Preceding gene: 86608210

Following gene: 86608207

Centisome position: 24.43

GC content: 59.27

Gene sequence:

>1488_bases
TTGAACAACCTAGATTCAGTGTTGCTTGCTGTTGAAGCCGCTGCCCCCCTTGAACCGGAAGGGGCTGCCAATCTTTTACC
CCTGATCTTGGCGGCGGTGCTGATGGCTCTGGTGGTCATCTATCTGGCCAGCCGTATTGCCGGAGAAATCGCCGTTCGCC
TCGGCTTTCCGCCGGTGCTGGGAGAATTGCTGGGGGGCGTTACGGTGGGAACCTCCGCTCTGGGGTTGCTTGTCTTCCCA
GAAGGACAAGTTTCCGGCCAAGAGCTGCACACCTTGGCTCAATCCTCAGCACTGATGCAATTTCTGCAAGCCACTGCCGG
ACTCGACGAGGGATCCCTGGTACAGGTGTTCTCCTCCCAAAGCCAGATCATCGACATCCTCTCCGAGATCGGGGTGATCG
TCCTTTTGTTTGAAATCGGCCTCGAGTCGGATCTGGCCGAGCTGTTGCGGGTCGGCCCTCAAGCCGCAGCCGTAGCCGTC
ATCGGGGTCGCTGTGCCTTTCCTGGCCGGAACCCTGGGCTTGCTCTACCTGTTTCATGTGCCCGTTATCCCCGCCATATT
TGCCGGCGCTGCCCTCACAGCAACCAGCATCGGCATCACCGCCCGCGTCTTGGCCGAGCTGCAAAAACTCACCTCCCCAG
AGGGGCAAGTGATCATTGGTGCCGCCGTCTTGGATGACGTGTTGGGCATCATCATCTTGGCCGTGGTGGCGGGCTTGGCC
AAAAACGGAGAAGTCAACCTTTCCGATATCGGCATCATCATCCTCAGTGCCATCGTCTTCTTGGTCGGCTCCATTGTTTT
GGGGCGCCTTCTCAGCCCCTACTTTGTTGCCCTTCTCAACAGCCTGAAGACCCGAGGTAACCCCCTTCTGCCCGCCCTTG
TGCTGGCCTTTCTGCTGGCTTATGTAGGGCAAATCATTCATCTAGAAGCGATTTTGGGCGCTTTTGCCGCTGGCCTGATC
TTGGCCGAAACCGAGAAACGGCAAGAGCTGGAAGAACAGATCAAGCCCATTTCCGACCTACTGGTGCCCATCTTCTTCGT
CTGCGTCGGGGCCAAAACCAACCTTGCCGTACTCAACCCCACCCTCCCCGTCAACCGAGAGGGGCTGATCATTGCCGTCT
TCTTGATCGGAGTTGCCATTGTGGGCAAGCTAGCAGCGGGCTTGGGGGCCTTTGGCAAGCCGGGCATCAACCGCTACGCC
ATCGGGGTGGGCATGATTCCCCGGGGTGAGGTGGGCCTGGTGTTTGCCGGTGTGGGGGCCGCCAGTGGGGTTCTCTCCGA
TGCCCTCGATGTCAGCATCATCGTCATGGTGATTGCCACCACCTTTGTCGCTCCCCTCTGGCTGCGGGGAGTGTTGATTG
GGGAAGCCAACTCCCCCTCCCTCCTGGACTTGCAGGCAGAAGCGTCAGAGCAAGACCGCAAAGACAGCACCGACGAGACC
GCGTCATCGCTCCCAGACTCAGAACGGGTGGGCATCCCCGAGGGTTAA

Upstream 100 bases:

>100_bases
TCTTCCAGCAGAAGGGCGAAAGGAATGGGAACGGCAGCGTTCCCACCAGGGCCGGCCCGAGACAAAAAGCTGTTCATCAT
TTGAGGGTGAGATCTTGCTG

Downstream 100 bases:

>100_bases
GTTATCTCAGCTTCCCCCTCAAACGCCCCCAGAGGGTCTGGAACAGCAGCCGCAGCGGATTGCGGCGTTGAGGCTTCACG
TCAATTCTCTCCGTCGTCTC

Product: high-affinity Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MNNLDSVLLAVEAAAPLEPEGAANLLPLILAAVLMALVVIYLASRIAGEIAVRLGFPPVLGELLGGVTVGTSALGLLVFP
EGQVSGQELHTLAQSSALMQFLQATAGLDEGSLVQVFSSQSQIIDILSEIGVIVLLFEIGLESDLAELLRVGPQAAAVAV
IGVAVPFLAGTLGLLYLFHVPVIPAIFAGAALTATSIGITARVLAELQKLTSPEGQVIIGAAVLDDVLGIIILAVVAGLA
KNGEVNLSDIGIIILSAIVFLVGSIVLGRLLSPYFVALLNSLKTRGNPLLPALVLAFLLAYVGQIIHLEAILGAFAAGLI
LAETEKRQELEEQIKPISDLLVPIFFVCVGAKTNLAVLNPTLPVNREGLIIAVFLIGVAIVGKLAAGLGAFGKPGINRYA
IGVGMIPRGEVGLVFAGVGAASGVLSDALDVSIIVMVIATTFVAPLWLRGVLIGEANSPSLLDLQAEASEQDRKDSTDET
ASSLPDSERVGIPEG

