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The map label for this gene is cobH-2 [H]

Identifier: 86607876

GI number: 86607876

Start: 394512

End: 395162

Strand: Direct

Name: cobH-2 [H]

Synonym: CYB_0379

Alternate gene names: 86607876

Gene position: 394512-395162 (Clockwise)

Preceding gene: 86607875

Following gene: 86607877

Centisome position: 12.95

GC content: 57.91

Gene sequence:

>651_bases
ATGGAGTGGCACGTAACCGATGCAGAGAGTTTGATGATCATCGACCAGGAGGTGGGCAAGCACGAGCTTTCTCCTGCTGA
GTATGAGGTGGTTCGTCGGGTTATTTATGCTACTGCCGACTTTGAGTACTTGAACCTCATCCGTTTTGGTAACGAAGCCT
TACAGGCTGGGGCGGCGGCCTTGGCAGCGCGTACCACCATTGTGGTCGATGAGCCGATGGTGCAGGTGGGCATTGCCTGG
GCTGTTCAGAACACCTTTTCCAACCCCATCTATTGCAGCAGCGAAGCCATTACCCGCCCCCAAAGGGACAAGACCCGCTC
CGCTTGGGGCTTGGAAACTCTGGCCCAACGCTACCCTGAGGCGATCTTTGTGATTGGCCAATCCCAGACTGCCCTCTCCA
CCTTGGTGCAGCTGATTAGAAAGAAGGAGGTGGCCCCTGCTCTGGTCATCGCCACGCCGGCTGGGTTTGTGAACGTGGTG
CAAGCCAAGCAGGAGCTAGCCGATTCCATGGTGCCCCACATCCGCACTGAGGGACGCAAAGGAGGCCCGGCAGTGGCTGC
AGCGGTGTTGGATGGCCTGCTGGACTTGGCTTGGCACGCCTATATACGGGTCAGCAGCGCAGACTATCCTGGCAAATCCG
CGGTTTCATGA

Upstream 100 bases:

>100_bases
CTGGCCCCCAGGTTGAGCGATGGTTTTTCCCACCCATTGGAGCCTCTGCAGGTACAATCCTGTCATTACGGAGGTAAACA
GCGGGCGGGGTCTGGGATCG

Downstream 100 bases:

>100_bases
CATGCTCCTTGCCCTTGGGCACCGTTCGCGGAAACAAGCCAAAACTTTGGCACTCAAAGCACATTTTTTCAGCAGTTGAC
TGCCCTGCCGCTGAAATCTC

Product: precorrin-8X methylmutase

Products: hydrogenobyrinate

Alternate protein names: Cobalt-precorrin isomerase; HBA synthase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MEWHVTDAESLMIIDQEVGKHELSPAEYEVVRRVIYATADFEYLNLIRFGNEALQAGAAALAARTTIVVDEPMVQVGIAW
AVQNTFSNPIYCSSEAITRPQRDKTRSAWGLETLAQRYPEAIFVIGQSQTALSTLVQLIRKKEVAPALVIATPAGFVNVV
QAKQELADSMVPHIRTEGRKGGPAVAAAVLDGLLDLAWHAYIRVSSADYPGKSAVS

Sequences:

>Translated_216_residues
MEWHVTDAESLMIIDQEVGKHELSPAEYEVVRRVIYATADFEYLNLIRFGNEALQAGAAALAARTTIVVDEPMVQVGIAW
AVQNTFSNPIYCSSEAITRPQRDKTRSAWGLETLAQRYPEAIFVIGQSQTALSTLVQLIRKKEVAPALVIATPAGFVNVV
QAKQELADSMVPHIRTEGRKGGPAVAAAVLDGLLDLAWHAYIRVSSADYPGKSAVS
>Mature_216_residues
MEWHVTDAESLMIIDQEVGKHELSPAEYEVVRRVIYATADFEYLNLIRFGNEALQAGAAALAARTTIVVDEPMVQVGIAW
AVQNTFSNPIYCSSEAITRPQRDKTRSAWGLETLAQRYPEAIFVIGQSQTALSTLVQLIRKKEVAPALVIATPAGFVNVV
QAKQELADSMVPHIRTEGRKGGPAVAAAVLDGLLDLAWHAYIRVSSADYPGKSAVS

Specific function: Catalyzes the conversion of cobalt-precorrin-8X to cobyrinic acid; a methyl migration reaction during the transformation of cobalt-precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: 5.4.1.2

Molecular weight: Translated: 23506; Mature: 23506

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWHVTDAESLMIIDQEVGKHELSPAEYEVVRRVIYATADFEYLNLIRFGNEALQAGAAA
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHH
LAARTTIVVDEPMVQVGIAWAVQNTFSNPIYCSSEAITRPQRDKTRSAWGLETLAQRYPE
HHHHEEEEECCCHHHHHHHHHHHHHCCCCEEECHHHHCCCCCHHHHHHHHHHHHHHHCCC
AIFVIGQSQTALSTLVQLIRKKEVAPALVIATPAGFVNVVQAKQELADSMVPHIRTEGRK
EEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCC
GGPAVAAAVLDGLLDLAWHAYIRVSSADYPGKSAVS
CCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCC
>Mature Secondary Structure
MEWHVTDAESLMIIDQEVGKHELSPAEYEVVRRVIYATADFEYLNLIRFGNEALQAGAAA
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHH
LAARTTIVVDEPMVQVGIAWAVQNTFSNPIYCSSEAITRPQRDKTRSAWGLETLAQRYPE
HHHHEEEEECCCHHHHHHHHHHHHHCCCCEEECHHHHCCCCCHHHHHHHHHHHHHHHCCC
AIFVIGQSQTALSTLVQLIRKKEVAPALVIATPAGFVNVVQAKQELADSMVPHIRTEGRK
EEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCC
GGPAVAAAVLDGLLDLAWHAYIRVSSADYPGKSAVS
CCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 8X

Specific reaction: precorrin-8X = hydrogenobyrinate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]