Sequences:

>Translated_495_residues
MNNLDSVLLAVEAAAPLEPEGAANLLPLILAAVLMALVVIYLASRIAGEIAVRLGFPPVLGELLGGVTVGTSALGLLVFP
EGQVSGQELHTLAQSSALMQFLQATAGLDEGSLVQVFSSQSQIIDILSEIGVIVLLFEIGLESDLAELLRVGPQAAAVAV
IGVAVPFLAGTLGLLYLFHVPVIPAIFAGAALTATSIGITARVLAELQKLTSPEGQVIIGAAVLDDVLGIIILAVVAGLA
KNGEVNLSDIGIIILSAIVFLVGSIVLGRLLSPYFVALLNSLKTRGNPLLPALVLAFLLAYVGQIIHLEAILGAFAAGLI
LAETEKRQELEEQIKPISDLLVPIFFVCVGAKTNLAVLNPTLPVNREGLIIAVFLIGVAIVGKLAAGLGAFGKPGINRYA
IGVGMIPRGEVGLVFAGVGAASGVLSDALDVSIIVMVIATTFVAPLWLRGVLIGEANSPSLLDLQAEASEQDRKDSTDET
ASSLPDSERVGIPEG
>Mature_495_residues
MNNLDSVLLAVEAAAPLEPEGAANLLPLILAAVLMALVVIYLASRIAGEIAVRLGFPPVLGELLGGVTVGTSALGLLVFP
EGQVSGQELHTLAQSSALMQFLQATAGLDEGSLVQVFSSQSQIIDILSEIGVIVLLFEIGLESDLAELLRVGPQAAAVAV
IGVAVPFLAGTLGLLYLFHVPVIPAIFAGAALTATSIGITARVLAELQKLTSPEGQVIIGAAVLDDVLGIIILAVVAGLA
KNGEVNLSDIGIIILSAIVFLVGSIVLGRLLSPYFVALLNSLKTRGNPLLPALVLAFLLAYVGQIIHLEAILGAFAAGLI
LAETEKRQELEEQIKPISDLLVPIFFVCVGAKTNLAVLNPTLPVNREGLIIAVFLIGVAIVGKLAAGLGAFGKPGINRYA
IGVGMIPRGEVGLVFAGVGAASGVLSDALDVSIIVMVIATTFVAPLWLRGVLIGEANSPSLLDLQAEASEQDRKDSTDET
ASSLPDSERVGIPEG

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=334, Percent_Identity=27.5449101796407, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1786232, Length=439, Percent_Identity=26.4236902050114, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322367, Length=346, Percent_Identity=26.5895953757225, Blast_Score=100, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 50873; Mature: 50873

Theoretical pI: Translated: 4.16; Mature: 4.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLDSVLLAVEAAAPLEPEGAANLLPLILAAVLMALVVIYLASRIAGEIAVRLGFPPVL
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
GELLGGVTVGTSALGLLVFPEGQVSGQELHTLAQSSALMQFLQATAGLDEGSLVQVFSSQ
HHHHCCHHHCCHHCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCH
SQIIDILSEIGVIVLLFEIGLESDLAELLRVGPQAAAVAVIGVAVPFLAGTLGLLYLFHV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVIPAIFAGAALTATSIGITARVLAELQKLTSPEGQVIIGAAVLDDVLGIIILAVVAGLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHC
KNGEVNLSDIGIIILSAIVFLVGSIVLGRLLSPYFVALLNSLKTRGNPLLPALVLAFLLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
YVGQIIHLEAILGAFAAGLILAETEKRQELEEQIKPISDLLVPIFFVCVGAKTNLAVLNP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
TLPVNREGLIIAVFLIGVAIVGKLAAGLGAFGKPGINRYAIGVGMIPRGEVGLVFAGVGA
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCH
ASGVLSDALDVSIIVMVIATTFVAPLWLRGVLIGEANSPSLLDLQAEASEQDRKDSTDET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCHHCCCCCCHHH
ASSLPDSERVGIPEG
HHHCCCCCCCCCCCC
>Mature Secondary Structure
MNNLDSVLLAVEAAAPLEPEGAANLLPLILAAVLMALVVIYLASRIAGEIAVRLGFPPVL
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
GELLGGVTVGTSALGLLVFPEGQVSGQELHTLAQSSALMQFLQATAGLDEGSLVQVFSSQ
HHHHCCHHHCCHHCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCH
SQIIDILSEIGVIVLLFEIGLESDLAELLRVGPQAAAVAVIGVAVPFLAGTLGLLYLFHV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVIPAIFAGAALTATSIGITARVLAELQKLTSPEGQVIIGAAVLDDVLGIIILAVVAGLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHC
KNGEVNLSDIGIIILSAIVFLVGSIVLGRLLSPYFVALLNSLKTRGNPLLPALVLAFLLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
YVGQIIHLEAILGAFAAGLILAETEKRQELEEQIKPISDLLVPIFFVCVGAKTNLAVLNP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
TLPVNREGLIIAVFLIGVAIVGKLAAGLGAFGKPGINRYAIGVGMIPRGEVGLVFAGVGA
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCH
ASGVLSDALDVSIIVMVIATTFVAPLWLRGVLIGEANSPSLLDLQAEASEQDRKDSTDET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCHHCCCCCCHHH
ASSLPDSERVGIPEG
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]